A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2
Open accessAbstract
An outbreak of coronavirus disease 2019 (COVID-19)1-3, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)4, has spread globally. Countermeasures are needed to treat and prevent further dissemination of the virus. Here we report the isolation of two specific human monoclonal antibodies (termed CA1 and CB6) from a patient convalescing from COVID-19. CA1 and CB6 demonstrated potent SARS-CoV-2-specific neutralization activity in vitro. In addition, CB6 inhibited infection with SARS-CoV-2 in rhesus monkeys in both prophylactic and treatment settings. We also performed structural studies, which revealed that CB6 recognizes an epitope that overlaps with angiotensin-converting enzyme 2 (ACE2)-binding sites in the SARS-CoV-2 receptor-binding domain, and thereby interferes with virus-receptor interactions by both steric hindrance and direct competition for interface residues. Our results suggest that CB6 deserves further study as a candidate for translation to the clinic.
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Polyclonal antibodies against multiple non-RBD spike epitopes might block viral attachment, add neutralizing activity, or prevent post-attachment fusion.
“A polyclonal antibody against multiple epitopes of the S protein beyond the RBD might, for example, inhibit viral attachment156–160, provide additional neutralizing activity161 and/or prevent post-attachment fusion162.”
From Immunological mechanisms of vaccine-induced protection against COVID-19 in humans (2021) · cites this paper as [160]
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Self-citation
- Authors
- Shi, R., Shan, C., Duan, X., Chen, Z., Liu, P., Song, J., Song, T., Bi, X., Han, C., Wu, L., Gao, G., Hu, X., Zhang, Y., Tong, Z., Huang, W., Liu, W. J., Wu, G., Zhang, B., Wang, L., Qi, J., Feng, H., Wang, F.-S., Wang, Q., Gao, G. F., Yuan, Z., & Yan, J.
- Affiliations
- Chinese Academy of Sciences (CN)
- Capital Medical University (CN)
- Chinese Center For Disease Control and Prevention (CN)
- Anhui University (CN)
- National Institutes for Food and Drug Control (CN)
- Junshi Biosciences (China) (CN)
- Corresponding author
- Gao, Ge
- Gao, George Fu
- Yuan, Zhiming
- Yan, Jinghua
- ORCID
- Venue
- Nature
- Published
- 2020-05-26
- Volume
- 584
- Issue
- 7819
- Pages
- 120-124
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W3032255042
- Cited by
- 1,286
- References
- 2
- Citations by year
- 2026: 30 · 2025: 59 · 2024: 91 · 2023: 129 · 2022: 292 · 2021: 482 · 2020: 201
- FWCI
- 36.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Natural Science Foundation of China (XDB29040201, 81922044, 81621091,, 2018119, 2018ZX09711003, 81973228)
- Youth Innovation Promotion Association of the Chinese Academy of Sciences (2018119)
- UC Berkeley College of Chemistry
- National Key Research and Development Program of China (SARS-CoV-2, 2018ZX09711003, 81621091, XDB29040201, 2020YFC0841400)
- Youth Innovation Promotion Association (2018119)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
- Keywords
- SARS-CoV-2, COVID-19 pandemic, neutralizing antibodies, monoclonal antibodies, receptor binding domain, ACE2, steric hindrance, rhesus macaque model
- MeSH terms
- Betacoronavirus, Angiotensin-Converting Enzyme 2, COVID-19, SARS-CoV-2, Animals, Antibodies, Viral, Binding, Competitive, Cell Line, Chlorocebus aethiops, Crystallization, Female, Humans, Peptidyl-Dipeptidase A, Macaca mulatta, Male, Models, Molecular, Neutralization Tests, Pneumonia, Viral, Protein Binding, Vero Cells, Coronavirus Infections, Crystallography, X-Ray, Viral Load, Antibodies, Neutralizing, Pandemics, Spike Glycoprotein, Coronavirus, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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