The quest to slow ageing through drug discovery

Metabolic maintenance of cell asymmetry following division in activated T lymphocytes

Verbist, K., Guy, C. S., Milasta, S., Liedmann, S., Kamiński, M. M., Wang, R., & Green, D. R. (2016) · Nature · doi:10.1038/nature17442 · Cited by 273

Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity

Conboy, M. J., Conboy, I. M., & Rando, T. A. (2013) · Aging Cell · doi:10.1111/acel.12065 · Cited by 265

Aspirin for the Primary Prevention of Cardiovascular Events: A Systematic Evidence Review for the U.S. Preventive Services Task Force

Guirguis‐Blake, J., Evans, C. V., Senger, C. A., O’Connor, E., & Whitlock, E. P. (2016) · Annals of Internal Medicine · doi:10.7326/m15-2113 · Cited by 264

An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers

Airhart, S. E., Shireman, L. M., Risler, L. J., Anderson, G. D., Gowda, G. A. N., Raftery, D., Tian, R., Shen, D. D., & O’Brien, K. D. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186459 · Cited by 264

17α-Estradiol Exerts Neuroprotective Effects on SK-N-SH Cells

Green, P. S., Bishop, J., & Simpkins, J. W. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-02-00511.1997 · Cited by 258

Higher spermidine intake is linked to lower mortality: a prospective population-based study

Kiechl, S. J., Pechlaner, R., Willeit, P., Notdurfter, M., Paulweber, B., Willeit, K., Werner, P., Ruckenstuhl, C., Iglseder, B., Weger, S., et al. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy102 · Cited by 257

Use of Sirolimus in Solid Organ Transplantation

Augustine, J. J., Bodziak, K. A., & Hricik, D. E. (2007) · Drugs · doi:10.2165/00003495-200767030-00004 · Cited by 248

D-Glucosamine supplementation extends life span of nematodes and of ageing mice

Weimer, S., Priebs, J., Kuhlow, D., Groth, M., Priebe, S., Mansfeld, J., Merry, T. L., Dubuis, S., Laube, B., Pfeiffer, A. F. H., et al. (2014) · Nature Communications · doi:10.1038/ncomms4563 · Cited by 245

Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8+ T cell differentiation

Pollizzi, K. N., Sun, I., Patel, C. H., Lo, Y.-C., Oh, M. H., Waickman, A. T., Tam, A. J., Blosser, R. L., Wen, J., Delgoffe, G. M., et al. (2016) · Nature Immunology · doi:10.1038/ni.3438 · Cited by 243

Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island

Apelo, S. I. A., & Lamming, D. W. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw090 · Cited by 241

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults

Konopka, A. R., Laurin, J. L., Schoenberg, H. M., Reid, J. J., Castor, W. M., Wolff, C. A., Musci, R. V., Safairad, O. D., Linden, M. A., Biela, L. M., et al. (2019) · Aging Cell · doi:10.1111/acel.12880 · Cited by 238

AMPK inhibits fatty acid-induced increases in NF-κB transactivation in cultured human umbilical vein endothelial cells

Cacicedo, J. M., Yagihashi, N., Keaney, J. F., Ruderman, N. B., & Ido, Y. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.09.177 · Cited by 236

Novel Insights into Lithium’s Mechanism of Action: Neurotrophic and Neuroprotective Effects

Quiroz, J. A., Machado‐Vieira, R., Zarate, C. A., & Manji, H. K. (2010) · Neuropsychobiology · doi:10.1159/000314310 · Cited by 233

Functional Gut Microbiota Remodeling Contributes to the Caloric Restriction-Induced Metabolic Improvements

Fabbiano, S., Suárez-Zamorano, N., Chevalier, C., Lazarević, V., Kieser, S., Rigo, D., Léo, S., Veyrat‐Durebex, C., Gaïa, N., Maresca, M., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.08.005 · Cited by 233

Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders

Chiu, C., & Chuang, D. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.07.006 · Cited by 232

Lower Risk of Cancer in Patients on Metformin in Comparison With Those on Sulfonylurea Derivatives

Ruiter, R., Visser, L. E., van Herk‐Sukel, M. P. P., Coebergh, J. W. W., Haak, H. R., Geelhoed-Duijvestijn, P. H. L. M., Straus, S. M. J. M., Herings, R. M. C., & Stricker, B. H. C. (2011) · Diabetes Care · doi:10.2337/dc11-0857 · Cited by 232

Estradiol protects against β-amyloid (25–35)-induced toxicity in SK-N-SH human neuroblastoma cells

Green, P. S., Gridley, K. E., & Simpkins, J. W. (1996) · Neuroscience Letters · doi:10.1016/s0304-3940(96)13148-7 · Cited by 231

Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice.

Ozcelik, S., Fraser, G., Castets, P., Schaeffer, V., Skachokova, Z., Breu, K., Clavaguera, F., Sinnreich, M., Kappos, L., Goedert, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062459 · Cited by 226

Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans

Edwards, C., Canfield, J., Copes, N., Brito, A. G., Rehan, M. A. Y., Lipps, D., Brunquell, J., Westerheide, S. D., & Bradshaw, P. C. (2015) · BMC Genetics · doi:10.1186/s12863-015-0167-2 · Cited by 226

Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice

Halloran, J. J., Hussong, S. A., Burbank, R. R., Podlutskaya, N., Fischer, K. E., Sloane, L. B., Austad, S. N., Strong, R., Richardson, A. G., Hart, M. J., et al. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.06.054 · Cited by 223

Critical evaluation of the role of acarbose in the treatment of diabetes: patient considerations

Rosak, C., & Mertes (2012) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s28340 · Cited by 221

Lithium levels in drinking water and risk of suicide

Ohgami, H., Terao, T., Shiotsuki, I., Ishii, N., & Iwata, N. (2009) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.108.055798 · Cited by 219

Chemical Inducers of Autophagy That Enhance the Clearance of Mutant Proteins in Neurodegenerative Diseases

Renna, M., Jiménez-Sánchez, M., Sarkar, S., & Rubinsztein, D. C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r109.072181 · Cited by 215

Exposure to a youthful circulation rejuvenates bone repair through modulation of β-catenin

Baht, G. S., Silkstone, D., Vi, L., Nadesan, P., Amani, Y., Whetstone, H., Wei, Q., & Alman, B. A. (2015) · Nature Communications · doi:10.1038/ncomms8131 · Cited by 214

Matching Dietary Amino Acid Balance to the In Silico-Translated Exome Optimizes Growth and Reproduction without Cost to Lifespan

Piper, M. D. W., Soultoukis, G. A., Blanc, E., Mesaros, A., Herbert, S. L., Juricic, P., He, X., Atanassov, I., Salmonowicz, H., Yang, M., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.02.005 · Cited by 214

Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism

Krishnaiah, S., Wu, G., Altman, B. J., Growe, J., Rhoades, S. D., Coldren, F., Venkataraman, A., Olarerin-George, A. O., Francey, L. J., Mukherjee, S., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.03.019 · Cited by 211

Lifelong rapamycin administration ameliorates age‐dependent cognitive deficits by reducing IL‐1β and enhancing NMDA signaling

Majumder, S., Caccamo, A., Medina, D. X., Benavides, A. D., Javors, M. A., Kraig, E., Strong, R., Richardson, A. G., & Oddo, S. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00791.x · Cited by 207

Metformin extends C. elegans lifespan through lysosomal pathway

Chen, J., Ou, Y., Li, Y., Hu, S., Shao, L.-W., & Liu, Y. (2017) · eLife · doi:10.7554/elife.31268 · Cited by 207

Two distinct functional high affinity receptors for mouse interleukin‐3 (IL‐3).

Hara, T., & Miyajima, A. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05239.x · Cited by 206

Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans

McColl, G., Killilea, D. W., Hubbard, A. E., Vantipalli, M. C., Melov, S., & Lithgow, G. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705028200 · Cited by 202

Regulation of T cells by mTOR: the known knowns and the known unknowns

Pollizzi, K. N., & Powell, J. D. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.11.005 · Cited by 202

Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila

Slack, C., Foley, A., & Partridge, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047699 · Cited by 199

Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain

Gontier, G., Iyer, M., Shea, J. M., Bieri, G., Wheatley, E. G., Ramalho-Santos, M., & Villeda, S. A. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.001 · Cited by 197

Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans

Hwang, A. B., Ryu, E.-A., Artan, M., Chang, H., Kabir, M. H., Nam, H.-J., Lee, D.-Y., Yang, J., Kim, S., Mair, W. B., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411199111 · Cited by 196

Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis

Castillo-Quan, J. I., Li, L., Kinghorn, K. J., Ivanov, D. K., Tain, L. S., Slack, C., Kerr, F., Nespital, T., Thornton, J. M., Hardy, J., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.03.041 · Cited by 194

Targeting polyamine metabolism for cancer therapy and prevention

Stewart, T. M., Woster, P. M., & Casero, R. A. (2016) · Biochemical Journal · doi:10.1042/bcj20160383 · Cited by 190

Rapamycin‐mediated mTORC 2 inhibition is determined by the relative expression of FK 506‐binding proteins

Schreiber, K. H., Ortiz, D., Academia, E. C., Anies, A. C., Liao, C., & Kennedy, B. K. (2015) · Aging Cell · doi:10.1111/acel.12313 · Cited by 183

Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults

Kulkarni, A. S., Brutsaert, E. F., Anghel, V., Zhang, K., Bloomgarden, N., Pollak, M., Mar, J. C., Hawkins, M., Crandall, J. P., & Barzilai, N. (2018) · Aging Cell · doi:10.1111/acel.12723 · Cited by 183

Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD(+) levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study

Dellinger, R. W., Santos, S. R., Morris, M., Evans, M., Alminana, D., Guarente, L., & Marcotulli, E. (2017) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-017-0016-9 · Cited by 181

Long-term lithium treatment in bipolar disorder is associated with longer leukocyte telomeres

Martinsson, L., Wei, Y., Xu, D., Melas, P. A., Mathé, A. A., Schalling, M., Lavebratt, C., & Backlund, L. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.37 · Cited by 179

Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy

Yue, F., Li, W., Zou, J., Jiang, X., Xu, G., Huang, H. W., & Liu, L. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-3462 · Cited by 178

The Role of Transposable Elements in Health and Diseases of the Central Nervous System

Reilly, M. T., Faulkner, G. J., Dubnau, J., Ponomarev, I., & Gage, F. H. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3369-13.2013 · Cited by 175

The impact of dietary protein intake on longevity and metabolic health

Kitada, M., Ogura, Y., Monno, I., & Koya, D. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.04.005 · Cited by 175

The Business of Anti-Aging Science

de Magalhães, J. P., Stevens, M., & Thornton, D. (2017) · Trends in biotechnology · doi:10.1016/j.tibtech.2017.07.004 · Cited by 174

Dietary protein, aging and nutritional geometry

Simpson, S. J., Le Couteur, D. G., Raubenheimer, D., Solon-Biet, S. M., Cooney, G. J., Cogger, V. C., & Fontana, L. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.03.001 · Cited by 169

Dietary rapamycin supplementation reverses age‐related vascular dysfunction and oxidative stress, while modulating nutrient‐sensing, cell cycle, and senescence pathways

Lesniewski, L. A., Seals, D. R., Walker, A. E., Henson, G. D., Blimline, M., Trott, D. W., Bosshardt, G. C., LaRocca, T. J., Lawson, B. R., Zigler, M. C., et al. (2016) · Aging Cell · doi:10.1111/acel.12524 · Cited by 168

The Influence of Type 2 Diabetes and Glucose-Lowering Therapies on Cancer Risk in the Taiwanese

Hsieh, M.-C., Lee, T.-C., Cheng, S.-M., Tu, S., Yen, M., & Tseng, C. (2012) · Experimental Diabetes Research · doi:10.1155/2012/413782 · Cited by 166

Glucose-lowering agents and cancer mortality rates in type 2 diabetes: assessing effects of time-varying exposure

Bowker, S. L., Yasui, Y., Veugelers, P. J., & Johnson, J. A. (2010) · Diabetologia · doi:10.1007/s00125-010-1750-8 · Cited by 166

Roles of O-GlcNAc in chronic diseases of aging

Banerjee, P. S., Lagerlöf, O., & Hart, G. W. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.05.005 · Cited by 165

Short‐term rapamycin treatment increases ovarian lifespan in young and middle‐aged female mice

Dou, X., Sun, Y., Li, J., Zhang, J., Hao, D., Liu, W., Wu, R., Kong, F., Peng, X., & Li, J. (2017) · Aging Cell · doi:10.1111/acel.12617 · Cited by 160

A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs

Urfer, S. R., Kaeberlein, T. L., Mailheau, S., Bergman, P. J., Creevy, K. E., Promislow, D. E. L., & Kaeberlein, M. (2017) · GeroScience · doi:10.1007/s11357-017-9972-z · Cited by 158

Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer’s disease

Lin, A., Jahrling, J. B., Zhang, W., DeRosa, N., Bakshi, V., Romero, P., Galván, V., & Richardson, A. G. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15621575 · Cited by 157

Effect of aspirin on the Wnt/β-catenin pathway is mediated via protein phosphatase 2A

Bos, C. L., Kodach, L. L., van den Brink, G. R., Diks, S. H., van Santen, M. M., Richel, D. J., Peppelenbosch, M. P., & Hardwick, J. C. H. (2006) · Oncogene · doi:10.1038/sj.onc.1209658 · Cited by 156

Preclinical Assessment of Young Blood Plasma for Alzheimer Disease

Middeldorp, J., Lehallier, B., Villeda, S. A., Miedema, S. S. M., Evans, E., Czirr, E., Zhang, H., Luo, J., Stan, T., Mosher, K. I., et al. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.3185 · Cited by 153

Anti-aging pharmacology: Promises and pitfalls

Vaiserman, A. M., Lushchak, O. V., & Koliada, A. K. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.004 · Cited by 148

Acarbose improves health and lifespan in aging HET3 mice

Harrison, D. E., Strong, R., Alavez, S., Astle, C. M., DiGiovanni, J., Fernández, E., Flurkey, K., Garratt, M., Gelfond, J., Javors, M. A., et al. (2019) · Aging Cell · doi:10.1111/acel.12898 · Cited by 140

60 years of metformin use: a glance at the past and a look to the future

Marshall, S. M. (2017) · Diabetologia · doi:10.1007/s00125-017-4343-y · Cited by 139

Low-dose lithium uptake promotes longevity in humans and metazoans

Zarse, K., Terao, T., Tian, J., Iwata, N., Ishii, N., & Ristow, M. (2011) · European Journal of Nutrition · doi:10.1007/s00394-011-0171-x · Cited by 137

Germline Signaling Mediates the Synergistically Prolonged Longevity Produced by Double Mutations in daf-2 and rsks-1 in C. elegans

Chen, D., Li, P. W.-L., Goldstein, B. A., Cai, W., Thomas, E. L., Chen, F., Hubbard, A., Melov, S., & Kapahi, P. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.11.018 · Cited by 134

Differential effects of metformin on age related comorbidities in older men with type 2 diabetes

Wang, C.-P., Lorenzo, C., Habib, S. L., Jo, B., & Espinoza, S. E. (2017) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2017.01.013 · Cited by 134

A pharmacological network for lifespan extension in C aenorhabditis elegans

Ye, X., Linton, J. M., Schork, N. J., Buck, L. B., & Petrascheck, M. (2013) · Aging Cell · doi:10.1111/acel.12163 · Cited by 132

Diagnosis and Management of Parkinson's Disease

Jankovic, J. J., & Tarakad, A. (2017) · Seminars in Neurology · doi:10.1055/s-0037-1601888 · Cited by 132

Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition

Dai, L., Huang, Q., & Boeke, J. D. (2011) · BMC Biochemistry · doi:10.1186/1471-2091-12-18 · Cited by 131

Three-dimensional human facial morphologies as robust aging markers

Chen, W., Qian, W., Wu, G., Chen, W., Xian, B., Chen, X., Cao, Y., Green, C. D., Zhao, F., Tang, K., et al. (2015) · Cell Research · doi:10.1038/cr.2015.36 · Cited by 130

Inhibiting Cellular Senescence: A New Therapeutic Paradigm for Age-Related Osteoporosis

Khosla, S., Farr, J. N., & Kirkland, J. L. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-02694 · Cited by 130

Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic

Moskalev, A., Chernyagina, E., Tsvetkov, V. O., Fedintsev, A., Shaposhnikov, M. V., Krutko, V. N., Zhavoronkov, A. A., & Kennedy, B. K. (2016) · Aging Cell · doi:10.1111/acel.12463 · Cited by 128

Yeast as a tool to identify anti-aging compounds

Zimmermann, A., Hofer, S. J., Pendl, T., Kainz, K., Madeo, F., & Carmona‐Gutiérrez, D. (2018) · FEMS Yeast Research · doi:10.1093/femsyr/foy020 · Cited by 126

Metformin: Do we finally have an anti-aging drug?

Anisimov, V. N. (2013) · Cell Cycle · doi:10.4161/cc.26928 · Cited by 125

Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease

Moskalev, A., Chernyagina, E., de Magalhães, J. P., Barardo, D., Thoppil, H., Shaposhnikov, M. V., Budovsky, A., Fraifeld, V. E., Garazha, A., Tsvetkov, V. O., et al. (2015) · Aging · doi:10.18632/aging.100799 · Cited by 123

Molecular mechanisms and biomedical applications of glucosamine as a potential multifunctional therapeutic agent

Dalirfardouei, R., Karimi, G., & Jamialahmadi, K. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.03.028 · Cited by 123

How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story

Richardson, A. G., Galván, V., Lin, A., & Oddo, S. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.12.002 · Cited by 122

Identification of potential caloric restriction mimetics by microarray profiling

Dhahbi, J. M., Mote, P. L., Fahy, G. M., & Spindler, S. R. (2005) · Physiological Genomics · doi:10.1152/physiolgenomics.00069.2005 · Cited by 122

Systemic Regulation of the Age-Related Decline of Pancreatic β-Cell Replication

Salpeter, S. J., Khalaileh, A., Weinberg-Corem, N., Ziv, O., Glaser, B., & Dor, Y. (2013) · Diabetes · doi:10.2337/db13-0160 · Cited by 122

Long-Term Treatment with Lithium Alleviates Memory Deficits and Reduces Amyloid-β Production in an Aged Alzheimer's Disease Transgenic Mouse Model

Zhang, X., Heng, X., Li, T., Li, L., Yang, D., Zhang, X., Du, Y., Doody, R. S., & Le, W. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101875 · Cited by 120

mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance

Haller, S., Kapuria, S., Riley, R. R., O’Leary, M. N., Schreiber, K. H., Andersen, J. K., Melov, S., Que, J., Rando, T. A., Rock, J. R., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.11.008 · Cited by 120

17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization

Stout, M. B., Steyn, F. J., Jurczak, M. J., Camporez, J.-P. G., Zhu, Y., Hawse, J. R., Jurk, D., Palmer, A. K., Xu, M., Pirtskhalava, T., et al. (2017) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glv309 · Cited by 119

Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity

Horiuchi, T., Sakata, N., Narumi, Y., Kimura, T., Hayashi, T., Nagano, K., Liu, K., Nishibori, M., Tsukita, S., Yamada, T., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.769380 · Cited by 119

Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function

Wang, J., Li, S., Wang, J., Wu, F., Chen, Y., Zhang, H., Guo, Y., Yan, L., Li, L., Yu, X., et al. (2020) · Aging · doi:10.18632/aging.102647 · Cited by 117

Clinical presentation and management of mTOR inhibitor-associated stomatitis

de Oliveira, M. A., Martins, F., Wang, Q., et al. (2011) · Oral Oncology · doi:10.1016/j.oraloncology.2011.08.009 · Cited by 114

Geroprotectors: A Unified Concept and Screening Approaches

Moskalev, A., Chernyagina, E., Kudryavtseva, A. V., & Shaposhnikov, M. V. (2017) · Aging and Disease · doi:10.14336/ad.2016.1022 · Cited by 110

A Proteomic Atlas of Senescence-Associated Secretomes for Aging Biomarker Development

(2019) · doi:10.1101/604306 · Cited by 110

Safety, Tolerability, and Feasibility of Young Plasma Infusion in the Plasma for Alzheimer Symptom Amelioration Study: A Randomized Clinical Trial

Sha, S. J., Deutsch, G. K., Tian, L., Richardson, K., Coburn, M., Gaudioso, J. L., Marcal, T., Solomon, E., Boumis, A., Bet, A., et al. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2018.3288 · Cited by 109

Compounds that confer thermal stress resistance and extended lifespan

Benedetti, M. G., Foster, A. L., Vantipalli, M. C., White, M. P., Sampayo, J. N., Gill, M. S., Olsen, A., & Lithgow, G. J. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.08.049 · Cited by 108

Preventive therapy for cancer

Cuzick, J. M. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30536-3 · Cited by 108

Ageing as a risk factor for ALS/FTD

Niccoli, T., Partridge, L., & Isaacs, A. M. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx247 · Cited by 106

Sex differences in lifespan extension with acarbose and 17‐α estradiol: gonadal hormones underlie male‐specific improvements in glucose tolerance and mTORC 2 signaling

Garratt, M., Bower, B., Garcia, G. G., & Miller, R. A. (2017) · Aging Cell · doi:10.1111/acel.12656 · Cited by 106

Non-steroidal anti-inflammatory drugs and risk of Parkinson’s disease in the elderly population: a meta-analysis

Poly, T. N., Islam, M. M., Yang, H., & Li, Y.-C. J. (2018) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-018-2561-y · Cited by 104

The Digital Ageing Atlas: integrating the diversity of age-related changes into a unified resource

Craig, T., Smelick, C., Tăcutu, R., Wuttke, D., Wood, S. H., Stanley, H., Janssens, G. E., Savitskaya, E. E., Moskalev, A., Arking, R., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku843 · Cited by 102

Lithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease

Sofola-Adesakin, O., Castillo-Quan, J. I., Rallis, C., Tain, L. S., Bjedov, I., Rogers, I., Li, L., Martinez, P., Khericha, M., Cabecinha, M., et al. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00190 · Cited by 100

A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans

Calvert, S., Tăcutu, R., Sharifi, S., Teixeira, R. M., Ghosh, P., & de Magalhães, J. P. (2015) · Aging Cell · doi:10.1111/acel.12432 · Cited by 100

Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to rapamycin

Xu, J., Pham, C. G., Albanese, S. K., Dong, Y., Oyama, T., Lee, C., Rodrik-Outmezguine, V. S., Yao, Z., Han, S. I., Chen, D., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86120 · Cited by 100

Glycine supplementation extends lifespan of male and female mice

Miller, R. A., Harrison, D. E., Astle, C. M., Bogue, M. A., BRIND, J. L., Fernández, E., Flurkey, K., Javors, M. A., Ladiges, W., Leeuwenburgh, C., et al. (2019) · Aging Cell · doi:10.1111/acel.12953 · Cited by 100

Nucleoside analogue reverse transcriptase inhibitors differentially inhibit human LINE-1 retrotransposition

Jones, R. B., Garrison, K. E., Wong, J. C., Duan, E. H., Nixon, D. F., & Ostrowski, M. A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001547 · Cited by 99

Digital health care for older adults

Evangelista, L., Steinhubl, S. R., & Topol, E. J. (2019) · The Lancet · doi:10.1016/s0140-6736(19)30800-1 · Cited by 98

Enhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Import

He, C. Z., Tsuchiyama, S. K., Nguyen, Q. T. T., Proshkina, E., Terrill, S. R., Sahibzada, S., Patel, B., Faulkner, A. R., Shaposhnikov, M. V., Tian, R., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004860 · Cited by 97

Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging

Janssens, G. E., Lin, X.-X., Millán-Ariño, L., Kavšek, A., Sen, I., Seinstra, R. I., Stroustrup, N., Nollen, E. A. A., & Riedel, C. G. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.044 · Cited by 96

Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice

Johnson, S. C., Yanos, M. E., Bitto, A., Castanza, A. S., Gagnidze, A., González, B., Gupta, K., Hui, J., Jarvie, C., Johnson, B. M., et al. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00247 · Cited by 93

Spermidine promotes retinal ganglion cell survival and optic nerve regeneration in adult mice following optic nerve injury

Noro, T., Namekata, K., Kimura, A. K., Guo, X., Azuchi, Y., Harada, C., Nakano, T., Tsuneoka, H., & Harada, T. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.93 · Cited by 93

Safety assessment of nicotinamide riboside, a form of vitamin B 3

Conze, D. B., Crespo-Barreto, J., & Kruger, C. L. (2016) · Human & Experimental Toxicology · doi:10.1177/0960327115626254 · Cited by 93

Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling

Zhou, Z.-Y., Ren, L.-W., Zhan, P., Yang, H.-Y., Chai, D.-D., & Yu, Z.-W. (2016) · Acta Pharmacologica Sinica · doi:10.1038/aps.2016.21 · Cited by 92

Interventions for age-related diseases: Shifting the paradigm

Figueira, I., Fernandes, A. M. A., Mladenović, A., Lopez-Contreras, A. J., Henriques, C. M., Selman, C., Ferreiro, E. B., Gonos, E. S., Trejo, J. L., Misra, J., et al. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.09.009 · Cited by 92

Hsp90 inhibitors as senolytic drugs to extend healthy aging

Fuhrmann-Stroissnigg, H., Niedernhofer, L. J., & Robbins, P. D. (2018) · Cell Cycle · doi:10.1080/15384101.2018.1475828 · Cited by 92

Polyamines in mammalian ageing: An oncological problem, too? A review

Scalabrino, G., & Ferioli, M. E. (1984) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(84)90090-3 · Cited by 91

A triple drug combination targeting components of the nutrient-sensing network maximizes longevity

Castillo-Quan, J. I., Tain, L. S., Kinghorn, K. J., Li, L., Grönke, S., Hinze, Y., Blackwell, T. K., Bjedov, I., & Partridge, L. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1913212116 · Cited by 91

Aspirin and other anti-inflammatory drugs

Vane, S. J. (2000) · Thorax · doi:10.1136/thorax.55.suppl_2.s3 · Cited by 90

Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling

Admasu, T. D., Batchu, K. C., Barardo, D., Ng, L. F., Lam, V. Y. M., Xiao, L., Cazenave‐Gassiot, A., Wenk, M. R., Tolwinski, N. S., & Gruber, J. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.09.001 · Cited by 87

A reappraisal on metformin

Adak, T., Samadi, A., Ünal, A. Z., & Sabuncuoğlu, S. (2017) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2017.12.023 · Cited by 86

mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases

Walters, H. E., & Cox, L. S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082325 · Cited by 85

Development of clinical trials to extend healthy lifespan

Justice, J. N., Niedernhofer, L., Robbins, P. D., Aroda, V. R., Espeland, M. A., Kritchevsky, S. B., Kuchel, G. A., & Barzilai, N. (2018) · Cardiovascular Endocrinology & Metabolism · doi:10.1097/xce.0000000000000159 · Cited by 84

Rapamycin preserves gut homeostasis during Drosophila aging

Fan, X., Liang, Q. D., Lian, T., Wu, Q., Gaur, U., Li, D., Yang, D., Mao, X., Jin, Z., Li, Y., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5895 · Cited by 82

Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway

Wan, Q.-L., Zheng, S., Wu, G.-S., & Luo, H. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.02.020 · Cited by 81

Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion

Liu, Y. J., Janssens, G. E., McIntyre, R. L., Molenaars, M., Kamble, R., Gao, A. W., Jongejan, A., van Weeghel, M., MacInnes, A. W., & Houtkooper, R. H. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1007633 · Cited by 81

Metformin directly targets the H3K27me3 demethylase KDM6A/UTX

Cuyàs, E., Verdura, S., Llorach-Parés, L., Fernández‐Arroyo, S., Luciano‐Mateo, F., Cabré, N., Štursa, J., Werner, L., Martı́n-Castillo, B., Viollet, B., et al. (2018) · Aging Cell · doi:10.1111/acel.12772 · Cited by 80

Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice

Cavalcante, M. B., Saccon, T. D., Nunes, A. D. C., Kirkland, J. L., Tchkonia, T., Schneider, A., & Masternak, M. M. (2020) · Aging · doi:10.18632/aging.102772 · Cited by 80

Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin

Popovich, I. G., Anisimov, V. N., Zabezhinski, M. A., Semenchenko, A. V., Тындык, М. Л., Yurova, M. N., & Blagosklonny, M. V. (2014) · Cancer Biology & Therapy · doi:10.4161/cbt.28164 · Cited by 79

Mechanisms and Αpplications of Ιnterleukins in Cancer Immunotherapy

Anestakis, D., Petanidis, S., Kalyvas, S., Nday, C. M., Tsave, O., Kioseoglou, E., & Salifoglou, A. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16011691 · Cited by 79

Anti‐aging drugs reduce hypothalamic inflammation in a sex‐specific manner

Sadagurski, M., Cady, G., & Miller, R. A. (2017) · Aging Cell · doi:10.1111/acel.12590 · Cited by 79

Rapamycin treatment attenuates age-associated periodontitis in mice

An, J. Y., Quarles, E. K., Mekvanich, S., Kang, A., Liu, A., Santos, D., Miller, R. A., Rabinovitch, P. S., Cox, T. C., & Kaeberlein, M. R. (2017) · GeroScience · doi:10.1007/s11357-017-9994-6 · Cited by 79

Glycine regulates the production of pro-inflammatory cytokines in lean and monosodium glutamate-obese mice

Alarcón-Aguilar, F. J., Almanza-Pérez, J. C., Blancas‐Flores, G., Mejía, S. Á., García-Macedo, R., Román, R. M., & Cruz, M. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.09.047 · Cited by 78

Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in Saccharomyces cerevisiae

Ha, C. W., & Huh, W.-K. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq895 · Cited by 77

Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy: A Consensus Statement From the American Diabetes Association and the European Association for the Study of Diabetes

Nathan, D. M., & On Behalf of the ADA/DASD Consensus Group (2006) · Diabetes Care · doi:10.2337/dc06-1864 · Cited by 73

Interaction between mTOR pathway inhibition and autophagy induction attenuates adriamycin-induced vascular smooth muscle cell senescence through decreased expressions of p53/p21/p16

Sung, J. Y., Lee, K. Y., Kim, J., & Choi, H. C. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.08.001 · Cited by 72

A Systems Approach to Reverse Engineer Lifespan Extension by Dietary Restriction

Hou, L., Wang, D., Chen, D., Liu, Y., Zhang, Y., Cheng, H., Xu, C., Sun, N., McDermott, J. R., Mair, W. B., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.02.002 · Cited by 71

Lack of evidence for GDF 11 as a rejuvenator of aged skeletal muscle satellite cells

Hinken, A. C., Powers, J. M., Luo, G., Holt, J. A., Billin, A. N., & Russell, A. J. (2016) · Aging Cell · doi:10.1111/acel.12475 · Cited by 71

Gene expression‐based drug repurposing to target aging

Dönertaş, H. M., Fuentealba, M., Partridge, L., & Thornton, J. M. (2018) · Aging Cell · doi:10.1111/acel.12819 · Cited by 71

Dysfunctional autophagy is a driver of muscle stem cell functional decline with aging

García-Prat, L., Muñoz-Cánoves, P., & Martinez-Vicente, M. (2016) · Autophagy · doi:10.1080/15548627.2016.1143211 · Cited by 70

Age-related compositional changes and correlations of gut microbiome, serum metabolome, and immune factor in rats

Zhang, X., Yang, Y., Su, J., Zheng, X., Wang, C., Chen, S., Liu, J., Lv, Y., Fan, S., Zhao, A., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00188-y · Cited by 70

Targeting glucose metabolism for healthy aging

Brewer, R. A., Gibbs, V. K., & Smith, D. L. (2016) · Nutrition and Healthy Aging · doi:10.3233/nha-160007 · Cited by 69

Alzheimer’s disease: where next for anti-amyloid therapies?

Hardy, J., & Strooper, B. D. (2017) · Brain · doi:10.1093/brain/awx059 · Cited by 69

In vitro and in vivo properties of chemically induced temperature-sensitive mutants of Chlamydia psittaci var. ovis: screening in a murine model

Rodolakis, A. (1983) · Infection and Immunity · doi:10.1128/iai.42.2.525-530.1983 · Cited by 68

Spermidine boosts autophagy to protect from synapse aging

Bhukel, A., Madeo, F., & Sigrist, S. J. (2016) · Autophagy · doi:10.1080/15548627.2016.1265193 · Cited by 68

In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state

Aliper, A. M., Belikov, A. V., Garazha, A., Jellen, L. C., Artemov, A. V., Suntsova, M., Ivanova, A., Venkova, L. S., Borisov, N. M., Buzdin, A. A., et al. (2016) · Aging · doi:10.18632/aging.101047 · Cited by 67

Rapamycin improves motor function, reduces 4-hydroxynonenal adducted protein in brain, and attenuates synaptic injury in a mouse model of synucleinopathy

Bai, X., Wey, M., Fernández, E., Hart, M. J., Gelfond, J., Bokov, A. F., Rani, S., & Strong, R. (2015) · Pathobiology of Aging & Age-related Diseases · doi:10.3402/pba.v5.28743 · Cited by 65

Influence of non-steroidal anti-inflammatory drugs on Drosophila melanogaster longevity

Danilov, A., Shaposhnikov, M., Shevchenko, O., Zemskaya, N., Zhavoronkov, A., & Moskalev, A. (2015) · Oncotarget · doi:10.18632/oncotarget.5118 · Cited by 64

Human geroprotector discovery by targeting the converging subnetworks of aging and age-related diseases

Yang, J., Peng, S., Zhang, B., Houten, S. M., Schadt, E. E., Zhu, J., Suh, Y., & Tu, Z. (2019) · GeroScience · doi:10.1007/s11357-019-00106-x · Cited by 64

Longevity in response to lowered insulin signaling requires glycine N‐methyltransferase‐dependent spermidine production

Tain, L. S., Jain, C., Nespital, T., Fröhlich, J., Hinze, Y., Grönke, S., & Partridge, L. (2019) · Aging Cell · doi:10.1111/acel.13043 · Cited by 64

Metformin reduces lipolysis in primary rat adipocytes stimulated by tumor necrosis factor-α or isoproterenol

Ren, T., He, J., Jiang, H., Zu, L., Pu, S., Guo, X., & Xu, G. (2006) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.02061 · Cited by 63

Implications of NAD metabolism in pathophysiology and therapeutics for neurodegenerative diseases

Hikosaka, K., Yaku, K., Okabe, K., & Nakagawa, T. (2021) · Nutritional Neuroscience · doi:10.1080/1028415x.2019.1637504 · Cited by 62

Anti-ageing pill pushed as bona fide drug

Hayden, E. C. (2015) · Nature · doi:10.1038/522265a · Cited by 60

Articulating the Case for the Longevity DividendPreprint

Olshansky, S. J. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025940 · Cited by 58

Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses

Maglione, M., Kochlamazashvili, G., Eisenberg, T., Rácz, B., Michael, E., Toppe, D., Stumpf, A., Wirth, A., Zeug, A., Müller, F. E., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-56133-3 · Cited by 58

Rapamycin treatment benefits glucose metabolism in mouse models of type 2 diabetes

Reifsnyder, P. C., Flurkey, K., Te, A. G., & Harrison, D. E. (2016) · Aging · doi:10.18632/aging.101117 · Cited by 57

A Young Blood Environment Decreases Aging of Senile Mice Kidneys

Huang, Q., Ning, Y., Liu, D., Zhang, Y., Li, D., Zhang, Y., Yin, Z., Fu, B., Cai, G., Sun, X., et al. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx183 · Cited by 56

Global Alliance for Chronic Disease researchers' statement on multimorbidity

Hurst, J. R., Dickhaus, J., Maulik, P. K., et al. (2018) · The Lancet Global Health · doi:10.1016/s2214-109x(18)30391-7 · Cited by 56

Effects of Lithium on Age-related Decline in Mitochondrial Turnover and Function in Caenorhabditis elegans

Tam, Z. Y., Gruber, J., Ng, L. F., Halliwell, B. B., & Gunawan, R. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt210 · Cited by 52

Testing Efficacy of Administration of the Antiaging Drug Rapamycin in a Nonhuman Primate, the Common Marmoset

Tardif, S. D., Ross, C. N., Bergman, P., Fernández, E., Javors, M., Salmon, A. B., Spross, J., Strong, R., & Richardson, A. G. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu101 · Cited by 52

Metabolic consequences of long-term rapamycin exposure on common marmoset monkeys (Callithrix jacchus)

Ross, C. N., Salmon, A. B., Strong, R., Fernández, E., Javors, M., Richardson, A. G., & Tardif, S. D. (2015) · Aging · doi:10.18632/aging.100843 · Cited by 52

Geroprotectors: A role in the treatment of frailty

Trendelenburg, A., Scheuren, A. C., Potter, P. K., Müller, R., & Bellantuono, I. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.03.002 · Cited by 52

Celecoxib extends C. elegans lifespan via inhibition of insulin-like signaling but not cyclooxygenase-2 activity

Ching, T., Chiang, W., Chen, C., & Hsu, A. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00688.x · Cited by 51

17‐α estradiol ameliorates age‐associated sarcopenia and improves late‐life physical function in male mice but not in females or castrated males

Garratt, M., Leander, D. C., Pifer, K., Bower, B., Herrera, J. J., Day, S. M., Fiehn, O., Brooks, S. V., & Miller, R. A. (2019) · Aging Cell · doi:10.1111/acel.12920 · Cited by 51

Initial metformin or sulphonylurea exposure and cancer occurrence among patients with type 2 diabetes mellitus

Qiu, H., Rhoads, G. G., Berlin, J. A., Marcella, S. W., & Demissie, K. (2012) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12036 · Cited by 49

Machine learning for predicting lifespan-extending chemical compounds

Barardo, D., Newby, D., Thornton, D., Ghafourian, T., de Magalhães, J. P., & Freitas, A. A. (2017) · Aging · doi:10.18632/aging.101264 · Cited by 49

An Engineering Approach to Extending Lifespan in C. elegans

Sagi, D., & Kim, S. K. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002780 · Cited by 47

17α‐estradiol acts through hypothalamic pro‐opiomelanocortin expressing neurons to reduce feeding behavior

Steyn, F. J., Ngo, S. T., Chen, V. P., Bailey‐Downs, L. C., Xie, T. Y., Ghadami, M., Brimijoin, S., Freeman, W. M., Rubinstein, M., Low, M. J., et al. (2017) · Aging Cell · doi:10.1111/acel.12703 · Cited by 47

Using the drug-protein interactome to identify anti-ageing compounds for humans

Fuentealba, M., Dönertaş, H. M., Williams, R., Labbadia, J. P., Thornton, J. M., & Partridge, L. (2019) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1006639 · Cited by 47

Matching Dietary Amino Acid Balance to the In Silico-Translated Exome Optimizes Growth and Reproduction without Cost to Lifespan

Piper, M. D. W., Soultoukis, G. A., Blanc, E., Mesaros, A., Herbert, S. L., Juricic, P., He, X., Atanassov, I., Salmonowicz, H., Yang, M., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.020 · Cited by 46

The role of cellular senescence in aging through the prism of Koch-like criteria

Yanai, H., & Fraifeld, V. E. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2017.10.004 · Cited by 45

The Economic Promise of Delayed AgingPreprint

Goldman, D. P. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025072 · Cited by 44

Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks

Stein, B. D., Calzolari, D., Hellberg, K., Hu, Y., He, L., Hung, C., Toyama, E. Q., Ross, D. S., Lillemeier, B. F., Cantley, L. C., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.117 · Cited by 44

Geroneuroprotectors: Effective Geroprotectors for the Brain

Schubert, D. A., Currais, A. J. M., Goldberg, J., Finley, K. D., Petrascheck, M., & Maher, P. A. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.09.008 · Cited by 43

Role of WNT/β-Catenin Signaling in Rejuvenating Myogenic Differentiation of Aged Mesenchymal Stem Cells from Cardiac Patients

Brunt, K. R., Zhang, Y., Mihic, A., Li, M., Li, S., Xue, P., Zhang, W., Basmaji, S., Tsang, K., Weisel, R. D., et al. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.08.021 · Cited by 42

Rapamycin and the inhibition of the secretory phenotype

Wang, R., Sunchu, B., & Pérez, V. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.01.026 · Cited by 42

The stress response factor daf-16/FOXO is required for multiple compound families to prolong the function of neurons with Huntington’s disease

Farina, F., Lambert, E., Commeau, L., Lejeune, F., Roudier, N., Fonte, C., Parker, J. A., Boddaert, J., Verny, M., Baulieu, É.-É., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-04256-w · Cited by 42

Emerging Trends in Metformin Prescribing in the United States from 2000 to 2015

Le, S., & Lee, G. C. (2019) · Clinical Drug Investigation · doi:10.1007/s40261-019-00799-0 · Cited by 42

Effect of inhibition of α-glucosidase on age-related glucose intolerance and pancreatic atrophy in rats

Yamamoto, M., & Otsuki, M. (2006) · Metabolism · doi:10.1016/j.metabol.2005.11.007 · Cited by 39

Aspirin disrupts the mTOR-Raptor complex and potentiates the anti-cancer activities of sorafenib via mTORC1 inhibition

Sun, D., Liu, H., Dai, X., Zheng, X., Yan, J., Wei, R., Fu, X., Huang, M., Shen, A., Huang, X., et al. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.06.029 · Cited by 38

PGC‐1a integrates a metabolism and growth network linked to caloric restriction

Miller, K. N., Clark, J. P., Martin, S. A., Howell, P. R., Burhans, M. S., Haws, S. A., Johnson, N. B., Rhoads, T. W., Pavelec, D. M., Eliceiri, K. W., et al. (2019) · Aging Cell · doi:10.1111/acel.12999 · Cited by 38

Alpha and beta estradiol protect neuronal but not native PC12 cells from paraquat-induced oxidative stress

Gélinas, S., Bureau, G. P., Valastro, B., et al. (2004) · Neurotoxicity Research · doi:10.1007/bf03033216 · Cited by 36

A High-Throughput Screen for Yeast Replicative Lifespan Identifies Lifespan-Extending Compounds

Sarnoski, E. A., Liu, P., & Açar, M. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.11.002 · Cited by 35

Therapeutic potential of systemic brain rejuvenation strategies for neurodegenerative disease

Horowitz, A. M., & Villeda, S. (2017) · F1000Research · doi:10.12688/f1000research.11437.1 · Cited by 32

Mortality in Individuals Treated With Glucose-Lowering Agents: A Large, Controlled Cohort Study

Claesen, M., Gillard, P., Smet, F. D., Callens, M., Moor, B. D., & Mathieu, C. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3184 · Cited by 31

Pharmaceutical inhibition of mTOR in the common marmoset: effect of rapamycin on regulators of proteostasis in a non-human primate

Lelegren, M. J., Liu, Y., Ross, C. N., Tardif, S. D., & Salmon, A. B. (2016) · Pathobiology of Aging & Age-related Diseases · doi:10.3402/pba.v6.31793 · Cited by 29

Dietary glycine supplementation mimics lifespan extension by dietary methionine restriction in Fisher 344 rats

BRIND, J. L., Malloy, V. L., Augie, I., et al. (2011) · The FASEB Journal · doi:10.1096/fasebj.25.1_supplement.528.2 · Cited by 28

Discontinuous low-dose flutamide–metformin plus an oral or a transdermal contraceptive in patients with hyperinsulinaemic hyperandrogenism: normalizing effects on CRP, TNF-α and the neutrophil/lymphocyte ratio

Ibáñez, L., Valls, C., & de Zegher, F. (2005) · Human Reproduction · doi:10.1093/humrep/dei329 · Cited by 28

Identifying Potential Ageing-Modulating Drugs In Silico

Dönertaş, H. M., Fuentealba, M., Partridge, L., & Thornton, J. M. (2018) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2018.11.005 · Cited by 28

Broadening the therapeutic scope for rapamycin treatment

Menzies, F. M., & Rubinsztein, D. C. (2010) · Autophagy · doi:10.4161/auto.6.2.11078 · Cited by 27

Systemic regulation of the age-related decline of pancreatic β-cell replication. Diabetes 2013;62:2843–2848

Salpeter, S., Khalaileh, A., Weinberg-Corem, N., Ziv, O., Gläser, B., & Dor, Y. (2013) · Diabetes · doi:10.2337/db13-er09 · Cited by 26

Finding Ponce de Leon’s Pill: Challenges in Screening for Anti-Aging Molecules

Kumar, S., & Lombard, D. B. (2016) · F1000Research · doi:10.12688/f1000research.7821.1 · Cited by 25

Metabolome analysis of effect of aspirin on Drosophila lifespan extension

Song, C., Zhu, C., Wu, Q., Qi, J., Gao, Y., Zhang, Z., Gaur, U., Yang, D., Fan, X., & Yang, M. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.04.010 · Cited by 25

Repurposed FDA-approved drugs targeting genes influencing aging can extend lifespan and healthspan in rotifers

Snell, T. W., Johnston, R. K., Matthews, A. B., Zhou, H., Gao, M., & Skolnick, J. (2018) · Biogerontology · doi:10.1007/s10522-018-9745-9 · Cited by 23

Mammalian Target of Rapamycin: A Target for (Lung) Diseases and Aging

Kennedy, B. K., & Pennypacker, J. K. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201609-680aw · Cited by 18

Screening lifespan-extending drugs in Caenorhabditis elegans via label propagation on drug-protein networks

Liu, H., Guo, M., Xue, T., Guan, J., Luo, L., & Zhuang, Z. (2016) · BMC Systems Biology · doi:10.1186/s12918-016-0362-4 · Cited by 17

A network-based meta-analysis for characterizing the genetic landscape of human aging

Blankenburg, H., Pramstaller, P. P., & Domingues, F. S. (2017) · Biogerontology · doi:10.1007/s10522-017-9741-5 · Cited by 17

Systematic Analysis of Cell Cycle Effects of Common Drugs Leads to the Discovery of a Suppressive Interaction between Gemfibrozil and Fluoxetine

Hoose, S. A., Duran, C. L., Malik, I., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036503 · Cited by 16

The synthetic estrogen 4-estren-3α,17β-diol (estren) induces estrogen-like neuroprotection

Cordey, M., Gundimeda, U., Gopalakrishna, R., & Pike, C. J. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.01.011 · Cited by 16

Therapeutic Manipulation of Ageing: Repurposing Old Dogs and Discovering New Tricks

Mallikarjun, V., & Swift, J. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.11.020 · Cited by 14

Pairwise combinations of chemical compounds that delay yeast chronological aging through different signaling pathways display synergistic effects on the extent of aging delay

Dakik, P., McAuley, M., Chancharoen, M., Mitrofanova, D., Rodriguez, M. E. L., Junio, J. A. B., Lutchman, V., Cortes, B., Simard, É., & Titorenko, V. I. (2019) · Oncotarget · doi:10.18632/oncotarget.26553 · Cited by 13

Lithium in drinking water

Schrauzer, G. N., & Shrestha, K. P. (2010) · The British Journal of Psychiatry · doi:10.1192/bjp.196.2.159a · Cited by 12

New drugs for pharmacological extension of replicative life span in normal and progeroid cells

Vatolin, S., Radivoyevitch, T., & Maciejewski, J. P. (2019) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-018-0032-4 · Cited by 10

PubChem

Central, I.-B., González‐Fabra, J., Álvarez, M., & Gumbau, M. (2017) · ioChem-BD Computational Chemistry Datasets · doi:10.19061/iochem-bd-6-3 · Cited by 9

Rapamycin keeps the reproductive clock ticking

Hine, C. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aan4296 · Cited by 8

Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300: response to correspondence by Borzì et al.

Sacitharan, P. K., Gharios, G. B., & Edwards, J. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0225-3 · Cited by 8

Medullary expiratory activity during opossum development

Farber, J. P. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.66.4.1606 · Cited by 5

Cellular senescence and cancer

(1999) · doi:10.1002/(sici)1096-9896(199901)187:1

Untitled work

(2013) · PubMed

Hallmarks of aging: An expanding universe

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023) · Cell · doi:10.1016/j.cell.2022.11.001 · Cited by 6,549

Autophagy in healthy aging and disease

Aman, Y., Schmauck-Medina, T., Hansen, M., Morimoto, R. I., Simon, A. K., Bjedov, I., Palikaras, K., Simonsen, A., Johansen, T., Tavernarakis, N., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00098-4 · Cited by 1,313

cGAS–STING drives ageing-related inflammation and neurodegeneration

Gulen, M. F., Samson, N., Keller, A., Schwabenland, M., Liu, C., Glück, S., Thacker, V. V., Favre, L., Mangeat, B., Kroese, L. J., et al. (2023) · Nature · doi:10.1038/s41586-023-06373-1 · Cited by 1,104

Meta-hallmarks of aging and cancer

López-Otín, C., Pietrocola, F., Roiz-Valle, D., Galluzzi, L., & Kroemer, G. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2022.11.001 · Cited by 529

Alzheimer’s disease drug development pipeline: 2021

Cummings, J., Lee, G., Zhong, K., Fonseca, J., & Taghva, K. (2021) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1002/trc2.12179 · Cited by 539

Two-step ageing and final size of G.P. zones in Al-Zn 10% alloy

Ceresara, S., & Giarda, A. (1974) · Philosophical magazine · doi:10.1080/14786437408226183 · Cited by 6

Radiochemical ageing of highly filled EPDM seals as revealed by accelerated ageing and ageing in-service for 21 years

Pourmand, P., Hedenqvist, M. S., Furó, I., et al. (2017) · Polymer Degradation and Stability · doi:10.1016/j.polymdegradstab.2017.09.008 · Cited by 17

Effect of Pre-Ageing on the Artificial Ageing Response of Al-Mg-Si(-Cu) Alloys

Cao, L. F., Rometsch, P. A., Zhong, H., et al. (2010) · Materials science forum · doi:10.4028/www.scientific.net/msf.654-656.918 · Cited by 4

The influence of natural ageing on the artificial ageing response of Al-Si-Cu-Mg casting alloys

Sjölander, E., & Seifeddine, S. (2013) · Frattura ed Integrità Strutturale · Cited by 4

HEART AND AGE (PART I): AGEING THEORIES AND MORPHOLOGICAL CHANGES

Akasheva, D. U., Strazhesko, I. D., Dudinskaya, Е. N., Naydenko, E. V., & Tkacheva, O. N. (2013) · CARDIOVASCULAR THERAPY AND PREVENTION · doi:10.15829/1728-8800-2013-1-88-94 · Cited by 4