Cited by 854Diet, Metabolism, and DiseaseObesity, Physical Activity, DietNutritional Studies and Diet

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The role of sugar-sweetened beverages in the global epidemics of obesity and chronic diseases

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Malik, Vasanti S., Hu, Frank B.·2022·Nature Reviews Endocrinology

DOI 10.1038/s41574-021-00627-6PMC PMC8778490

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Abstract

Sugar-sweetened beverages (SSBs) are a major source of added sugars in the diet. A robust body of evidence has linked habitual intake of SSBs with weight gain and a higher risk (compared with infrequent SSB consumption) of type 2 diabetes mellitus, cardiovascular diseases and some cancers, which makes these beverages a clear target for policy and regulatory actions. This Review provides an update on the evidence linking SSBs to obesity, cardiometabolic outcomes and related cancers, as well as methods to grade the strength of nutritional research. We discuss potential biological mechanisms by which constituent sugars can contribute to these outcomes. We also consider global trends in intake, alternative beverages (including artificially-sweetened beverages) and policy strategies targeting SSBs that have been implemented in different settings. Strong evidence from cohort studies on clinical outcomes and clinical trials assessing cardiometabolic risk factors supports an aetiological role of SSBs in relation to weight gain and cardiometabolic diseases. Many populations show high levels of SSB consumption and in low-income and middle-income countries, increased consumption patterns are associated with urbanization and economic growth. As such, more intensified policy efforts are needed to reduce intake of SSBs and the global burden of obesity and chronic diseases. Evidence from cohort studies and clinical trials supports an aetiological role of sugar-sweetened beverage (SSB) intake in the development of obesity and related chronic diseases. This Review provides an up-to-date view, considering the evidence, potential mechanisms and policy actions to reduce the global intake of SSBs.

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Authors: Malik, V. S., & Hu, F. B.
Affiliations: Harvard University (US)
Brigham and Women's Hospital (US)
Corresponding author: Malik, Vasanti S.
Hu, Frank B.
ORCID: Malik, Vasanti S.
Hu, Frank B.
Venue: Nature Reviews Endocrinology
Publisher: Springer Science and Business Media LLC
Published: 2022-01-21
Volume: 18
Issue: 4
Pages: 205-218
ISSN: 1759-5029 (ISSN-L)
1759-5037
DOI: 10.1038/s41574-021-00627-6
PMC: PMC8778490
OpenAlex: W4207002397
Cited by: 854
References: 155
Citations by year: 2026: 162 · 2025: 236 · 2024: 227 · 2023: 160 · 2022: 69
FWCI: 24.63
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Reviews Endocrinology (publishedVersion, cc-by)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: sugar-sweetened beverages, obesity, type 2 diabetes, cardiovascular disease, cancer risk, cardiometabolic risk, added sugars, weight gain, urbanization, low- and middle-income countries, beverage consumption trends, artificially sweetened beverages, level of evidence, biological mechanisms
MeSH terms: Sugars, Sugar-Sweetened Beverages, Cardiovascular Diseases, Chronic Disease, Diabetes Mellitus, Type 2, Humans, Obesity, Weight Gain, Epidemics

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The role of sugar-sweetened beverages in the global epidemics of obesity and chronic diseases

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