Cited by 154Gut microbiota and healthClostridium difficile and Clostridium perfringens researchGastrointestinal motility and disorders

Recipient factors in faecal microbiota transplantation: one stool does not fit all

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Danne, Camille, Rolhion, Nathalie, Sokol, Harry·2021·Nature Reviews Gastroenterology & Hepatology

Abstract

Faecal microbiota transplantation (FMT) is a promising therapy for chronic diseases associated with gut microbiota alterations. FMT cures 90% of recurrent Clostridioides difficile infections. However, in complex diseases, such as inflammatory bowel disease, irritable bowel syndrome and metabolic syndrome, its efficacy remains variable. It is accepted that donor selection and sample administration are key determinants of FMT success, yet little is known about the recipient factors that affect it. In this Perspective, we discuss the effects of recipient parameters, such as genetics, immunity, microbiota and lifestyle, on donor microbiota engraftment and clinical efficacy. Emerging evidence supports the possibility that controlling inflammation in the recipient intestine might facilitate engraftment by reducing host immune system pressure on the newly transferred microbiota. Deciphering FMT engraftment rules and developing novel therapeutic strategies are priorities to alleviate the burden of chronic diseases associated with an altered gut microbiota such as inflammatory bowel disease.

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  • The high efficacy rate of FMT in rCDI is not observed under other conditions where the characteristics of donors, recipients, and working protocols appear to largely impact clinical outcomes.

    “This concept is supported by evidence that the high efficacy rate of FMT in rCDI is not observed under other conditions where the characteristics of donors, 26,39 recipients, 41,42 and working protocols, 43 appear to largely impact clinical outcomes.”

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Authors
Danne, C., Rolhion, N., & Sokol, H.
Affiliations
Inserm (FR)
Corresponding author
Sokol, Harry
Venue
Nature Reviews Gastroenterology & Hepatology
Published
2021-04-27
Volume
18
Issue
7
Pages
503-513
ISSN
  • 1759-5045 (ISSN-L)
  • 1759-5053
OpenAlex
W3157096715
Cited by
154
References
159
Citations by year
2026: 25 · 2025: 30 · 2024: 30 · 2023: 21 · 2022: 35 · 2021: 13
FWCI
2.60
Type
journal article
Language
en
Locations
  • Nature Reviews Gastroenterology & Hepatology (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
  • HAL (submittedVersion)
Funders
Agence Nationale de la Recherche (ANR-17-CE15-0019)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
fecal microbiota transplantation, recipient factors, donor selection, host genetics, host immunity, intestinal inflammation, gut microbiota, inflammatory bowel disease, irritable bowel syndrome, metabolic syndrome, Clostridium difficile infection, treatment efficacy
MeSH terms
Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Digestive System Diseases, Humans, Inflammation, Life Style, Treatment Outcome, Donor Selection

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