Fecal microbiota transplantation as therapy for inflammatory bowel disease: A systematic review and meta-analysis
Open accessAbstract
Background and aims: Fecal microbiota transplantation (FMT) has gained interest as a novel treatment option for inflammatory bowel diseases (IBD). While publications describing FMT as therapy for IBD have more than doubled since 2012, research that investigates FMT treatment efficacy has been scarce. We conducted a systematic review and meta-analysis to evaluate the efficacy of FMT as treatment for patients with IBD. Methods: A systematic literature search was performed through May 2014. Inclusion criteria required FMT as the primary therapeutic agent. Clinical remission (CR) and/or mucosal healing were defined as primary outcomes. Studies were excluded if they did not report clinical outcomes or included patients with infections. Results: Eighteen studies (9 cohort studies, 8 case studies and 1 randomized controlled trial) were included. 122 patients were described (79 ulcerative colitis (UC); 39 Crohn's disease (CD); 4 IBD unclassified). Overall, 45% (54/119) of patients achieved CR during follow-up. Among the cohort studies, the pooled proportion of patients that achieved CR was 36.2% (95% CI 17.4%–60.4%), with a moderate risk of heterogeneity (Cochran's Q, P = 0.011; I2 = 37%). Subgroup analyses demonstrated a pooled estimate of clinical remission of 22% (95% CI 10.4%–40.8%) for UC (P = 0.37; I2 = 0%) and 60.5% (95% CI 28.4%–85.6%) for CD (P = 0.05; I2 = 37%). Six studies performed microbiota analysis. Conclusions: This analysis suggests that FMT is a safe, but variably efficacious treatment for IBD. More randomized controlled trials are needed and should investigate frequency of FMT administration, donor selection and standardization of microbiome analysis.
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A systematic review and meta-analysis of fecal microbiota transplantation in IBD found that overall 45% (54/119) of patients achieved clinical remission.
“overall 45% (54/119) achieved clinical remission.”
From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [75]
In the same meta-analysis, when only cohort studies were analysed, 36% achieved clinical remission.
“When only cohort studies were analysed 36% achieved clinical remission.75”
From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [75]
Small studies of FMT in children and adults with UC, Crohn's disease, and pouchitis have had mixed results.
“These reports were followed by a number of small studies of FMT in children and adults with UC, CD, and pouchitis with mixed results.64–72”
From Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook (2015) · cites this paper as [72]
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- Authors
- Colman, R. J., & Rubin, D. T.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Rubin, David T.
- Venue
- Journal of Crohn's and Colitis
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-12-01
- Volume
- 8
- Issue
- 12
- Pages
- 1569-1581
- ISSN
- 1873-9946 (ISSN-L)
- 1876-4479
- PMC
- PMC4296742
- OpenAlex
- W2056515449
- Cited by
- 475
- References
- 55
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- FWCI
- 7.86
- Type
- journal article
- Language
- en
- Update notices
- expression_of_concern (2022-01-24)
- Open access
- bronze
- doi.org
- Locations
- Journal of Crohn s and Colitis (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- PubMed Central (acceptedVersion)
- Funders
- Digestive Diseases Research Core Center (DDRCC) (NIDDK P30DK42086)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Microscopic Colitis
- Keywords
- fecal microbiota transplantation, inflammatory bowel disease
- MeSH terms
- Feces, Humans, Intestinal Mucosa, Remission Induction, Transplantation, Inflammatory Bowel Diseases, Gastrointestinal Tract, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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