The DOI matches its Crossref record; 203 of the 203 references it cites were found in a registry or an index.
The gut microbiome as a modulator of healthy ageing
Open accessAbstract
The gut microbiome is a contributory factor in ageing-related health loss and in several non-communicable diseases in all age groups. Some age-linked and disease-linked compositional and functional changes overlap, while others are distinct. In this Review, we explore targeted studies of the gut microbiome of older individuals and general cohort studies across geographically distinct populations. We also address the promise of the targeted restoration of microorganisms associated with healthier ageing.
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“The microbiota and its metabolites are altered during ageing; for example, the abundance of the anti-inflammatory bacterium Faecalibacterium decreases, whereas that of proinflammatory Fusobacterium increases, leading to intestinal inflammation.234”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [234]
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“Finally, late life ushers in tertiary succession, which is marked by declining α- and β-diversity and loss of keystone commensals like Faecalibacterium and Bifidobacterium.39,40”
From Gut dysbiosis in oncology: a risk factor for immunoresistance (2026) · cites this paper as [40]
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“However, the composition and activity of this microbial ecosystem undergoes continuous changes during aging, which finally results in a substantial decrease in diversity.”
From Meta-hallmarks of aging and cancer (2023) · cites this paper as [88]
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1 retracted
Retracted: Gut Microbiome Signatures of Risk and Prodromal Markers of Parkinson Disease
Heinzel, S., Aho, V. T. E., Suenkel, U., von Thaler, A., Schulte, C., Deuschle, C., Paulin, L., Hantunen, S., Brockmann, K., Eschweiler, G. W., et al. (2020) · Annals of Neurology · doi:10.1002/ana.25788 · Cited by 95
RetractedLópez-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413
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Ley, R. E., Hamady, M., Lozupone, C., Turnbaugh, P. J., Ramey, R. R., Bircher, J. S., Schlegel, M. L., Tucker, T. A., Schrenzel, M. D., Knight, R., et al. (2008) · Science · doi:10.1126/science.1155725 · Cited by 3,747
The Human Intestinal Microbiome in Health and Disease
Lynch, S. V., & Pedersen, O. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1600266 · Cited by 3,637
Gut microbiota composition correlates with diet and health in the elderly
Claesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O’Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., et al. (2012) · Nature · doi:10.1038/nature11319 · Cited by 3,314
Self-citationDepommier, C., Everard, A., Druart, C., Plovier, H., Van Hul, M., Vieira-Silva, S., Falony, G., Raes, J., Maiter, D., Delzenne, N. M., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0495-2 · Cited by 2,357
The role of the gut microbiota in nutrition and health
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Liu, Y., Wang, C., Cui, L., Guo, X., Wang, X., & 宁, 玉. (2026) · Metabolites · doi:10.3390/metabo16100787
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Zhao, X., Gong, J., Lv, J., Li, P., Ji, X., Geng, Y., & Xing, L. (2026) · Research Square · doi:10.21203/rs.3.rs-11068213/v1
Boro, S., Bharadwaj, B., & Nakrani, S. (2026) · IGI Global eBooks · doi:10.4018/979-8-2600-4190-1.ch003
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Юн, К. Ч. (n.d.) · CyberLeninK (CyberLeninka)
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Metadata
- Authors
- Ghosh, T. S., Shanahan, F., & O’Toole, P. W.
- Affiliations
- National University of Ireland (IE)
- Corresponding author
- O’Toole, Paul W.
- Venue
- Nature Reviews Gastroenterology & Hepatology
- Published
- 2022-04-25
- Volume
- 19
- Issue
- 9
- Pages
- 565-584
- ISSN
- 1759-5045 (ISSN-L)
- 1759-5053
- PMC
- PMC9035980
- OpenAlex
- W4224868124
- Cited by
- 817
- References
- 203
- Citations by year
- 2026: 217 · 2025: 230 · 2024: 223 · 2023: 120 · 2022: 26
- FWCI
- 15.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Reviews Gastroenterology & Hepatology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota, healthy aging, non-communicable diseases, older adults, microbiota composition, microbiome function, microbiota restoration
- MeSH terms
- Gastrointestinal Microbiome, Healthy Aging, Humans
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