The gut microbiome as a modulator of healthy ageing

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982

The Microbiota-Gut-Brain Axis

Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413

Evolution of mammals and their gut microbes

Ley, R. E., Hamady, M., Lozupone, C., Turnbaugh, P. J., Ramey, R. R., Bircher, J. S., Schlegel, M. L., Tucker, T. A., Schrenzel, M. D., Knight, R., et al. (2008) · Science · doi:10.1126/science.1155725 · Cited by 3,747

The Human Intestinal Microbiome in Health and Disease

Lynch, S. V., & Pedersen, O. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1600266 · Cited by 3,637

Gut microbiota composition correlates with diet and health in the elderly

Claesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O’Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., et al. (2012) · Nature · doi:10.1038/nature11319 · Cited by 3,314

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: A proof-of-concept exploratory study

Depommier, C., Everard, A., Druart, C., Plovier, H., Van Hul, M., Vieira-Silva, S., Falony, G., Raes, J., Maiter, D., Delzenne, N. M., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0495-2 · Cited by 2,357

The role of the gut microbiota in nutrition and health

Flint, H. J., Scott, K. P., Louis, P., & Duncan, S. H. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.156 · Cited by 2,283

Human gut microbes impact host serum metabolome and insulin sensitivity

Pedersen, H. K., Gudmundsdottir, V., Nielsen, H. B., Hyotylainen, T., Nielsen, T., Jensen, B. A. H., Forslund, K., Hildebrand, F., Prifti, E., Falony, G., et al. (2016) · Nature · doi:10.1038/nature18646 · Cited by 2,116

Alteration of gut microbiota in wild-borne long-tailed macaques after 1-year being housed in hygienic captivity

Sawaswong, V., Chanchaem, P., Kemthong, T., Warit, S., Chaiprasert, A., Malaivijitnond, S., & Payungporn, S. (2023) · Scientific Reports · doi:10.1038/s41598-023-33163-6 · Cited by 20

Microbial dysbiosis and the aging process: a review on the potential age-deceleration role of Lactiplantibacillus plantarum

Gupta, N., El-Gawaad, N. S. A., Mallasiy, L. O., Gupta, H., Yadav, V. K., Alghamdi, S. A., & Qusty, N. F. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1260793 · Cited by 20

A diet of oxidative stress–adapted bacteria improves stress resistance and lifespan in C. elegans via p38-MAPK

Bhat, A., Cox, R. L., Hendrickson, B. G., Das, N. K., Schaller, M. L., Tuckowski, A. M., Wang, E., Shah, Y. M., & Leiser, S. F. (2024) · Science Advances · doi:10.1126/sciadv.adk8823 · Cited by 20

Microbiota mitochondria disorders as hubs for early age-related macular degeneration

Fehér, J., Élő, Á., István, L., Nagy, Z. Z., Radak, Z. O., Scuderi, G., Artico, M., & Kovács, I. (2022) · GeroScience · doi:10.1007/s11357-022-00620-5 · Cited by 20

A double-blind intervention trial in healthy women demonstrates the beneficial impact on Bifidobacterium with low dosages of prebiotic galacto-oligosaccharides

Looijesteijn, E., Schoemaker, M. H., van den Belt, M., Hester, E. R., Kortman, G. A. M., van Dongen, M. V., & Nauta, A. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1440319 · Cited by 19

The gut microbiome: an emerging epicenter of antimicrobial resistance?

Deshpande, S. V., Sujith, S., Jobby, R., Rajasekharan, S. K., Ravichandran, V., & Solomon, A. P. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1593065 · Cited by 19

Alzheimer’s disease and depression in the elderly: A trajectory linking gut microbiota and serotonin signaling

Cutuli, D., Giacovazzo, G., Decandia, D., & Coccurello, R. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1010169 · Cited by 19

Gut microbiota in relation to frailty and clinical outcomes

D’Amico, F., Barone, M., Brigidi, P., & Turroni, S. (2023) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000926 · Cited by 19

Lactiplantibacillus plantarum CCFM8661 alleviates d -galactose-induced brain aging in mice by the regulation of the gut microbiota

Chen, F., Pan, J., Yu, L., Wang, S., Zhang, C., Zhao, J., Narbad, A., Zhai, Q., & Tian, F. (2023) · Food & Function · doi:10.1039/d3fo03377e · Cited by 19

Engraftment of aging-related human gut microbiota and the effect of a seven-species consortium in a pre-clinical model

Ye, H., Ghosh, T. S., Hueston, C. M., Vlčková, K., Golubeva, A. V., Hyland, N. P., & O’Toole, P. W. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2282796 · Cited by 19

Gut Microbiota Defined Epigenomes of Alzheimer’s and Parkinson’s Diseases Reveal Novel Targets for Therapy

Nohesara, S., Abdolmaleky, H. M., Thiagalingam, S., & Zhou, J. (2023) · Epigenomics · doi:10.2217/epi-2023-0342 · Cited by 20

Good girl goes bad: Understanding how gut commensals cause disease

Dey, P. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.106617 · Cited by 19

Probiotic intervention improves metabolic outcomes in gestational diabetes mellitus: A meta-analysis of randomized controlled trials

Lan, X., Li, B., Zhao, J., Stanton, C., Ross, R. P., Chen, W., & Yang, B. K. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.05.020 · Cited by 19

Nutritional needs and health outcomes of ageing cats and dogs: is it time for updated nutrient guidelines?

Bermingham, E. N., Patterson, K., Shoveller, A. K. K., Fraser, K., Butowski, C. F., & Thomas, D. G. (2024) · Animal Frontiers · doi:10.1093/af/vfae008 · Cited by 19

Longitudinal gut microbiome dynamics in relation to age and senescence in a wild animal population

Worsley, S. F., Davies, C. S., Lee, C. Z., Mannarelli, M., Burke, T. A., Komdeur, J., Dugdale, H. L., & Richardson, D. S. (2024) · Molecular Ecology · doi:10.1111/mec.17477 · Cited by 19

Interactions between anthocyanins and gut microbiota in promoting healthy aging

Chen, Y., Song, G., Zhao, C., Qi, W., & Wang, Y. (2024) · Journal of Future Foods · doi:10.1016/j.jfutfo.2024.07.002 · Cited by 19

Exploring the acute and chronic effects of a multistrain probiotic supplement on cognitive function and mood in healthy older adults: a randomized controlled trial

Eastwood, J., van Hemert, S., Stolaki, M., Williams, C. M., Walton, G., & Lamport, D. J. (2025) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2025.04.002 · Cited by 19

The Use of Gut Microbial Modulation Strategies as Interventional Strategies for Ageing

Siddiqui, R., Mungroo, M. R., Alharbi, A. M., Alfahemi, H. H., & Khan, N. A. (2022) · Microorganisms · doi:10.3390/microorganisms10091869 · Cited by 19

Age-related impairment of intestinal inflammation resolution through an eicosanoid-immune-microbiota axis

Goepp, M., Milburn, J. V., Zhang, B., Dong, Y., Tyrrell, V. J., Zheng, X., Marshall, J. M., Bolsega, S., Basic, M., Glendinning, L., et al. (2025) · Cell Host & Microbe · doi:10.1016/j.chom.2025.04.014 · Cited by 18

Distinct gut microbiota profiles and network properties in older Korean individuals with subjective cognitive decline, mild cognitive impairment, and Alzheimer’s disease

Son, S. J., Wu, X., Roh, H. W., Cho, Y. H., Hong, S., Nam, Y. J., Hong, C. H., & Park, S. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01820-9 · Cited by 18

Gut Microbiota Metabolites Targeting the Immune Response in Sepsis: Mechanisms and Therapies

Xu, P. (2025) · International Journal of General Medicine · doi:10.2147/ijgm.s539237 · Cited by 18

Bifidobacterium animalis subsp. lactis BPL1™ and Its Lipoteichoic Acid Modulate Longevity and Improve Age/Stress-Related Behaviors in Caenorhabditis elegans

Balaguer, F., Barrena, M., Enrique, M., Maicas, M., Álvarez, B., Tortajada, M., Chenoll, E., Ramón, D., & Martorell, P. (2023) · Antioxidants · doi:10.3390/antiox12122107 · Cited by 18

Targeting the Hallmarks of Aging with Vitamin D: Starting to Decode the Myth

Ruggiero, C., Tafaro, L., Cianferotti, L., Tramontana, F., Macchione, I. G., Caffarelli, C., Virdis, A., Ferracci, M., Rinonapoli, G., Mecocci, P., et al. (2024) · Nutrients · doi:10.3390/nu16060906 · Cited by 18

Dietary patterns and intrinsic capacity in older adults: a 6-year prospective cohort study

Kim, J. H., Lee, Y., Kim, M., Won, C. W., Kim, M. K., & Shim, J. (2024) · The journal of nutrition health & aging · doi:10.1016/j.jnha.2024.100314 · Cited by 18

Umbilical cord mesenchymal stem cells in ulcerative colitis treatment: efficacy and possible mechanisms

Jiang, X., Luo, X., Cai, C., Bai, Y., Ding, H., Yue, H., Li, Y., Yang, Z., Zhang, H., Liang, Y., et al. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03878-y · Cited by 18

Green Synthesis and Multifunctional Applications of Moringa Oleifera-enhanced TiO2 Nanocomposites

Hema, K., Anishia, S. R., Rajeswari, S., Padmavathy, V., Sujatha, S., & Thiyagu, M. (2025) · Journal of Environmental Nanotechnology · doi:10.13074/jent.2025.03.2511225 · Cited by 17

Progressive gut microbiota shifts and functional alterations across aging stages and frailty in mice

Jiao, X., Li, H., Wang, T., Fu, H., Wang, S., Liu, H., Wang, L., Li, X., Deng, A., & Li, Z. (2025) · iScience · doi:10.1016/j.isci.2025.112985 · Cited by 17

Mesaconic acid as a key metabolite with anti-inflammatory and anti-aging properties produced by Lactobacillus plantarum 124 from centenarian gut microbiota

Wu, L., He, H., Liang, T., Du, G., Li, L., Zhong, H., Li, Y., Zhang, J., Chen, N., Jiang, T., et al. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00812-9 · Cited by 17

Meal timing trajectories in older adults and their associations with morbidity, genetic profiles, and mortality

Dashti, H. S., Liu, C., Deng, H., Sharma, A., Payton, A., Maharani, A., & Didikoğlu, A. (2025) · Communications Medicine · doi:10.1038/s43856-025-01035-x · Cited by 17

The gut microbiome shapes social behaviour across animal species

Griffiths, J. A., Nirmalkar, K., Wu, W., Krajmalnik‐Brown, R., & Mazmanian, S. K. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-025-01262-y · Cited by 19

The microbiome-gut-brain axis in nutritional neuroscience

Schellekens, H., Ribeiro, G., Cuesta‐Marti, C., & Cryan, J. F. (2022) · Nutritional Neuroscience · doi:10.1080/1028415x.2022.2128007 · Cited by 17

Using Inflammatory Biological Age To Evaluate the Preventing Aging Effect of a Polyphenol-Probiotic-Enhanced Dietary Pattern in Adults Aged 50 Years and Older

Meng, N., Zhou, Y., Zhang, Q., Yu, X., Li, H., Liu, Y., Liu, M., & Li, Q. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c07241 · Cited by 17

Toxicity and Impact of Silica Nanoparticles on the Configuration of Gut Microbiota in Immunodeficient Mice

Shabbir, S., Hu, Y., He, X., Huang, K., & Xu, W. (2023) · Microorganisms · doi:10.3390/microorganisms11051183 · Cited by 17

Boosting microbiome science worldwide could save millions of children’s lives

Browne, H. P., Iqbal, N. T., Osman, M., Tigoi, C., Lawley, T. D., Gordon, J. I., Ahmed, T., & Kariuki, S. (2024) · Nature · doi:10.1038/d41586-024-00017-8 · Cited by 17

Fecal microbiota transplantation from female donors restores gut permeability and reduces liver injury and inflammation in middle-aged male mice exposed to alcohol

Lamas‐Paz, A., Mesquita, M., Garcia-Lacarte, M., Estévez‐Vázquez, O., Benedé‐Ubieto, R., Gutierrez, A. H., Wu, H., Leal-Lassalle, H., Vaquero, J., Bañares, R., et al. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1393014 · Cited by 17

Exploring the interactions of JAK inhibitor and S1P receptor modulator drugs with the human gut microbiome: Implications for colonic drug delivery and inflammatory bowel disease

Favaron, A., Abdalla, Y., McCoubrey, L. E., Nandiraju, L. P., Shorthouse, D., Gaisford, S., Basit, A. W., & Orlu, M. (2024) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2024.106845 · Cited by 17

Enteropathway: the metabolic pathway database for the human gut microbiota

Shiroma, H., Darzi, Y., Terajima, E., Nakagawa, Z., Tsuchikura, H., Tsukuda, N., Moriya, Y., Okuda, S., Goto, S., & Yamada, T. (2024) · Briefings in Bioinformatics · doi:10.1093/bib/bbae419 · Cited by 17

Gut dysbiosis in primary sarcopenia: potential mechanisms and implications for novel microbiome-based therapeutic strategies

Yang, W., Si, S.-C., Wang, W., Li, J., Ma, Y.-X., Zhao, H., & Liu, J. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1526764 · Cited by 18

Gut Microbiota: An Ally in the Mechanisms and Interventions of Healthy Aging

Chatterjee, S. S., Hebbani, A. V., & Syed, K. (2025) · Gastrointestinal Disorders · doi:10.3390/gidisord7040068 · Cited by 16

Predicting healthspan and disease risks through biological age

Li, G., Cheng, L., Wong, I. N., Yin, Y., Chen, J., Liu, L., & Zhang, K. (2025) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2025.10.006 · Cited by 16

Microbial network signatures of early colonizers in infants with eczema

Huang, L., Pan, G., Feng, Y., Fan, Z., Ma, K., Wang, R., Wang, G., Huang, G., Huang, S., Hou, Y., et al. (2023) · iMeta · doi:10.1002/imt2.90 · Cited by 16

A novel immune modulator IM33 mediates a glia-gut-neuronal axis that controls lifespan

Xu, W., Rustenhoven, J., Nelson, C. A., Dykstra, T., Ferreiro, A. L., Papadopoulos, Z., Burnham, C. D., Dantas, G. A., Fremont, D. H., & Kipnis, J. (2023) · Neuron · doi:10.1016/j.neuron.2023.07.010 · Cited by 16

Dietary Marine Hydrolysate Improves Memory Performance and Social Behavior through Gut Microbiota Remodeling during Aging

Mougin, C., Chataigner, M., Lucas, C., Leyrolle, Q., Pallet, V., Layé, S., Bouvret, E., Dinel, A., & Joffre, C. (2023) · Foods · doi:10.3390/foods12234199 · Cited by 16

Disentangling the age-related manner in the associations between gut microbiome and women’s health: a multi-cohort microbiome study

Dong, C., Guan, Q., Xu, W., Zhang, X., Jin, B., Yu, S., Xu, X., & Xia, Y. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2290320 · Cited by 17

Gut microb-aging and its relevance to frailty aging

Cosquer, G. L., Vergnolle, N., & Motta, J. (2024) · Microbes and Infection · doi:10.1016/j.micinf.2024.105309 · Cited by 16

Healthy and Unhealthy Aging and the Human Microbiome

Simbirtseva, K., & O’Toole, P. W. (2024) · Annual Review of Medicine · doi:10.1146/annurev-med-042423-042542 · Cited by 16

Mendelian randomization analyses support causal relationships between gut microbiome and longevity

Chen, S., Chen, W., Wang, X., & Liu, S. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05823-2 · Cited by 17

Beyond the Gut, Emerging Microbiome Areas of Research: A Focus on Early-Life Microbial Colonization

Vemuri, R., & Herath, M. P. (2023) · Microorganisms · doi:10.3390/microorganisms11020239 · Cited by 16

Incorporation of probiotics with pressure-sensitive pectin-fructooligosaccharide hydrogel for potential intestinal delivery

Duan, M., Che, L., Wu, X., Quek, S. Y., Zhang, B., Lin, H., & He, N. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.123566 · Cited by 15

Gut microbiota heterogeneity in non-alcoholic fatty liver disease: a narrative review of drivers, mechanisms, and clinical relevance

Guo, Y., Zhang, N., & Pei, D. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1645298 · Cited by 15

Impact of gut microbiota on host stem cells across the gastrointestinal tract

Jeong, H., Lee, Y., & Nam, K. T. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2606477 · Cited by 15

Identification of taxonomic changes in the fecal bacteriome associated with colorectal polyps and cancer: potential biomarkers for early diagnosis

Grion, B. A. R., Fonseca, P. L. C., Kato, R. B., García, G. J. Y., Vaz, A. B. M., Jiménez, B. N., Lapitz, A., García‐Etxebarria, K., Brenig, B., Azevedo, V., et al. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1292490 · Cited by 15

The effect of oral probiotics on response to vaccination in older adults: a systematic review of randomised controlled trials

Tunc, H. A., Childs, C. E., Swann, J. R., & Calder, P. C. (2024) · Age and Ageing · doi:10.1093/ageing/afae033 · Cited by 15

Long COVID as a disease of accelerated biological aging: An opportunity to translate geroscience interventions

Shafqat, A., Masters, M. C., Tripathi, U., Tchkonia, T., Kirkland, J. L., & Hashmi, S. K. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102400 · Cited by 15

Electroacupuncture remodels gut microbiota and metabolites in mice with perioperative neurocognitive impairment

Tang, L., Zhang, X., Zhang, B., Chen, T., Du, Z., Song, W., Chen, W., & Wang, C. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112507 · Cited by 15

Gut aging: A wane from the normal to repercussion and gerotherapeutic strategies

Abankwah, J. K., Wang, Y., Wang, J., Enechojo, O. S., Pozzo, L. D., Chu, X., & Bian, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e37883 · Cited by 15

Gut microbe–host interactions in post-COVID syndrome: a debilitating or restorative partnership?

Scheithauer, T. P. M., Montijn, R. C., & Mieremet, A. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2402544 · Cited by 15

Stability in fecal metabolites amid a diverse gut microbiome composition: a one-month longitudinal study of variability in healthy individuals

Sangermani, M., Desiati, I., Jørgensen, S. M., Li, J. V., Andreassen, T., Bathen, T. F., & Giskeødegård, G. F. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2427878 · Cited by 15

Sex hormones–Gut microbiome axis: An update of what is known so far

Zommiti, M., & Feuilloley, M. G. J. (2025) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2025.100571 · Cited by 15

Aging and the microbiome: implications for health and disease

Gao, W., Lee, H.-Y., & Min, K. (2026) · BMB Reports · doi:10.5483/bmbrep.2025-0152 · Cited by 14

The Microbiome in Advanced Melanoma: Where Are We Now?

Fortman, D. D., Hurd, D. E., & Davar, D. (2023) · Current Oncology Reports · doi:10.1007/s11912-023-01431-3 · Cited by 14

Multi-omics analysis reveals substantial linkages between the oral-gut microbiomes and inflamm-aging molecules in elderly pigs

Qiao, C., He, M., Wang, S., Jiang, X., Wang, F., Li, X., Tan, S., Chao, Z., Xin, W., Gao, S., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1250891 · Cited by 14

TIGIT+ NK cells in combination with specific gut microbiota features predict response to checkpoint inhibitor therapy in melanoma patients

Tsakmaklis, A., Farowski, F., Zenner, R., Lesker, T. R., Strowig, T., Schlößer, H., Lehmann, J. M., von Bergwelt‐Baildon, M., Mauch, C., Schlaak, M. S., et al. (2023) · BMC Cancer · doi:10.1186/s12885-023-11551-5 · Cited by 14

Ageing, microbes and health

O’Toole, P. W. (2024) · Microbial Biotechnology · doi:10.1111/1751-7915.14477 · Cited by 14

Modulation of human gut microbiota by linear and branched fructooligosaccharides in anin vitrocolon model (TIM-2)

Popov, I. V., Koopmans, B., & Venema, K. (2024) · Journal of Applied Microbiology · doi:10.1093/jambio/lxae170 · Cited by 14

Strawberry dietary intervention influences diversity and increases abundances of SCFA-producing bacteria in healthy elderly people

Meiners, F., Kreikemeyer, B., Newels, P., Zude, I., Walter, M., Hartmann, A., Palmer, D. H., Fuellen, G., & Barrantes, I. (2025) · Microbiology Spectrum · doi:10.1128/spectrum.01913-24 · Cited by 14

Effects of Probiotics Supplementation on Short-Chain Fatty Acids: A Systematic Review of Randomized Controlled Trials

Brasiel, P. G. D. A., & Luquetti, S. C. P. D. (2025) · Nutrition Reviews · doi:10.1093/nutrit/nuaf047 · Cited by 14

Probiotic Combination of Limosilactobacillus fermentum HF07 and Lactococcus lactis HF08 Targeting Gut Microbiota–Secondary Bile Acid Metabolism Ameliorates Inflammation and Intestinal Barrier Dysfunction in Aging Colitis

Liu, X., Guan, K., Ma, Y., Jiang, L., Li, Q., Liu, Y., Mao, K., & Wang, R. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c12392 · Cited by 15

Pharmaco-psychiatry and gut microbiome: a systematic review of effects of psychotropic drugs for bipolar disorder

Bui, T. A., O’Croinin, B. R., Dennett, L., Winship, I. R., & Greenshaw, A. J. (2025) · Microbiology · doi:10.1099/mic.0.001568 · Cited by 14

A metagenomics study reveals the gut microbiome as a sex-specific modulator of healthy aging in Hainan centenarians

Luan, Z., Fu, S., Qi, S., Li, C., Chen, J., Zhao, Y., Zhang, H., Wu, J., Zhao, Z. J., Zhang, J., et al. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2023.112356 · Cited by 14

Young gut microbiota transplantation improves the metabolic health of old mice

Xie, J., Kim, T., Liu, Z., Panier, H. A., Bokoliya, S. C., Xu, M., & Zhou, Y. (2025) · mSystems · doi:10.1128/msystems.01601-24 · Cited by 13

Intestinal aging-related immune dysfunction: mechanisms and interventions

Shen, X., Gao, X., & Wang, L. (2025) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2025157 · Cited by 13

Microbiome signatures and their role in uveitis: Pathogenesis, diagnostics, and therapeutic perspectives

Agrawal, K., Hong, A. S. Y., Cifuentes‐González, C., Kumar, V. S., Rojas-Carabali, W. A., Zhang, S., Wang, Q., de‐la‐Torre, A., Gijs, M., Gill, T., et al. (2025) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2025.101409 · Cited by 13

The oral microbiome in aging: a window into health and longevity

Yue, Z., Li, C., Yan, F., Guan, S., Fan, Y., & Chen, X. (2025) · Journal of Oral Microbiology · doi:10.1080/20002297.2025.2589648 · Cited by 13

Fecal Microbiota, Live-jslm for the Prevention of Recurrent Clostridioides difficile Infection

Feuerstadt, P., Crawford, C. V., Tan, X., Pokhilko, V., Bancke, L. L., Ng, S., Guthmueller, B., Bidell, M. R., Tillotson, G., Johnson, S., et al. (2023) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001947 · Cited by 13

Guideline for designing microbiome studies in neoplastic diseases

Mikó, E., Sipos, A., Tóth, E., Lehoczki, A., Fekete, M., Sebő, É., Kardos, G., & Bai, P. (2024) · GeroScience · doi:10.1007/s11357-024-01255-4 · Cited by 13

Liquid-liquid phase separation in aging: Novel insights in the pathogenesis and therapeutics

Wang, H., Tang, J., Yan, S., Li, C., Li, Z., Xiong, Z., Li, Z., & Tu, C. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102583 · Cited by 13

Exercise-driven gut microbiota alterations enhance colonization resistance against methicillin-resistant Staphylococcus aureus

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