The DOI matches its Crossref record; 267 of the 267 references it cites were found in a registry or an index.
The intestinal microbiota fuelling metabolic inflammation
Abstract
Low-grade inflammation is the hallmark of metabolic disorders such as obesity, type 2 diabetes and nonalcoholic fatty liver disease. Emerging evidence indicates that these disorders are characterized by alterations in the intestinal microbiota composition and its metabolites, which translocate from the gut across a disrupted intestinal barrier to affect various metabolic organs, such as the liver and adipose tissue, thereby contributing to metabolic inflammation. Here, we discuss some of the recently identified mechanisms that showcase the role of the intestinal microbiota and barrier dysfunction in metabolic inflammation. We propose a concept by which the gut microbiota fuels metabolic inflammation and dysregulation.
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“Growing evidence shows that gut microbiome-derived metabolites can reach systemic circulation through the gut barrier and fuel metabolic inflammation.179”
From Interaction between microbiota and immunity in health and disease (2020) · cites this paper as [179]
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Metadata
- Authors
- Tilg, H., Zmora, N., Adolph, T. E., & Elinav, E.
- Affiliations
- Innsbruck Medical University (AT)
- Tel Aviv Sourasky Medical Center (IL)
- German Cancer Research Center (DE)
- Corresponding author
- Tilg, Herbert
- Elinav, Eran
- Venue
- Nature Reviews Immunology
- Published
- 2019-08-06
- Volume
- 20
- Issue
- 1
- Pages
- 40-54
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2965140029
- Semantic Scholar
- 075fe4860874305da0e6be3e1bf99792c631d395
- Cited by
- 1,089
- References
- 267
- Citations by year
- 2026: 149 · 2025: 152 · 2024: 169 · 2023: 162 · 2022: 184 · 2021: 171 · 2020: 88 · 2019: 12
- FWCI
- 10.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, metabolic inflammation, low-grade inflammation, obesity, type 2 diabetes, non-alcoholic fatty liver disease, intestinal barrier dysfunction, microbial metabolites, adipose tissue, liver
- MeSH terms
- Gastrointestinal Microbiome, Animals, Chronic Disease, Humans, Inflammation, Intestinal Mucosa, Metabolic Diseases, Dysbiosis
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