Cited by 717Gut microbiota and healthEscherichia coli research studiesGastrointestinal motility and disorders

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Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier

Martens, Eric C., Neumann, Mareike, Desai, Mahesh S.·2018·Nature Reviews Microbiology

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Abstract

The intestinal mucosal barrier is composed of epithelial cells that are protected by an overlying host-secreted mucous layer and functions as the first line of defence against pathogenic and non-pathogenic microorganisms. Some microorganisms have evolved strategies to either survive in the mucosal barrier or circumvent it to establish infection. In this Review, we discuss the current state of knowledge of the complex interactions of commensal microorganisms with the intestinal mucosal barrier, and we discuss strategies used by pathogenic microorganisms to establish infection by either exploiting different epithelial cell lineages or disrupting the mucous layer, as well as the role of defects in mucus production in chronic disease.

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Authors: Martens, E. C., Neumann, M., & Desai, M. S.
Affiliations: University of Michigan (US)
Luxembourg Institute of Health (LU)
University of Southern Denmark (DK)
Corresponding author: Martens, Eric C.
Desai, Mahesh S.
ORCID: Martens, Eric C.
Neumann, Mareike
Desai, Mahesh S.
Venue: Nature Reviews Microbiology
Publisher: Springer Science and Business Media LLC
Published: 2018-06-14
Volume: 16
Issue: 8
Pages: 457-470
ISSN: 1740-1526 (ISSN-L)
1740-1534
DOI: 10.1038/s41579-018-0036-x
OpenAlex: W2807724532
Cited by: 711
References: 156
Citations by year: 2026: 62 · 2025: 93 · 2024: 106 · 2023: 104 · 2022: 149 · 2021: 96 · 2020: 54 · 2019: 41 · 2018: 6
FWCI: 4.82
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Microbiology (publishedVersion)
PubMed (publishedVersion)
University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
Funders: Kenneth Rainin Foundation
National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: intestinal barrier, commensal microorganisms, enteric pathogens, mucus layer, intestinal epithelial cells, host defense, chronic intestinal diseases
MeSH terms: Bacteria, Humans, Intestinal Mucosa, Symbiosis, Bacterial Physiological Phenomena

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Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier

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