Cited by 717Gut microbiota and healthEscherichia coli research studiesGastrointestinal motility and disorders

The DOI matches its Crossref record; 156 of the 156 references it cites were found in a registry or an index.

Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier

Martens, Eric C., Neumann, Mareike, Desai, Mahesh S.·2018·Nature Reviews Microbiology

Open this paper in CoChat — free account

Abstract

The intestinal mucosal barrier is composed of epithelial cells that are protected by an overlying host-secreted mucous layer and functions as the first line of defence against pathogenic and non-pathogenic microorganisms. Some microorganisms have evolved strategies to either survive in the mucosal barrier or circumvent it to establish infection. In this Review, we discuss the current state of knowledge of the complex interactions of commensal microorganisms with the intestinal mucosal barrier, and we discuss strategies used by pathogenic microorganisms to establish infection by either exploiting different epithelial cell lineages or disrupting the mucous layer, as well as the role of defects in mucus production in chronic disease.

Integrity signals

Registry

Crossref · 10.1038/s41579-018-0036-x

Cites

156 of 156 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100
Toll-like receptor signalling
Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549
The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413
The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
den Besten, G., van Eunen, K., Groen, A. K., Venema, K., Reijngoud, D.-J., & Bakker, B. M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r036012 · Cited by 5,048
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
Intestinal mucosal barrier function in health and disease
Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952
Intestinal epithelial cells: regulators of barrier function and immune homeostasis
Peterson, L. W., & Artis, D. (2014) · Nature reviews. Immunology · doi:10.1038/nri3608 · Cited by 3,367
The gut microbiota, bacterial metabolites and colorectal cancer
Louis, P., Hold, G. L., & Flint, H. J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3344 · Cited by 2,925

Show all 156 references

Research works printed but not linked: 2

Amat, C. B., Motta, J.-P., Chadee, K. & Buret, A. G. Giardia duodenalis directly depletes mucins in intestinal goblet cells. FASEB J 30, 162.1–162.1 (2016).
Brockhausen, I., Schachter, H., S. P. Essentials of Glycobiology (Cold Spring Harbor Laboratory Press, 2009).

Sorted by citations

Items 401–500 of 717

Ant may well destroy a whole dam: glycans of colonic mucus barrier disintegrated by gut bacteria
Li, S., Chen, M., Wang, Z., Abudourexiti, W., Zhang, L., Ding, C., Ding, L., & Gong, J. (2024) · Microbiological Research · doi:10.1016/j.micres.2023.127599 · Cited by 11
Metabolites mediate the causal associations between gut microbiota and NAFLD: a Mendelian randomization study
Ouyang, C., Liu, P., Liu, Y., Lan, J., & Liu, Q. (2024) · BMC Gastroenterology · doi:10.1186/s12876-024-03277-w · Cited by 13
Gut Lactococcus garvieae promotes protective immunity to foodborne Clostridium perfringens infection
Wang, X.-Y., Fan-hua, M., Zhang, M., Li, F.-X., Lei, Y.-X., Ma, Z.-G., Li, J., Lou, Y.-N., Chu, Y., Ma, K., et al. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.04025-23 · Cited by 11
Correlation between intestinal CRE colonization and consequent systemic infection in hospitalized patients in China
Xiao, Y., Duan, J., Tan, C., Zou, J., Chen, S., Liu, T., Zhang, L. N., Chen, X., Xu, Y., Li, Y., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-76261-9 · Cited by 12
Pathological mechanism of intestinal mucosal barrier injury of large intestine dampness-heat syndrome rats and the protective effect of Yujin powder
Yao, W., Zhang, Y., Zhang, W., Wen, Y., Yang, R., Dong, J., Zhang, X., Hua, Y., Ji, P., & Wei, Y. (2022) · Research in Veterinary Science · doi:10.1016/j.rvsc.2022.09.014 · Cited by 11
Vibrio vulnificus induces the death of a major bacterial species in the mouse gut via cyclo-Phe-Pro
Kim, J., Jang, B.-R., Kim, Y.-R., Jung, Y.-C., Kim, K., & Lee, K. (2021) · Microbiome · doi:10.1186/s40168-021-01095-w · Cited by 11
Applications of traditional Chinese medicine in cancer immunotherapy via gut microbiota modulation: Current status, mechanisms, challenges and perspectives
Tao, H., Mao, K., Zhang, Z., Wei, W., Huang, X., Chen, Y., Mei, S., & Tian, X. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.108020 · Cited by 12
Sulfoconjugation of protein peptides and glycoproteins in physiology and diseases
Xu, P., Cai, X., Guan, X., & Xie, W. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108540 · Cited by 10
Integrated microbiomic and metabolomics insight into the ameliorating mechanisms of dietary Polygonatum cyrtonema saponin on ulcerative colitis
Xiao, J., Xie, L., Zheng, B., Chen, Y., Xie, J., Huang, H., Hu, X., & Yu, Q. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.103871 · Cited by 10
The Role of Iron in Intestinal Mucus: Perspectives from Both the Host and Gut Microbiota
Liu, S., Yin, J., Wan, D., & Yin, Y. (2024) · Advances in Nutrition · doi:10.1016/j.advnut.2024.100307 · Cited by 12
Mucosal immunization with the lung Lactobacillus-derived amphiphilic exopolysaccharide adjuvanted recombinant vaccine improved protection against P. aeruginosa infection
Zhang, H. C., Sheng, S., Li, C., Bao, X., Zhao, L., Chen, J., Guan, P., Li, X., Pan, N., Liang, Y., et al. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012696 · Cited by 10
Gut Barrier, Microbial Metabolites, and Immune Homeostasis in Autoimmune Hepatitis: From Molecular Mechanisms to Strategies
Zhang, X., Wan, L., Zheng, Y., & Ai, Y. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl27747 · Cited by 10
When We Stop Thinking about Microbes as Cells
van Gestel, J., & Kolter, R. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.05.004 · Cited by 9
Transkingdom network analysis provides insight into host-microbiome interactions in Atlantic salmon
Strand, M. A., Jin, Y. O., Sandve, S. R., Pope, P. B., & Hvidsten, T. R. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.01.038 · Cited by 10
Toxicokinetics of mono-(2-ethylhexyl) phthalate with low-dose exposure applying fluorescence tracing technique
Yuan, Y.-Z., Ye, C., Sun, J.-H., Hu, M., Huo, S., Zhu, Y., Xiang, S.-Y., & Yu, S. (2021) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2021.115814 · Cited by 10
Interleukin‐22 Ameliorates Dextran Sulfate Sodium‐Induced Colitis through the Upregulation of lncRNA‐UCL to Accelerate Claudin‐1 Expression via Sequestering miR‐568 in Mice
He, C., Chen, Z., Huang, J., Gan, R., Wang, J., Wang, L., Li, D., & Yao, J. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8543720 · Cited by 10
Interaction between mucus layer and gut microbiota in non-alcoholic fatty liver disease: Soil and seeds
Zhang, B., Li, J., Fu, J., Shao, L., Yang, L., & Shi, J. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002711 · Cited by 11
NOX1 down-regulation attenuated the autophagy and oxidative damage in pig intestinal epithelial cell following transcriptome analysis of transport stress
Li, H., He, Y., Zhang, C., Ba, T., Guo, Z., Zhuo, Y., He, L., & Dai, H. (2020) · Gene · doi:10.1016/j.gene.2020.145071 · Cited by 10
Exopolysaccharide from Leuconostoc pseudomesenteroides XG5 delay the onset of autoimmune diabetes by modulating gut microbiota and its metabolites SCFAs in NOD mice
Pan, L., Zhou, Z., & Han, Y. H. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104427 · Cited by 10
Myoglobin diet affected the colonic mucus layer and barrier by increasing the abundance of several beneficial gut bacteria
Jiang, S., Xue, D., Zhang, M., Li, Q., Liu, H., Zhao, D., Zhou, G., & Li, C. (2022) · Food & Function · doi:10.1039/d2fo01799g · Cited by 10
Synergistic effects of alginate oligosaccharide and cyanidin-3-O-glucoside on the amelioration of intestinal barrier function in mice
Li, J., Guo, Y., Ma, L., Liu, Y., Zou, C., Kuang, H., Han, B., Xiao, Y., & Wang, Y. (2023) · Food Science and Human Wellness · doi:10.1016/j.fshw.2023.03.047 · Cited by 10
Epithelial NELF guards intestinal barrier function to ameliorate colitis by maintaining junctional integrity
Ou, J., Guan, X., Wang, J., Wang, T., Zhang, B., Li, R., Xu, H., Hu, X., & Guo, X.-K. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00465-9 · Cited by 10
Oral administration of heat-inactivated Escherichia coli during suckling alleviated Salmonella typhimurium-derived intestinal injury after rat weaning
Cui, M., Tang, G., Yan, F., Wang, S., Wang, X., Yao, J., & Xu, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1119747 · Cited by 9
Protective Mechanism of Polysaccharide ORP‐1 Isolated from Oudemansiella raphanipes against Age‐Related Cognitive Decline through the Microbiota‐Gut‐Brain Axis
Ren, Y., Cui, W., Jiang, K., He, K., Lu, Y., Chen, Y., & Pan, W. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300739 · Cited by 10
Isatidis root polysaccharides ameliorates post-weaning diarrhea by promoting intestinal health and modulating the gut microbiota in piglets
Zhou, M., Yan, Z., Wang, D., Li, C., Wang, L., Li, R., Yin, J., & Yin, Y. (2025) · Veterinary Quarterly · doi:10.1080/01652176.2024.2447600 · Cited by 9
The signature of the small intestinal epithelial and immune cells in health and diseases
Gao, X., Yang, C., Feng, Z., Liu, P., & Liu, Z. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003615 · Cited by 12
Chemical exchange saturation transfer MRI-trackable peptide hydrogel for drug release monitoring and targeted therapy in inflammatory bowel disease
Li, F., Zhao, R., Ding, W., Yang, J., Wen, Q., Dou, W., Chen, L., Zhang, J., Qiu, B., Bulte, J. W. M., et al. (2025) · Cell Biomaterials · doi:10.1016/j.celbio.2025.100098 · Cited by 10
Protective Roles of Prebiotics and Probiotics Against Environmental Pollutant‐Induced Toxicities: A Systematic Review of Animal Studies
Zarezadeh, M., Saedisomeolia, A., Mahmoudinezhad, M., Iskandar, M. M., Lü, F., & Kubow, S. J. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70175 · Cited by 9
Microecological preparation combined with an modified low-carbon diet improves glucolipid metabolism and cardiovascular complication in obese patients
Liu, J., Liehui, X., Nie, H., Pan, Y., Liu, Y., Zhang, Z., Lin, X., Zhang, Y., Cai, J., Yang, M., et al. (2021) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-021-00697-6 · Cited by 9
Amelioration of dextran sulfate sodium-induced colitis by autoinducer-2-deficient Lactiplantibacillus plantarum is mediated by anti-inflammatory effects and alleviation of dysbiosis of the gut microbiota
Qian, Y., Ma, L., Zeng, M., & Liu, Z. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1013586 · Cited by 9
Gut Bacterial Community Determines the Therapeutic Effect of Ginsenoside on Canine Inflammatory Bowel Disease by Modulating the Colonic Mucosal Barrier
Mao, A., Zhao, W., Zhu, Y., Kong, F., Chen, D., Si, H., & Xu, C. (2023) · Microorganisms · doi:10.3390/microorganisms11112616 · Cited by 10
Intestine Health and Barrier Function in Fattening Rabbits Fed Bovine Colostrum
Aidos, L., Pallaoro, M., Mirra, G., Serra, V., Castrica, M., Agradi, S., Curone, G., Vigo, D., Riva, F., Balzaretti, C. M., et al. (2023) · Veterinary Sciences · doi:10.3390/vetsci10110657 · Cited by 10
Gallnut tannic acid alleviates gut damage induced by Salmonella pullorum in broilers by enhancing barrier function and modulating microbiota
Zou, J., Luan, H.-Y., Xi, P., Xue, J., Fan, J., Zhong, X., Zhou, X. C., Song, X., Zhao, X., Zou, Y., et al. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1382288 · Cited by 9
Stabilization of hypoxia-inducible factor 1α and regulation of specific gut microbes by EGCG contribute to the alleviation of ileal barrier disorder and obesity
Ma, H., Wang, Y., Wei, J., Wang, X., Yang, H., & Wang, S. (2024) · Food & Function · doi:10.1039/d4fo02283a · Cited by 9
Fractions from natural Cordyceps sinensis alleviated intestinal injury in cyclophosphamide-induced mice
Fang, Q.-Y., Chen, S., Wang, J., Huang, X., Nie, Q., Phillips, G. O., Cui, S. W., Li, Y., & Nie, S. (2021) · Bioactive Carbohydrates and Dietary Fibre · doi:10.1016/j.bcdf.2021.100271 · Cited by 9
Role of TLR5 in the Translocation and Dissemination of Commensal Bacteria in the Intestine after Traumatic Hemorrhagic Shock
Zhang, Y., Zhang, J., Xu, T., Zhang, C., Yu, W., Wei, T., Zhang, B., Chen, Q., Qiu, J., Li, H.-J., et al. (2021) · Journal of Immunology Research · doi:10.1155/2021/6417658 · Cited by 9
The Effect of Endotoxin on the Intestinal Mucus Layer in Non- and Post-pregnancy Mice
Yan, D., Qiang, Y., Tian, T., Lu, D., & Wu, C. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.824170 · Cited by 9
Histological and Comparative Transcriptome Analyses Provide Insights into Small Intestine Health in Diarrheal Piglets after Infection with Clostridium Perfringens Type C
Yan, Z., Cai, L., Huang, X., Sun, W., Li, S., Wang, P., Yang, Q., Jiang, T., & Gun, S. (2019) · Animals · doi:10.3390/ani9050269 · Cited by 10
Lentils and Yeast Fibers: A New Strategy to Mitigate Enterotoxigenic Escherichia coli (ETEC) Strain H10407 Virulence?
Sauvaitre, T., Herreweghen, F. V., Delbaere, K., Durif, C., Landuyt, J. V., Fadhlaoui, K., Huille, S., Chaucheyras‐Durand, F., Etienne‐Mesmin, L., Blanquet‐Diot, S., et al. (2022) · Nutrients · doi:10.3390/nu14102146 · Cited by 8
Calycosin Improves Intestinal Mucosal Barrier Function after Gastrectomy in Rats through Alleviating Bacterial Translocation, Inflammation, and Oxidative Stress
Peng, H., Jin, L., Zhang, Q., Shen, Y., Wang, Z., Zhou, F., & Yu, Q. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/7412331 · Cited by 8
Development of small intestinal barrier function and underlying mechanism in Chinese indigenous and Duroc piglets during suckling and weaning periods
Ding, S., Cheng, Y., Azad, M. A. K., Zhu, Q., Huang, P., & Kong, X. (2023) · Animal nutrition · doi:10.1016/j.aninu.2023.09.005 · Cited by 8
Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation
Mortensen, J. S., Bohr, S. S.-R., Krog, L. S., Boetker, J. P., Kapousidou, V., Saaby, L., Hatzakis, N. S., Nielsen, H. M., Nguyen, D. N., & Rønholt, S. (2024) · Scientific Reports · doi:10.1038/s41598-024-58356-5 · Cited by 9
HucMSC-Ex alleviates DSS-induced colitis in mice by decreasing mast cell activation via the IL-33/ST2 axis
Wei, Z. (2024) · American Journal of Translational Research · doi:10.62347/exze5413 · Cited by 8
Vitamin E alleviates zebrafish intestinal damage and microbial disturbances caused by pyraclostrobin
Zhang, M., Zhao, F., Guo, M., Duan, M., Xie, Y., & Qiu, L. (2024) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2024.106221 · Cited by 8
Lactiplantibacillus plantarum CCFM8661 improves intestinal barrier function and regulates gut microbiota to alleviate enterotoxigenic Escherichia coli-induced diarrhea in mice
Zhang, Y., Chen, C., Zhao, J., Stanton, C., Ross, R. P., Chen, W., & Yang, B. K. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.106229 · Cited by 8
Chlorpyrifos Inhibits Intestinal Stem Cell Proliferation and Differentiation at the Acceptable Daily Intake and Disrupts Immune Responses at High Doses
Yuan, X., Wu, F., Cheng, L., Ji, T., Zheng, C., Ma, Y., Jin, Y., Dong, J., Jin, Y., & Fang, B. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c13249 · Cited by 8
Immunomodulatory role of gut microbiota in autoimmune disorders and the advancement of gut microbiota based therapeutic strategies
Fatima, S. N., Arif, F., Khalid, R., Khan, M., & Naseem, K. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.107882 · Cited by 11
The Improvement of Intestinal Mucosal Epithelial Barrier Integrity by 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone in Rat Experimental Colitis
Szandruk-Bender, M., Wiatrak, B., Merwid‐Ląd, A., Dzimira, S., Szeląg, A., Magdalan, J., Szczukowski, Ł., Świątek, P., Duda-Madej, A., Gębarowski, T., et al. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s527041 · Cited by 8
Dynamic balance of the lung microbiome in health and respiratory diseases
Wang, X., Bi, L., Li, J., Liu, D., Li, W., & Wang, Z. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003712 · Cited by 8
Trophic attenuation and transmission of antibiotic resistance in the aquatic food webs
Xue, X., Jiang, S., Ge, Y., Chen, Y., Gao, D., Ren, L., & Kuang, Z. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.140407 · Cited by 8
Lactobacillus reuteri postbiotics improved growth performance and intestinal health of broilers with necrotic enteritis
Wu, M., Zha, Y., Xiong, Y., Zhang, Y., Zhang, Y., Jiale, L., Yan, J., Li, P., Li, C., & Guo, S. (2025) · BMC Veterinary Research · doi:10.1186/s12917-025-05178-w · Cited by 8
Dihydromyricetin Attenuates High-Intensity Exercise-Induced Intestinal Barrier Dysfunction Associated with the Modulation of the Phenotype of Intestinal Intraepithelial Lymphocytes
Hou, P., Wang, D., Lang, H., Yao, Y., Zhou, J., Zhou, M., Zhu, J., Yi, L., & Mi, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010221 · Cited by 8
Lactobacillus plantarum ZJUIDS04 alleviates DSS-induced colitis via modulating gut microbiota
Yu, C., Liu, J., Liu, Z., Ding, Q., Zhu, Q., Chen, N., Fu, J., Valencak, T. G., & Ren, D. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105794 · Cited by 8
Mechanistic overview of gut microbiota and mucosal pathogens with respect to cardiovascular diseases
Shayista, H., Prasad, M. N. N., Raj, S. N., Ranjini, H. K., Manju, K., & Baker, S. (2024) · The Microbe · doi:10.1016/j.microb.2024.100160 · Cited by 10
Effect of supplementation with Lactobacillus rhamnosus GG powder on intestinal and liver damage in broiler chickens challenged by lipopolysaccharide
Zhang, X., Sun, L., Wu, M., Yu, C., Zhao, D., Wang, L., Zhang, Z., Yi, D., Hou, Y., & Wu, T. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1466274 · Cited by 8
Rational design of metal-based antimicrobial nanomaterials in environmental applications
Chong, Y., & Ge, C. (2021) · Environmental Science Nano · doi:10.1039/d1en00714a · Cited by 8
A Non-Invasive Neonatal Signature Predicts Later Development of Atopic Diseases
Sérémé, Y., Michel, M., Mezouar, S., Guindo, C. O., Kaba, L., Grine, G., Mura, T., Mège, J., Tran, T.-A., Corbeau, P., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11102749 · Cited by 8
Improvement of gut microbiome and intestinal permeability following splenectomy plus pericardial devascularization in hepatitis B virus-related cirrhotic portal hypertension
Zhao, Y., Zhou, R., Guo, Y., Chen, X., Zhang, A., Wang, J., Ji, F., Qin, B., Geng, J., Kong, G., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.941830 · Cited by 7
Surface layer protein A from hypervirulent Clostridioides difficile ribotypes induce significant changes in the gene expression of tight junctions and inflammatory response in human intestinal epithelial cells
Noori, M., Azimirad, M., Eslami, G., Looha, M. A., Yadegar, A., Ghalavand, Z., & Zali, M. R. (2022) · BMC Microbiology · doi:10.1186/s12866-022-02665-0 · Cited by 12
Protective effect of extracorporeal membrane oxygenation on intestinal mucosal injury after cardiopulmonary resuscitation in pigs
Liang, Y., Li, C., Liu, B., Zhang, Q., Yuan, X., Zhang, Y., Ling, J.-Y., & Zhao, L. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.8087 · Cited by 8
Probiotics: mechanism of action and gastrointestinal health: gut guardians: unlocking the power of probiotics
Rana, A., & Smriti (2026) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.70275 · Cited by 7
Fluorescent metabolic labeling-based quick antibiotic susceptibility test for anaerobic bacteria
Gao, J., Qin, J., Ding, C., Gao, Y., Guo, J., Li, M., Yang, C. J., & Wang, W. (2022) · RSC Chemical Biology · doi:10.1039/d2cb00163b · Cited by 7
A comprehensive immunobiology review of IBD: With a specific glance to Th22 lymphocytes development, biology, function, and role in IBD
Lv, J., Ibrahim, Y. S., Yumashev, A., Hjazi, A., Faraz, A., Alnajar, M. J., Qasim, M. T., Ghildiyal, P., Zwamel, A. H., & Mustafa, Y. F. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112486 · Cited by 10
Sanguinarine chloride hydrate mitigates colitis symptoms in mice through the regulation of the intestinal microbiome and metabolism of short-chain fatty acids
Xin, J., He, L., Li, Y., Pu, Q., Du, X., Ban, F., & Han, D. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167579 · Cited by 7
Protective Role of Indole-3-Acetic Acid Against Salmonella Typhimurium: Inflammation Moderation and Intestinal Microbiota Restoration
Fan, Y., Song, Q., Li, S., Tu, J., Yang, F., Zeng, X., Yu, H., Qiao, S., & Wang, G. (2024) · Microorganisms · doi:10.3390/microorganisms12112342 · Cited by 8
Proteus mirabilis exacerbates ulcerative colitis by inhibiting mucin production
Jiang, Z., Li, P., Qiu, K., Liao, Y., Chen, X., Xuan, J., Wang, F., Ma, H., Wang, Y., & Zhu, M. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1556953 · Cited by 8
Research progress on the correlation between microbiota and endometriosis
Wang, J., & Wang, X. (2025) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2025.114671 · Cited by 8
The effects of phenolic acid supplementation on intestinal barrier function: a review
Xia, L., Lin, X., Zhou, Y., Li, Y., Liao, Y., Lin, Y., Lin, L., Wu, P., & Xie, J. (2025) · Food & Function · doi:10.1039/d5fo03351a · Cited by 9
Probiotics for ulcerative colitis: mechanisms, therapeutic advances, and emerging strategies
Niu, C., Wang, J., Lu, X., & Yu, Y. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1787284 · Cited by 7
Enterohaemorrhagic Escherichia coli activates nitrate respiration to benefit from the inflammatory response for initiation of microcolony-formation
Nada, R., Ebihara, S., Yen, H., & Tobe, T. (2020) · BMC Microbiology · doi:10.1186/s12866-020-01946-w · Cited by 6
Bifidobacterium breve modulates lactic acid to curtail Escherichia coli expansion and alleviate inflammatory bowel disease
Gao, X., Xia, Y., Sun, X., Dou, W., Chen, R., Huang, P., Yu, L., Tian, F., Zhao, J., Chen, W., et al. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.104626 · Cited by 7
Applications of β-defensins against infectious pathogenic microorganisms
Li, X., Wang, X., Du, J., Bu, X., Peng, C., Duan, X., & Fu, C. (2024) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2024.2377677 · Cited by 7
Helicobacter hepaticus CdtB Triggers Colonic Mucosal Barrier Disruption in Mice via Epithelial Tight Junction Impairment Mediated by MLCK/pMLC2 Signaling Pathway
Wang, T., Meng, X., Qian, M., Jin, S., Bao, R., Zhu, L., & Zhang, Q. (2025) · Veterinary Sciences · doi:10.3390/vetsci12020174 · Cited by 7
Freeze–Thaw Imaging for Microorganism Classification Assisted with Artificial Intelligence
Xie, H., Zhu, X., Chen, K., Zhang, Z., Liu, J., Wang, W., Wan, C., Wang, J., Peng, D., Li, Y., et al. (2025) · ACS Nano · doi:10.1021/acsnano.4c16949 · Cited by 7
The Protective Effects of Sour Orange (Citrus aurantium L.) Polymethoxyflavones on Mice Irradiation-Induced Intestinal Injury
Jiang, Z., Li, Z., Wang, F., & Zhou, Z. (2022) · Molecules · doi:10.3390/molecules27061934 · Cited by 7
SARS-CoV-2 Infection, Inflammation, Immunonutrition, and Pathogenesis of COVID-19
Yu, L., Ghani, M. K. A., Aghemo, A., Barh, D., Bassetti, M., Catena, F., Gallo, G., Gholamrezanezhad, A., Kamal, M. A., Lal, A., et al. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867330666230330092725 · Cited by 8
Inhibition of bacterial swimming by heparin binding of flagellin FliC from Escherichia coli strain Nissle 1917
Yang, G., Yang, L., & Zhou, X. (2023) · Archives of Microbiology · doi:10.1007/s00203-023-03622-9 · Cited by 7
Xuanhuang Runtong Tablets Relieve Slow Transit Constipation in Mice by Regulating TLR5/IL‐17A Signaling Mediated by Gut Microbes
Liang, X., Wan, D., Cai, Y., Yue, W., Wang, X., Zhou, H., Zhou, R., Du, Q., Juan, X., & Zhang, S. (2023) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2023/6506244 · Cited by 8
Effects of Combined Live Bifidobacterium, Lactobacillus, Enterococcus, and Bacillus Cereus Tablets on the Structure and Function of the Intestinal Flora in Rabbits Undergoing Hepatic Artery Infusion Chemotherapy
Yan, X.-D., Bai, L., Lv, J., Qi, P., Song, X., & Zhang, L. (2024) · Biology · doi:10.3390/biology13050327 · Cited by 6
Oryzanol ameliorates MCD-induced metabolic dysfunction-associated steatohepatitis in mice via gut microbiota reprogramming and TLR4/NF-κB signaling suppression
Alam, N., Ding, X., Fu, Y., Jia, L., Ali, S. M., & Liu, E. (2025) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00190.2024 · Cited by 6
Restoration of gut integrity by Bacteroides acidifaciens in water-deprived conditions
Fan, S., Cai, X., Cui, W., Ma, P., Wu, M., Guo, J., Zhang, Y., Xuan, K., & Li, Z. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.151917 · Cited by 6
Corynebacterium glutamicum alleviated colitis by downregulating the TNF signaling pathway mediated by cIAP1/2 in mice
Liu, T., Meng, Q., Zhang, Y., Yu, M., Ye, J., Song, W., Luo, Y., & Yue, T. (2025) · Food & Function · doi:10.1039/d5fo01880c · Cited by 6
Lactiplantibacillus plantarum ZGS521 attenuates colitis by regulating intestinal epithelial proliferation and differentiation and the gut microbiota
Xia, W., Li, X., Liu, W., & Zhou, T. (2025) · Food & Function · doi:10.1039/d5fo02720a · Cited by 6
Guiren Runchang granules alleviate slow transit constipation in mice by modulating gut microbiota and short-chain fatty acids
Bai, X., Wang, Y., Wang, K., Chu, W., & Bai, T. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1615297 · Cited by 6
Mechanisms of acupuncture in the treatment of type 2 diabetes mellitus: insights from the regulation of the gut microecology
Niu, H., Zhou, M., Zhou, L., Wu, H., Wu, F., Zhu, S.-X., Chen, R., Liang, F.-X., & Zhang, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1682521 · Cited by 7
Context-dependent roles of the gut microbiome in food allergy tolerance versus sensitization
Delaroque, C., & Desai, M. S. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2590830 · Cited by 6
Self-citation
Short-chain fatty acids alleviated fluoride-induced neuroinflammation via the gut-brain axis in rats
Zhao, W., Zhu, S.-Q., Yin, Z.-H., Ommati, M. M., Zhang, Y.-W., Zhao, J., Zhou, B.-H., & Wang, H. (2025) · Environmental Pollution · doi:10.1016/j.envpol.2025.127503 · Cited by 7
Mucosal glycans: key drivers of the development of inflammatory bowel disease and a potential new therapeutic target
Pinho, S. S., Torres, J., & Colombel, J. F. (2026) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01164-7 · Cited by 7
Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies
Popov, J., Caputi, V., Nandeesha, N., Rodriguez, D. A., & Pai, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111365 · Cited by 12
Characterization of intestinal fungal community diversity in people living with HIV/AIDS (PLWHA)
Meng, P., Zhang, G., Ma, X., Ding, X., Song, X., Dang, S., Yang, R., & Xu, L. (2024) · AIDS Research and Therapy · doi:10.1186/s12981-023-00589-x · Cited by 6
Bifidobacterium longum K5 Prevents Enterohaemorrhagic Escherichia coli O157:H7 Infection in Mice through the Modulation of the Gut Microbiota
Liu, D., Li, C., Cao, T., Lv, X., Yue, Y., Li, S., Yang, C., Liu, F., Huo, G., & Li, B. (2024) · Nutrients · doi:10.3390/nu16081164 · Cited by 6
Host-intestinal microbiota interactions in Edwardsiella piscicida-induced lethal enteritis in big-belly seahorses: Novel insights into the role of Carbohydrate-Active enzymes and host transcriptional responses
Jia, L., Zhang, L., Yang, H., Li, L., Zheng, S., Ma, Y., Xue, Y., Zhang, J., Li, M., Su, X., et al. (2024) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2024.110024 · Cited by 6
Integrated microbiome, transcriptome and metabolome insight into the alleviating mechanisms of sheep milk in a DSS-induced colitis mouse model
Yao, W., Du, R., Yan, S., Bao, T., Zhang, H., Yang, F., Xue, Y., Zhao, Y., Bao, S., Li, X., et al. (2025) · Journal of Functional Foods · doi:10.1016/j.jff.2025.106691 · Cited by 6
Dietary Effects of Different Proportions of Fermented Straw as a Corn Replacement on the Growth Performance and Intestinal Health of Finishing Pigs
Ji, X., Tong, W., Sun, X., Xiao, L., Wu, M., Li, P., Hu, Y., & Liang, Y. (2025) · Animals · doi:10.3390/ani15030459 · Cited by 6
Transcriptome analysis reveals the protective role of fructo-oligosaccharide in colonic mucosal barriers in exercise-induced stressed mice
Cao, W., Li, R. W., Chin, Y., Wang, Y., Xue, C., & Tang, Q. (2021) · Food & Function · doi:10.1039/d0fo02556a · Cited by 6
The Analysis of Transcriptomes and Microorganisms Reveals Differences between the Intestinal Segments of Guinea Pigs
Tang, C., Ma, J., Kong, F., Li, B., Du, Q., Zhang, Y., Wang, H., Tang, Q., Hu, S., Liu, L., et al. (2022) · Animals · doi:10.3390/ani12212925 · Cited by 6
Should we target TNF receptors in the intestinal epithelium with glucocorticoids during systemic inflammation?
Looveren, K. V., & Libert, C. (2018) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2018.1539078 · Cited by 6
Nutraceuticals in the Treatment of Inflammatory Bowel Disease: How the Panorama has Changed in the Last Decade?
Smeriglio, A., Marcoccia, D., Denaro, M., & Trombetta, D. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220428110427 · Cited by 6
Effects of heat stress on the intestinal microorganisms in poultry and its nutritional regulations: a review
Chen, Q., Wang, Z., Shao, D., & Shi, S. (2022) · World s Poultry Science Journal · doi:10.1080/00439339.2022.2106344 · Cited by 6
Toxic effects of glyphosate on histopathology and intestinal microflora of juvenile Litopenaeus vannamei
Mo, B., Li, J., Liao, G., Wang, L., & Fan, L. (2023) · Aquatic Toxicology · doi:10.1016/j.aquatox.2023.106399 · Cited by 6

Authors: Martens, E. C., Neumann, M., & Desai, M. S.
Affiliations: University of Michigan (US)
Luxembourg Institute of Health (LU)
University of Southern Denmark (DK)
Corresponding author: Martens, Eric C.
Desai, Mahesh S.
ORCID: Martens, Eric C.
Neumann, Mareike
Desai, Mahesh S.
Venue: Nature Reviews Microbiology
Publisher: Springer Science and Business Media LLC
Published: 2018-06-14
Volume: 16
Issue: 8
Pages: 457-470
ISSN: 1740-1526 (ISSN-L)
1740-1534
DOI: 10.1038/s41579-018-0036-x
OpenAlex: W2807724532
Cited by: 711
References: 156
Citations by year: 2026: 62 · 2025: 93 · 2024: 106 · 2023: 104 · 2022: 149 · 2021: 96 · 2020: 54 · 2019: 41 · 2018: 6
FWCI: 4.82
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Microbiology (publishedVersion)
PubMed (publishedVersion)
University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
Funders: Kenneth Rainin Foundation
National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: intestinal barrier, commensal microorganisms, enteric pathogens, mucus layer, intestinal epithelial cells, host defense, chronic intestinal diseases
MeSH terms: Bacteria, Humans, Intestinal Mucosa, Symbiosis, Bacterial Physiological Phenomena

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks