Cited by 806Protein Structure and DynamicsEnzyme Structure and FunctionMachine Learning in Bioinformatics

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Advances in protein structure prediction and design

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Kuhlman, Brian, Bradley, Philip·2019·Nature Reviews Molecular Cell Biology

DOI 10.1038/s41580-019-0163-xPMC PMC7032036

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Abstract

The prediction of protein three-dimensional structure from amino acid sequence has been a grand challenge problem in computational biophysics for decades, owing to its intrinsic scientific interest and also to the many potential applications for robust protein structure prediction algorithms, from genome interpretation to protein function prediction. More recently, the inverse problem - designing an amino acid sequence that will fold into a specified three-dimensional structure - has attracted growing attention as a potential route to the rational engineering of proteins with functions useful in biotechnology and medicine. Methods for the prediction and design of protein structures have advanced dramatically in the past decade. Increases in computing power and the rapid growth in protein sequence and structure databases have fuelled the development of new data-intensive and computationally demanding approaches for structure prediction. New algorithms for designing protein folds and protein-protein interfaces have been used to engineer novel high-order assemblies and to design from scratch fluorescent proteins with novel or enhanced properties, as well as signalling proteins with therapeutic potential. In this Review, we describe current approaches for protein structure prediction and design and highlight a selection of the successful applications they have enabled.

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Authors: Kuhlman, B., & Bradley, P.
Affiliations: University of North Carolina at Chapel Hill (US)
University of Washington (US)
Corresponding author: Kuhlman, Brian
Bradley, Philip
ORCID: Kuhlman, Brian
Bradley, Philip
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2019-08-15
Volume: 20
Issue: 11
Pages: 681-697
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/s41580-019-0163-x
PMC: PMC7032036
OpenAlex: W2968494487
Cited by: 806
References: 175
Citations by year: 2026: 53 · 2025: 106 · 2024: 153 · 2023: 156 · 2022: 137 · 2021: 136 · 2020: 60 · 2019: 5
FWCI: 7.46
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of General Medical Sciences (R01GM117968, R01GM121487, R01GM123378, R35GM131923)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Machine Learning in Bioinformatics
Keywords: protein structure prediction, protein design, protein folding, protein structure modeling, protein-protein interfaces, fluorescent protein engineering, signalling proteins, rational protein design, protein function prediction
MeSH terms: Algorithms, Animals, Humans, Models, Molecular, Protein Conformation, Proteins, Sequence Analysis, Protein, Databases, Protein

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