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Recognising the signals for endosomal trafficking

Weeratunga, Saroja, Paul, Blessy, Collins, Brett M.·2020·Current Opinion in Cell Biology
DOI 10.1016/j.ceb.2020.02.005
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Abstract

The endosomal compartment is a major sorting station controlling the balance between endocytic recycling and lysosomal degradation, and its homeostasis is emerging as a central factor in various neurodegenerative diseases such as Alzheimer's and Parkinson's. Membrane trafficking is generally coordinated by the recognition of specific signals in transmembrane protein cargos by different transport machineries. A number of different protein trafficking complexes are essential for sequence-specific recognition and retrieval of endosomal cargos, recycling them to other compartments and acting to counter-balance the default endosomal sorting complex required for transport-mediated degradation pathway. In this review, we provide a summary of the key endosomal transport machineries, and the molecular mechanisms by which different cargo sequences are specifically recognised.

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  • Receptor recycling from endosomes is a complex process that involves distinct pathways involving different adaptors, protein sorting machinery, and membrane composition.

    “Receptor recycling from endosomes is a complex process that involves distinct pathways involving different adaptors, protein sorting machinery, and membrane composition[23–25].”

    From Genome-scale CRISPR screening for modifiers of cellular LDL uptake (2021) · cites this paper as [25]

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Metadata

Authors
Weeratunga, S., Paul, B., & Collins, B. M.
Venue
Current Opinion in Cell Biology
Publisher
Elsevier BV
Published
2020-08
Volume
65
Pages
17-27
ISSN
0955-0674
DOI
10.1016/j.ceb.2020.02.005
Cited by
83
References
5
Language
en
Licence
Funders
  • National Health and Medical Research Council
  • BrightFocus Foundation

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