The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
The functional universe of membrane contact sites
Open accessAbstract
Organelles compartmentalize eukaryotic cells, enhancing their ability to respond to environmental and developmental changes. One way in which organelles communicate and integrate their activities is by forming close contacts, often called ‘membrane contact sites’ (MCSs). Interest in MCSs has grown dramatically in the past decade as it is has become clear that they are ubiquitous and have a much broader range of critical roles in cells than was initially thought. Indeed, functions for MCSs in intracellular signalling (particularly calcium signalling, reactive oxygen species signalling and lipid signalling), autophagy, lipid metabolism, membrane dynamics, cellular stress responses and organelle trafficking and biogenesis have now been reported. Although organelles compartmentalize eukaryotic cells, they can communicate and integrate their activities by connecting at membrane contact sites (MCSs). The roles of MCSs in biology are becoming increasingly clear, with MCSs now known to function in intracellular signalling, lipid metabolism, membrane dynamics, organelle biogenesis and the cellular stress response.
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Metadata
- Authors
- Prinz, W. A., Toulmay, A., & Balla, T.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2019-11-15
- Volume
- 21
- Issue
- 1
- Pages
- 7-24
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2987979134
- Cited by
- 726
- References
- 21
- FWCI
- 7.35
- Type
- journal article
- Language
- en
- Open access
- green
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