The DOI matches its Crossref record; 286 of the 287 references it cites were found in a registry or an index.
mTOR at the nexus of nutrition, growth, ageing and disease
Open accessAbstract
The mTOR pathway integrates a diverse set of environmental cues, such as growth factor signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half decades, mapping of the mTOR signalling landscape has revealed that mTOR controls biomass accumulation and metabolism by modulating key cellular processes, including protein synthesis and autophagy. Given the pathway's central role in maintaining cellular and physiological homeostasis, dysregulation of mTOR signalling has been implicated in metabolic disorders, neurodegeneration, cancer and ageing. In this Review, we highlight recent advances in our understanding of the complex regulation of the mTOR pathway and discuss its function in the context of physiology, human disease and pharmacological intervention.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“a notable feature of effective anti-aging interventions, such as lowered insulin/IGF-1 signaling 296 and disruption of the TORC1 complex 296,297 , is the diverse mechanisms by which they target different aging hallmarks in different tissues to maintain healthspan of the whole organism.”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [296]
In the citing paper
“Conversely, during protein breakdown, the amino acids released by lysosome and proteasome directly stimulate mTOR5 and therefore, protein synthesis might increase during muscle atrophy.”
From Mechanisms of muscle atrophy and hypertrophy: implications in health and disease (2021) · cites this paper as [5]
In the citing paper
“This kinase integrates multiple stimuli coming not only from hormones but also from cytokines, nutrients, ATP/AMP ratio, and signals to the translation machinery via p70S6K1, which controls the ribosomal protein S6, and factor 4E binding protein 1 (4EBP1), which negatively regulates the ribosomal eukaryotic translation initiator factor 4E5.”
From Mechanisms of muscle atrophy and hypertrophy: implications in health and disease (2021) · cites this paper as [5]
In the citing paper
“While mTORC2 is related to glucose and lipids homeostasis5, mTORC1 regulates several anabolic processes, including protein synthesis, ribosome, and mitochondria biogenesis.”
From Mechanisms of muscle atrophy and hypertrophy: implications in health and disease (2021) · cites this paper as [5]
In the citing paper
“Amino acids, especially the branched ones, are well-known growth-promoting agents because they directly stimulate mTOR5.”
From Mechanisms of muscle atrophy and hypertrophy: implications in health and disease (2021) · cites this paper as [5]
In the citing paper
“The mTOR kinase is part of the multiprotein complexes mTORC1 and mTORC2, which participate in the sensing of high amino acid concentrations and regulate multiple aspects of anabolic metabolism.219”
From Meta-hallmarks of aging and cancer (2023) · cites this paper as [219]
In the citing paper
“Hamartin (encoded by TSC1)–tuberin (encoded by TSC2) complexes negatively regulate mTORC1 by inhibiting GTP binding protein RHEB”
From Autophagy in kidney homeostasis and disease (2020) · cites this paper as [15]
In the citing paper
“mTORC1 is a master regulator of autophagy that is activated by amino acids or growth factors, such as insulin and insulin-like growth factor-1”
From Autophagy in kidney homeostasis and disease (2020) · cites this paper as [15]
In the citing paper
“Under nutrient-rich conditions, active mTORC1 suppresses autophagy by phosphorylating ULK1 and ATG13 to inhibit the ULK1–ULK2 complex.”
From Autophagy in kidney homeostasis and disease (2020) · cites this paper as [15]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
Sarbassov, D. D., Guertin, D. A., Ali, S. M., & Sabatini, D. M. (2005) · Science · doi:10.1126/science.1106148 · Cited by 6,216
Self-citationInhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244
Cui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,794
AMPK: guardian of metabolism and mitochondrial homeostasis
Herzig, S., & Shaw, R. J. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.95 · Cited by 4,192
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914
Cited by
Sorted by citations
Items 101–200 of 1,004
Signal pathways in the treatment of Alzheimer’s disease with traditional Chinese medicine
Ding, M.-R., Qu, Y.-J., Hu, B., & An, H. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113208 · Cited by 145
Goodwin, J. M., Walkup, W. G., Hooper, K., Li, T., Kishi-Itakura, C., Ng, A., Lehmberg, T., Jha, A., Kommineni, S., Fletcher, K., et al. (2021) · Science Advances · doi:10.1126/sciadv.abj2485 · Cited by 145
Lysosomal Exocytosis: The Extracellular Role of an Intracellular Organelle
Tancini, B., Buratta, S., Delo, F., Sagini, K., Chiaradia, E., Pellegrino, R. M., Emiliani, C., & Urbanelli, L. (2020) · Membranes · doi:10.3390/membranes10120406 · Cited by 144
Petan, T. (2020) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2020_51 · Cited by 145
Gene Regulation and Cellular Metabolism: An Essential Partnership
Carthew, R. W. (2020) · Trends in Genetics · doi:10.1016/j.tig.2020.09.018 · Cited by 143
Mohseni, A. H., Casolaro, V., Bermúdez‐Humarán, L. G., Keyvani, H., & Taghinezhad‐S, S. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1886844 · Cited by 143
LIM, C., NUNES, E. A., CURRIER, B. S., MCLEOD, J. C., THOMAS, A. C. Q., & PHILLIPS, S. M. (2022) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002929 · Cited by 142
The role of BCAA metabolism in metabolic health and disease
Choi, B. H., Hyun, S., & Koo, S. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01263-6 · Cited by 150
Non-canonical mTORC1 signaling at the lysosome
Napolitano, G., Malta, C. D., & Ballabio, A. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.04.012 · Cited by 139
Moreira, N. C. D. S., Lima, J. E. B. D. F., Marchiori, M. F., Carvalho, I., & Sakamoto‐Hojo, E. T. (2022) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-210061 · Cited by 137
Control of tumor-associated macrophage responses by nutrient acquisition and metabolism
Zhang, X., Ji, L., & Li, M. O. (2023) · Immunity · doi:10.1016/j.immuni.2022.12.003 · Cited by 136
Regulation of nucleotide metabolism in cancers and immune disorders
Ali, E. S., & Ben‐Sahra, I. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.03.003 · Cited by 137
Vascular smooth muscle cells in intimal hyperplasia, an update
Déglise, S., Bechelli, C., & Allagnat, F. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2022.1081881 · Cited by 133
A gene toolbox for monitoring autophagy transcription
Bordi, M., De Cegli, R., Testa, B., Nixon, R. A., Ballabio, A., & Cecconi, F. (2021) · Cell Death & Disease · doi:10.1038/s41419-021-04121-9 · Cited by 131
The Janus-like role of proline metabolism in cancer
Burke, L. E. C.-A., Guterman, I., Palacios-Gallego, R., Britton, R. G., Burschowsky, D., Tufarelli, C., & Rufini, A. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-00341-8 · Cited by 131
Autophagy in health and disease: From molecular mechanisms to therapeutic target
Lu, G. X., Wang, Y., Shi, Y. P., Zhang, Z., Huang, C., He, W., Wang, C., & Shen, H. (2022) · MedComm · doi:10.1002/mco2.150 · Cited by 135
The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging
Fernandes, S., & Demetriades, C. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.707372 · Cited by 131
Prospects of targeting PI3K/AKT/mTOR pathway in pancreatic cancer
Mortazavi, M., Moosavi, F., Martini, M., Giovannetti, E., & Firuzi, O. (2022) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2022.103749 · Cited by 129
Yuan, X., Xu, P., Yu, Y., & Xiong, Y. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2015400117 · Cited by 122
How does mTOR sense glucose starvation? AMPK is the usual suspect
Leprivier, G., & Rotblat, B. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-0260-9 · Cited by 121
Myelin lipid metabolism and its role in myelination and myelin maintenance
Barnes-Vélez, J. A., Aksoy Yasar, F. B., & Hu, J. (2023) · The Innovation · doi:10.1016/j.xinn.2022.100360 · Cited by 73
Neuroprotection in glaucoma: Mechanisms beyond intraocular pressure lowering
Tribble, J. R., Hui, F., Quintero, H., Hajji, S. E., Bell, K. C., Polo, A. D., & Williams, P. A. (2023) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2023.101193 · Cited by 124
The Lysosome at the Intersection of Cellular Growth and Destruction
Shin, H. R., & Zoncu, R. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.06.010 · Cited by 121
BCAA–BCKA axis regulates WAT browning through acetylation of PRDM16
Ma, Q., Zhu, W.-Y., Lu, X., Jiang, D., Xu, F., Li, J., Zhang, L., Wu, Y., Chen, Z., Yin, M., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-021-00520-6 · Cited by 122
Signaling Pathways That Regulate the Crustacean Molting Gland
Mykles, D. L. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.674711 · Cited by 117
Kaspy, M. S., Hannaian, S. J., Bell, Z. W., & Churchward‐Venne, T. A. (2023) · Nutrition Research Reviews · doi:10.1017/s0954422423000197 · Cited by 117
mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif
Baffi, T. R., Lordén, G., Wozniak, J. M., Feichtner, A., Yeung, W., Kornev, A. P., King, C. C., Rio, J. C. D., Limaye, A. J., Bogomolovas, J., et al. (2021) · Science Signaling · doi:10.1126/scisignal.abe4509 · Cited by 116
Zhou, Z., Wang, H., Zhang, X., Song, M., Yao, S., Jiang, P., Liu, D., Wang, Z., Lv, H., Li, R., et al. (2022) · Autophagy · doi:10.1080/15548627.2022.2038994 · Cited by 115
Haythorne, E., Lloyd, M., Walsby-Tickle, J., Tarasov, A. I., Sandbrink, J. B., Portillo, I., Terrón-Expósito, R., Sachse, G., Cyranka, M., Rohm, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34095-x · Cited by 118
The PI3K/Akt/mTOR pathway: A potential pharmacological target in COVID-19
Basile, M. S., Cavalli, E., McCubrey, J. A., Hernández‐Bello, J., Muñóz-Valle, J. F., Fagone, P., & Nicoletti, F. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.11.002 · Cited by 114
CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity
Long, L., Wei, J., Lim, S. A., Raynor, J. L., Shi, H., Connelly, J. P., Wang, H., Guy, C. S., Xie, B., Chapman, N. M., et al. (2021) · Nature · doi:10.1038/s41586-021-04109-7 · Cited by 113
An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy
Khalil, B. D., Sánchez, R., Rahman, T., Rodríguez-Tirado, C., Moritsch, S., Martínez, A. R., Miles, B. A., Farias, E., Mezei, M., Nobre, A. R., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210836 · Cited by 113
Wang, Y., Qin, T., Hao, Y., Yao, W., Lu, J., Chen, C., Chen, X., Lin, Y., Huang, Q., Xu, L., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-01090-1 · Cited by 113
Research progress in the role and mechanism of Leucine in regulating animal growth and development
Rehman, S. U., Ali, R., Zhang, H., Zafar, M. H., & Wang, M. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1252089 · Cited by 113
A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration
Du, J., Zheng, L., Gao, P., Yang, H., Yang, W., Guo, F., Liang, R., Feng, M., Wang, Z., Zhang, Z., et al. (2022) · Cell stem cell · doi:10.1016/j.stem.2022.03.009 · Cited by 112
Van Nostrand, J. L., Hellberg, K., Luo, E.-C., Van Nostrand, E. L., Dayn, A., Yu, J., Shokhirev, M. N., Dayn, Y., Yeo, G. W., & Shaw, R. J. (2020) · Genes & Development · doi:10.1101/gad.339895.120 · Cited by 111
The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1
Böhm, R., Imseng, S., Jakob, R. P., Hall, M. N., Maier, T., & Hiller, S. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.03.031 · Cited by 111
Rheb-regulated mitochondrial pyruvate metabolism of Schwann cells linked to axon stability
Jia, L., Liao, M., Mou, A., Zheng, Q., Yang, W., Yu, Z., Cui, Y., Xia, X., Qin, Y. N., Chen, M., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.09.013 · Cited by 112
Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3
Villegas, F., Lehalle, D., Mayer, D., Rittirsch, M., Stadler, M. B., Zinner, M., Olivieri, D., Vabres, P., Duplomb-Jego, L., De Bont, E. S. J. M., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2018.11.021 · Cited by 110
Hypoxia Signaling in Cancer: From Basics to Clinical Practice
Sebestyén, A., Kopper, L., Dankó, T., & Tímár, J. (2021) · Pathology and Oncology Research · doi:10.3389/pore.2021.1609802 · Cited by 110
Coupling of Ribosome Synthesis and Translational Capacity with Cell Growth
Dai, X., & Zhu, M. (2020) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2020.04.010 · Cited by 109
Uzhachenko, R. V., Bharti, V., Ouyang, Z., Blevins, A., Mont, S., Saleh, N., Lawrence, H. A., Shen, C., Chen, S., Ayers, G. D., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108944 · Cited by 109
Altered Metabolism in Alzheimer Disease Brain: Role of Oxidative Stress
Rummel, N. G., & Butterfield, D. A. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0177 · Cited by 111
Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity
Abdellatif, M., Trummer-Herbst, V., Heberle, A. M., Humnig, A., Pendl, T., Durand, S., Cerrato, G., Hofer, S. J., Islam, M., Voglhuber, J., et al. (2022) · Circulation · doi:10.1161/circulationaha.122.059863 · Cited by 108
The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation
Bjedov, I., & Rallis, C. (2020) · Genes · doi:10.3390/genes11091043 · Cited by 108
Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review
Lin, Y., He, F., Wu, L., Xu, Y., & Du, Q. (2022) · Drug Design Development and Therapy · doi:10.2147/dddt.s349678 · Cited by 108
Nutrient-sensing mTORC1 and AMPK pathways in chronic kidney diseases
Huynh, C. Q., Ryu, J., Lee, J., Inoki, A., & Inoki, K. (2022) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00648-y · Cited by 109
Jung, B.-K., Park, Y., Yoon, B., Bae, J.-S., Han, S.-W., Heo, J. E., Kim, D., & Ryu, K. (2023) · Autophagy · doi:10.1080/15548627.2023.2180202 · Cited by 110
Expanding the View of IKK: New Substrates and New Biology
Antonia, R. J., Hagan, R. S., & Baldwin, A. S. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.12.003 · Cited by 106
Cancer Plasticity: The Role of mRNA Translation
Lee, L. J., Papadopoli, D. J., Jewer, M., Rincon, S. V. D., Topisirović, I., Lawrence, M. G., & Postovit, L.-M. M. (2020) · Trends in cancer · doi:10.1016/j.trecan.2020.09.005 · Cited by 104
Tissue-specific immunity for a changing world
Weisberg, S. P., Ural, B. B., & Färber, D. L. (2021) · Cell · doi:10.1016/j.cell.2021.01.042 · Cited by 104
Reciprocal regulation of cellular mechanics and metabolism
Evers, T. M. J., Holt, L. J., Alberti, S., & Mashaghi, A. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00384-w · Cited by 106
Metabolomic profiling of single enlarged lysosomes
Zhu, H., Li, Q., Liao, T., Yin, X., Chen, Q., Wang, Z., Dai, M., Yi, L., Ge, S., Miao, C., et al. (2021) · Nature Methods · doi:10.1038/s41592-021-01182-8 · Cited by 103
Regulation of mTORC1 by Upstream Stimuli
Melick, C. H., & Jewell, J. L. (2020) · Genes · doi:10.3390/genes11090989 · Cited by 104
Mechanisms and Therapeutic Implications of GSK-3 in Treating Neurodegeneration
Rippin, I., & Eldar-Finkelman, H. (2021) · Cells · doi:10.3390/cells10020262 · Cited by 102
PI3K drives the de novo synthesis of coenzyme A from vitamin B5
Dibble, C. C., Barritt, S. A., Perry, G. E., Lien, E. C., Geck, R. C., DuBois-Coyne, S. E., Bartee, D., Zengeya, T. T., Cohen, E. B., Yuan, M., et al. (2022) · Nature · doi:10.1038/s41586-022-04984-8 · Cited by 102
PI3K–AKT-Targeting Breast Cancer Treatments: Natural Products and Synthetic Compounds
Yuan, Y., Long, H., Zhou, Z., Fu, Y., & Jiang, B. (2023) · Biomolecules · doi:10.3390/biom13010093 · Cited by 101
Statzer, C., Jin, M., Venz, R., Bland, M. S., Robida-Stubbs, S., Patel, K. K., Petrovic, D., Emsley, R., Liu, P., Morantte, I. G., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28599-9 · Cited by 100
Surviving and Adapting to Stress: Translational Control and the Integrated Stress Response
Wek, R. C., Anthony, T. G., & Staschke, K. A. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0123 · Cited by 99
Beclin-1: a therapeutic target at the intersection of autophagy, immunotherapy, and cancer treatment
Cao, Z., Tian, K., Ran, Y., Zhou, H., Zhou, L., Ding, Y., & Tang, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1506426 · Cited by 101
The dialogue between the ubiquitin-proteasome system and autophagy: Implications in ageing
Sun‐Wang, J. L., Ivanova, S., & Antonio Zorzano, A. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101203 · Cited by 98
Folliculin: A Regulator of Transcription Through AMPK and mTOR Signaling Pathways
Ramírez-Reyes, J. M. J., Cuesta, R., & Pause, A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.667311 · Cited by 98
Liu, F., Tian, T., Zhang, Z., Xie, S., Yang, J., Zhu, L., Wang, W., Shi, C., Sang, L., Guo, K., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00616-7 · Cited by 97
Beyond controlling cell size: functional analyses of S6K in tumorigenesis
Wu, X., Xie, W., Xie, W., Wei, W., & Guo, J. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05081-4 · Cited by 96
Geibl, F. F., Henrich, M. T., Xie, Z., Zampese, E., Ueda, J., Tkatch, T., Wokosin, D. L., Nasiri, E., Grotmann, C. A., Dawson, V. L., et al. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00756-2 · Cited by 99
Hormonal control of the crustacean molting gland: Insights from transcriptomics and proteomics
Mykles, D. L., & Chang, E. S. (2020) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2020.113493 · Cited by 95
The Molecular Link from Diet to Cancer Cell Metabolism
Bose, S., Allen, A. E., & Locasale, J. W. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.05.018 · Cited by 94
mTOR Activity and Autophagy in Senescent Cells, a Complex Partnership
Cayo, Á., Segovia, R., Venturini, W., Moore‐Carrasco, R., Valenzuela, C. A., & Brown, N. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158149 · Cited by 96
Predominant Role of mTOR Signaling in Skin Diseases with Therapeutic Potential
Karagianni, F., Pavlidis, A., Malakou, L. S., Piperi, C., & Papadavid, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031693 · Cited by 95
Parallel global profiling of plant TOR dynamics reveals a conserved role for LARP1 in translation
Scarpin, M. R., Leiboff, S., & Brunkard, J. O. (2020) · eLife · doi:10.7554/elife.58795 · Cited by 94
Structure of the nutrient-sensing hub GATOR2
Valenstein, M. L., Rogala, K. B., Lalgudi, P. V., Brignole, E. J., Gu, X., Saxton, R. A., Chantranupong, L., Kolibius, J., Quast, J.-P., & Sabatini, D. M. (2022) · Nature · doi:10.1038/s41586-022-04939-z · Cited by 94
Self-citationmTOR signaling networks: mechanistic insights and translational frontiers in disease therapeutics
Zhang, H., Xiao, X., Pan, Z., & Dokudovskaya, S. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02493-4 · Cited by 94
Eukaryotic Cell Size Control and Its Relation to Biosynthesis and Senescence
Xie, S., Swaffer, M. P., & Skotheim, J. M. (2022) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-120219-040142 · Cited by 93
Ovarian aging: energy metabolism of oocytes
Bao, S., Yin, T., & Liu, S. (2024) · Journal of Ovarian Research · doi:10.1186/s13048-024-01427-y · Cited by 92
Ng, M. Y. W., Charsou, C., Lapao, A., Singh, S., Trachsel-Moncho, L., Schultz, S. W., Nakken, S., Munson, M. J., & Simonsen, A. (2022) · Nature Communications · doi:10.1038/s41467-022-33933-2 · Cited by 59
Nüchel, J., Tauber, M., Nolte, J. L., Mörgelin, M., Türk, C., Eckes, B., Demetriades, C., & Plomann, M. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.06.017 · Cited by 90
Integration of glucose and cardiolipin anabolism confers radiation resistance of HCC
Fang, Y., Zhan, Y., Xie, Y., Du, S., Chen, Y., Zeng, Z., Zhang, Y., Chen, K., Wang, Y., Li, L., et al. (2021) · Hepatology · doi:10.1002/hep.32177 · Cited by 90
TFEB‐dependent lysosome biogenesis is required for senescence
Curnock, R., Yalci, K., Palmfeldt, J., Jäättelä, M., Liu, B., & Carroll, B. (2023) · The EMBO Journal · doi:10.15252/embj.2022111241 · Cited by 91
Insulin and aging – a disappointing relationship
Kolb, H., Kempf, K., & Martin, S. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1261298 · Cited by 92
Targeting the nucleolus as a therapeutic strategy in human disease
Corman, A., Sirozh, O., Lafarga, V., & Fernández-Capetillo, Ó. (2022) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2022.09.006 · Cited by 89
Advances in the study of the correlation between insulin resistance and infertility
Lei, R., Chen, S., & Li, W. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1288326 · Cited by 90
Oxidative Stress-Driven Cellular Senescence: Mechanistic Crosstalk and Therapeutic Horizons
Stojanović, B., Jovanovic, I., Stojanovic, M. D., Stojanović, B., Kovačević, V., Radosavljević, I., Jovanović, D., Kovačević, M. M., Zornić, N., Arsić, A. A., et al. (2025) · Antioxidants · doi:10.3390/antiox14080987 · Cited by 89
Exaptive Evolution of Target of Rapamycin Signaling in Multicellular Eukaryotes
Brunkard, J. O. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.06.022 · Cited by 89
Tarazona, O. A., & Pourquié, O. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.06.035 · Cited by 88
Build-UPS and break-downs: metabolism impacts on proteostasis and aging
Ottens, F., Franz, A., & Hoppe, T. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-020-00682-y · Cited by 88
Zanco, B., Mirth, C. K., Sgrò, C. M., & Piper, M. D. W. (2021) · eLife · doi:10.7554/elife.62335 · Cited by 88
Pathogenesis of cancers derived from thyroid follicular cells
Fagin, J. A., Krishnamoorthy, G. P., & Landa, I. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00598-y · Cited by 88
Plant target of rapamycin signaling network: Complexes, conservations, and specificities
Liu, Y., & Xiong, Y. (2021) · Journal of Integrative Plant Biology · doi:10.1111/jipb.13212 · Cited by 86
The homeostatic regulation of ribosome biogenesis
Ni, C., & Buszczak, M. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.03.043 · Cited by 89
Lysosomal quality control: molecular mechanisms and therapeutic implications
Yang, H., & Tan, J. X. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.01.001 · Cited by 86
Fan, J., Zhang, X., Zhang, J., Zhao, T., Burley, S. K., & Zheng, X. F. S. (2026) · Cell Reports · doi:10.1016/j.celrep.2025.116811 · Cited by 86
mTOR pathway: Insights into an established pathway for brain mosaicism in epilepsy
Gerasimenko, A., Baldassari, S., & Baulac, S. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106144 · Cited by 85
Cholesterol Metabolism in Aging and Age-Related Disorders
Saher, G. (2023) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-091922-034237 · Cited by 88
Zhao, J., Jin, D., Huang, M., Ji, J., Xu, X., Wang, F., Zhou, L., Bao, B., Jiang, F., Xu, W., et al. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1416472 · Cited by 84
mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity
Pagán, A. J., Lee, L. J., Edwards-Hicks, J., Moens, C. B., Tobin, D. M., Busch‐Nentwich, E. M., Pearce, E. L., & Ramakrishnan, L. (2022) · Cell · doi:10.1016/j.cell.2022.08.018 · Cited by 84
Sharma, M. D., Pacholczyk, R., Shi, H., Berrong, Z., Zakharia, Y., Greco, A., Chang, C.-S. S., Eathiraj, S., Kennedy, E. P., Cash, T., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.09.005 · Cited by 83
E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
Wang, D., Xu, C., Yang, W., Chen, J., Ou, Y., Guan, Y., Guan, J., & Liu, Y. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.01.002 · Cited by 83
Killackey, S. A., Bi, Y., Soares, F., Hammi, I., Winsor, N. J., Sater, A. A. A., Philpott, D. J., Arnoult, D., & Girardin, S. E. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.06.004 · Cited by 83
Solanki, S. A., Sanchez, K., Ponnusamy, V., Kota, V., Bell, H. N., Cho, C., Kowalsky, A. H., Green, M., Lee, J. H., & Shah, Y. M. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.11.014 · Cited by 83
Burns, J. C., Cotleur, B., Walther, D. M., Bajrami, B., Rubino, S. J., Wei, R., Franchimont, N., Cotman, S. L., Ransohoff, R. M., & Mingueneau, M. (2020) · eLife · doi:10.7554/elife.57495 · Cited by 82
Metadata
- Authors
- Liu, G. Y., & Sabatini, D. M.
- Affiliations
- Broad Institute (US)
- Corresponding author
- Sabatini, David M.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2020-01-14
- Volume
- 21
- Issue
- 4
- Pages
- 183-203
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- PMC
- PMC7102936
- OpenAlex
- W2999421965
- Cited by
- 2,737
- References
- 287
- Citations by year
- 2026: 356 · 2025: 469 · 2024: 462 · 2023: 447 · 2022: 436 · 2021: 412 · 2020: 152
- FWCI
- 34.98
- Type
- journal article
- Language
- en
- Update notices
- correction (2020-01-31)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
- Funders
- National Cancer Institute (R01CA103866, R01CA129105, F31CA232340)
- National Institute of General Medical Sciences (T32GM007287)
- National Institute of Allergy and Infectious Diseases (R37AI047389)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- mTOR signaling, nutrient sensing, cell growth, protein synthesis, autophagy, metabolic homeostasis, aging, neurodegeneration, cancer, metabolic disorders
- MeSH terms
- Aging, Animals, Autophagy, Humans, Metabolic Diseases, Neoplasms, Nutritional Status, Protein Biosynthesis, Signal Transduction, TOR Serine-Threonine Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
