Cellular adaptation to hypoxia through hypoxia inducible factors and beyond

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351

A role for mitochondria in nlrp3 inflammasome activation

Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602

Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

Bootman, M. D., Missiaen, L., Parys, J. B., SMEDT, H. D., & Casteels, R. (1995) · Biochemical Journal · doi:10.1042/bj3060445 · Cited by 5,131

Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

Locatelli, F., Fishbane, S. N., Block, G. A., & Macdougall, I. C. (2017) · American Journal of Nephrology · doi:10.1159/000455166 · Cited by 4,836

Mitochondria, Oxidants, and Aging

Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

Hetz, C. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3270 · Cited by 4,223

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

Yoshida, H., Matsui, T., Yamamoto, A., Okada, T., & Mori, K. (2001) · Cell · doi:10.1016/s0092-8674(01)00611-0 · Cited by 4,054

HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

Kim, J.-W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.002 · Cited by 3,905

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837

MiR-155 deficiency and hypoxia results in metabolism switch in the leukemic B-cells

Golovina, E., Heizer, T., Daumová, L., Báječný, M., Fontana, S., Griggio, V., Jones, R., Coscia, M., Riganti, C., & Vargová, K. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03437-8 · Cited by 2

Microbial genotoxin-elicited host DNA mutations related to mitochondrial dysfunction, a momentous contributor for colorectal carcinogenesis

Xue, Y., Gan, Y., Zhang, Y., Liu, Z., Geng, J., & Wang, W. (2024) · mSystems · doi:10.1128/msystems.00887-24 · Cited by 2

Protocol for evaluating physiological and psychological acclimatization mechanisms in Tibetan plateau environment: a clinical study of doctors from Peking Union Medical College Hospital

Xu, H., Yang, D., Li, S., He, K., Bian, M., Liu, Z., Xu, C., & Wu, D. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1490647 · Cited by 2

HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection

Fry, L., Washam, C. L., Roys, H., Bowlin, A. K., Venugopal, G., Bird, J. T., Byrum, S. D., & Weinkopff, T. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1487311 · Cited by 2

The Role of Hypoxia and HIF Transcription Factors in the Development of Ulcerative Colitis and Associated Colorectal Cancer

Silina, M. V., Dzhalilova, D. S., & Makarova, O. V. (2025) · Moscow University Biological Sciences Bulletin · doi:10.3103/s0096392525600681 · Cited by 3

Lymphatic biology and medicine

Jiang, X., Tian, W., Nicolls, M. R., & Rockson, S. G. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822546-2.00009-5 · Cited by 2

Protamine 1 as a secreted colorectal cancer-specific antigen facilitating G1/S phase transition under nutrient stress conditions

Ren, S., Yang, D., Dong, Y., Ni, W., Wang, M., Xing, L., Liu, T., Hou, W., Sun, W., Zhang, H., et al. (2023) · Cellular Oncology · doi:10.1007/s13402-022-00754-w · Cited by 2

Hyperbaric Oxygen Therapy

Moghadam, N., Amiri, A. A., & Amiri, A. A. (2025) · Springer eBooks · doi:10.1007/978-3-031-44270-4_30 · Cited by 2

Metabolic dysregulation in cancer progression

Arfin, S., Agrawal, K., Kumar, A., Kumar, A. J., Rathi, B., & Kumar, D. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-99879-6.00008-0 · Cited by 2

DNA topological regulation by topoisomerase IIβ-DNA-PK interaction is important for controlled hypoxia-inducible gene expressionPreprint

Bunch, H., Park, J., Solverson, J. K., Lee, J., Yoo, J.-S., Lu, H., Jang, J., Yoon, Y.-R., Jeon, J., Schellenberg, M. J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.06.631366 · Cited by 2

Neural Predictors of Functional Genomic Responses to Negative Social Evaluation in Adolescent FemalesPreprint

von Guttenberg, M., Gassen, J., & Slavich, G. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.18.660364 · Cited by 2

Genome-wide CRISPRi screen identifies basigin loss as protective in cardiac hypoxiaPreprint

Flanigan, W., Midha, A. D., Blume, S. Y., Martí-Mateos, Y., Costa, M. W., Huang, Y., Baik, A. H., Huynh, H., Susarla, G., Bennett, N. K., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.26.701810 · Cited by 2

Morphofunctional Assessment of Tissue Hypoxia Parameters in Lacunar Stroke in Humans

Baranich, T. I., Лазаревич, А. П., Gofman, A. A., Воронков, Д. Н., Glinkina, V. V., Gulevskaya, T. S., & Sukhorukov, V. S. (2021) · Human Physiology · doi:10.1134/s0362119721080028 · Cited by 1

SET and MYND domain-containing protein 2 (SMYD2): A prognostic biomarker associated with immune infiltrates in cervical squamous cell carcinoma and endocervical adenocarcinoma

An, Z., Cai, D., Lin, X., Xu, S., Bin, J., & Jin, X. (2022) · Archives of Biological Sciences · doi:10.2298/abs220413014a · Cited by 1

Metabolites and gene expression in the myocardium of fasting rats in an acute hypoxic environment

Zhao, R., Wang, X., Zhou, X., Jiang, S., Zhang, L., & Yu, Z. (2023) · BMC Genomics · doi:10.1186/s12864-023-09309-1 · Cited by 1

Protective autophagy enhances antistress ability through AMPK/ULK1 signaling pathway in human immortalized keratinocytes

Shi, Z., Wang, J., Li, M., Gu, L., Xu, Z., Zhai, X., Zhou, S., Zhao, J., Gu, L., Chen, L., et al. (2024) · Cell Biology International · doi:10.1002/cbin.12149 · Cited by 1

Serum Magnesium Levels and Their Association with Severe Pneumonia in Children

Saxena, S., Rajeshwari, K., Kumar, D., & Goswami, B. (2024) · Journal of Pediatric Pulmonology · doi:10.4103/jopp.jopp_11_24 · Cited by 1

Mint3 as a Molecular Target Activated in the Early Stage of Hepatocarcinogenesis

Nishitani, M., Okada, H., Nio, K., Hayashi, T., Terashima, T., Iida, N., Shimakami, T., Takatori, H., Honda, M., Kaneko, S., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041430 · Cited by 1

Responses of gut microbiota to altitude in a small mammal on Qinghai-Tibetan Plateau

Zhang, Y., Wang, Y., Yao, B., Tan, Z., Chen, X., Wang, R., Ji, W., & Qu, J. (2025) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2025.101467 · Cited by 3

Emerging Roles of Noncoding RNAs in Tumor Hypoxia

Das, S. K., & Ponmani, P. (2025) · Springer eBooks · doi:10.1007/978-981-96-1016-7_6 · Cited by 1

A novel internal standard ratio fluorescent probe for nitroreductase detection in cells

Zeng, H., Wang, H., Huang, M., Wu, Y., Wang, Y., Li, Y., & Hou, S. (2025) · New Journal of Chemistry · doi:10.1039/d5nj01597a · Cited by 1

Hyperoxic recovery impacts on metabolic adaptations induced by hypoxic exercise: A lipidomics approach

Serrao, S., Bossi, E., Denti, V., Burtscher, J., Faulhaber, M., Weiß, G., Schobersberger, W., Dünnwald, T., & Paglia, G. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2025.159647 · Cited by 1

Lidocaine Affects Collagen Breakdown Without Compromising Cell Viability in Cultured Human Tenocytes: An In Vitro Study

Randelli, F., Mazzoleni, M. G., Menon, A., Fioruzzi, A., Henin, D., Sommariva, M., & Gagliano, N. (2025) · Cells · doi:10.3390/cells14130988 · Cited by 1

A highly sensitive ESIPT fluorescent probe for visualization of HK2-mediated lung cancer progression via imaging nitroreductase

Chen, M., Wang, K., Zhang, H., Tang, B., Qu, Y., Luan, J., Luo, M., Li, H., Luo, C., Luo, Z., et al. (2025) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2025.126845 · Cited by 1

Circulating extracellular RNAs, myocardial remodeling, and elevated BMI in patients with acute coronary syndrome

Tak, K. A. (2025) · American Journal of Cardiovascular Disease · doi:10.62347/hmvt2954 · Cited by 1

STAT3/Snail Signaling and Progression of Hypoxia Tolerance in Breast Cancer Cells

Andreeva, O. E., Sorokin, D. V., Scherbakov, A. M., Vinokurova, S., Kopnin, P., Elkina, N. V., Fedorova, M. D., Katargin, A. N., Елкин, Д. С., & Ma, K. (2025) · Biochemistry (Moscow) · doi:10.1134/s0006297925601315 · Cited by 1

A Brief Review of the Role of Macrophage Hypoxia in SiO 2 ‐Induced Pulmonary Fibrosis

Fu, Y., Liu, Y., Hu, H., Zhang, Z., & Gong, W. (2025) · Journal of Applied Toxicology · doi:10.1002/jat.4906 · Cited by 1

Oleanolic Acid Regulates Intestinal Cell Proliferation and Protein Synthesis Capacity in Piglets via the Bile Acid-TGR5/AMPK/mTOR Axis

Zhai, Z., Zeng, W., Niu, K., Wang, R., Sheng, P. X., Hu, L., Guo, X., Liu, J., & Cai, L. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c03418 · Cited by 1

Hypoxia-induced dependency of Lasioderma serricorne on the purine salvage pathway unveiled by multi-omics analysis

Shen, C., Yin, L., Wang, H., Zhang, F., Wang, J., Dong, H., Bian, W., Liu, Z., Liu, Z., & Shu, J. (2025) · Journal of Stored Products Research · doi:10.1016/j.jspr.2025.102719 · Cited by 1

Cutting-edge approaches to diagnosing and treating limb ischemia in peripheral arterial disease

Okoro, G., Owunnah, F. K., Applegate, C. C., Nelappana, M. B., Dobrucki, I. T., & Dobrucki, L. W. (2025) · Progress in Biomedical Engineering · doi:10.1088/2516-1091/ae16f1 · Cited by 1

Immunometabolic costs of parasitism under warming: Impaired mitochondrial function and thermal tolerance in an Amazonian fish

da Costa, J. C., Heinrichs-Caldas, W., da Silva, J. M., Sousa, J. A., Medeiros-Leal, W. M., da Silva, M. D. N. P., & Val, A. L. (2025) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2025.110959 · Cited by 1

Restoring normoxia in hypoxic cancer cells via hemoglobin-loaded MOF nanoparticles

Jakljevič, E., Bor, G., Arnholdt, L., Coll-Satue, C., & Hosta‐Rigau, L. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.148520 · Cited by 1

Liquid biopsy in orthopedic trauma: exosomes as functional mediators and mechanistic indicators in post-traumatic complications

Gan, J., Zhong, S., Xie, J., & Zou, L. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1707928 · Cited by 1

Altitude and type 2 diabetes mellitus: an inverse ecological association across two representative Andean populations

Baquerizo-Sedano, L., Lizcano, F., Oliveros, H., Chaquila, J. A., Goñi, L., & González‐Muniesa, P. (2025) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2025.112996 · Cited by 1

A Small-Molecule Mitofusin 1 Agonist Enhances Islet Survival Under Hypoxic Conditions In Vitro and Improves Transplantation Outcomes

Wang, Y., Yang, B., Song, P., Ji, Z., Zhang, D., Chen, W., Du, L., & Liu, L. (2025) · Biomolecules · doi:10.3390/biom15111585 · Cited by 1

Serum angiogenesis-hypoxia biomarkers in relapsing-remitting multiple sclerosis

Yong, H. Y. F., Batty, N. J., Phillips, S., Ghuman, M., Zhang, Y., & Camara-Lemarroy, C. R. (2026) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2026.107356 · Cited by 1

Maternal Hypoxia and Its Epigenetic Imprint: Long-Term Implications on Immune System Ontogeny and Forensic Biomarker Identification in Offspring

Ihim, A. C., Onyeje, C. F., Ikwelle, T. A., Obi, P. C., Edeh, I., Ozuruoke, D. F. N., & Ogalagu, R. O. (2025) · Journal of Drug Delivery and Therapeutics · doi:10.22270/jddt.v15i11.7431 · Cited by 1

Arthrospira platensis Preserves Uterine Function by Modulating Electromechanical Coupling and Redox Pathways During Resistance Training in Female Rats

Barros, B. C., Diniz, A. F. A., Júnior, F. F. L., Souza, P. P. D. S., Alves, A. F., Ferreira, P. B., Cavalcante, F. D. A., & da Silva, B. A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262311440 · Cited by 1

Identification and validation of key biomarkers of the glycolysis-ketone body metabolism in heart failure based on multi-omics and machine learning

Xiao, N., Liu, J., Chen, Z., & Geng, X. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1672513 · Cited by 1

Functional polymers in the development of hemoglobin-based oxygen carriers

Lv, X., Sheng, J., & Gu, N. (2025) · Science China Technological Sciences · doi:10.1007/s11431-025-3126-x · Cited by 1

Magnetic field strategies in organ preservation

Pan, J., Yang, S., Wang, X., Song, C., & Zhang, X. (2025) · Magnetic Medicine · doi:10.1016/j.magmed.2025.100050 · Cited by 1

Three-generations low-altitude adaptations: Embryonic development, eggshell properties, and metabolic gene expression of snowy white chickens originated from Tibetan-plateau

Peng, L., Wu, L., Hu, Y., Zhang, Y., Wang, Y., Ye, L., & Zhao, X. (2025) · Poultry Science · doi:10.1016/j.psj.2025.106295 · Cited by 1

HIF-2α accumulation in human monocytes upon transfer of hypoxia-associated miRNAs via plasma-derived small extracellular vesicles from head and neck cancer patients

Theodoraki, M., Hofmann, L., Bauer, H. F., Fleckner, J., Depping, R., Idel, C., Plötze‐Martin, K., Penxová, Z., Rades, D., Hoffmann, T. K., et al. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2025.1701388 · Cited by 1

MOTS-c attenuates cardiac dysfunction following high altitude exposure by promoting mitophagy

Feng, Z., Yuan, X., Lou, J., Li, H., Zhang, Z., Li, M., Zhu, Q., Cui, Y., Li, J., Gao, F., et al. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.01.064 · Cited by 1

Gut-confined fullerene reprograms lactate metabolism to Rescue hypoxia-induced exercise intolerance

Chen, S., Pan, Y., Liu, M., Liu, C., Xu, Y., Ma, J., Li, J., Wang, C., Yang, L., Wang, Y., et al. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124075 · Cited by 1

Divergent roles of circMPP6 and its parental gene MPP6 in non-small cell lung cancer

Gao, W., Pan, F., Qiu, K., Ou, C., Tian, F., & Yu, C. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1722916 · Cited by 1

Exploring shared hypoxic pathways in cancer and obstructive sleep apnea: A critical review of extracellular vesicles-non-coding RNA signaling and biological plausibility

Cammarata, G., Pinsino, A., Bue, A. L., Salvaggio, A., Afonso, J., Oliveira, L. V. F., Insalaco, G., & Taverna, S. (2026) · Sleep Medicine · doi:10.1016/j.sleep.2026.108865 · Cited by 1

Effects of low-level lead exposure on hematological parameters and the possible underlying mechanisms

Liao, X., Lin, T., Zhang, Z., He, P., Wu, H., Ouyang, X., Li, Q., Yu, Z., Zhang, Z., Wu, J., et al. (2026) · Environmental Pollution · doi:10.1016/j.envpol.2026.127884 · Cited by 1

Mitochondrial Metabolism in Breast Cancer

Hu, Q., Luo, Z., Yuan, W., Zou, Q., Wang, L., He, Y., Shen, Y., Wen, X., Chen, S., Liu, Q., et al. (2026) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl45543 · Cited by 1

Multi-omics exploration of hypoxia in gastric cancer

Zhu, Y., & Wu, X. (2026) · World Journal of Surgical Oncology · doi:10.1186/s12957-026-04321-7 · Cited by 1

Carbon nanomaterials: a rising star in gas therapy—current advances and future perspectives

Yang, Y., Gao, K.-L., Ning, X.-F., Zhou, M.-Z., Wu, W., Zeng, B., & Liu, M.-X. (2026) · Acta Biomaterialia · doi:10.1016/j.actbio.2026.05.028 · Cited by 2

A Metabolic NanoLock strategy enhances cuproptosis in hypoxic tumors by enforcing mitochondrial respiration and suppressing glycolysis

Qin, Y., Lu, H., Wang, J.-H., & Shu, Y. (2026) · Acta Biomaterialia · doi:10.1016/j.actbio.2026.05.046 · Cited by 1

The Complex Role of Methylation in Regulating Vascular Smooth Muscle Cell Phenotypic States in Vascular Remodeling and Atherosclerosis

Basak, S. C., & Gomez, D. A. (2026) · Biomolecules · doi:10.3390/biom16060825 · Cited by 1

Regulatory mechanisms of hypoxia-inducible factors on ferroptosis in ischemic stroke

Yuan, S., Yong, P. H., Ng, Z. X., Wei, L., Ren, B., Liang, L., & Wei, G. (2026) · PeerJ · doi:10.7717/peerj.21274 · Cited by 1

Abrogation of CFA-induced rheumatoid arthritis by folate associated Quercetin loaded bio-synthesized silver nanoparticles

Bhoi, A., Singh, M., Singh, D., Sinha, S., Ajaz, A., & Keshavkant, S. (2026) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2026.108626 · Cited by 1

Framework for evaluating in vitro vasculogenic mimicry using structural and metabolic parameters

Santander, N., Babbitt, N., Veas-Torres, J., Silva-Rojas, M., Mingo, G., Valdivia, A., Espinoza, A., de Salas, S., Canales, C., Cabrera, G., et al. (2026) · Cell Reports Methods · doi:10.1016/j.crmeth.2026.101515 · Cited by 1

Pathobiology of Spinal Cord Compression

Ossandón-Pino, N., & Vidal, P. M. (2026) · Neurosurgery Clinics of North America · doi:10.1016/j.nec.2026.05.002 · Cited by 1

Epigenetic regulation and ROS signaling in plant stress adaptation: an integrated framework

Bhanbhro, N., Bakhsh, Q., Shi, S., Ma, J.-J., Basit, M. F., Wang, H.-J., Yun, Z., Jakhar, A. M., Ullah, U., Shalmani, A., et al. (2026) · Theoretical and Applied Genetics · doi:10.1007/s00122-026-05344-0 · Cited by 1

A VHL-HIF signaling axis orchestrates invariant natural killer T cell development and fate decisions

Li, Q., Zhang, C., Tang, A., Li, J., & Liu, Y. (2026) · Developmental Cell · doi:10.1016/j.devcel.2026.07.017 · Cited by 1

Impact of Hypoxia on Astrocyte Induced Pathogenesis

Munir, F., Islam, N., Nasir, M. H., Anis, Z. B., Bano, S., Naeem, S., Baig, A. A., & Sohail, Z. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.106263 · Cited by 1

Mitochondria-Associated Molecular Mechanisms in Endometriosis - A Mini Review

Tana, W. (2022) · Open Access Journal of Gynecology · doi:10.23880/oajg-16000247 · Cited by 1

Argon gas poisoning leading to persistent memory impairment: A 2-year case report

Gao, W., She, J., Wang, M., Li, S., Chen, X., & Zhu, R. (2024) · Medicine · doi:10.1097/md.0000000000038545 · Cited by 1

Comparable effects of continuous exercise training and intermittent hypoxia on angiogenic upregulations in the heart tissue of male Wistar rats

Farhadi, H., Karimi, P., Rahimifardin, S., KHANI, M., & Mousavinezhad, M. (2024) · Turkish Bulletin of Hygiene and Experimental Biology · doi:10.5505/turkhijyen.2024.45577 · Cited by 1

Hypoxia-driven Dental Pulp Stem Cells as a Promising Strategy for Tissue Regeneration

Liao, C., Chen, L., Xiang, M., Long, S., Xiang, M., Xiao, L., Long, Q., Liu, J., & Guan, X. (2024) · Current Stem Cell Research & Therapy · doi:10.2174/011574888x312892240625091241 · Cited by 1

Hematopoietic cells emerging from hemogenic endothelium exhibit lineage-specific oxidative stress responses

Biezeman, H., Nubiè, M., & Oburoglu, L. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107815 · Cited by 1

Metabolic effects following short-term cyclic hypoxia in a penaeid shrimp (juvenile and adult) and a caridean shrimp (under different salinities) (Crustacea: Decapoda)

Prevost, C., & Pomory, C. M. (2024) · Hydrobiologia · doi:10.1007/s10750-024-05788-9 · Cited by 1

Development of a near-infrared fluorescent probe for the selective detection of severe hypoxia

Kasai, T., Fujita, K., Komatsu, T., Ueno, T., Kojima, R., Hanaoka, K., & Urano, Y. (2025) · RSC Chemical Biology · doi:10.1039/d4cb00243a · Cited by 1

Whole‐body vibration protects against chronic high‐altitude hypoxic bone loss by regulating the nitric oxide/ HIF ‐1α axis in osteoblasts

Wang, D., Liu, R., Ding, Y., Pei, Q., Sun, T., Shao, X., Jiang, M., Liu, J., Huang, J., Yan, Z., et al. (2025) · The FASEB Journal · doi:10.1096/fj.202402629r · Cited by 2

Blocking lactate: kick T cells when they are down

Horková, V., Everts, B., & Brenner, D. (2025) · Immunometabolism · doi:10.1097/in9.0000000000000059 · Cited by 1

Early short-term hypoxia exposure potentiates anti-tumor activity of natural killer cells

Kim, K., Lee, M., & Kwon, S. (2025) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-025-00202-0 · Cited by 1

Pathophysiological Mechanisms Linking Obstructive Sleep Apnea to Nonalcoholic Fatty Liver Disease

Dongol, E. M., Hamdan, F. R. A., Ahmed, O., Abdel-Aziz, R. H., Younes, M., & Toghan, R. (2025) · Sleep Medicine Research · doi:10.17241/smr.2025.02859 · Cited by 1

Exploring the causal relationship between hemoglobin and pancreatic cancer and its potential mechanisms through bioinformatics and Mendelian randomization

Wang, S., Huang, S., Ren, X., Zhang, H., Tian, Y., Luo, Z., & Wang, H. (2025) · Discover Oncology · doi:10.1007/s12672-025-03352-y · Cited by 1

Low Wall Shear Stress Promotes Atheroma via Arterial Iron Accumulation

Zheng, L., Zhang, Z., Liu, Y., Cheng, C., Zhao, B., Ji, R., Chen, Z., Yang, L., Cai, J., Li, K., et al. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.125.322495 · Cited by 1

Data-driven universal insights into tumorigenesis via hallmark networks

Wang, J., Wu, Y., Hou, Y., Li, Y., Xu, D., Zhuge, C., & Han, Y. (2025) · npj Systems Biology and Applications · doi:10.1038/s41540-025-00602-1 · Cited by 1

Hypoxic preconditioning increases mitochondrial respiration and H2O2 production

Bergmeister, L., Doerrier, C., Fogli, B., Komlódi, T., Fischer, A., Springer, K., Schwarzer, C., & Gnaiger, E. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1628567 · Cited by 1

High-altitude hypoxia exacerbates gastric mucosal damage and regulates the Nrf2 signaling pathway in Helicobacter pylori-infected mice

Li, C., Wang, X., & Cui, S. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2025.1724998 · Cited by 1

Review of neuroprotective potential of natural products against hypoxia-induced neuronal injury

Zhang, Y., Yi, X., Wang, D., Kong, C., Xu, Y., & Xie, J. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1746683 · Cited by 1

Alpha-ketoglutarate enhances adipose-derived stem cells survival in wound healing by hypoxia-inducible factor 1-alpha-mediated redox homeostasis and glycogen-dependent bioenergetics

Dilimulati, D., Dilimulati, D., & Cui, L. (2026) · World Journal of Stem Cells · doi:10.4252/wjsc.v18.i2.113694 · Cited by 1

Synergistic proanthocyanidin-copper oxygen-generating microneedle enhances anti-inflammatory activity in dental pulp stem cells and macrophage efferocytosis

Miao, Y., Wang, Y., Yang, Y., Luo, Z., Wang, Y., Lei, B., & Liu, R. (2026) · BMC Oral Health · doi:10.1186/s12903-026-07870-1 · Cited by 1

Multi-tissue adaptive responses of triploid rainbow trout to chronic hypoxia: Effects on antioxidant, inflammatory, mitophagy and apoptosis

Han, Y., Meng, Y., Huang, D., Chen, Y., Sun, J., Wu, Z., Sun, G., & Ma, R. (2026) · Aquaculture Reports · doi:10.1016/j.aqrep.2026.103582 · Cited by 1

Olfactory Decline in Elderly at High Altitudes: A Narrative Review

Chen, X., & Guo, Y. (2026) · International Journal of General Medicine · doi:10.2147/ijgm.s594165 · Cited by 1

Age-Related Expression and Localization of HIF-1α and HIF-2α in Different Tissues of Yak

Wu, Q., Yang, H., Chen, J., ZhiXin, C. H. A. I., Zhao, H., & Wu, Z. (2026) · Oxygen · doi:10.3390/oxygen6020010 · Cited by 1

Wavelength-Dependent Modulation of Mesenchymal Stem Cell Fate: A Systems Biology Framework for Tissue Repair and Regenerative Medicine

Amouroux, B., Asghari, K. M., de Sousa, M., Gueguen, V., Chauvierre, C., Barzegari, A., & Pavon‐Djavid, G. (2026) · Cells · doi:10.3390/cells15100861 · Cited by 1

Hypoxia Impairs CD8+ T Cell Fitness and Is Associated with a Dysfunctional CD8+ T Cell State in Pancreatic Cancer

Mello, A. M., di Magliano, M. P., & Lee, K. P. (2026) · Cancers · doi:10.3390/cancers18101508 · Cited by 1

miR-206 regulates hypoxia-induced mitophagy and phenotypic remodeling in yak pulmonary artery smooth muscle cells

Zhao, P., Yang, S., Wei, P., Li, S., He, J., Cui, Y., & Yu, S. (2026) · Molecular Biology of the Cell · doi:10.1091/mbc.e25-11-0529 · Cited by 1

Clinically approved HIF-PHIs modulate redox metabolism, cell growth, and angiogenesis independent of HIF-1α/HIF-2α

Mennerich, D., Khoder‐Agha, F., Beter, M., Dimova, E. Y., Ylä-Herttuala, S., & Kietzmann, T. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104206 · Cited by 1

Microneedles with therapeutic gas: integrating drug propulsion and intrinsic bioactivity

Lv, C., Luo, E., Wang, W., Zhi, D., & Huang, D. (2026) · Science China Materials · doi:10.1007/s40843-025-4027-0 · Cited by 1

Metabolic host-microbe crosstalk in stabilization of epithelial HIF

Dowdell, A. S., Roer, R. L., Bhagavatula, G., Cartwright, I. M., Cohen, R. H., Countess, J. A., Koch, S. D., Lee, J. S., Liu, L., Steiner, C. A., et al. (2026) · Microbiome · doi:10.1186/s40168-026-02431-8 · Cited by 1

Angiogenesis and Ischemic Stroke

Li, G., Liu, Z., Li, W., Jiang, W., Han, H., & Dong, P. (2026) · Current Neurovascular Research · doi:10.2174/0115672026474613260430063445 · Cited by 1

DNA hydrogel-delivered hypoxic exosomes alleviate radiation-induced skin injury by stabilizing AKT

Yin, Q., Deng, S., Liu, Y., Luo, H., Yuan, S., Fei, Y., Xu, G., Liu, T., Zhang, T., Jiang, Z., et al. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04653-2 · Cited by 1

Platelet-membrane-coated photosynthetic oxygen production system for diabetic wound repair

Pan, K., Huang, Z., Tian, H., Dai, Z., Yu, J., Yang, K., Wang, Y., Zhu, J., Wang, Q., Fan, S., et al. (2026) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2026.103401 · Cited by 1

Hypoxia-Induced Epas1-Myl9/12 Axis Shapes the Pathology of Pulmonary Hypertension

Kuriyama, S., Iwamura, C., Kiuchi, M., Nagaoka, T., Kurosugi, A., Sasaki, A., Masuda, Y., Kusakari, K., Nagata, Y., Chen, S. J., et al. (2026) · Circulation Research · doi:10.1161/circresaha.125.327791 · Cited by 1

Spatial anchoring of lipid metabolism shapes immune fate in the tumor microenvironment

Zheng, S., Tan, Z., Bao, Y., Gong, X., & Zhong, X. (2026) · Lipids in Health and Disease · doi:10.1186/s12944-026-03011-3 · Cited by 1

Hypoxia-induced exosomal LNCOC1 orchestrates bladder cancer progression via the YBX1/PIK3CA axis and serves as a potential liquid biopsy biomarker

Xu, H., Yang, C., Fu, Q., Zeng, S., Yang, Y., Cao, Z., Wang, J., Xiao, Y., Zhang, X., & Wang, W. (2026) · Cellular Oncology · doi:10.1007/s13402-026-01257-8 · Cited by 1

Integrated O 2 and H 2 Gas Therapy via Microneedle‐Assisted Photocatalytic Water Splitting for Accelerating Diabetic Full‐Thickness Skin Wound Healing

Chen, Z., Yu, Y., Xiao, X., Cheng, W., Yang, Y., Zhang, Z., Wang, W., Zhou, Z., Hu, W., Wang, X., et al. (2026) · Advanced Science · doi:10.1002/advs.77413 · Cited by 1

Advanced cell-instructive bio-inks: Engineering multiscale niches for functional tissue formation

Ng, W. L., Xu, Y., Liu, F., & Bártolo, P. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.10.002 · Cited by 1

Effect of hypoxia on proliferation and glucocorticoid resistance of T-cell acute lymphoblastic leukaemia

Li, Y., Wei, Y., & Gu, L. (2021) · Hematology · doi:10.1080/16078454.2021.1980689 · Cited by 1

A Single Hypoxic Event Ameliorates Pilocarpine Induced Hyperkinetic Movements in Planaria

Neufeld, T., Carniello, T. N., & Dotta, B. T. (2022) · Natural Science · doi:10.4236/ns.2022.144014 · Cited by 1

Guilt by Association: Stepwise Entanglement of the Role of Hypoxia-inducible Factor in Pulmonary Hypertension

Crnković, S., & Kwapiszewska, G. (2023) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2023-0103ed · Cited by 1

Quantitative Analysis of the Concentration of Trifluridine in Tumor Hypoxic Regions Using a Novel Platform Combining Functional Endoscopy and Mass Spectrometry

Koganemaru, S., Fuchigami, H., Yamashita, H., Morizono, C., Sunakawa, H., Kawazoe, A., Nakamura, Y., Kuboki, Y., Shitara, K., Yano, T., et al. (2023) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.3066 · Cited by 1

Cellular and Molecular Defenses Against Hypoxia

Frede, S., & Fandrey, J. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8772-2_2 · Cited by 8

Hypoxia Inducible Factor Pathway and Physiological Adaptation: A Cell Survival Pathway?

Kumar, H., & Choi, D. (2015) · Mediators of Inflammation · doi:10.1155/2015/584758 · Cited by 192

Abstract IA017: Impact of oxygen and nutrient availability on sarcoma tumor neighborhood

Simon, M. C. (2022) · Clinical Cancer Research · doi:10.1158/1557-3265.sarcomas22-ia017

Molecular aspects of oxygen sensing in physiological adaptation to hypoxia

Czyzyk-Krzeska, M. (1997) · Respiration Physiology · doi:10.1016/s0034-5687(97)00076-5 · Cited by 61

HIF hydroxylation and the mammalian oxygen-sensing pathway

Safran, M., & Kaelin, W. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18181 · Cited by 368