Cellular adaptation to hypoxia through hypoxia inducible factors and beyond

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351

A role for mitochondria in nlrp3 inflammasome activation

Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602

Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

Bootman, M. D., Missiaen, L., Parys, J. B., SMEDT, H. D., & Casteels, R. (1995) · Biochemical Journal · doi:10.1042/bj3060445 · Cited by 5,131

Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

Locatelli, F., Fishbane, S. N., Block, G. A., & Macdougall, I. C. (2017) · American Journal of Nephrology · doi:10.1159/000455166 · Cited by 4,836

Mitochondria, Oxidants, and Aging

Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

Hetz, C. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3270 · Cited by 4,223

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

Yoshida, H., Matsui, T., Yamamoto, A., Okada, T., & Mori, K. (2001) · Cell · doi:10.1016/s0092-8674(01)00611-0 · Cited by 4,054

HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

Kim, J.-W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.002 · Cited by 3,905

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837

The Roles and Molecular Mechanisms of HIF-1α in Pulpitis

Shao, L., Wang, Q., Chen, B., & Zheng, Y. (2025) · Journal of Dental Research · doi:10.1177/00220345251320970 · Cited by 12

Spindle-Shaped Multifunctional Nanozymes with NIR-Enhanced Catalytic Activity for Treating Methicillin-Resistant Staphylococcus aureus (MRSA)-Infected Wounds through Bacterial Cuproptosis-like Death

Yu, C., Lu, Q., Wang, Y., Liu, Z., Sathishkumar, G., D’Amora, U., Kang, E. T., Xu, L., Xu, J., & Rao, X. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c05553 · Cited by 12

Lack of MOF Decreases Susceptibility to Hypoxia and Promotes Multidrug Resistance in Hepatocellular Carcinoma via HIF-1α

Wang, M., Liu, H., Zhang, X., Zhao, W., Lin, X., Zhang, F., Li, D., Xu, C., Xie, F., Wu, Z., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.718707 · Cited by 12

Hypoxic Incubation Conditions for Optimized Manufacture of Tenocyte-Based Active Pharmaceutical Ingredients of Homologous Standardized Transplant Products in Tendon Regenerative Medicine

Jeannerat, A., Peneveyre, C., Armand, F., Chiappe, D., Hamelin, R., Scaletta, C., Hirt‐Burri, N., Roessingh, A. D. B., Raffoul, W., Applegate, L. A., et al. (2021) · Cells · doi:10.3390/cells10112872 · Cited by 12

Effect of Hypoxia on the Function of the Human Serotonin1A Receptor

Dutta, A., Sarkar, P., Shrivastava, S. K., & Chattopadhyay, A. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00181 · Cited by 12

MicroRNA‐210‐mediated mtROS confer hypoxia‐induced suppression of STOCs in ovine uterine arteries

Hu, X., Song, R., Dasgupta, C., Romero, M., Juarez, R., Hanson, J., Blood, A. B., Wilson, S. M., & Zhang, L. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15914 · Cited by 13

Hypoxia–Immune-Related Gene SLC19A1 Serves as a Potential Biomarker for Prognosis in Multiple Myeloma

Li, W., Yuan, P., Liu, W., Xiao, L., Xu, C., Mo, Q., Xu, S., He, Y., Jiang, D., & Wang, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.843369 · Cited by 12

Hypoxia-induced LINC00674 facilitates hepatocellular carcinoma progression by activating the NOX1/mTOR signaling pathway

Zhu, N., Chen, X., Zhao, J., Fang, L., Yao, Y., Zhou, F., Liang, T., & Xu, Q. (2022) · Journal of Cancer · doi:10.7150/jca.76458 · Cited by 12

Iron metabolism disorder regulated by BMP signaling in hypoxic pulmonary hypertension

Jiang, Y., Guo, Y., Feng, X., Yang, P., Liu, Y., Dai, X., Zhao, F., Lei, D., Li, X., Liu, Y., et al. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166589 · Cited by 12

Involvement of hypoxia‐inducible factor activity in inevitable air‐exposure treatment upon differentiation in a three‐dimensional keratinocyte culture

Teshima, H., Endo, M., Furuyama, Y., Takama, H., Akiyama, M., Tsuji, T., Tatsukawa, H., & Hitomi, K. (2022) · FEBS Journal · doi:10.1111/febs.16707 · Cited by 12

Current data regarding homeostasis of tissues oxygenation in pathophysiological and therapeutic circumstances

Munteanu, C., Călin, M. A., Manea, D., Popescu, C., Iliescu, M. G., Ionescu, E. V., Stanciu, L., Minea, M., Oprea, C., Oprea, D., et al. (2023) · Balneo and PRM Research Journal · doi:10.12680/balneo.2022.565 · Cited by 12

VDAC1 Protein Regulation of Oxidative Damage and Mitochondrial Dysfunction-Mediated Cytotoxicity by Silica Nanoparticles in SH-SY5Y Cells

Ning, X., Li, X., Ma, K., Pang, H., Tian, T., Hao, H., Hou, Q., Li, M., Liu, T., Hou, S., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03491-9 · Cited by 12

The context-dependent role of the Na+/Ca2+-exchanger (NCX) in pancreatic stellate cell migration

Loeck, T., Rugi, M., Todesca, L. M., Kalinowska, P., Soret, B., Neumann, I., Schimmelpfennig, S., Najder, K., Pethő, Z., Farfariello, V., et al. (2023) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-023-02847-3 · Cited by 12

Chronic hypoxia stabilizes 3βHSD1 via autophagy suppression

Qin, L., Berk, M. P., Chung, Y., Cui, D., Zhu, Z., Chakraborty, A. A., & Sharifi, N. (2024) · Cell Reports · doi:10.1016/j.celrep.2023.113575 · Cited by 12

Hypoxia-induced NAD+ interventions promote tumor survival and metastasis by regulating mitochondrial dynamics

Yan, X., Qu, X., Tian, R., Xu, L., Jin, X., Yu, S., Zhao, Y., Ma, J., Liu, Y., Sun, L., et al. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118171 · Cited by 13

Hypoxia-dependent signaling in perioperative and critical care medicine

Hirota, K. (2021) · Journal of Anesthesia · doi:10.1007/s00540-021-02940-w · Cited by 12

Lessons from Comparison of Hypoxia Signaling in Plants and Mammals

Doorly, C. M., & Graciet, E. (2021) · Plants · doi:10.3390/plants10050993 · Cited by 13

Alterations of the salivary microbiome in obstructive sleep apnea and their association with periodontitis

Li, J., Gao, J., Ma, Y., Li, W., Chen, X., Li, Z., & Zhang, X.-J. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1642766 · Cited by 12

A Novel PHD2/VHL-mediated Regulation of YAP1 Contributes to VEGF Expression and Angiogenesis

Bora-Singhal, N., Saha, B., Mohankumar, D., Padmanabhan, J., Coppola, D., & Chellappan, S. (2022) · Cancer Research Communications · doi:10.1158/2767-9764.crc-21-0084 · Cited by 11

Aging Disrupts Circadian Rhythms in Mouse Liver Mitochondria

Xu, W. Q., & Li, X. (2023) · Molecules · doi:10.3390/molecules28114432 · Cited by 11

Physiological and skeletal muscle responses to high-intensity interval exercise in Thoroughbred horses

Mukai, K., Ohmura, H., Takahashi, Y., Ebisuda, Y., Yoneda, K., & Miyata, H. (2023) · Frontiers in Veterinary Science · doi:10.3389/fvets.2023.1241266 · Cited by 11

Fluorinated Cell-Penetrating Peptide for Co-Delivering siHIF-1α and Sorafenib to Enhance In Vitro Anti-Tumor Efficacy

Wan, Y., Yang, Y., Lai, Q., Wang, W., Wu, M., & Feng, S. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15122789 · Cited by 11

ALKBH1 promotes HIF-1α-mediated glycolysis by inhibiting N-glycosylation of LAMP2A

Liu, Y., Li, M., Lin, M., Liu, X., Guo, H., Tan, J., Hu, L., Li, J., & Zhou, Q. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05152-z · Cited by 11

Cigarette Smoke Extract Induces MUC5AC Expression Through the ROS/ IP3R/Ca2+ Pathway in Calu-3 Cells

Wu, X., Zhang, G., & Du, X. (2024) · International Journal of COPD · doi:10.2147/copd.s469866 · Cited by 11

Therapeutic and responsive release mechanisms of polymer drug conjugates with diverse polymer skeletons

Zhao, W., Sun, K., Yan, J., Sun, Y. Y., & Wei, D. (2024) · Nano Today · doi:10.1016/j.nantod.2024.102526 · Cited by 11

Oxygen control in cell culture – Your cells may not be experiencing what you think!

Rogers, Z. J., Flood, D., Bencherif, S. A., & Taylor, C. T. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.11.036 · Cited by 13

HIF1A facilitates hypoxia-induced changes in H3K27ac modification to promote myometrial contractility

Ji, K., Wen, B., Wang, X., Chen, L., Chen, Y., Wang, L., Bao, J., Pan, X., Zhang, G., Jiang, Y., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-07880-9 · Cited by 11

Radiotherapy-induced alterations in tumor microenvironment: metabolism and immunity

Chen, J., Wang, S., Ding, Y., Duo, X., & Zheng, S. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1568634 · Cited by 13

Sestrin2 is a central regulator of mitochondrial stress responses in disease and aging

Machado, I. F., Palmeira, C. M., & Rolo, A. P. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102762 · Cited by 12

Cancer progression through the lens of age-induced metabolic reprogramming

Lazure, F., & Gomes, A. P. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00845-4 · Cited by 11

Single Mitochondrion Morphology‐Function Relationship Analysis Using Fluorescent Probes and Artificial Intelligence

Ding, Y., Fang, B., Li, Q., Zhang, B., Li, J., Bai, H., Voelcker, N. H., Peng, B., Yang, X., & Li, L. (2025) · Advanced Science · doi:10.1002/advs.202509140 · Cited by 11

Metabolic regulation of the HBV-specific T cell function

Barili, V., Boni, C., Rossi, M., Vecchi, A. L., Zecca, A., Penna, A., Missale, G., Ferrari, C. I., & Fisicaro, P. (2020) · Antiviral Research · doi:10.1016/j.antiviral.2020.104989 · Cited by 12

Disturbance of Hypoxia Response and Its Implications in Kidney Diseases

Li, Z., Wang, B., Wen, Y., Wu, Q., Lv, L., & Liu, B. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0271 · Cited by 11

RNA-seq and qRT-PCR analyses reveal the physiological response to acute hypoxia and reoxygenation in Epinephelus coioides

Lai, X., Zhong, Z., Bing, L., Wu, Y., Ma, Y., Zhang, C., Yang, Y., Zhang, M., Qin, W., Fu, X., et al. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.1049776 · Cited by 11

Integrated transcriptomic and metabolomic analysis of cortical neurons reveals dysregulated lipid metabolism, enhanced glycolysis and activated HIF-1 signaling pathways in acute hypoxia

Zhang, W., Han, B. R., Zhang, H., Fu, R., Lu, Y., & Zhang, G. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e14949 · Cited by 11

ABL kinases regulate the stabilization of HIF-1α and MYC through CPSF1

Mayro, B., Hoj, J. P., Cerda-Smith, C. G., Hutchinson, H. M., Caminear, M. W., Thrash, H. L., Winter, P. S., Wardell, S. E., McDonnell, D. P., Wu, C., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2210418120 · Cited by 11

Multi‐omic profiling reveals an RNA processing rheostat that predisposes to prostate cancer

Stentenbach, M., Ermer, J. A., Rudler, D. L., Perks, K. L., Raven, S. A., Lee, R. G., McCubbin, T., Marcellin, E., Siira, S. J., Rackham, O., et al. (2023) · EMBO Molecular Medicine · doi:10.15252/emmm.202317463 · Cited by 11

Unveiling the hypoxia-induced mitophagy process through two-channel real-time imaging of NTR and viscosity under the same excitation

Wen, L., Shao, M., Li, Y., Zhang, Y., Peng, C., Yu, H., & Zhang, K. (2023) · Talanta · doi:10.1016/j.talanta.2023.125028 · Cited by 11

Hypoxia signaling in bone physiology and energy metabolism

Valle-Tenney, R., Melis, S., & Maes, C. (2023) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2023.100473 · Cited by 11

The Hypoxia Response Pathway: A Potential Intervention Target in Parkinson's Disease?

Daalen, J. M. J., Koopman, W. J. H., Saris, C. G. J., Meinders, M. J., Thijssen, D. H. J., & Bloem, B. R. (2023) · Movement Disorders · doi:10.1002/mds.29688 · Cited by 11

Transcriptional elongation control of hypoxic response

Soliman, S. H. A., Iwanaszko, M., Zheng, B., Gold, S. R., Howard, B. C., Das, M., Chakrabarty, R. P., Chandel, N. S., & Shilatifard, A. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2321502121 · Cited by 13

Rhodol-derived turn-on fluorescent chemosensor for ultrasensitive detection of nitroreductase activity in bacteria and bioimaging in oral cancer cells

Wang, Y., Meng, X., Ma, A., Sun, M., Jiao, S., & Wang, C. (2021) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2021.120836 · Cited by 10

Molecular and Functional Characteristics of Airway Epithelium under Chronic Hypoxia

Wong, S. L., Kardia, E., Vijayan, A., Umashankar, B., Pandžić, E., Zhong, L., Jaffé, A., & Waters, S. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076475 · Cited by 11

Roles of circRNA dysregulation in esophageal squamous cell carcinoma tumor microenvironment

Li, J., Song, Y., Cai, H., Zhou, B., & Ma, J. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1153207 · Cited by 10

Therapeutic targeting of hypoxia inducible factor in acute respiratory distress syndrome

Tran, T., Eltzschig, H. K., & Yuan, X. (2023) · The Journal of Physiology · doi:10.1113/jp284599 · Cited by 10

Protein aggregation and biomolecular condensation in hypoxic environments (Review)

Li, C., Hao, B., Yang, H., Wang, K., Fan, L., & Xiao, W. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5357 · Cited by 10

Hypoxic stabilization of RIPOR3 mRNA via METTL3-mediated m6A methylation drives breast cancer progression and metastasis

Xiong, J., Zhou, Z., Jiang, Y., Li, Q., Geng, Z., Guo, J., Yan, C., & Zhang, J. (2024) · Oncogene · doi:10.1038/s41388-024-03180-4 · Cited by 11

PRKAA2-mediated mitophagy regulates oxygen consumption in yak renal tubular epithelial cells under chronic hypoxia

Bai, X., Lu, H., Cui, Y., Yu, S., Ma, R., Yang, S., & He, J. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111450 · Cited by 10

Ablating VHL in rod photoreceptors modulates RPE glycolysis and improves preclinical model of retinitis pigmentosa

Caruso, S. M., Cui, X., Robbings, B. M., Heaps, N., Demirkol, A., da Costa, B. L., Hass, D. T., Quinn, P. M. J., Du, J., Hurley, J. B., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci185796 · Cited by 10

Estrogen via GPER downregulated HIF-1a and MIF expression, attenuated cardiac arrhythmias, and myocardial inflammation during hypobaric hypoxia

Wowui, P. I., Mprah, R., Noah, M. L. N., Adu‐Amankwaah, J., Kanoseh, A. W. L., Li, T., Chulu, D., Yalley, S. K., Shaheen, S., & Sun, H. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01144-2 · Cited by 10

HIF-1α regulates mitochondria function for oxidative stress and autophagy during oocyte maturation

Pan, W., Ma, R., Hou, Y., Wang, Y., & Sun, S. (2025) · Animal Advances · doi:10.48130/animadv-0025-0014 · Cited by 10

Tumor hypoxia shapes natural killer cell anticancer activities

Retamal, M. A., Salazar‐Onfray, F., González, F. E., & Tittarelli, A. (2025) · Journal of Molecular Medicine · doi:10.1007/s00109-025-02557-6 · Cited by 10

Shenfu injection inhibits myocardial fibrosis by regulating glycolysis through the PI3K-AKT/HIF-1α signaling pathway

Li, X., Li, D., Liu, S., Wang, Y., Fan, X., Yan, Z., Tan, S., Zhuang, P., & Zhang, Y. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157529 · Cited by 10

A mechanism for adaptive genome regulation in cancer

França, G. S., & Yanai, I. (2026) · Nature · doi:10.1038/s41586-026-10269-1 · Cited by 16

CaMKIIα Expressing Neurons to Report Activity-Related Endogenous Hypoxia upon Motor-Cognitive Challenge

Butt, U. J., Hassouna, I. A., Garcia‐Agudo, L. F., Steixner-Kumar, A. A., Depp, C., Barnkothe, N., Zillmann, M. R., Ronnenberg, A., Bonet, V., Goebbels, S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063164 · Cited by 10

Loss of mitochondrial transcription factor A in neural stem cells leads to immature brain development and triggers the activation of the integral stress response in vivo

Kuroda, R., Tominaga, K., Kasashima, K., Kuroiwa, K., Sakashita, E., Hayakawa, H., Kouki, T., Ohno, N., Kawai, K., & Endo, H. (2021) · PLoS ONE · doi:10.1371/journal.pone.0255355 · Cited by 12

Hypoxia-Induced circRNAs in Human Diseases: From Mechanisms to Potential Applications

Huang, Q. Q., Yang, J., Goh, R. M., You, M., Wang, L., & Ma, Z. (2022) · Cells · doi:10.3390/cells11091381 · Cited by 10

Oxygen sensing and transcriptional regulation under hypoxia exposure in the mollusk Crassostrea gigas

Meng, J., Wang, T., Li, B., Li, L., & Zhang, G. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.158557 · Cited by 11

Supramolecular Host–Guest Strategy for the Accelerating Detection of Nitroreductase

Zhang, L., Jiao, Y., Yang, H. X., Jia, X., Li, H., He, C., Si, W., & Duan, C. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c22851 · Cited by 10

Is cancer an intelligent species?

Nicolazzo, C., Francescangeli, F., Magri, V., Giuliani, A., Zeuner, A., & Gazzaniga, P. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-023-10123-0 · Cited by 10

Pitfalls of Mitochondrial Redox Signaling Research

Ježek, P. (2023) · Antioxidants · doi:10.3390/antiox12091696 · Cited by 11

A highly selective ratio-metric fluorescent sensor for visualizing nitroreductase in hypoxic cells

Xu, Y., Hu, B., Cui, Y., Li, L., Nian, F., Zhang, Z., & Wang, W. (2023) · Chemical Communications · doi:10.1039/d3cc05063g · Cited by 10

The role of serum acylcarnitine profiling for the detection of multiple solid tumors in humans

Wu, L., Ye, C., Yao, Q., Li, Q., Zhang, C., & Li, Y. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e23867 · Cited by 10

Tolerability and first hints for potential efficacy of motor‐cognitive training under inspiratory hypoxia in health and neuropsychiatric disorders: A translational viewpoint

Mennen, S.-S., Franta, M., Begemann, M., Wilke, J. B. H., Schröder, R., Butt, U. J., Cortés‐Silva, J., Çakır, U., Güra, M., de Marées, M., et al. (2024) · Neuroprotection/Neuroprotection (Chichester, England. Print) · doi:10.1002/nep3.47 · Cited by 10

Temporal Quantitative Proteomics Reveals Proteomic and Phosphoproteomic Alterations Associated with Adaptive Response to Hypoxia in Melanoma Cells

Datta, K. K., Periasamy, P., Mohan, S. V., Ziegman, R., & Gowda, H. (2021) · Cancers · doi:10.3390/cancers13092175 · Cited by 12

Antitumor Therapy under Hypoxic Microenvironment by the Combination of 2-Methoxyestradiol and Sodium Dichloroacetate on Human Non-Small-Cell Lung Cancer

Romero, Y., Castillejos-López, M. D. J., Romero‐Garcia, S., Salgado-Aguayo, A. R., Herrera, I., Garcia-Martin, M. O. M. O., Espíndola, L. M. T., Negrete-García, M. C., Olvera, A. C., Huerta‐Cruz, J. C., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/3176375 · Cited by 10

Polysulfide inhibits hypoxia-elicited hypoxia-inducible factor activation in a mitochondria-dependent manner

Uba, T., Matsuo, Y., Sumi, C., Shoji, T., Nishi, K., Kusunoki, M., Harada, H., Kimura, H., Bono, H. U., & Hirota, K. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.06.007 · Cited by 10

A Systematic Review on Extracellular Vesicles-Enriched Fat Grafting: A Shifting Paradigm

Ghiasloo, M., Wilde, L., Singh, K., Tonnard, P., Verpaele, A., Wever, O. D., & Blondeel, P. N. (2020) · Aesthetic Surgery Journal · doi:10.1093/asj/sjaa362 · Cited by 10

Cancer Metabolism under Limiting Oxygen ConditionsPreprint

Kim, L. C., Lesner, N. P., & Simon, M. C. (2023) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041542 · Cited by 11

Subtype Transdifferentiation in Human Cancer: The Power of Tissue Plasticity in Tumor Progression

Fedele, M., Cerchia, L., & Battista, S. (2024) · Cells · doi:10.3390/cells13040350 · Cited by 9

Clinically applicable optimized periprosthetic joint infection diagnosis via AI based pathology

Tao, Y., Luo, Y., Hu, H. M., Wang, W., Zhao, Y., Wang, S., Zheng, Q., Zhang, T., Zhang, G., Li, J., et al. (2024) · npj Digital Medicine · doi:10.1038/s41746-024-01301-7 · Cited by 10

Effects of camel whey protein hydrolysate on growth, nutrient metabolism, and tight junction protein gene expression in Oreochromis niloticus under hypoxia stress

Dahran, N. A., Alotaibi, B. S., Abd‐Elhakim, Y. M., Ibrahim, R. E., Metwally, M. M. M., Khamis, T., El‐Far, A. H., Osman, A., Eskandrani, A. A., Babteen, N. A., et al. (2025) · Aquaculture International · doi:10.1007/s10499-024-01815-7 · Cited by 9

Adaptation mechanisms in cancer: Lipid metabolism under hypoxia and nutrient deprivation as a target for novel therapeutic strategies (Review)

Koizume, S., & Miyagi, Y. (2025) · Molecular Medicine Reports · doi:10.3892/mmr.2025.13448 · Cited by 10

Multiomics and Systematic Analyses Reveal the Roles of Hemoglobin and the HIF‐1 Pathway in Polycystic Ovary Syndrome

Wang, G., Mao, W., Zhang, Y., Yang, H., Zhu, M., Li, Y., Chen, W., Chen, Y., Lou, C., Li, P., et al. (2025) · Advanced Science · doi:10.1002/advs.202411679 · Cited by 9

Mechanisms and strategies for organ recovery

Andrijević, D., Spajic, A., Hameed, I., Sheth, K. N., Parnia, S., Griesemer, A., Montgomery, R. A., & Šestan, N. (2025) · Nature Reviews Bioengineering · doi:10.1038/s44222-025-00293-7 · Cited by 10

Endoplasmic reticulum stress: an emerging therapeutic target for preeclampsia

Chen, M., Jin, Y., & Cao, X. (2025) · Biology of Reproduction · doi:10.1093/biolre/ioaf071 · Cited by 11

An erythroid-biased FOShi hematopoietic multipotent progenitor subpopulation contributes to adaptation to chronic hypoxia

Liu, W., Zhang, X., Liu, J., Pu, L., Ai, L., Xu, H., Wang, G., Wang, D., Song, X., Zhang, Y., et al. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.03.010 · Cited by 9

EPO Enhances Adaptation to Hypoxic Environment in the Freshwater Teleost ( Micropterus salmoides ) through the PI3K/AKT Pathway

Yan, H., Zhao, L., He, K., Liu, H., Zhang, C., Liu, Q., Song, K., Yang, H., Xu, T., & Yang, S. Y. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.5c00093 · Cited by 9

Modulation of NAD metabolism by oxygen availability

Burtscher, J., Dünnwald, T., & Paglia, G. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.07.014 · Cited by 9

ERCC6L-mediated stabilization of HIF-1α enhances glycolysis and stemness properties of lung adenocarcinoma cells

Lu, Z., Yao, X., Jiang, J., & Hou, G. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07879-4 · Cited by 9

A Sustained Oxygen- and Nitric Oxide-Producing Hydrogel Accelerates Methicillin-Resistant Staphylococcus aureus -Infected Diabetic Wound Healing under Hypoxia

Bai, Q., Hu, F., Gao, Q., Zheng, C., Zhang, Y., Ramakrishna, S., Wu, X., & Lu, T. (2025) · Chemistry of Materials · doi:10.1021/acs.chemmater.5c00474 · Cited by 9

Physiological Differences Underlying Divergent Hypoxia Responses and Altitude Adaptations in Humans, Rats and Mice

Burtscher, J., Mallet, R. T., Sah, A., Gassmann, M., Burtscher, M., & Iturriaga, R. (2025) · Comprehensive physiology · doi:10.1002/cph4.70077 · Cited by 9

Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock

Sakamoto, T., Fukui, Y., Kondoh, Y., Honda, K., Shimizu, T., Hara, T., Hayashi, T., Saitoh, Y., Murakami, Y., Inoue, J., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02701-1 · Cited by 9

A novel fluorescent probe derived from isophorone and its application in imaging in vivo hypoxia

Guo, L., Wang, P., Chen, H., Fan, X., Zhu, H.-L., & Li, Z. (2022) · Materials Today Chemistry · doi:10.1016/j.mtchem.2022.100928 · Cited by 9

Metformin prevents hypoxia‐induced podocyte injury by regulating the ZEB2 / TG2 axis

Kolligundla, L. P., Kavvuri, R., Singh, A., Mukhi, D., & Pasupulati, A. K. (2022) · Nephrology · doi:10.1111/nep.14121 · Cited by 9

Proteomic Analysis Reveals That Mitochondria Dominate the Hippocampal Hypoxic Response in Mice

Shao, Q., Liu, J., Li, G., Gu, Y., Guo, M., Guan, Y., Tian, Z., Ma, W., Wang, C., & Ji, X. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214094 · Cited by 9

Research progress on the mechanism of phenotypic transformation of pulmonary artery smooth muscle cells induced by hypoxia

Mao, J., & Ma, L. (2022) · Journal of Zhejiang University (Medical Sciences) · doi:10.3724/zdxbyxb-2022-0282 · Cited by 9

Neuroglobin Facilitates Neuronal Oxygenation through Tropic Migration under Hypoxia or Anemia in Rat: How Does the Brain Breathe?

Li, C., Jiang, H., Li, L., Lai, X., Liu, Q.-R., Yu, S.-B., Yi, C., & Chen, X. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01040-x · Cited by 9

Hub genes identification and association of key pathways with hypoxia in cancer cells: A bioinformatics analysis

Aziz, F., Shoaib, N., & Rehman, A. (2023) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2023.103752 · Cited by 9

Role of hypoxic exosomes and the mechanisms of exosome release in the CNS under hypoxic conditions

Yang, R., Li, Z., Xu, J., Luo, J., Qu, Z., Chen, X., Yu, S., & Shu, H. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1198546 · Cited by 9

The Effects of Hypoxia-Preconditioned Dental Stem Cell-Derived Secretome on Tissue Regeneration

Liu, Y., Ren, L., Li, M., Zheng, B., & Liu, Y. (2024) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2024.0054 · Cited by 9

Stanniocalcin 2 governs cancer cell adaptation to nutrient insufficiency through alleviation of oxidative stress

Qie, S., Xiong, H., Liu, Y., Yan, C., Wang, Y., Tian, L., Wang, C., & Sang, N. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06961-7 · Cited by 9

EPAS1 induction drives myocardial degeneration in desmoplakin-cardiomyopathy

Kyriakopoulou, E., van Kampen, S. J., Wehrens, M., Han, S. J., de Ruiter, H., Monshouwer‐Kloots, J., Marshall, E., Brodehl, A., van der Kraak, P. H., Riele, A. S. J. M. T., et al. (2025) · iScience · doi:10.1016/j.isci.2025.111895 · Cited by 9

Hypoxia-inducible factor 2α mediates nonesterified fatty acids and hypoxia-induced lipid accumulation in bovine hepatocytes

Kong, F., Lei, L., Cai, L., Li, J., Zhao, C., Liu, M., Qi, D., Gao, J., Li, E., Gao, W., et al. (2025) · Journal of Dairy Science · doi:10.3168/jds.2024-25839 · Cited by 10

Preclinical Retinal Disease Models: Applications in Drug Development and Translational Research

Pandi, S. P. S., Winter, H., Smith, M. R., Harkin, K., & Bojdo, J. (2025) · Pharmaceuticals · doi:10.3390/ph18030293 · Cited by 9

Hypoxic stress enhances extension and branching of dorsal root ganglion neuronal outgrowth

Ma, J., Stefanoska, D., Stone, L. S., Hildebrand, M., van Donkelaar, C. C., Zou, X., Basoli, V., Grad, S., Alini, M., & Peroglio, M. (2020) · JOR Spine · doi:10.1002/jsp2.1090 · Cited by 9

Discovery of neuroprotective agents that inhibit human prolyl hydroxylase PHD2

Richardson, N., O'Malley, L. J., Weissberger, D., Tumber, A., Schofield, C. J., Griffith, R., Jones, N. M., & Hunter, L. (2021) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2021.116115 · Cited by 9

Protective Role of miR-34c in Hypoxia by Activating Autophagy through BCL2 Repression

Kim, S., Han, J., Ahn, Y., Ha, C. H., Hwang, J. J., Lee, S. E., Kim, J., & Kim, N. (2022) · Molecules and Cells · doi:10.14348/molcells.2022.2010 · Cited by 9

Direct interaction between mortalin and HIF ‐1α at the mitochondria inhibits apoptosis by blocking recruitment of Bax

Yfantis, A., Mylonis, I., & Simos, G. (2023) · FEBS Journal · doi:10.1111/febs.16762 · Cited by 12

Tolerance of aquifer stoneflies to repeated hypoxia exposure and oxygen dynamics in an alluvial aquifer

Malison, R. L., DelVecchia, A. G., Woods, H. A., Hand, B. K., Luikart, G., & Stanford, J. A. (2020) · Journal of Experimental Biology · doi:10.1242/jeb.225623 · Cited by 9

Cellular and Molecular Defenses Against Hypoxia

Frede, S., & Fandrey, J. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8772-2_2 · Cited by 8

Hypoxia Inducible Factor Pathway and Physiological Adaptation: A Cell Survival Pathway?

Kumar, H., & Choi, D. (2015) · Mediators of Inflammation · doi:10.1155/2015/584758 · Cited by 192

Abstract IA017: Impact of oxygen and nutrient availability on sarcoma tumor neighborhood

Simon, M. C. (2022) · Clinical Cancer Research · doi:10.1158/1557-3265.sarcomas22-ia017

Molecular aspects of oxygen sensing in physiological adaptation to hypoxia

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HIF hydroxylation and the mammalian oxygen-sensing pathway

Safran, M., & Kaelin, W. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18181 · Cited by 368