Cellular adaptation to hypoxia through hypoxia inducible factors and beyond

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351

A role for mitochondria in nlrp3 inflammasome activation

Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602

Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

Bootman, M. D., Missiaen, L., Parys, J. B., SMEDT, H. D., & Casteels, R. (1995) · Biochemical Journal · doi:10.1042/bj3060445 · Cited by 5,131

Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

Locatelli, F., Fishbane, S. N., Block, G. A., & Macdougall, I. C. (2017) · American Journal of Nephrology · doi:10.1159/000455166 · Cited by 4,836

Mitochondria, Oxidants, and Aging

Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

Hetz, C. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3270 · Cited by 4,223

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

Yoshida, H., Matsui, T., Yamamoto, A., Okada, T., & Mori, K. (2001) · Cell · doi:10.1016/s0092-8674(01)00611-0 · Cited by 4,054

HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

Kim, J.-W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.002 · Cited by 3,905

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837

Hypoxia-induced phase separation of ZHX2 alters chromatin looping to drive cancer metastasis

Gao, C., Gao, A., Jiang, Y., Gao, R., Guo, Y., Peng, Z., Jiang, W., Zhang, M., Zhou, Z., Yan, C., et al. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.03.009 · Cited by 26

Renal hypoxia–HIF–PHD–EPO signaling in transition metal nephrotoxicity: friend or foe?

Thévenod, F., Schreiber, T., & Lee, W. (2022) · Archives of Toxicology · doi:10.1007/s00204-022-03285-3 · Cited by 27

Host cell egress of Brucella abortus requires BNIP3L‐mediated mitophagy

Verbeke, J., Fayt, Y., Martin, L. S., Yilmaz, O., Sędzicki, J., Reboul, A., Jadot, M., Renard, P., Dehio, C., Renard, H., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2022112817 · Cited by 32

Microbial‐Enabled Photosynthetic Oxygenation for Disease Treatment

Yang, Z., Li, P., Feng, W., & Chen, Y. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202305866 · Cited by 26

Hypoxia-triggered exosome-mimetics accelerate vascularized osteogenesis

Zhong, Z., Li, Y., Sun, Z., Wu, X., Li, J., Jiang, S., Wang, Y., Wang, J., Du, Y., & Zhang, S. (2024) · Materials Today · doi:10.1016/j.mattod.2023.09.026 · Cited by 26

Harnessing CD8+ T cell dynamics in hepatitis B virus‐associated liver diseases: Insights, therapies and future directions

Yue, B., Gao, Y., Hu, Y., Zhan, M., Wu, Y., & Lu, L. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1731 · Cited by 26

Metabolic Escape Routes of Cancer Stem Cells and Therapeutic Opportunities

Turdo, A., Porcelli, G., D’Accardo, C., Franco, S. D., Verona, F., Forte, S., Giuffrida, D., Memeo, L., Todaro, M., & Stassi, G. (2020) · Cancers · doi:10.3390/cancers12061436 · Cited by 27

Cell Competition Boosts Clonal Evolution and Hypoxic Selection in Cancer

Madan, E., Peixoto, M. L., Dimitrion, P. M., Eubank, T. D., Yekelchyk, M., Talukdar, S., Fisher, P. B., Mi, Q., Moreno, E., & Gogna, R. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.10.002 · Cited by 26

Immunometabolism of Tissue-Resident Macrophages – An Appraisal of the Current Knowledge and Cutting-Edge Methods and Technologies

Zago, G., Saavedra, P. H. V., Keshari, K. R., & Perry, J. S. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.665782 · Cited by 26

Circadian clocks' interactions with oxygen sensing and signalling

Adamovich, Y., Dandavate, V., & Asher, G. (2022) · Acta Physiologica · doi:10.1111/apha.13770 · Cited by 27

Thermosensitive Hydrogel with Programmable, Self‐Regulated HIF‐1α Stabilizer Release for Myocardial Infarction Treatment

Deng, K., Hua, Y., Gao, Y., Zheng, H., Jiang, Y., Wang, Y., Gao, C., Ren, T., & Zhu, Y. (2024) · Advanced Science · doi:10.1002/advs.202408013 · Cited by 25

Gut-lung immunometabolic crosstalk in sepsis: from microbiota to respiratory failure

Li, Q., Song, X.-C., Li, K., & Wang, J. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1685044 · Cited by 25

Transcriptional response of key metabolic and stress response genes of a nuculanid bivalve, Lembulus bicuspidatus from an oxygen minimum zone exposed to hypoxia-reoxygenation

Amorim, K., Piontkivska, H., Zettler, M. L., Sokolov, E. P., Hinzke, T., Nair, A. M., & Sokolova, I. M. (2021) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2021.110617 · Cited by 25

The endothelial glycocalyx in critical illness: A pediatric perspective

Richter, R. P., Payne, G. A., Ambalavanan, N., Gaggar, A., & Richter, J. R. (2022) · Matrix Biology Plus · doi:10.1016/j.mbplus.2022.100106 · Cited by 25

Recent Developments in PET and SPECT Radiotracers as Radiopharmaceuticals for Hypoxia Tumors

Nguyen, A. T., & Kim, H. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15071840 · Cited by 25

Positive selection in the genomes of two Papua New Guinean populations at distinct altitude levels

André, M., Brucato, N., Hudjashov, G., Pankratov, V., Yermakovich, D., Montinaro, F., Kreevan, R., Kariwiga, J., Muke, J., Boland, A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47735-1 · Cited by 27

Hypoxia-Driven Changes in Tumor Microenvironment: Insights into Exosome-Mediated Cell Interactions

Wang, C., Xu, S., & Yang, X. J. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s479533 · Cited by 27

Carbon dioxide-dependent signal transduction in mammalian systems

Phelan, D. E., Mota, C., Lai, C., Kierans, S. J., & Cummins, E. P. (2021) · Interface Focus · doi:10.1098/rsfs.2020.0033 · Cited by 27

Connections between metabolism and epigenetic modifications in cancer

Wang, G., & Han, J. J. (2021) · Medical Review · doi:10.1515/mr-2021-0015 · Cited by 27

Self-reinforcement hydrogel with sustainable oxygen-supply for enhanced cell ingrowth and potential tissue regeneration

Gao, C., Huang, Y., Zhang, L., Wei, P., Wei, J., Wang, H., Yuan, Z., Zhang, D., Yu, Y., Yang, X., et al. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.213105 · Cited by 24

Severe inbreeding, increased mutation load and gene loss-of-function in the critically endangered Devils Hole pupfish

Tian, D., Patton, A. H., Turner, B. J., & Martin, C. H. (2022) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2022.1561 · Cited by 25

ADAMTS12 promotes oxaliplatin chemoresistance and angiogenesis in gastric cancer through VEGF upregulation

Jiang, Y., Huang, J., Huang, Z., Li, W., Tan, R., Li, T., Chen, Z., Tang, X., Zhao, Y., Qiu, J., et al. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110866 · Cited by 24

The journey from erythropoietin to 2019 Nobel Prize: Focus on hypoxia-inducible factors in the kidney

Pan, S., Chiang, W., & Chen, Y. (2020) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2020.06.006 · Cited by 24

The hepatic microenvironment and regulatory T cells

Osei‐Bordom, D., Bozward, A. G., & Oo, Y. H. (2020) · Cellular Immunology · doi:10.1016/j.cellimm.2020.104195 · Cited by 24

Mitochondria in hypoxic pulmonary hypertension, roles and the potential targets

Geng, Y., Hu, Y., Zhang, F., Tuo, Y., Ge, R., & Bai, Z. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1239643 · Cited by 26

Epigenetic remodelling under hypoxia

Verdikt, R., & Thienpont, B. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.10.005 · Cited by 24

Elevated SLC1A5 associated with poor prognosis and therapeutic resistance to transarterial chemoembolization in hepatocellular carcinoma

Zhang, G., Xiao, Y., Tan, J., Liu, H., Fan, W., & Li, J. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05298-1 · Cited by 23

Targeting Mitochondrial Dysfunction in Cerebral Ischemia: Advances in Pharmacological Interventions

Belenichev, I. F., Popazova, O., Bukhtiyarova, N. V., Ryzhenko, V. P., Pavlov, S. V., Suprun, E. V., Oksenych, V., & Kamyshnyi, O. (2025) · Antioxidants · doi:10.3390/antiox14010108 · Cited by 25

Development and validation of a hypoxia-associated signature for lung adenocarcinoma

Lane, B. S., Khan, M. T., Choudhury, A., Salem, A., & West, C. (2022) · Scientific Reports · doi:10.1038/s41598-022-05385-7 · Cited by 23

Metabolic codependencies in the tumor microenvironment and gastric cancer: Difficulties and opportunities

Zhao, X., Li, K., Chen, M., & Liu, L. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114601 · Cited by 23

Environmental and behavioral regulation of HIF-mitochondria crosstalk

Burtscher, J., Hohenauer, E., Burtscher, M., Millet, G. P., & Egg, M. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.06.015 · Cited by 27

Neutrophil-mediated hypoxia drives pathogenic CD8+ T cell responses in cutaneous leishmaniasis

Fowler, E. A., Amorim, C. F., Mostacada, K., Yan, A., Sacramento, L. A., Stanco, R. A., Hales, E. D. S., Varkey, A., Zong, W., Wu, G. D., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci177992 · Cited by 26

Hypoxic responses in Oncorhynchus mykiss involve angiogenesis, lipid, and lactate metabolism, which may be triggered by the cortisol stress response and epigenetic methylation

Léger, J. A. D., Athanàsio, C. G., Zhera, A., Chauhan, M. F., & Simmons, D. B. D. (2021) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2021.100860 · Cited by 23

Fatal attraction – The role of hypoxia when alpha-synuclein gets intimate with mitochondria

Burtscher, J., Syed, M. M. K., Keller, M. A., Lashuel, H. A., & Millet, G. P. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.07.017 · Cited by 25

Introducing the brain erythropoietin circle to explain adaptive brain hardware upgrade and improved performance

Ehrenreich, H., Garcia‐Agudo, L. F., Steixner-Kumar, A. A., Wilke, J. B. H., & Butt, U. J. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01551-5 · Cited by 23

Myostatin/HIF2α-Mediated Ferroptosis Is Involved in Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease

Zhang, L., Li, D., Chang, C., & Sun, Y. (2022) · International Journal of Chronic Obstructive Pulmonary Disease · doi:10.2147/copd.s377226 · Cited by 22

Oxygen‐regulated post‐translation modifications as master signalling pathway in cells

Batie, M., Fasanya, T., Kenneth, N. S., & Rocha, S. (2023) · EMBO Reports · doi:10.15252/embr.202357849 · Cited by 18

Polyphenol-hyaluronic acid-based hydrogel remodels the wound microenvironment and eliminates bacterial infection for accelerating wound healing

Liu, T., Cao, H., Wang, R., Yang, Q., Wei, S., Pan, P., & Shi, H. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.135931 · Cited by 22

Living photosynthetic microneedle patches for in situ oxygenation and postsurgical melanoma therapy

Jia, J., Guo, X., Wang, Y., Wu, M., Wang, X., Zhao, M., & Zhao, Y. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02982-8 · Cited by 22

Considerations about Hypoxic Changes in Neuraxis Tissue Injuries and Recovery

Stoica, S. I., Bleoţu, C., Ciobanu, V., Ionescu, A. M., Albadi, I., Onose, G., & Munteanu, C. (2022) · Biomedicines · doi:10.3390/biomedicines10020481 · Cited by 23

Hypoxia‐Inducible Factor‐2α Signaling in the Skeletal System

Mendoza, S. V., Genetos, D. C., & Yellowley, C. E. (2023) · JBMR Plus · doi:10.1002/jbm4.10733 · Cited by 26

Anti-PCSK9 Treatment Attenuates Liver Fibrosis via Inhibiting Hypoxia-Induced Autophagy in Hepatocytes

Ning, L., Zou, Y., Li, S., Cao, Y., Xu, B., Zhang, S., & Cai, Y. (2023) · Inflammation · doi:10.1007/s10753-023-01865-8 · Cited by 22

Current advances in nanoformulations of therapeutic agents targeting tumor microenvironment to overcome drug resistance

Fakhri, S., Moradi, S. Z., Faraji, F., Farhadi, T., Hesami, O., Iranpanah, A., Webber, K. J., & Bishayee, A. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-023-10119-w · Cited by 24

Natural products target glycolysis in liver disease

Li, S., Hao, L., & Hu, X. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1242955 · Cited by 22

Long Noncoding RNA HCG18 Promotes Malignant Phenotypes of Breast Cancer Cells via the HCG18/miR-103a-3p/UBE2O/mTORC1/HIF-1α–Positive Feedback Loop

Liu, X., Qiao, K., Zhu, K., Li, X., Zhao, C., Li, J., Feng, D., Yu, F., Wang, P., Qian, C., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.675082 · Cited by 22

Deletion of prolyl hydroxylase domain-containing enzyme 3 (phd3) in zebrafish facilitates hypoxia tolerance

Liao, Q., Deng, H., Wang, Z., Yu, G., Zhu, C., Jia, S., Liu, W., Bai, Y., Sun, X., Chen, X., et al. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105420 · Cited by 23

Identification of Hypoxia‐ALCAMhigh Macrophage‐ Exhausted T Cell Axis in Tumor Microenvironment Remodeling for Immunotherapy Resistance

Xun, Z., Zhou, H., Shen, M., Liu, Y., Sun, C., Du, Y., Jiang, Z., Yang, L., Zhang, Q. H., Lin, C., et al. (2024) · Advanced Science · doi:10.1002/advs.202309885 · Cited by 27

The Contact Allergen NiSO4 Triggers a Distinct Molecular Response in Primary Human Dendritic Cells Compared to Bacterial LPS

Höper, T., Siewert, K., Dumit, V. I., von Bergen�, M., Schubert, K. A., & Haase, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.644700 · Cited by 21

The Impact of COVID-19 Infection on Oxygen Homeostasis: A Molecular Perspective

Alayash, A. I. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.711976 · Cited by 21

QSAR study of phenolic compounds and their anti-DPPH radical activity by discriminant analysis

Lu, A., Yuan, S.-M., Xiao, H., Yang, D., Ai, Z.-Q., Li, Q., Zhao, Y., Chen, Z., & Wu, X. (2022) · Scientific Reports · doi:10.1038/s41598-022-11925-y · Cited by 21

Long-term p21 and p53 dynamics regulate the frequency of mitosis events and cell cycle arrest following radiation damage

Tran, A. P., Tralie, C. J., Reyes, J. S., Moosmüller, C., Belkhatir, Z., Kevrekidis, I. G., Levine, A. J., Deasy, J. O., & Tannenbaum, A. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01069-x · Cited by 21

Commonly Overlooked Factors in Biocompatibility Studies of Neural Implants

Kumosa, L. S. (2023) · Advanced Science · doi:10.1002/advs.202205095 · Cited by 21

Physiological responses to acute hypoxia in the liver of largemouth bass by alteration of mitochondrial function and Ca2+ exchange

Zhao, L., Liao, L., Yan, H., Tang, X. H., He, K., Liu, Q., Luo, J., Du, Z. J., Chen, S. Y., Zhang, X., et al. (2023) · Aquatic Toxicology · doi:10.1016/j.aquatox.2023.106436 · Cited by 21

Hypoxic State of Cells and Immunosenescence: A Focus on the Role of the HIF Signaling Pathway

Troise, D. E., Infante, B., Mercuri, S., Netti, G. S., Ranieri, E., Gesualdo, L., Stallone, G., & Pontrelli, P. (2023) · Biomedicines · doi:10.3390/biomedicines11082163 · Cited by 22

Targeting the Mitochondrial Chaperone TRAP1 Alleviates Vascular Pathologies in Ischemic Retinopathy

Kim, S., Yoon, N. G., Im, J. Y., Lee, J. H., Kim, J., Jeon, Y., Choi, Y. J., Lee, J., Uemura, A., Park, D. H., et al. (2023) · Advanced Science · doi:10.1002/advs.202302776 · Cited by 21

Microenvironment of pancreatic inflammation: calling for nanotechnology for diagnosis and treatment

Liu, L., Zhang, Y., Li, X., & Deng, J. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02200-x · Cited by 23

Redefining the role of hypoxia-inducible factors (HIFs) in oxygen homeostasis

Arias, C. F., Acosta, F. J., Bertocchini, F., & Fernández-Arias, C. (2025) · Communications Biology · doi:10.1038/s42003-025-07896-1 · Cited by 22

Multidimensional tumor heterogeneity and its role in therapeutic resistance

Mubin, N., Alnukhali, M., Ahmad, N., Driscoll, J. J., & Ahmad, A. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1794130 · Cited by 21

The role of the Na+/Ca2+-exchanger (NCX) in cancer-associated fibroblasts

Loeck, T., & Schwab, A. (2023) · Biological Chemistry · doi:10.1515/hsz-2022-0253 · Cited by 20

Lactylation constrains OXPHOS under hypoxia

Ren, H., & Zhang, D. (2024) · Cell Research · doi:10.1038/s41422-023-00872-6 · Cited by 20

Whole genome re-sequencing reveals high altitude adaptation signatures and admixture in Ladakhi cattle

Koloi, S., Ganguly, I., Singh, S., & Dixit, S. (2024) · Gene · doi:10.1016/j.gene.2024.148957 · Cited by 20

Metabolic Changes in Tumor Microenvironment: How Could They Affect γδ T Cells Functions?

Corsale, A. M., Simone, M. D., Presti, E. L., Picone, C., Dieli, F., & Meraviglia, S. (2021) · Cells · doi:10.3390/cells10112896 · Cited by 21

Hypoxia signaling and oxygen metabolism in cardio-oncology

Baik, A. H. (2022) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.12.013 · Cited by 20

MYB sustains hypoxic survival of pancreatic cancer cells by facilitating metabolic reprogramming

Anand, S., Khan, M. A., Zubair, H., Sudan, S. K., Vikramdeo, K. S., Deshmukh, S. K., Azim, S., Srivastava, S. K., Singh, S., & Singh, A. P. (2023) · EMBO Reports · doi:10.15252/embr.202255643 · Cited by 20

Methyltransferase SMYD3 impairs hypoxia tolerance by augmenting hypoxia signaling independent of its enzymatic activity

Wang, Z., Chen, X., Fan, S., Zhu, C., Deng, H., Tang, J., Sun, X., Jia, S., Liao, Q., Xiao, W., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102633 · Cited by 19

Growth and adaptation mechanisms of tumour spheroids with time-dependent oxygen availability

Murphy, R. J., Gunasingh, G. P., Haass, N. K., & Simpson, M. J. (2023) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1010833 · Cited by 19

Microfluidic Mixer for In Situ Ammonia Analysis of Single Cells in Mass Spectrometry

Yi, X., Zhang, Q., Xie, T., Feng, S., Xu, N., & Lin, J. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.2c04181 · Cited by 19

Nano-Electrochemical Characterization of a 3D Bioprinted Cervical Tumor Model

Becconi, M., Zio, S. D., Falciani, F., Santamaria, M., Malferrari, M., & Rapino, S. (2023) · Cancers · doi:10.3390/cancers15041327 · Cited by 19

Exploiting moderate hypoxia to benefit patients with brain disease: Molecular mechanisms and translational research in progress

Ehrenreich, H., Gassmann, M., Poustka, L., Burtscher, M., Hammermann, P., Sirén, A., Nave, K., & Miskowiak, K. W. (2023) · Neuroprotection/Neuroprotection (Chichester, England. Print) · doi:10.1002/nep3.15 · Cited by 19

Crosstalk between hypoxic cellular micro-environment and the immune system: a potential therapeutic target for infectious diseases

Akinsulie, O. C., Shahzad, S., Ogunleye, S. C., Oladapo, I. P., Joshi, M., Ugwu, C. E., Gbadegoye, J. O., Hassan, F. O., Adeleke, R. A., Akande, Q. A., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1224102 · Cited by 19

Different dissolved oxygen effects on growth and O2-sensing pathway in juvenile bighead carp (Hypophthalmichthys nobilis)

Zhou, X., Wu, Y., Zhou, Y., Zhang, Z., Chen, G., Yu, X., & Tong, J. (2024) · Aquaculture · doi:10.1016/j.aquaculture.2024.740672 · Cited by 19

Roles of β-Cell Hypoxia in the Progression of Type 2 Diabetes

Yamagata, K., Tsuyama, T., & Sato, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084186 · Cited by 20

Controlling Pericellular Oxygen Tension in Cell Culture Reveals Distinct Breast Cancer Responses to Low Oxygen Tensions

Rogers, Z. J., Colombani, T., Khan, S., Bhatt, K., Nukovic, A., Zhou, G., Woolston, B. M., Taylor, C. T., Gilkes, D. M., Slavov, N., et al. (2024) · Advanced Science · doi:10.1002/advs.202402557 · Cited by 20

Natural products as potent inhibitors of hypoxia-inducible factor-1α in cancer therapy

Zhong, J., Li, X., Lyu, W.-Y., Ye, W., & Zhang, D. (2020) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(20)60008-5 · Cited by 19

Prognostic and Clinicopathological Significance of Hypoxia-Inducible Factor-1α in Endometrial Cancer: A Meta-Analysis

Zhu, P., Shen, L., Ren, Q., Zeng, Q., & Xiaocui, H. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.587420 · Cited by 20

More Than Meets the Eye: Revisiting the Roles of Heat Shock Factor 4 in Health and Diseases

Syafruddin, S. E., Ling, S., Low, T. Y., & Mohtar, M. A. (2021) · Biomolecules · doi:10.3390/biom11040523 · Cited by 19

Hypoxia-inducing cryogels uncover key cancer-immune cell interactions in an oxygen-deficient tumor microenvironment

Colombani, T., Rogers, Z. J., Bhatt, K., Sinoimeri, J., Gerbereux, L., Hamrangsekachaee, M., & Bencherif, S. A. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.06.021 · Cited by 19

Spatiotemporal Heterogeneity of Tumor Glucose Metabolism Reprogramming: From Single-Cell Mechanisms to Precision Interventions

Chai, X., Tao, Q., & Li, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146901 · Cited by 18

Pharmacological Diversity of Flavonoids and Their Clinical Application Prospects in Neurological Disorders

Cheng, S., Gao, H., Yang, Y., Zhang, M., Wang, J., Li, N., Ji, Y., Wang, H., & You, Z. (2025) · Phytotherapy Research · doi:10.1002/ptr.70097 · Cited by 20

Gut HIF2α signaling is increased after VSG, and gut activation of HIF2α decreases weight, improves glucose, and increases GLP-1 secretion

Evers, S. S., Shao, Y., Ramakrishnan, S. K., Shin, J. H., Bozadjieva-Kramer, N., Irmler, M., Stemmer, K., Sandoval, D. A., Shah, Y. M., & Seeley, R. J. (2022) · Cell Reports · doi:10.1016/j.celrep.2021.110270 · Cited by 18

Oxygen Measurement in Microdevices

Grist, S. M., Bennewith, K. L., & Cheung, K. C. (2022) · Annual Review of Analytical Chemistry · doi:10.1146/annurev-anchem-061020-111458 · Cited by 20

Hypoxia-triggered O-GlcNAcylation in the brain drives the glutamate–glutamine cycle and reduces sensitivity to sevoflurane in mice

He, Q., Yang, M. G., Huang, J. L., Wu, W., Tang, K., Zhang, Y., Zhou, J., Ou, W., Xie, M., Liang, Y., et al. (2022) · British Journal of Anaesthesia · doi:10.1016/j.bja.2022.06.041 · Cited by 18

Pseudocatalytic Hydrogels with Intrinsic Antibacterial and Photothermal Activities for Local Treatment of Subcutaneous Abscesses and Breast Tumors

Ma, Y., Sun, Y., Xu, L., Li, X., Gong, D., Miao, Z., & Qian, H. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202201023 · Cited by 18

Short-term hypoxia triggers ROS and SAFB mediated nuclear matrix and mRNA splicing remodeling

Taze, C., Drakouli, S., Samiotaki, M. K., Panayotou, G., Simos, G., Georgatsou, E., & Mylonis, I. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102545 · Cited by 18

Nrf2 and Parkin-Hsc70 regulate the expression and protein stability of p62/SQSTM1 under hypoxia

Siswanto, F. M., Mitsuoka, Y., Nakamura, M., Oguro, A., & Imaoka, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-25784-0 · Cited by 19

Hypothalamic Oxytocin Neuron Activation Attenuates Intermittent Hypoxia-Induced Hypertension and Cardiac Dysfunction in an Animal Model of Sleep Apnea

Rodriguez, J., Escobar, J. B., Cheung, E. C., Kowalik, G., Russo, R., Dyavanapalli, J., Alber, B. R., Harral, G., Gill, A., Melkie, M., et al. (2023) · Hypertension · doi:10.1161/hypertensionaha.122.20149 · Cited by 18

The NAD salvage pathway in mesenchymal cells is indispensable for skeletal development in mice

Warren, A. D., Porter, R. M., Reyes‐Castro, O., Ali, M. M., Marques-Carvalho, A., Kim, H., Gatrell, L. B., Schipani, E., Nookaew, I., O’Brien, C. A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39392-7 · Cited by 20

Tumor microenvironment-responsive degradable silica nanoparticles: design principles and precision theranostic applications

Zhang, J., Tang, K., Liu, Z., Zhang, Z., Duan, S., Wang, H., Yang, H. Y., Yang, D., & Fan, W. (2023) · Nanoscale Horizons · doi:10.1039/d3nh00388d · Cited by 18

Hypoxia and its effect on the cellular system

Rahane, D., Dhingra, T., Chalavady, G., Datta, A., Ghosh, B., Rana, N., Borah, A., Saraf, S., & Bhattacharya, P. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.3940 · Cited by 20

Spatially resolved analysis of microenvironmental gradient impact on cancer cell phenotypes

Auxillos, J., Crouigneau, R., Li, Y.-F., Dai, Y., Stigliani, A., Tavernaro, I., Resch‐Genger, U., Sandelin, A., Marie, R., & Pedersen, S. F. (2024) · Science Advances · doi:10.1126/sciadv.adn3448 · Cited by 18

Application of Advanced Mass Spectrometry-Based Proteomics to Study Hypoxia Driven Cancer Progression

Vinaiphat, A., Low, J. K., Yeoh, K. W., Chng, W. J., & Sze, S. K. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.559822 · Cited by 19

Proteomic-Based Analysis of Hypoxia- and Physioxia-Responsive Proteins and Pathways in Diffuse Large B-Cell Lymphoma

Duś‐Szachniewicz, K., Gdesz-Birula, K., Zduniak, K., & Wiśniewski, J. R. (2021) · Cells · doi:10.3390/cells10082025 · Cited by 21

Identification of a miRNA–mRNA Regulatory Networks in Placental Tissue Associated With Tibetan High Altitude Adaptation

Tenzing, N., van Patot, M. C. T., Liu, H., Xu, Q., Liu, J., Wang, Z., Wang, Y., Wuren, T., & Ge, R. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.671119 · Cited by 18

Precise and fast control of the dissolved oxygen level for tumor-on-chip

Bouquerel, C., César, W., Barthod, L., Arrak, S., Battistella, A., Gropplero, G., Mechta‐Grigoriou, F., Zalcman, G., Parrini, M. C., Verhulsel, M., et al. (2022) · Lab on a Chip · doi:10.1039/d2lc00696k · Cited by 18

The microenvironment of secondary lymphedema. The key to finding effective treatments?

Hossain, L., Gomes, K. P., Safarpour, S., & Gibson, S. B. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167677 · Cited by 17

Adaptation of Natural Killer Cells to Hypoxia: A Review of the Transcriptional, Translational, and Metabolic Processes

Chang, T., Chen, Y.-J., Luo, J., Zhang, C., Chen, S.-Y., Lin, Z.-Q., Zhang, P., Shen, Y., Tang, T.-X., Li, H., et al. (2025) · ImmunoTargets and Therapy · doi:10.2147/itt.s492334 · Cited by 18

Tumour acidosis remodels the glycocalyx to control lipid scavenging and ferroptosis

Bång-Rudenstam, A., Cerezo-Magaña, M., Horvath, M., Hugo Talbot, A., Gustafsson, E., Jonathan, S., Chakraborty, C., Nissen, I., de Oliveira, K. G., Boukredine, A., et al. (2026) · Nature Cell Biology · doi:10.1038/s41556-026-01879-y · Cited by 17

Cobalt chloride-stimulated hypoxia promotes the proliferation of cholesteatoma keratinocytes via the PI3K/Akt signaling pathway

Zhang, C., Chen, M., Tao, Q., & Chi, Z. (2021) · International Journal of Medical Sciences · doi:10.7150/ijms.60617 · Cited by 18

Hypoxia-responsive lncRNA G077640 promotes ESCC tumorigenesis via the H2AX–HIF1α–glycolysis axis

Huang, X., Liu, C., Li, H. R., Dai, T., Luo, G., Zhang, C., Li, T., & Lü, M. (2023) · Carcinogenesis · doi:10.1093/carcin/bgad036 · Cited by 17

Regulation of CD73 on NAD metabolism: Unravelling the interplay between tumour immunity and tumour metabolism

Zhan, J., Huang, L., Niu, L., Lu, W., Sun, C., Liu, S., Ding, Z., & Li, E. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01755-y · Cited by 17

Cellular and Molecular Defenses Against Hypoxia

Frede, S., & Fandrey, J. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8772-2_2 · Cited by 8

Hypoxia Inducible Factor Pathway and Physiological Adaptation: A Cell Survival Pathway?

Kumar, H., & Choi, D. (2015) · Mediators of Inflammation · doi:10.1155/2015/584758 · Cited by 192

Abstract IA017: Impact of oxygen and nutrient availability on sarcoma tumor neighborhood

Simon, M. C. (2022) · Clinical Cancer Research · doi:10.1158/1557-3265.sarcomas22-ia017

Molecular aspects of oxygen sensing in physiological adaptation to hypoxia

Czyzyk-Krzeska, M. (1997) · Respiration Physiology · doi:10.1016/s0034-5687(97)00076-5 · Cited by 61

HIF hydroxylation and the mammalian oxygen-sensing pathway

Safran, M., & Kaelin, W. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18181 · Cited by 368