Cited by 480Muscle Physiology and DisordersCongenital heart defects researchMesenchymal stem cell research

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Control of satellite cell function in muscle regeneration and its disruption in ageing

Sousa-Victor, Pedro, García-Prat, Laura, Muñoz-Cánoves, Pura·2022·Nature Reviews Molecular Cell Biology

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Abstract

Skeletal muscle contains a designated population of adult stem cells, called satellite cells, which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically and usually by asymmetric cell division to replace myofibres damaged by daily activity and maintain the stem cell pool. However, satellite cells can also be robustly activated upon tissue injury, after which they undergo symmetric divisions to generate new stem cells and numerous proliferating myoblasts that later differentiate to muscle cells (myocytes) to rebuild the muscle fibre, thereby supporting skeletal muscle regeneration. Recent discoveries show that satellite cells have a great degree of population heterogeneity, and that their cell fate choices during the regeneration process are dictated by both intrinsic and extrinsic mechanisms. Extrinsic cues come largely from communication with the numerous distinct stromal cell types in their niche, creating a dynamically interactive microenvironment. This Review discusses the role and regulation of satellite cells in skeletal muscle homeostasis and regeneration. In particular, we highlight the cell-intrinsic control of quiescence versus activation, the importance of satellite cell-niche communication, and deregulation of these mechanisms associated with ageing. The increasing understanding of how satellite cells are regulated will help to advance muscle regeneration and rejuvenation therapies.

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Authors: Sousa-Victor, P., García-Prat, L., & Muñoz-Cánoves, P.
ORCID: Muñoz-Cánoves, Pura
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2021-10-18
Volume: 23
Issue: 3
Pages: 204-226
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/s41580-021-00421-2
OpenAlex: W3205354997
Cited by: 476
References: 299
Citations by year: 2026: 107 · 2025: 126 · 2024: 118 · 2023: 78 · 2022: 45 · 2021: 2
FWCI: 6.48
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
Funders: Canadian Institutes of Health Research (201910MFE-430959-284655)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords: satellite cells, skeletal muscle regeneration, muscle aging, muscle stem cells, quiescence, cell activation, asymmetric cell division, symmetric cell division, myogenesis, stem cell niche, niche microenvironment, stromal cells, muscle homeostasis, cell-intrinsic regulation
MeSH terms: Cell Differentiation, Stem Cells, Muscle, Skeletal, Satellite Cells, Skeletal Muscle

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Control of satellite cell function in muscle regeneration and its disruption in ageing

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