Cited by 126Mitochondrial Function and PathologyCalcium signaling and nucleotide metabolismIon Channels and Receptors

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The roles of mitochondria in global and local intracellular calcium signalling

Cartes-Saavedra, Benjamín, Ghosh, Arijita, Hajnóczky, György·2025·Nature Reviews Molecular Cell Biology

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Abstract

Activation of Ca 2+ channels in Ca 2+ stores in organelles and the plasma membrane generates cytoplasmic calcium ([Ca 2+]c) signals that control almost every aspect of cell function, including metabolism, vesicle fusion and contraction. Mitochondria have a high capacity for Ca 2+ uptake and chelation, alongside efficient Ca 2+ release mechanisms. Still, mitochondria do not store Ca 2+ in a prolonged manner under physiological conditions and lack the capacity to generate global [Ca 2+]c signals. However, mitochondria take up Ca 2+ at high local [Ca 2+]c signals that originate from neighbouring organelles, and also during sustained global elevations of [Ca 2+]c. Accumulated Ca 2+ in the mitochondria stimulates oxidative metabolism and upon return to the cytoplasm, can produce spatially confined rises in [Ca 2+]c to exert control over processes that are sensitive to Ca 2+. Thus, the mitochondrial handling of [Ca 2+]c is of physiological relevance. Furthermore, dysregulation of mitochondrial Ca 2+ handling can contribute to debilitating diseases. We discuss the mechanisms and relevance of mitochondria in local and global calcium signals.

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See all 126

Authors: Cartes-Saavedra, B., Ghosh, A., & Hajnóczky, G.
Affiliations: Thomas Jefferson University (US)
Corresponding author: Hajnóczky, György
ORCID: Cartes-Saavedra, Benjamín
Ghosh, Arijita
Hajnóczky, György
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2025-01-27
Volume: 26
Issue: 6
Pages: 456-475
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/s41580-024-00820-1
OpenAlex: W4406871717
Cited by: 126
References: 314
Citations by year: 2026: 87 · 2025: 38
FWCI: 11.06
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (R03TR004644)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK125897)
National Center for Advancing Translational Sciences
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: mitochondria, intracellular calcium signaling, mitochondrial calcium uptake, mitochondrial calcium release, intracellular calcium stores, calcium channels, intracellular calcium, oxidative metabolism, disease
MeSH terms: Animals, Calcium, Cytoplasm, Humans, Mitochondria, Calcium Channels, Calcium Signaling

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The roles of mitochondria in global and local intracellular calcium signalling

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