Cited by 430Memory and Neural MechanismsNeural dynamics and brain functionMemory Processes and Influences

The DOI matches its Crossref record; 256 of the 256 references it cites were found in a registry or an index.

The hippocampal sharp wave-ripple in memory retrieval for immediate use and consolidation

Open access

Joo, Hannah R., Frank, Loren M.·2018·Nature Reviews Neuroscience

DOI 10.1038/s41583-018-0077-1PMC PMC6794196

Open this paper in CoChat — free account

Abstract

Various cognitive functions have long been known to require the hippocampus. Recently, progress has been made in identifying the hippocampal neural activity patterns that implement these functions. One such pattern is the sharp wave-ripple (SWR), an event associated with highly synchronous neural firing in the hippocampus and modulation of neural activity in distributed brain regions. Hippocampal spiking during SWRs can represent past or potential future experience, and SWR-related interventions can alter subsequent memory performance. These findings and others suggest that SWRs support both memory consolidation and memory retrieval for processes such as decision-making. In addition, studies have identified distinct types of SWR based on representational content, behavioural state and physiological features. These various findings regarding SWRs suggest that different SWR types correspond to different cognitive functions, such as retrieval and consolidation. Here, we introduce another possibility - that a single SWR may support more than one cognitive function. Taking into account classic psychological theories and recent molecular results that suggest that retrieval and consolidation share mechanisms, we propose that the SWR mediates the retrieval of stored representations that can be utilized immediately by downstream circuits in decision-making, planning, recollection and/or imagination while simultaneously initiating memory consolidation processes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/s41583-018-0077-1

Cites

256 of 256 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Human-level control through deep reinforcement learning
Mnih, V., Kavukcuoglu, K., Silver, D., Rusu, A. A., Veness, J., Bellemare, M. G., Graves, A., Riedmiller, M., Fidjeland, A. K., Ostrovski, G., et al. (2015) · Nature · doi:10.1038/nature14236 · Cited by 30,357
LOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONS
Scoville, W. B., & Milner, B. (1957) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.20.1.11 · Cited by 7,322
Place navigation impaired in rats with hippocampal lesions
Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340
The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat
O'Keefe, J., & Dostrovsky, J. (1971) · Brain Research · doi:10.1016/0006-8993(71)90358-1 · Cited by 6,151
Why there are complementary learning systems in the hippocampus and neocortex: insights from the successes and failures of connectionist models of learning and memory
McClelland, J. L., McNaughton, B. L., & O'Reilly, R. C. (1995) · Psychological Review · doi:10.1037/0033-295x.102.3.419 · Cited by 5,256
Episodic memory: from mind to brain
Tulving, E. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135114 · Cited by 4,950
Memory - A century of consolidation
McGaugh, J. L. (2000) · Science · doi:10.1126/science.287.5451.248 · Cited by 4,250
Catastrophic Interference in Connectionist Networks: The Sequential Learning Problem
McCloskey, M., & Cohen, N. J. (1989) · Psychology of Learning and Motivation · doi:10.1016/s0079-7421(08)60536-8 · Cited by 3,770
Speed of processing in the human visual system
Thorpe, S., Fize, D., & Marlot, C. (1996) · Nature · doi:10.1038/381520a0 · Cited by 3,538
The Medial Temporal Lobe Memory System
Squire, L. R., & Zola-Morgan, S. (1991) · Science · doi:10.1126/science.1896849 · Cited by 3,282

Show all 256 references

Research works printed but not linked: 3

Cohen, N. J. & Eichenbaum, H. Memory, Amnesia, and the Hippocampal System (MIT Press, 1993).
O’Keefe, J. & Nadel, L. The Hippocampus as a Cognitive Map (Oxford Univ. Press, 1978).
O’Reilly, R. C. & Rudy, J. W. Computational principles of learning in the neocortex and hippocampus. Hippocampus 10, 389–397 (2000). · DOI

Sorted by citations

Memory engrams: Recalling the past and imagining the future
Josselyn, S. A., & Tonegawa, S. (2020) · Science · doi:10.1126/science.aaw4325 · Cited by 1,087
Sleep—A brain-state serving systems memory consolidation
Brodt, S., Inostroza, M., Niethard, N., & Born, J. (2023) · Neuron · doi:10.1016/j.neuron.2023.03.005 · Cited by 343
Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer’s disease
Chen, J.-F., Liu, K., Hu, B., Li, R.-R., Xin, W., Chen, H., Wang, F., Chen, L., Li, R.-X., Ren, S.-Y., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.05.012 · Cited by 346
Constant Sub-second Cycling between Representations of Possible Futures in the Hippocampus
Kay, K., Chung, J. E., Sosa, M., Schor, J. S., Karlsson, M. P., Larkin, M. C., Liu, D. F., & Frank, L. M. (2020) · Cell · doi:10.1016/j.cell.2020.01.014 · Cited by 312
Self-citation
Competing Roles of Slow Oscillations and Delta Waves in Memory Consolidation versus Forgetting
Kim, J., Gulati, T., & Ganguly, K. (2019) · Cell · doi:10.1016/j.cell.2019.08.040 · Cited by 254
Hippocampal sharp-wave ripples linked to visual episodic recollection in humans
Norman, Y., Yeagle, E. M., Khuvis, S., Harel, M., Mehta, A. D., & Malach, R. (2019) · Science · doi:10.1126/science.aax1030 · Cited by 270
Bidirectional prefrontal-hippocampal dynamics organize information transfer during sleep in humans
Helfrich, R. F., Lendner, J. D., Mander, B. A., Guillen, H., Paff, M., Mnatsakanyan, L., Vadera, S., Walker, M. P., Lin, J. J., & Knight, R. T. (2019) · Nature Communications · doi:10.1038/s41467-019-11444-x · Cited by 222
Dynamics of awake hippocampal-prefrontal replay for spatial learning and memory-guided decision making
Shin, J. D., Tang, W., & Jadhav, S. P. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.012 · Cited by 199
Hippocampal replay reflects specific past experiences rather than a plan for subsequent choice
Gillespie, A. K., Maya, D. A., Denovellis, E. L., Liu, D. F., Kastner, D. B., Coulter, M. E., Roumis, D. K., Eden, U. T., & Frank, L. M. (2021) · Neuron · doi:10.1016/j.neuron.2021.07.029 · Cited by 207
Self-citation
Alzheimer’s disease as a synaptopathy: Evidence for dysfunction of synapses during disease progression
Meftah, S., & Gan, J. (2023) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2023.1129036 · Cited by 205
Replay of cortical spiking sequences during human memory retrieval
Vaz, A. P., Wittig, J. H., Inati, S. K., & Zaghloul, K. A. (2020) · Science · doi:10.1126/science.aba0672 · Cited by 196
Endogenous memory reactivation during sleep in humans is clocked by slow oscillation-spindle complexes
Schreiner, T., Petzka, M., Staudigl, T., & Staresina, B. P. (2021) · Nature Communications · doi:10.1038/s41467-021-23520-2 · Cited by 161
Neuronal Computation Underlying Inferential Reasoning in Humans and Mice
Barron, H. C., Reeve, H. M., Koolschijn, R. S., Perestenko, P. V., Shpektor, A., Nili, H., Rothaermel, R., Campo-Urriza, N., O’Reilly, J. X., Bannerman, D. M., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.035 · Cited by 184
A consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations
Liu, A. A., Henin, S. E., Abbaspoor, S., Bragin, A., Buffalo, E. A., Farrell, J. S., Foster, D. J., Frank, L. M., Gedankien, T., Gotman, J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33536-x · Cited by 188
Self-citation
An Integrated Index: Engrams, Place Cells, and Hippocampal Memory
Goode, T. D., Tanaka, K. Z., Sahay, A., & McHugh, T. J. (2020) · Neuron · doi:10.1016/j.neuron.2020.07.011 · Cited by 170
Navigating for reward
Sosa, M., & Giocomo, L. M. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00479-z · Cited by 146
Basal forebrain cholinergic signalling: development, connectivity and roles in cognition
Ananth, M. R., Rajebhosale, P., Kim, R., Talmage, D. A., & Role, L. W. (2023) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00677-x · Cited by 148
Hippocampal ripples and their coordinated dialogue with the default mode network during recent and remote recollection
Norman, Y., Raccah, O., Liu, S., Parvizi, J., & Malach, R. (2021) · Neuron · doi:10.1016/j.neuron.2021.06.020 · Cited by 140
Engram neurons: Encoding, consolidation, retrieval, and forgetting of memory
Guskjolen, A. J., & Cembrowski, M. S. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02137-5 · Cited by 161
What Are Memories For? The Hippocampus Bridges Past Experience with Future Decisions
Biderman, N., Bakkour, A., & Shohamy, D. (2020) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2020.04.004 · Cited by 160
The brain in motion: How ensemble fluidity drives memory-updating and flexibility
Mau, W., Hasselmo, M. E., & Cai, D. J. (2020) · eLife · doi:10.7554/elife.63550 · Cited by 148
Memory consolidation as an adaptive process
Cowan, E. T., Schapiro, A. C., Dunsmoor, J. E., & Murty, V. P. (2021) · Psychonomic Bulletin & Review · doi:10.3758/s13423-021-01978-x · Cited by 133
Dorsal and Ventral Hippocampal Sharp-Wave Ripples Activate Distinct Nucleus Accumbens Networks
Sosa, M., Joo, H. R., & Frank, L. M. (2019) · Neuron · doi:10.1016/j.neuron.2019.11.022 · Cited by 118
Self-citation
Selection of experience for memory by hippocampal sharp wave ripples
Yang, W., Sun, C., Huszár, R., Hainmueller, T., Kiselev, K., & Buzsáki, G. (2024) · Science · doi:10.1126/science.adk8261 · Cited by 121
Reward revaluation biases hippocampal replay content away from the preferred outcome
Carey, A. A., Tanaka, Y., & van der Meer, M. A. A. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0464-6 · Cited by 106
Hippocampo-cortical circuits for selective memory encoding, routing, and replay
Harvey, R. E., Robinson, H. L., Liu, C., Oliva, A., & Fernandez-Ruiz, A. (2023) · Neuron · doi:10.1016/j.neuron.2023.04.015 · Cited by 101
Impaired neural replay of inferred relationships in schizophrenia
Nour, M. M., Liu, Y., Arumuham, A., Kurth-Nelson, Z. L., & Dolan, R. J. (2021) · Cell · doi:10.1016/j.cell.2021.06.012 · Cited by 101
Early Hippocampal Sharp-Wave Ripple Deficits Predict Later Learning and Memory Impairments in an Alzheimer’s Disease Mouse Model
Jones, E. A. A., Gillespie, A. K., Yoon, S. Y., Frank, L. M., & Huang, Y. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.056 · Cited by 103
Self-citation
Sleep Deprivation by Exposure to Novel Objects Increases Synapse Density and Axon–Spine Interface in the Hippocampal CA1 Region of Adolescent Mice
Spano, G. M., Banningh, S. W., Marshall, W., de Vivo, L., Bellesi, M., Loschky, S. S., Tononi, G., & Cirelli, C. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0380-19.2019 · Cited by 99
Diversity and function of corticopetal and corticofugal GABAergic projection neurons
Melzer, S., & Monyer, H. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0344-9 · Cited by 101
Neurophysiology of Remembering
Buzsáki, G., McKenzie, S., & Davachi, L. (2022) · Annual Review of Psychology · doi:10.1146/annurev-psych-021721-110002 · Cited by 84
Hippocampal replay of experience at real-world speeds
Denovellis, E. L., Gillespie, A. K., Coulter, M. E., Sosa, M., Chung, J. E., Eden, U. T., & Frank, L. M. (2021) · eLife · doi:10.7554/elife.64505 · Cited by 89
Self-citation
Cross-species neuroscience: closing the explanatory gap
Barron, H. C., Mars, R. B., Dupret, D., Lerch, J. P., & Sampaio‐Baptista, C. (2020) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0633 · Cited by 89
How the Human Brain Sleeps: Direct Cortical Recordings of Normal Brain Activity
von Ellenrieder, N., Gotman, J., Zelmann, R., Rogers, C., Nguyen, D. K., Kahane, P., Dubeau, F., & Frauscher, B. (2019) · Annals of Neurology · doi:10.1002/ana.25651 · Cited by 91
High-density soft bioelectronic fibres for multimodal sensing and stimulation
Khatib, M., Zhao, E. T., Wei, S., Park, J., Abramson, A., Bishop, E. S., Thomas, A.-L. A., Chen, C.-H., Emengo, P. O., Xu, C., et al. (2025) · Nature · doi:10.1038/s41586-025-09481-2 · Cited by 91
Coupled sleep rhythms for memory consolidation
Staresina, B. P. (2024) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2024.02.002 · Cited by 93
Long-Term Characterization of Hippocampal Remapping during Contextual Fear Acquisition and Extinction
Schuette, P. J., Reis, F. M., Maesta‐Pereira, S., Chakerian, M., Torossian, A., Blair, G. J., Wang, W., Blair, H. T., Fanselow, M. S., Kao, J. C., et al. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1022-20.2020 · Cited by 80
The Best Laid Plans: Computational Principles of Anterior Cingulate Cortex
Holroyd, C. B., & Verguts, T. (2021) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2021.01.008 · Cited by 87
Imagination as a fundamental function of the hippocampus
Comrie, A. E., Frank, L. M., & Kay, K. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0336 · Cited by 91
Self-citation
Dynamic representations in networked neural systems
Ju, H., & Bassett, D. S. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0653-3 · Cited by 80
Cortical–hippocampal coupling during manifold exploration in motor cortex
Kim, J., Joshi, A., Frank, L., & Ganguly, K. (2023) · Nature · doi:10.1038/s41586-022-05533-z · Cited by 77
Self-citation
Sleep loss diminishes hippocampal reactivation and replay
Giri, B. K., Kinsky, N. R., Kaya, U., Maboudi, K., Abel, T. G., & Diba, K. (2024) · Nature · doi:10.1038/s41586-024-07538-2 · Cited by 79
Consciousness and sleep
Tononi, G., Boly, M., & Cirelli, C. (2024) · Neuron · doi:10.1016/j.neuron.2024.04.011 · Cited by 70
Neuromodulation of the mind-wandering brain state: the interaction between neuromodulatory tone, sharp wave-ripples and spontaneous thought
O’Callaghan, C., Walpola, I. C., & Shine, J. M. (2020) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0699 · Cited by 77
Understanding the Need for Sleep to Improve Cognition
Leong, R. L. F., & Chee, M. W. L. (2022) · Annual Review of Psychology · doi:10.1146/annurev-psych-032620-034127 · Cited by 95
Can sleep protect memories from catastrophic forgetting?
Gonzalez, O. C., Sokolov, Y., Krishnan, G. P., Delanois, J. E., & Bazhenov, M. (2020) · eLife · doi:10.7554/elife.51005 · Cited by 68
The evolving view of replay and its functions in wake and sleep
Findlay, G., Tononi, G., & Cirelli, C. (2020) · SLEEP Advances · doi:10.1093/sleepadvances/zpab002 · Cited by 66
Aperiodic sleep networks promote memory consolidation
Helfrich, R. F., Lendner, J. D., & Knight, R. T. (2021) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2021.04.009 · Cited by 72
Hippocampal gamma and sharp-wave ripple oscillations are altered in a Cntnap2 mouse model of autism spectrum disorder
Paternò, R., Marafiga, J. R., Ramsay, H. J., Li, T., Salvati, K. A., & Baraban, S. C. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109970 · Cited by 74
Net decrease in spine-surface GluA1-containing AMPA receptors after post-learning sleep in the adult mouse cortex
Miyamoto, D., Marshall, W., Tononi, G., & Cirelli, C. (2021) · Nature Communications · doi:10.1038/s41467-021-23156-2 · Cited by 60
Probing subthreshold dynamics of hippocampal neurons by pulsed optogenetics
Valero, M., Zutshi, I., Yoon, E., & Buzsáki, G. (2022) · Science · doi:10.1126/science.abm1891 · Cited by 66
Resting-state global brain activity affects early β-amyloid accumulation in default mode network
Han, F., Liu, X., Mailman, R. B., Huang, X., Liu, X., & Initiative, T. A. D. N. (2023) · Nature Communications · doi:10.1038/s41467-023-43627-y · Cited by 68
High frequency oscillations in human memory and cognition: a neurophysiological substrate of engrams?
Kucewicz, M. T., Cimbálník, J., García‐Salinas, J. S., Brázdil, M., & Worrell, G. A. (2024) · Brain · doi:10.1093/brain/awae159 · Cited by 60
How our understanding of memory replay evolves
Chen, Z. S., & Wilson, M. A. (2023) · Journal of Neurophysiology · doi:10.1152/jn.00454.2022 · Cited by 68
Looking for the neural basis of memory
Kragel, J. E., & Voss, J. L. (2021) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2021.10.010 · Cited by 52
Causal Contribution of Awake Post-encoding Processes to Episodic Memory Consolidation
Tambini, A., & D’Esposito, M. (2020) · Current Biology · doi:10.1016/j.cub.2020.06.063 · Cited by 54
Ripple-locked coactivity of stimulus-specific neurons and human associative memory
Kunz, L., Staresina, B. P., Reinacher, P. C., Brandt, A., Guth, T. A., Schulze‐Bonhage, A., & Jacobs, J. (2024) · Nature Neuroscience · doi:10.1038/s41593-023-01550-x · Cited by 63
Human lesions and animal studies link the claustrum to perception, salience, sleep and pain
Atilgan, H., Doody, M., Oliver, D. K., McGrath, T., Shelton, A. M., Echeverria-Altuna, I., Tracey, I., Vyazovskiy, V. V., Manohar, S., & Packer, A. M. (2022) · Brain · doi:10.1093/brain/awac114 · Cited by 59
The Hippocampal Horizon: Constructing and Segmenting Experience for Episodic Memory
Ross, T. W., & Easton, A. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.11.038 · Cited by 50
Replay in minds and machines
Wittkuhn, L., Chien, S., Hall-McMaster, S., & Schuck, N. W. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.08.002 · Cited by 49
Atypical perineuronal nets in the CA2 region interfere with social memory in a mouse model of social dysfunction
Cope, E. C., Zych, A. D., Katchur, N. J., Waters, R. C., Laham, B. J., Diethorn, E. J., Park, C. Y., Meara, W. R., & Gould, E. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01174-2 · Cited by 49
Ripples reflect a spectrum of synchronous spiking activity in human anterior temporal lobe
Tong, A. P. S., Vaz, A. P., Wittig, J. H., Inati, S. K., & Zaghloul, K. A. (2021) · eLife · doi:10.7554/elife.68401 · Cited by 42
Effects of sleep and waking on the synaptic ultrastructure
Cirelli, C., & Tononi, G. (2020) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0235 · Cited by 47
Global coordination of brain activity by the breathing cycle
Tort, A. B. L., Laplagne, D. A., Draguhn, A., & González, J. (2025) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-00920-7 · Cited by 65
Skipping ahead: A circuit for representing the past, present, and future
Robinson, J. C., & Brandon, M. P. (2021) · eLife · doi:10.7554/elife.68795 · Cited by 49
Hippocampal ensembles represent sequential relationships among an extended sequence of nonspatial events
Shahbaba, B., Li, L., Agostinelli, F., Saraf, M., Cooper, K. W., Haghverdian, D., Elias, G. A., Baldi, P., & Fortin, N. J. (2022) · Nature Communications · doi:10.1038/s41467-022-28057-6 · Cited by 53
Mental navigation and the neural mechanisms of insight
Aru, J., Drüke, M., Pikamäe, J., & Larkum, M. E. (2023) · Trends in Neurosciences · doi:10.1016/j.tins.2022.11.002 · Cited by 38
Reorganization of CA1 dendritic dynamics by hippocampal sharp-wave ripples during learning
Rolotti, S. V., Blockus, H., Sparks, F. T., Priestley, J. B., & Losonczy, A. (2022) · Neuron · doi:10.1016/j.neuron.2021.12.017 · Cited by 50
Rhythmic coordination and ensemble dynamics in the hippocampal-prefrontal network during odor-place associative memory and decision making
Symanski, C. A., Bladon, J. H., Kullberg, E. T., Miller, P. C., & Jadhav, S. P. (2022) · eLife · doi:10.7554/elife.79545 · Cited by 50
Spindle-locked ripples mediate memory reactivation during human NREM sleep
Schreiner, T., Griffiths, B., Kutlu, M., Vollmar, C., Kaufmann, E., Quach, S., Rémi, J., Noachtar, S., & Staudigl, T. (2024) · Nature Communications · doi:10.1038/s41467-024-49572-8 · Cited by 55
Remembering to Forget: A Dual Role for Sleep Oscillations in Memory Consolidation and Forgetting
Langille, J. J. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00071 · Cited by 50
Differential effect of sleep deprivation on place cell representations, sleep architecture, and memory in young and old mice
Yuan, R. K., Lopez, M. R., Ramos‐Álvarez, M. M., Normandin, M. E., Thomas, A. S., Uygun, D. S., Cerda, V. R., Grenier, A. E., Wood, M. T., Gagliardi, C. M., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109234 · Cited by 41
Selective engram coreactivation in idling brain inspires implicit learning
Aly, M. H., Abdou, K., Okubo-Suzuki, R., Nomoto, M., & Inokuchi, K. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2201578119 · Cited by 39
Deep learning-based feature extraction for prediction and interpretation of sharp-wave ripples in the rodent hippocampus
Navas-Olivé, A., Amaducci, R., Jurado-Parras, M.-T., Sebastian, E. R., & de la Prida, L. M. (2022) · eLife · doi:10.7554/elife.77772 · Cited by 43
Offline ensemble co-reactivation links memories across days
Zaki, Y., Pennington, Z. T., Morales-Rodriguez, D., Bacon, M. E., Ko, B., Francisco, T. R., LaBanca, A. R., Sompolpong, P., Dong, Z., Lamsifer, S. I., et al. (2024) · Nature · doi:10.1038/s41586-024-08168-4 · Cited by 55
It’s not the thought that counts: Allostasis at the core of brain function
Theriault, J. E., Katsumi, Y., Reimann, H. M., Zhang, J., Deming, P., Dickerson, B. C., Quigley, K. S., & Barrett, L. F. (2025) · Neuron · doi:10.1016/j.neuron.2025.09.028 · Cited by 64
A time-dependent role for the transcription factor CREB in neuronal allocation to an engram underlying a fear memory revealed using a novel in vivo optogenetic tool to modulate CREB function
Park, A., Jacob, A. D., Walters, B. J., Park, S., Rashid, A. J., Jung, J. H., Lau, J., Woolley, G. A., Frankland, P. W., & Josselyn, S. A. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0588-0 · Cited by 41
Stability of ripple events during task engagement in human hippocampus
Chen, Y., Aponik-Gremillion, L., Bartoli, E., Yoshor, D., Sheth, S. A., & Foster, B. L. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109304 · Cited by 38
Hippocampal ripples signal contextually mediated episodic recall
Sakon, J. J., & Kahana, M. J. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2201657119 · Cited by 40
Distinct replay signatures for prospective decision-making and memory preservation
Wimmer, G. E., Liu, Y., McNamee, D., & Dolan, R. J. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2205211120 · Cited by 47
A neural mechanism for learning from delayed postingestive feedback
Zimmerman, C. A., Bolkan, S. S., Pan-Vazquez, A., Wu, B., Keppler, E., Meares-Garcia, J. B., Guthman, E. M., Fetcho, R. N., McMannon, B., Lee, J., et al. (2025) · Nature · doi:10.1038/s41586-025-08828-z · Cited by 49
Engram mechanisms of memory linking and identity
Choucry, A., Nomoto, M., & Inokuchi, K. (2024) · Nature reviews. Neuroscience · doi:10.1038/s41583-024-00814-0 · Cited by 41
Memory engram stability and flexibility
Zaki, Y., & Cai, D. J. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01979-z · Cited by 40
Learning offline: memory replay in biological and artificial reinforcement learning
Roscow, E. L., Chua, R., Costa, R. P., Jones, M. W., & Lepora, N. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.07.007 · Cited by 36
Potential factors influencing replay across CA1 during sharp-wave ripples
de la Prida, L. M. (2020) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0236 · Cited by 35
Sleep loss is a metabolic disorder
Feeney, S. P., McCarthy, J. M., Petruconis, C. R., & Tudor, J. C. (2025) · Science Signaling · doi:10.1126/scisignal.adp9358 · Cited by 38
Allocentric representations of space in the hippocampus
Danjo, T. (2019) · Neuroscience Research · doi:10.1016/j.neures.2019.06.002 · Cited by 34
Hippocampal cholecystokinin-expressing interneurons regulate temporal coding and contextual learning
Guerrero, D. K. R., Balueva, K., Barayeu, U., Baracskay, P., Gridchyn, I., Nardin, M., Roth, C. N., Wulff, P., & Csicsvari, J. (2024) · Neuron · doi:10.1016/j.neuron.2024.03.019 · Cited by 35
Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology
Han, F., Lee, J., Chen, X., Ziontz, J., Ward, T. J., Landau, S. M., Baker, S. L., Harrison, T. M., Jagust, W. J., & Initiative, A. D. N. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14296 · Cited by 42
Variable specificity of memory trace reactivation during hippocampal sharp wave ripples
Swanson, R. A., Levenstein, D., McClain, K., Tingley, D., & Buzsáki, G. (2020) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2020.02.008 · Cited by 32
A large majority of awake hippocampal sharp-wave ripples feature spatial trajectories with momentum
Krause, E. L., & Drugowitsch, J. (2021) · Neuron · doi:10.1016/j.neuron.2021.11.014 · Cited by 34
Hippocampal sharp-wave ripples correlate with periods of naturally occurring self-generated thoughts in humans
Iwata, T., Yanagisawa, T., Ikegaya, Y., Smallwood, J., Fukuma, R., Oshino, S., Tani, N., Khoo, H. M., & Kishima, H. (2024) · Nature Communications · doi:10.1038/s41467-024-48367-1 · Cited by 40
Detrimental impacts of mixed-ion radiation on nervous system function
Klein, P., Parihar, V. K., Szabo, G. G., Zöldi, M., Angulo, M. C., Allen, B. D., Amin, A. N., Nguyen, Q.-A., Katona, I., Baulch, J. E., et al. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105252 · Cited by 34
Incidence and prevalence of inflammatory bowel disease in Devon, UK
Hamilton, B., Green, H., Heerasing, N. M., Hendy, P. J., Moore, L., Chanchlani, N., Walker, G., Bewshea, C., Kennedy, N. A., Ahmad, T., et al. (2020) · Frontline Gastroenterology · doi:10.1136/flgastro-2019-101369 · Cited by 32
Sex-specific regulation of inhibition and network activity by local aromatase in the mouse hippocampus
Hernández‐Vivanco, A., Cano-Adamuz, N., Sánchez-Aguilera, A., González‐Alonso, A., Rodríguez-Fernández, A., Azcoitia, Í., de la Prida, L. M., & Méndez, P. (2022) · Nature Communications · doi:10.1038/s41467-022-31635-3 · Cited by 37
Beyond hippocampus: Thalamic and prefrontal contributions to an evolving memory
Yadav, N., Toader, A. C., & Rajasethupathy, P. (2024) · Neuron · doi:10.1016/j.neuron.2023.12.021 · Cited by 31
Microcircuit mechanisms for the generation of sharp-wave ripples in the basolateral amygdala: A role for chandelier interneurons
Perumal, M. B., Latimer, B., Xu, L., Stratton, P. G., Nair, S. S., & Sah, P. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109106 · Cited by 29
Activation of the CA2-ventral CA1 pathway reverses social discrimination dysfunction in Shank3B knockout mice
Cope, E. C., Wang, S. H., Waters, R. C., Gore, I. R., Vasquez, B., Laham, B. J., & Gould, E. (2023) · Nature Communications · doi:10.1038/s41467-023-37248-8 · Cited by 36
Brain temperature affects quantitative features of hippocampal sharp wave ripples
Petersen, P. C., Vöröslakos, M., & Buzsáki, G. (2022) · Journal of Neurophysiology · doi:10.1152/jn.00047.2022 · Cited by 34
BRAIN Initiative: Cutting-Edge Tools and Resources for the Community
Litvina, E. Y., Adams, A. B., Barth, A. L., Bruchez, M. P., Carson, J. A., Chung, J. E., Dupre, K. B., Frank, L. M., Gates, K. M., Harris, K. M., et al. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1169-19.2019 · Cited by 28
Self-citation

Authors: Joo, H. R., & Frank, L. M.
Affiliations: University of California, San Francisco (US)
Howard Hughes Medical Institute (US)
Corresponding author: Joo, Hannah R.
Frank, Loren M.
ORCID: Joo, Hannah R.
Frank, Loren M.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2018-10-24
Volume: 19
Issue: 12
Pages: 744-757
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/s41583-018-0077-1
PMC: PMC6794196
OpenAlex: W2898268489
Cited by: 430
References: 256
Citations by year: 2026: 50 · 2025: 79 · 2024: 71 · 2023: 56 · 2022: 56 · 2021: 60 · 2020: 35 · 2019: 23
FWCI: 3.94
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health
National Institute of Mental Health (R01MH105174, F30MH115582)
National Institute of General Medical Sciences (T32GM007618)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords: hippocampus, memory consolidation, memory retrieval, decision-making, recollection, memory replay
MeSH terms: Memory Consolidation, Animals, Hippocampus, Humans, Nerve Net, Mental Recall, Brain Waves

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The hippocampal sharp wave-ripple in memory retrieval for immediate use and consolidation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks