Cited by 427Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

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Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders

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Brandebura, Ashley N., Paumier, Adrien, Onur, Tarik S., Allen, Nicola J.·2023·Nature Reviews Neuroscience

DOI 10.1038/s41583-022-00641-1PMC PMC10198620

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Abstract

There is increasing appreciation that non-neuronal cells contribute to the initiation, progression and pathology of diverse neurodegenerative disorders. This Review focuses on the role of astrocytes in disorders including Alzheimer disease, Parkinson disease, Huntington disease and amyotrophic lateral sclerosis. The important roles astrocytes have in supporting neuronal function in the healthy brain are considered, along with studies that have demonstrated how the physiological properties of astrocytes are altered in neurodegenerative disorders and may explain their contribution to neurodegeneration. Further, the question of whether in neurodegenerative disorders with specific genetic mutations these mutations directly impact on astrocyte function, and may suggest a driving role for astrocytes in disease initiation, is discussed. A summary of how astrocyte transcriptomic and proteomic signatures are altered during the progression of neurodegenerative disorders and may relate to functional changes is provided. Given the central role of astrocytes in neurodegenerative disorders, potential strategies to target these cells for future therapeutic avenues are discussed.

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Authors: Brandebura, A. N., Paumier, A., Onur, T. S., & Allen, N. J.
Affiliations: Salk Institute for Biological Studies (US)
Corresponding author: Allen, Nicola J.
ORCID: Brandebura, Ashley N.
Paumier, Adrien
Onur, Tarik S.
Allen, Nicola J.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2022-10-31
Volume: 24
Issue: 1
Pages: 23-39
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/s41583-022-00641-1
PMC: PMC10198620
OpenAlex: W4307895613
Cited by: 427
References: 201
Citations by year: 2026: 94 · 2025: 121 · 2024: 130 · 2023: 78 · 2022: 4
FWCI: 8.56
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (F32NS117776)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: astrocytes, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, astrocyte dysfunction, disease initiation, disease progression, genetic mutations, astrocyte-targeted therapy, glial cells
MeSH terms: Amyotrophic Lateral Sclerosis, Astrocytes, Humans, Neurons, Neurodegenerative Diseases, Proteomics

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Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders

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