Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359

Neurotoxic reactive astrocytes are induced by activated microglia

Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β

Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268

Glutamate uptake

Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

Hutton, M., Lendon, C. L., Rizzu, P., Baker, M., Froelich, S., Houlden, H., Pickering-Brown, S., Chakraverty, S., Isaacs, A., Grover, A., et al. (1998) · Nature · doi:10.1038/31508 · Cited by 3,498

The Classical Complement Cascade Mediates CNS Synapse Elimination

Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.036 · Cited by 3,313

Single-cell transcriptomic analysis of Alzheimer’s disease

Mathys, H., Davila-Velderrain, J., Peng, Z., Gao, F., Mohammadi, S., Young, J. Z., Menon, M., He, L., Abdurrob, F., Jiang, X., et al. (2019) · Nature · doi:10.1038/s41586-019-1195-2 · Cited by 2,568

Reactive astrocyte nomenclature, definitions, and future directions

Escartin, C., Galea, E., Lakatos, A., O’Callaghan, J. P., Petzold, G. C., Serrano-Pozo, A., Steinhäuser, C., Volterra, A., Carmignoto, G., Agarwal, A., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00783-4 · Cited by 2,513

Single-Cell Transcriptome Analysis of the Retina During the Development of Normal Tension Glaucoma in Mice

Liu, X. N., Zhang, D., Du, M., Shao, Z., Xu, X., Song, W., Chen, S., Li, X., Qiu, L., Guo, F., et al. (2025) · Inflammation · doi:10.1007/s10753-025-02422-1 · Cited by 5

The Gut–Brain–Immune Axis in Glioma: Emerging Mechanisms and Therapeutic Opportunities

Feng, R., Yang, Z., Zhou, Y., & Zhao, H. (2026) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-026-01680-3 · Cited by 7

Role Shift of Glial Cells from Physiology to Pathology in Alzheimer’s Disease: The Regulatory Impact of Exercise

Liu, R., Deng, Q., Gong, L., & Yang, L. (2026) · Neuroscience Bulletin · doi:10.1007/s12264-026-01598-2 · Cited by 5

Oral GLP-1 receptor agonist promotes astrocyte-neuron lactate and lipid transfer with neuroprotective effects

Du, Y., Sun, C., Wu, L., Wu, Z., Tong, Y., Tian, H., Mao, Y., Shi, X., Ding, H., Xie, W., et al. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2026.05.014 · Cited by 6

The identification of a Distinct Astrocyte Subtype that Diminishes in Alzheimer’s Disease

Wei, H., Withrow, J. S., Rakshit, J., Amin, F. U., Nahm, J., Mowry, F. E., Mao, Z., Bhattacharjee, M. B., Zhu, J., Yang, Y., et al. (2024) · Aging and Disease · doi:10.14336/ad.2024.0205-1 · Cited by 7

Efficient gene delivery admitted by small metabolites specifically targeting astrocytes in the mouse brain

Zhou, H., Dai, J., Li, D., Wang, L., Ye, M., Hu, X., LoTurco, J. J., Hu, J., & Sun, W. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.01.006 · Cited by 7

The Discovery of Phages in the Substantia Nigra and Its Implication for Parkinson’s Disease

Zhao, Y., Xiong, C., Wang, B., Li, D., Liu, J., Wei, S., Hou, Y., Zhou, Y., & Zheng, R. (2025) · Research · doi:10.34133/research.0657 · Cited by 5

Porcine Astrocytes and Their Relevance for Translational Neurotrauma Research

Purvis, E. M., Fedorczak, N., Prah, A., Han, D. J., & O’Donnell, J. C. (2023) · Biomedicines · doi:10.3390/biomedicines11092388 · Cited by 5

Asteroid impact: the potential of astrocytes to modulate human neural networks within organoids

Lavekar, S. S., Patel, M. D., Parra, M. D. M., & Krencik, R. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1305921 · Cited by 5

Exposure to microcystin-LR promotes astrocyte proliferation both in vitro and in vivo via Hippo signaling pathway

Xue, Q., Yan, Y., Zhang, K., Zhang, H., & Zhao, Y. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116480 · Cited by 5

A Mouse Model of Sporadic Alzheimer’s Disease with Elements of Major Depression

Бобкова, Н. В., Chuvakova, L. N., Kovalev, V. I., Zhdanova, D. Y., Chaplygina, A. V., Rezvykh, A. P., & Evgen’ev, M. B. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04346-7 · Cited by 5

Role of astrocytes in Alzheimer's disease pathogenesis and the impact of exercise-induced remodeling

Shao, J., Deng, Q., Feng, S., Wu, C., Liu, X., & Yang, L. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150418 · Cited by 5

A Screen of Plant-Based Natural Products Revealed That Quercetin Prevents Pyroglutamylated Amyloid-β (Aβ3(pE)-42) Uptake in Astrocytes As Well As Resulting Astrogliosis and Synaptic Dysfunction

Arndt, H., Bachurski, M., Yuanxiang, P., Franke, K., Wessjohann, L. A., Kreutz, M. R., & Grochowska, K. M. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04509-6 · Cited by 5

Frontiers of Neurodegenerative Disease Treatment: Targeting Immune Cells in Brain Border Regions

Satyanarayanan, S. K., Han, Z., Xiao, J., Yuan, Q., Yung, W., Ke, Y., Chang, R. C., Zhu, M. H., Su, H., Su, K. P., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.10.007 · Cited by 5

Surface engineered multimodal magnetic nanoparticles for neurodegenerative diseases

Vardikar, A., Das, U., Mandal, S., Mandlik, S. K., Bari, D. B., Gholap, A. D., Pardeshi, C. V., & Rajput, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23841-3.00007-8 · Cited by 5

Proliferating Astrocytes in Primary Culture Do Not Depend upon Mitochondrial Respiratory Complex I Activity or Oxidative Phosphorylation

Silva, E. A., Dalla Costa, A. P., Ruas, J. S., Siqueira-Santos, E. S., Francisco, A., & Castilho, R. F. (2023) · Cells · doi:10.3390/cells12050683 · Cited by 5

Aging with TBI vs. Aging: 6-month temporal profiles for neuropathology and astrocyte activation converge in behaviorally relevant thalamocortical circuitry of male and female ratsPreprint

Sabetta, Z., Krishna, G., Curry, T., Adelson, P. D., & Thomas, T. C. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.06.527058 · Cited by 5

Increased FAN1 expression by mRNA-LNP attenuates CAG repeat expansion in Huntington patients’ iPSC-derived astrocytesPreprint

Cheng, Y., Nocula-Lugowska, G., Ramirez, J. A., Fan, X., Jin, F., Jiang, Z., Bennett, E. M., Li, J., Hokanson, D. E., Grandhi, S., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.24.568451 · Cited by 5

A single-cell transcriptomic dataset of pluripotent stem cell-derived astrocytes via NFIB/SOX9 overexpression

Yi, R., Chen, S., Guan, M., Liao, C., Zhu, Y., Ip, J. P. K., Tao, Y., & Chen, Y. (2024) · Scientific Data · doi:10.1038/s41597-024-03823-x · Cited by 4

PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylationPreprint

Wang, S., Baumert, R., Sejourne, G. M., Bindu, D. S., Dimond, K., Sakers, K., Vazquez, L., Moore, J. L., Tan, C. X., Takano, T., et al. (2025) · eLife · doi:10.7554/elife.107556 · Cited by 6

Defective Astrocyte Maturation Drives Cerebellar Neuroinflammation and Degeneration

Mockenhaupt, K., Zarei‐Kheirabadi, M., Gonsiewski, A. K., Hariprashad, A., Dain, L., Verheijen, J., Singh, S. K., & Kordula, T. (2025) · The FASEB Journal · doi:10.1096/fj.202501225rr · Cited by 4

Targeting Multilayered Metabolic Networks in Brain Diseases: Emerging Perspectives on Nanodelivery Strategies

Zhou, J., & Jiang, C. (2025) · Advanced Science · doi:10.1002/advs.202503645 · Cited by 4

Emerging roles of astrocytes in autonomic control of blood pressure and hypertension

Verma, H., & Feng, Y. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00587.2025 · Cited by 5

Mapping transcription factor functions in astrocytes using in vivo gain-of-function Perturb-seq

Zhang, L., Ma, Q. L., Kong, X., Zou, W., Wang, B., Wu, B., Cai, S., Bai, T., Tan, R., Dai, Z., et al. (2026) · Science · doi:10.1126/science.adw2156 · Cited by 5

Thermal proteome profiling reveals the glial toxicity of dencichine via inhibiting proteasome

Zhang, Q., Liu, G., Li, Y., Yang, B., Guo, W., Zhang, Y., Pan, L., Zhang, P., Zhang, W., & Kong, D. (2023) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.114146 · Cited by 4

Biomarker Identification for Gender Specificity of Alzheimer's Disease Based on the Glial Transcriptome Profiles

Liu, H., Yang, H., Liu, S., Li, S., Yang, W. J., Ayesha, A., Tan, X., Jiang, C., Liu, Y., & Xie, L. (2024) · Journal of Visualized Experiments · doi:10.3791/66552 · Cited by 4

Sleep disturbance impaired memory consolidation via lateralized disruption of metabolite in the thalamus and hippocampus: A cross-sectional proton magnetic resonance spectroscopy study

Fan, X., Mao, X., Yu, P., Han, D., Chen, C., Wang, H., Zhang, X., Liu, S., Chen, W., Chen, Z., et al. (2024) · Journal of Alzheimer s Disease · doi:10.1177/13872877241295401 · Cited by 5

Physical exercise protects neurons from energy deficit and improves cognitive function by upregulating astrocytic Slc2a1 in Alzheimer's disease

Li, S., Zheng, F., Liu, S., Wu, R., Zhang, L., He, X., Li, M., & Li, L. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115493 · Cited by 5

Elevated Neurodegeneration Markers in the Aqueous Humor of Primary Open Angle and Normal Tension Glaucoma Patients Correlate With Disease Severity

Nair, A. P., Tejwani, S., Dinakaran, S., Shetty, N., Shetty, R., Ghosh, A., & Sethu, S. (2025) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.66.13.24 · Cited by 5

Long-term plasticity of astrocytic phenotypes and their control by neurons in health and disease

Wardlaw, K. S., & Hardingham, G. E. (2023) · Essays in Biochemistry · doi:10.1042/ebc20220090 · Cited by 4

Astroglial morphological changes in periaqueductal grey in different pain and itch mice models

Wang, C., Yang, X., Gao, T., Zhao, Y., Yang, Y., Li, X., Yang, Y., Yi, T., Wang, Y., & Mi, W. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115075 · Cited by 5

Neuroimmune Dysfunction in Alzheimer’s Disease and Other Forms of Dementia

Yamane, T., Yoshioka, T., & Shimo, Y. (2024) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c23-00464 · Cited by 4

High-Impact AMPAkines Elevate Calcium Levels in Cortical Astrocytes by Mobilizing Endoplasmic Reticular Calcium Stores

Radin, D. P., Cerne, R., Witkin, J. M., & LIPPA, A. S. (2024) · Neuroglia · doi:10.3390/neuroglia5030023 · Cited by 4

Anisomycin alleviates cognitive impairments and pathological features in 3xTg-AD mice

Jiao, J., Hu, Y., Cui, Y., Tuo, C.-M., Wang, Y.-X., Li, X., Zhang, Y., & Wu, M. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110159 · Cited by 4

The Phenotype Changes of Astrocyte During Different Ischemia Conditions

Meng, F., Cui, J., Wang, P., Wang, J., Sun, J., & Li, L. (2024) · Brain Sciences · doi:10.3390/brainsci14121256 · Cited by 6

Hippocampal Astrocyte Morphology Follows an Unexpected Trajectory With Age in a Transgenic Rodent Model of Tauopathy

Augustin, E., Vinasco‐Sandoval, T., Riquelme‐Perez, M., Plassard, D., Gaudin, M., Aurégan, G., Mitja, J., Bernier, S., Joséphine, C., Petit, F., et al. (2025) · Glia · doi:10.1002/glia.70019 · Cited by 4

An astrocyte-derived cytokine TIMP-1 restores synaptic plasticity in an Alzheimer’s disease modelPreprint

Sarkar, S., Gharami, K., Paidi, R. K., Srikumar, B. N., & Biswas, S. C. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.18.533245 · Cited by 4

Interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunctionPreprint

Henry, R., Barrett, J. P., Vaida, M., Khan, N. Z., Makarevich, O., Ritzel, R., Faden, A., & Stoica, B. (2023) · bioRxiv · doi:10.1101/2023.07.28.550986 · Cited by 12

PRDM16-DT: A Brain and Astrocyte-Specific lncRNA Implicated in Alzheimer’s DiseasePreprint

Schröder, S., Fuchs, U., Gisa, V., Peña, T., Krüger, D. M., Hempel, N., Burkhardt, S., Salinas, G., Schütz, A., Delalle, I., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.27.600964 · Cited by 4

A convenient model of serum-induced reactivity of human astrocytes to investigate astrocyte-derived extracellular vesicles

White, K. E., Bailey, H. L., Shaw, B., Geiszler, P. C., Mesquita-Ribeiro, R., Scott, D., Layfield, R., & Serres, S. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1414142 · Cited by 3

Digirseophene A promotes recovery in injured developing cerebellum via AMPK/AKT/GSK3β pathway-mediated neural stem cell proliferation

Tang, X., Huang, Y., Fu, W., Wang, P., Feng, L., Yang, J., Zhu, H., Huang, X., Ming, Q., & Li, P. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117046 · Cited by 3

Homeostasis to Allostasis: Prefrontal Astrocyte Roles in Cognitive Flexibility and Stress Biology

Wulaer, B., Holtz, M., & Nagai, J. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-64839-7_6 · Cited by 4

Adolescent mice exposed to TBI developed PD-like pathology in middle age

Sha, R., Wu, M., Wang, P., Chen, Z., Lei, W., Wang, S., Gong, S., Liang, G., Zhao, R., & Tao, Y. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03232-7 · Cited by 4

Pedunculoside regulates the differentiation of neural stem cells into neurons via the PI3K/AKT/GSK-3β pathway

Jiang, R., Wang, Y., Shen, Y., Tang, J., Tang, X., Ma, H., & Yi, P. (2025) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2025.05.002 · Cited by 3

Chemogenetic Modulation of Astrocytic Activity Rescues Hippocampus Associated Neurodegeneration in Alzheimer’s Disease Mice Model 5xFAD

Gerasimov, E., Berg, M., Bolshakova, A. V., Борисович, Б. И., & Власова, О. Л. (2025) · Neural Plasticity · doi:10.1155/np/9880933 · Cited by 3

Phytochemicals as modulators of Astrocytes in Alzheimer's disease: A therapeutic perspective

Wang, S., Zhang, Z., Liu, Y., Gao, S., Wang, L., Yang, J., & Wang, Y. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157347 · Cited by 3

Understanding glial cells: Implications for multiple sclerosis pathogenesis and therapeutics

Lalmani, Y. S., & Deshmukh, R. R. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102961 · Cited by 3

Viral reprogramming of glial metabolism as a driver of neuroinflammation

Rodrigues, T. S., Beltrão, G. S., Girardi, H., & Pinto, A. R. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1686774 · Cited by 5

Astrocyte heterogeneity in the neocortex: developmental origins, molecular diversity, and functional implications

Zhou, J., & Bocchi, R. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1787840 · Cited by 3

Conserved Pathways, Divergent Outcomes: A Cross-Species Genomic Perspective on the Cancer–Neurodegeneration Paradox

Rajarathinam, B., Nandan, D., Venugopal, P., Nair, A. M., John, S., Nair, B. G., & Aradhya, R. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27072989 · Cited by 5

Astrocytic dysfunction in Parkinson’s disease pathogenesis: focusing on alpha-synuclein

Al-Qahtani, Z., Al‐kuraishy, H. M., Al-Gareeb, A. I., Albuhadily, A. K., Abdelaziz, A. M., Alruwaili, M., & Batiha, G. E. (2026) · Inflammopharmacology · doi:10.1007/s10787-026-02176-8 · Cited by 3

New insights into astrocyte diversity from the lens of transcriptional regulation and their implications for neurodegenerative disease treatments

Saliu, I. O., & Zhao, G. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01790 · Cited by 3

Preventive cognitive protection based on AAV9 overexpression of IGF1 in hippocampal astrocytes

Peralta, F., Escobedo, A. A. V., Hanotte, J. L., Avallone, M., Björklund, T., Reggiani, P. C., & Pardo, J. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106612 · Cited by 3

Different intensities of physical activity for amyotrophic lateral sclerosis and Parkinson disease: A Mendelian randomization study and meta-analysis

Xu, W., Zhao, X., Wang, J., Guo, Y., Ren, Z., Cai, L., Wu, S.-B., & Zhou, M. (2024) · Medicine · doi:10.1097/md.0000000000040141 · Cited by 3

Role of non-neuronal cells in neurorepair: a focus on proteinopathy and neurodegeneration

Rodríguez-Carreiro, S., Nogales, M. D. C., Jiménez-Galán, D., Carmona-Lorenzo, S., Caro-Martín, A., Navarro, E., & Esteras, N. (2024) · Regenerative medicine reports . · doi:10.4103/regenmed.regenmed-d-24-00005 · Cited by 2

AAV-mediated GBA1 and GDNF rescue neurological defects in a murine model of neuronopathic Gaucher disease

Meng, Y., Zhang, J., Fan, R., Pang, W., Zeng, W., Guo, Q., Han, X., Liu, Y., & Luo, G. (2025) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2025.102506 · Cited by 3

Temporal Profiling of Male Cortical Astrocyte Transcription Predicts Molecular Shifts From Early Development to Aging

Wei, X., Li, J., & Olsen, M. L. (2025) · Glia · doi:10.1002/glia.70010 · Cited by 2

Neural tube defects induce abnormal astrocyte development by activation and epigenetic permissiveness of STAT3

Janik, K., Jin, L., Kyzy, K. Z., Kaminski, R., Smith, G. M., & Krynska, B. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115231 · Cited by 3

Identification of the abnormalities in astrocytic functions as potential drug targets for neurodegenerative disease

Syvänen, V., Koıstınaho, J., & Lehtonen, Š. (2024) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2024.2322988 · Cited by 4

Oligodendrocytes, the Forgotten Target of Gene Therapy

Ozgür-Gunes, Y., Stunff, C. L., & Bougneres, P. F. (2024) · Cells · doi:10.3390/cells13231973 · Cited by 4

Revisiting the advance of age-dependent α-synuclein propagation and aggregation

Song, D., & Li, J. (2025) · Ageing and Neurodegenerative Diseases · doi:10.20517/and.2024.44 · Cited by 4

Plasma vesicle-associated membrane protein 2 and glial fibrillary acidic protein associate with synaptic density in older adults without dementia

Meyer, S. D., Alali, S., Laroy, M., Casteele, T. V., Cauwenberge, M. G. A. V., Goossens, J., Rocker, C. D., Vanbrabant, J., Vanmechelen, E., den Stock, J. V., et al. (2025) · Brain Communications · doi:10.1093/braincomms/fcaf207 · Cited by 3

Stimulation of Neurons and Astrocytes via Temporally Interfering Electric FieldsPreprint

Ahtiainen, A., Leydolph, L., Tanskanen, J., Hunold, A., Haueisen, J., & Hyttinen, J. (2023) · bioRxiv · doi:10.1101/2023.10.30.564774 · Cited by 2

Glia-derived secretory fatty acid binding protein Obp44a regulates lipid storage and efflux in the developing Drosophila brainPreprint

Yin, J., Chen, H.-L., Grigsby-Brown, A., He, Y., Cotten, M. L., Short, J., Dermady, A., Lei, J., Gibbs, M., Cheng, E. S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.10.588417 · Cited by 3

On Multicell-Interaction Chip: In Situ Observing the Interactions between the Astrocytes with Lysosomal Dysfunction and BBB Cells

Zhao, Y., Zhang, C., Liang, C., Lv, X., Zhou, D., Deng, Y., & Zhang, R. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.4c04893 · Cited by 2

Alzheimer’s disease brain-derived tau extracts show differential processing and transcriptional effects in human astrocytes

Reid, M. J., Leija‐Salazar, M., Troakes, C., Lynham, S., Srivastava, D. P., Perez‐Nievas, B. G., & Noble, W. J. (2025) · iScience · doi:10.1016/j.isci.2025.112793 · Cited by 2

Adolescent intermittent alcohol exposure induces adult cognitive deficits via disrupting the septo-hippocampal cholinergic projections

Hou, J., Deng, Q., Wu, J., & Chen, W. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123795 · Cited by 2

Glia-derived noncanonical fatty acid binding protein modulates brain lipid storage and clearance

Yin, J., Chen, H.-L., Grigsby-Brown, A., He, Y., Cotten, M. L., Short, J., Dermady, A., Lei, J., Gibbs, M., Cheng, E. S., et al. (2025) · Science Advances · doi:10.1126/sciadv.adv2902 · Cited by 8

Sigma-1 receptor: A potential target for modulating chronic pain and depression

Zhang, Y., Bai, Y., Du, Y., Liu, M., Zhang, M., & Wang, G. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178084 · Cited by 2

NETSseq reveals inflammatory and aging mechanisms in distinct cell types, driving cerebellar decline in ataxia telangiectasia

Stirparo, G. G., Xu, X., Toni, T., Page, K. J., Harvey, J. R. M., Cadwalladr, D., Lawrence, J. M. K., Burley, R., Juvvanapudi, J., Megan, R., et al. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1636787 · Cited by 2

Neurocognitive and neurobiological effects of low dose organophosphate exposure

Nguyen, K. M. C., Swami, D., Goyal, N., Jalwadi, M. G., Acharya, M. M., & Baulch, J. E. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00733 · Cited by 2

Bola-amphiphilic glycodendrimers for targeting glial cells in the brain

Bian, Z., Zhang, W., Garofalo, S., Dhumal, D. M., Zheng, J., Roussel, T., Laurini, E., Galanakou, C., Lauro, C., Maresca, M., et al. (2025) · Nanoscale · doi:10.1039/d5nr03017j · Cited by 2

Attenuating α-synuclein pathology in mice with in situ engineered astrocytes

Du, X., Zhou, J., Zhu, J., Zhang, L., Lü, S., Liang, S., Cui, F., Zhang, H., Chen, F., Jiao, M.-Y., et al. (2025) · Translational Neurodegeneration · doi:10.1186/s40035-025-00518-0 · Cited by 2

Stage-Dependent Function of Astrocytes in Alzheimer’s Disease: A Review

Azari, H. B., Babaei, P., & Nakhjiri, M. T. (2026) · Neuroscience Insights · doi:10.1177/26331055261422166 · Cited by 2

Targeting p75NTR activity alleviates the neurotoxic effect of high glucose on iPSC-derived dopaminergic neurons

Chanoumidou, K., Zota, I., Papadopoulou, M. A., Konstantinou, C., Tsimpolis, A., Tsagliotis, E., Tziortziou, M., Ntarntani, K., Grünewald, A., Lavigne, M. D., et al. (2026) · Stem Cell Research & Therapy · doi:10.1186/s13287-026-04965-y · Cited by 2

Amyloid-β clearance: an astrocytic perspective

Li, J., Lv, Z., Chen, X. P., Fu, F., Yang, K., Lai, G., Wu, H., & Xie, G. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1812081 · Cited by 3

Neurovascular unit remodeling: focusing on glial cells in stroke injury and recovery

Gong, M., Li, X., Yuan, Q., Lina, P. A. N. G., Ye, X., Li, S., Li, Y., Guo, H., & Jin, S. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1821227 · Cited by 2

Targeting mitochondrial dysfunction to quell neuroinflammation in central nervous system (CNS): a new strategy for treating CNS disease with nanomedicines

Wang, S., Liu, M., Shi, X., Xiong, T., Li, R., Zheng, W., Huang, Q., Nan, Y., & Ai, K. (2026) · 中国科学通报：英文版 · doi:10.1016/j.scib.2026.05.020 · Cited by 2

NF-κB Involvement in Glaucoma-Associated Neuroinflammation: Focus on Glial Cells

Veglianti, F., Nolfi, M. D. V., Flati, I., Dall’Aglio, F., Giovanni, F. D., Verzella, D., Capece, D., Angelucci, A., Alesse, E., Zazzeroni, F., et al. (2026) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl45644 · Cited by 3

The Dual Role of Glial Extracellular Vesicles in Neurodegeneration: Insights from iPSC-Based Models

Scrivo, A., Bernardino, L. I., & Consiglio, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27125182 · Cited by 2

A Comprehensive Review of the Gut–Microbiota–Brain Axis in Alzheimer’s Disease: From Pathophysiology to Potential Therapies

Ziaka, M. (2026) · Pathogens · doi:10.3390/pathogens15070659 · Cited by 2

Microglia–astrocyte crosstalk as a key organizing principle of Alzheimer’s disease: from homeostatic cooperation to maladaptive signaling loops

Gong, M., Lan, J. X., & Miao, J. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1908574 · Cited by 3

Pós COVID na Atenção Primária à Saúde e Ambulatorial Especializada: Reunindo evidências para o Sistema Único de Saúde e à Plataforma Clínica Global da OMS

da Saúde, O. P.-A. (2024) · doi:10.37774/9789275728383 · Cited by 7

Astroglial Activation Is Exacerbated in a Down Syndrome Mouse Model

Zhou, Z., Bi, Y., Zhi, C., Chen, S., Chen, D., Wei, Z. C., & Jiang, X. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.04.003 · Cited by 2

Integration of deep learning in the diagnosis, chemical analysis, and therapeutic approaches for neurodegenerative disorders

Zhou, W., Sun, C., & Liu, L. (2024) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2024.106971 · Cited by 2

Magnetic Resonance Spectroscopy Insights Into Late‐Life Depression: Advances in Brain Metabolic Profiling

Wu, Q., Mao, W.-Y., Gao, Y., Wen, Z.-P., Chen, B., Zhang, J., Xu, Y. J., & Liu, S. (2025) · Depression and Anxiety · doi:10.1155/da/9633212 · Cited by 2

Altered Neuroinflammatory Transcriptomic Profile in the Hippocampal Dentate Gyrus Three Weeks After Lateral Fluid Percussion Injury in Rats

DeSana, A. J., Alfawares, Y., Khatri, R., Hopkins, T., Best, F. V., McGuire, J. L., & Ngwenya, L. B. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26189140 · Cited by 2

Targeting astrocytic TDAG8 with delayed CO2 postconditioning improves functional outcomes after controlled cortical impact injury in mice

Zhang, S., Yin, J., Jing, L.-J., Cheng, Y., Miao, Y.-L., Fan, B., Zhang, H., Yang, C., Wang, S., Li, Y., et al. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114892 · Cited by 2

PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylationPreprint

Wang, S., Baumert, R., Sejourne, G. M., Bindu, D. S., Dimond, K., Sakers, K., Vazquez, L., Moore, J. L., Tan, C. X., Takano, T., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.09.536178 · Cited by 2

DNL343 is an investigational CNS penetrant eIF2B activator that prevents and reverses the effects of neurodegeneration caused by the Integrated Stress ResponsePreprint

Yulyaningsih, E., Suh, J. H., Fanok, M. H., Chau, R., Solanoy, H. O., Takahashi, R., Bakardjiev, A. I., Becerra, I. A., Benitez, N. B., Chiu, C., et al. (2023) · eLife · doi:10.7554/elife.92173.1 · Cited by 2

Hippocampal purinergic P2X7 receptor level is increased in Alzheimer’s disease patients, and associated with amyloid and tau pathologiesPreprint

Maschio, C., Wang, J., Maheshwari, U., Keller, A., Rominger, A., Konietzko, U., Nordberg, A. K., Höck, C., Nitsch, R. M., & Ni, R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.28.582443 · Cited by 2

DNL343 is an investigational CNS penetrant eIF2B activator that prevents and reverses the effects of neurodegeneration caused by the Integrated Stress ResponsePreprint

Yulyaningsih, E., Suh, J. H., Fanok, M. H., Chau, R., Solanoy, H. O., Takahashi, R., Bakardjiev, A. I., Becerra, I. A., Benitez, N. B., Chiu, C., et al. (2024) · eLife · doi:10.7554/elife.92173.2 · Cited by 2

Supervised Deep Learning with Gene Annotation for Cell ClassificationPreprint

Lin, Z., Gao, Y., & Sun, W. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.15.603527 · Cited by 2

Muti-omics characterization reveals brain-wide disruption of synapses and region- and age-specific changes in neurons and glia in Sp4 mutant mice, a genetic model of schizophrenia and bipolar disorderPreprint

Kwon, M. J., Mandell, K. A. P., Aryal, S., Geng, C., Nicolella, A. A., Valle-Tojeiro, A., Natarajan, S., Misri, D., Hall, A., Song, B. J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.12.618006 · Cited by 2

Proteostasis dysregulation in p.A53T-α-Synuclein iPSC-derived astrocytes exacerbates neurodegeneration in a Parkinson’s disease model with Lewy-like pathologyPreprint

Paschou, C., Apokotou, O., Κόλλιας, Α., Charmpi, K., Dede, S., Samiotaki, M. K., Palese, F., Dimoula, K., Emmanouilidou, E., Taoufik, E., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.06.621638 · Cited by 2

Gene therapy prevents disease and death from non-ketotic hyperglycinemiaPreprint

Lopez‐Ramirez, A., Bali, A., Alam†, M. S., Padmanabhan, P. K., Calhoun, S., Bickerton, C., Flores‐Mireles, A. L., & Haldar, K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.26.645560 · Cited by 3

Astrocytic Activation Completely Corrects Memory Performance in an Alzheimer’s Disease ModelPreprint

Kreisel, T., Weinstein, Y., Groysman, M., Doron, A., Refaeli, R., London, M., & Goshen, I. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.29.679133 · Cited by 2

Deletion of astrocyte intermediate filaments GFAP and Vimentin enhances protein synthesis and prevents early synaptic and cognitive dysfunction in a mouse model of Alzheimer’s diseasePreprint

Boers-Escuder, C., Kater, M. S. J., van der Zwan, M., Gouwenberg, Y., Klaassen, R. V., Huffels, C. F. M., Pekny, M., Hol, E. M., Smit, A. B., & Verheijen, M. H. G. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.24.713865 · Cited by 2

Green Nanotechnology for Addressing Neurodegenerative Disorders

Barsola, B., Saklani, S., & Pathania, D. (2023) · Springer eBooks · doi:10.1007/978-981-99-9510-3_4 · Cited by 1

Contribution of astrocytes to neuropathology of neurodegenerative diseases

Acıoğlu, Ç., Li, L., & Elkabes, S. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147291 · Cited by 119

Mechanisms of Disease: astrocytes in neurodegenerative disease

Maragakis, N. J., & Rothstein, J. D. (2006) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0355 · Cited by 836

Common alterations to astrocytes across neurodegenerative disorders

Derevyanko, A., Tao, T., & Allen, N. J. (2025) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2025.102970 · Cited by 10

Astrocytes in Neurodegenerative Disease: Table 1.

Phatnani, H., & Maniatis, T. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020628 · Cited by 420

Astrocytes: The Stars in Neurodegeneration?

Dittlau, K. S., & Freude, K. (2024) · Biomolecules · doi:10.3390/biom14030289 · Cited by 39