Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359

Neurotoxic reactive astrocytes are induced by activated microglia

Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β

Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268

Glutamate uptake

Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

Hutton, M., Lendon, C. L., Rizzu, P., Baker, M., Froelich, S., Houlden, H., Pickering-Brown, S., Chakraverty, S., Isaacs, A., Grover, A., et al. (1998) · Nature · doi:10.1038/31508 · Cited by 3,498

The Classical Complement Cascade Mediates CNS Synapse Elimination

Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.036 · Cited by 3,313

Single-cell transcriptomic analysis of Alzheimer’s disease

Mathys, H., Davila-Velderrain, J., Peng, Z., Gao, F., Mohammadi, S., Young, J. Z., Menon, M., He, L., Abdurrob, F., Jiang, X., et al. (2019) · Nature · doi:10.1038/s41586-019-1195-2 · Cited by 2,568

Reactive astrocyte nomenclature, definitions, and future directions

Escartin, C., Galea, E., Lakatos, A., O’Callaghan, J. P., Petzold, G. C., Serrano-Pozo, A., Steinhäuser, C., Volterra, A., Carmignoto, G., Agarwal, A., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00783-4 · Cited by 2,513

The important role of astrocytes in activity pattern transition of the subthalamopallidal network related to Parkinson's disease

Zhao, Y., Zhang, H., & Cao, Z. (2024) · Electronic Research Archive · doi:10.3934/era.2024185 · Cited by 1

3-N-Butylphthalide alleviate Aβ-induced cellular senescence through the CDK2-pRB1-Caspase3 axis

Tian, Y., Li, W., & Zhang, Y. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149435 · Cited by 1

Astrocytes in Primary Familial Brain Calcification (PFBC): Emphasis on the Importance of Induced Pluripotent Stem Cell-Derived Human Astrocyte Models

Kavakli, E., Gul, N., Begentas, O. C., & Kiris, E. (2025) · Advances in experimental medicine and biology · doi:10.1007/5584_2024_840 · Cited by 1

Transcriptomic Regulation by Astrocytic m6A Methylation in the mPFC

Wen, Y.-L., Guo, F., Gu, T.-T., Zeng, Y., & Cao, X. (2025) · Genes to Cells · doi:10.1111/gtc.70003 · Cited by 3

Deciphering the Janus‐Faced Nature of the Apolipoprotein Superfamily in Parkinsonian Neurodegeneration: Molecular Crosstalk Between the Astroglial Secretome and Neuronal Homeostasis

Dai, Y., Bi, M., Jiao, Q., Du, X., Chen, X., Yan, C., & Jiang, H. F. (2025) · Movement Disorders · doi:10.1002/mds.30294 · Cited by 2

Astrocyte activation: A key mediator underlying chronic intermittent hypoxia-induced cognitive dysfunction

Chu, H., Jiang, W., Zuo, N., Sun, F., Wu, C., & Liu, S. (2025) · Sleep Medicine · doi:10.1016/j.sleep.2025.106692 · Cited by 1

Astrocyte Secretome Profiling via Biorthogonal Labeling Unveils Novel Factors Relevant to Neurodegenerative Diseases

Liu, J., Gao, J., Guo, L., Ma, G., Guan, M., Xia, C., He, J., Yang, Y., Wu, Y., Xu, J., et al. (2025) · Glia · doi:10.1002/glia.70079 · Cited by 2

Astrocyte regulates neuroinflammation and myelination in BCCAO-Related cognitive impairment via the PIAS1-STAT1 pathway.

Ding, H., Wu, S., Huang, D., & Shan, L. (2025) · Brain Research · doi:10.1016/j.brainres.2025.150107 · Cited by 1

Reinventing brain immunity in neurodegeneration

Huang, H., Han, Y., Han, Z., Yang, H., Fu, Y., & Liu, Q. (2025) · Immunity & Inflammation · doi:10.1007/s44466-025-00011-3 · Cited by 1

AAV9 gene therapy optimization for SMARD1/CMT2S: safety and long-term efficacy comparison of two vectors in a SMARD1 preclinical model

Pagliari, E., Anastasia, A., Bellandi, F., Garbellini, M., Ongaro, J., Taiana, M. M., Comi, G. P., Ottoboni, L., Sierra-Delgado, J. A., Likhite, S. B., et al. (2026) · Journal of Biomedical Science · doi:10.1186/s12929-025-01204-z · Cited by 1

Astrocyte-mediated Hopfield Neural Network: modeling, dynamical analysis, and hardware implementation

Chen, K., Li, Z., Yin, Y., & Wang, M. (2026) · Chaos Solitons & Fractals · doi:10.1016/j.chaos.2025.117852 · Cited by 1

Targeting the astrocytic metabolic cascade in Alzheimer’s disease: mechanisms, challenges and opportunities

Cao, H., Liang, J., Dong, X., Xia, Z., Luo, X., & Liu, B. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1767811 · Cited by 1

Interplay between DYRK1A dosage and aneuploidy-induced neuropathology in Down syndrome

Nambara, T., Lee, J. Y., Minami, M., Okamoto, S., Kawatani, K., Kusakabe, H., Yoshimatsu, H., Hirata, K., Yoshimi, K., Mashimo, T., et al. (2026) · Communications Biology · doi:10.1038/s42003-026-09902-6 · Cited by 1

Exposure to manganese during juvenile development increases microglial activation in the hippocampus following systemic infection with A/California/04/2009 Influenza A H1N1 virus

Hager, M. R., Schuller, A. J., Yanouri, O. A., Bantle, C. M., Smeyne, R. J., & Tjalkens, R. B. (2026) · Frontiers in Toxicology · doi:10.3389/ftox.2026.1789730 · Cited by 1

A microbiome quantitative trait locus in SLC39A8 modulates disease severity in synucleinopathy-induced models of Parkinson’s disease

Yang, J. C., Situ, J., Troutman, R., Zhu, R., Black, M., Buri, H., Gutta, A., Tian, F., Kang, A., Aja, E., et al. (2026) · Human Molecular Genetics · doi:10.1093/hmg/ddag024 · Cited by 1

Translatome profiling of spinal cord astrocytes reveals distinct gene signatures associated with acute and chronic pain

Siliezar-Doyle, J., Perez, R. K., Stauffenberg, E., Nippert, A. R., & Tawfik, V. L. (2026) · iScience · doi:10.1016/j.isci.2026.115719 · Cited by 1

α1A-adrenergic receptor activation ameliorates fragmented spatial exploration by improving astrocyte-neuronal coupling in the medial entorhinal cortex of Alzheimer's disease mice

Wu, F., Fan, J., Yang, Z., Huang, M., Wang, H., Liu, Y., Cai, Z., Yang, S., Zhou, X., Gong, M., et al. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107398 · Cited by 1

Single-nucleus brain transcriptomics reveals microglia dysfunction in multiple system atrophy

Rydbirk, R., Sørensen, F. N. F., Folke, J., Haukedal, H., Asenjo-Martínez, A., Vargas, I. L., McGarry, S., Hollmann, O. C., Gherardelli, C., Sepulveda, S. E., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-71525-6 · Cited by 2

PTP1B in astrocytes drives pathogen-induced neurodegeneration

He, Z., Xing, Y., Gu, J., Xu, D., He, P., Lin, X., Cui, W., Lv, H., Ding, H., Sui, K., et al. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03837-9 · Cited by 1

CCL2 and PAK6 as Candidate Biomarkers of Neuroinflammation in Parkinson’s Disease: An Integrated Machine Learning and Single-Nucleus Transcriptomic Study

Zhu, Q., Zhang, Z., Zhang, L., Li, Q., Zhang, T., & Yang, F. (2026) · Brain Sciences · doi:10.3390/brainsci16050463 · Cited by 1

Metabolic crosstalk in the ageing brain: astrocyte-neuron coupling as a target for homeostatic restoration and therapy

Qian, L., Deng, Y., Song, M., Zhang, Z., Cheng, J., Zhu, B., Wu, M., Zhang, H., & Hu, Y. (2026) · Translational Neurodegeneration · doi:10.1186/s40035-026-00562-4 · Cited by 3

Self-assembling supramolecular dendrimers for biomedical applications

Elkihel, A., Wu, J., & Peng, L. (2026) · Comptes Rendus Chimie · doi:10.5802/crchim.451 · Cited by 1

Central nervous system histopathological findings in classic infantile Pompe disease: a systematic review with clinical relevance

van den Dorpel, J. J. A., Faraguna, M. C., Verdijk, R. M., van der Beek, N. A. M. E., Pijnappel, W. W. M. P., van der Ploeg, A. T., & van den Hout, J. M. P. (2026) · Journal of Neurology · doi:10.1007/s00415-026-13991-y · Cited by 1

The development of cerebral vasculature and related diseases

Ma, J., Min, X., Wu, M., & Zhang, J. (2023) · Scientia Sinica Vitae · doi:10.1360/ssv-2023-0092 · Cited by 1

The Effect of Astrocytes in Synaptic Transmission and Rhythmogenesis in Hippocampus

Lebedeva, A., Maltseva, K., Barabash, N. V., Sokolov, R., Rozov, A. V., & Levanova, T. A. (2023) · International Conference Neurotechnologies and Neurointerfaces (CNN) · doi:10.1109/cnn59923.2023.10275261 · Cited by 1

Glial Cell Metabolism and Neurodegenerative Diseases: The Current Perspective

Jaldhi, Yadav, H., & Maurya, S. K. (2024) · Springer eBooks · doi:10.1007/978-981-97-4288-2_4 · Cited by 1

Silencing HMGB1 secretion inhibited EV71-induced blood-brain barrier dysfunction and neural inflammation by depressing astrocyte activation via sHh signal blockage

Zhang, Y., Liu, Y., Wan, H., Deng, H., Xu, P., Cao, L., Yang, X., & Li, H. (2025) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2025.106797 · Cited by 1

Arsenite-Mediated Transcriptional Regulation of Glutathione Synthesis in Mammalian Primary Cortical Astrocytes

Leisawitz, J. P., He, J., Baggeroer, C. E., & Hewett, S. J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115375 · Cited by 1

Neurotoxicants driving glial aging: role of astrocytic aging in non-cell autonomous neurodegeneration

Reina-Gonzalez, P., Ay, M., Langley, M. R., Plunk, E. C., Strazdins, R., Abu-Salah, A., Anchan, A., Shah, A., & Sarkar, S. (2025) · Toxicological Sciences · doi:10.1093/toxsci/kfaf088 · Cited by 1

Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular maturationPreprint

Andrade, M. F., Comin, C. H., Dyken, P. C. V., Ouellette, J., Raman‐Nair, J., Blakeley, N., Liu, Q. Y., Leclerc, S., Pan, Y., Liu, Z., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.29.538807 · Cited by 1

DNL343 is an investigational CNS penetrant eIF2B activator that prevents and reverses the effects of neurodegeneration caused by the Integrated Stress ResponsePreprint

Yulyaningsih, E., Suh, J. H., Fanok, M. H., Chau, R., Solanoy, H., Takahashi, R. H., Bakardjiev, A., Becerra, I., Benitez, N. B., Chiu, C.-L., et al. (2024) · bioRxiv · doi:10.1101/2023.08.21.554203 · Cited by 4

Multimodal generation of astrocyte by integrating single-cell multi-omics data via deep learningPreprint

Mao, J., Wang, J., Zeb, A., & No, K. T. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.30.569500 · Cited by 1

Cannabidiol protects against neurotoxic reactive astrocytes-induced neuronal death in mouse models of epilepsyPreprint

Ye, H., Wan, Y., Wang, X., Wang, S., Zhao, X., Wang, X., Yu, T., Yan, C., Chen, Z., & Liu, X. (2024) · Research Square · doi:10.21203/rs.3.rs-3878760/v1 · Cited by 1

Circadian regulation of endoplasmic reticulum calcium response in mouse cultured astrocytesPreprint

Ryu, J. E., Shim, K.-W., Roh, H. W., Park, M., Lee, J., & Kim, E. Y. (2024) · eLife · doi:10.7554/elife.96357.1 · Cited by 1

A Human Brain-Chip for modelling brain pathologies and screening of BBB crossing therapeutic strategiesPreprint

Chim, S. M., Howell, K., Kokkosis, A. G., Zambrowicz, B., Karalis, K. P., & Pavlopoulos, E. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.11.607509 · Cited by 1

Astrocyte-specific secretome profiling reveals its correlation with neurological disordersPreprint

Liu, J., Gao, J., Guo, L., Ma, G., Guan, M., Xia, C., He, J., Yang, Y., Wu, Y., Xu, J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.21.624658 · Cited by 1

The Combination of Neuropsychiatric Symptoms and Blood-Based Biomarkers Enhances Early Detection of Mild Cognitive ImpairmentPreprint

Leow, Y. J., Ismail, Z., Saffari, S. E., Sandhu, G. K., Tanoto, P., Lee, F. P. H. E., Ghildiyal, S., Liew, S. Y., Bhalla, G., Ying, S. X., et al. (2024) · medRxiv · doi:10.1101/2024.12.08.24318690 · Cited by 1

Reactive Astrocytes Drive Extracellular Acidification to Mediate α-Synuclein NeurodegenerationPreprint

Song, J., Park, H., Choi, Y., Ryu, T., Shin, J., Kim, S.-H., Park, A., Wang, J., Biswas, D., Chou, S.-C., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.06.697893 · Cited by 1

Neurological Disorder after Severe Pneumonia is Associated with Translocation of Bacteria from Lung to BrainPreprint

Ma, Q., Yao, C., Wu, Y., Wang, H., Fan, Q., Yang, Q., Xu, J., Dai, H., Zhang, Y., Xu, F., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.30.522351

Is platelet activation a link between metabolic syndrome and cognitive impairment in patients with schizophrenia?Preprint

Okusaga, O. O., Vijayan, K. V., & Rumbaut, R. E. (2023) · medRxiv · doi:10.1101/2023.01.10.23284409

Comprehensive analyses identify IRF8 in microglia as a possible regulatory target for Parkinson’s DiseasePreprint

Yao, H., Liu, C., Jin, L., & Song, Y. (2023) · Research Square · doi:10.21203/rs.3.rs-3412881/v1

Attenuating amyloid-beta pathology in mice with in situ programmed astrocytesPreprint

Zhang, L., Lü, S., Jia, Y., Hou, S., Zhu, J., Liu, X., Sun, X., Huang, Y., Zhao, Y.-X., Ren, H., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.30.564697

Reviewer #1 (Public Review): DNL343 is an investigational CNS penetrant eIF2B activator that prevents and reverses the effects of neurodegeneration caused by the Integrated Stress Response

Yulyaningsih, E., Suh, J. H., Fanok, M. H., et al. (2023) · eLife · doi:10.7554/elife.92173.1.sa2

Circadian regulation of endoplasmic reticulum calcium response in cultured mouse astrocytes

Ryu, J. E., Shim, K.-W., Roh, H. W., Park, M., Lee, J., & Kim, E. Y. (2024) · eLife · doi:10.7554/elife.96357.3

Exercise-Induced Changes in Aging Mouse Hippocampus: A Single-Cell Transcriptomic AnalysisPreprint

Huang, X., Li, X., Yu, J. Z., Wei, C., & Zhang, Y. (2024) · Research Square · doi:10.21203/rs.3.rs-4035975/v1

The role of soluble epoxide hydrolase in macrophage and astrocyte polarization

Li, X. (2024) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.85784

Strategies for precise regulation of autophagy by traditional Chinese medicine and natural products and their application in neurodegenerative disease models

Dong, Y. J., & Lu, J. (2024) · Scientia Sinica Vitae · doi:10.1360/ssv-2024-0039

Properties of Alzheimer’s disease brain-derived tau aggregates define tau processing by human astrocytesPreprint

Reid, M. J., Leija‐Salazar, M., Troakes, C., Lynham, S., Srivastava, D. P., Perez‐Nievas, B. G., & Noble, W. J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.04.610753

Nervous System, Neurons, and Metabolism

Konukoğlu, D. (2024) · doi:10.69860/nobel.9786053359166.1

Circadian regulation of endoplasmic reticulum calcium response in cultured mouse astrocytesPreprint

Ryu, J. E., Shim, K.-W., Roh, H. W., Park, M., Lee, J., & Kim, E. Y. (2024) · eLife · doi:10.7554/elife.96357.2

The OMICS and PD models: Hopes or hypes

Elsamman, K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-16128-5.00020-7

ATP Alters the Oxylipin Profiles in Astrocytes: Modulation by High Glucose and Metformin

Drozhdev, A. I., Gorbatenko, V. O., Goriainov, S. V., Chistyakov, D. V., & Sergeeva, M. G. (2025) · Brain Sciences · doi:10.3390/brainsci15030293

Study of gut microbiota in the context of neurological disorders

Roubalová, R., & Procházková, P. (2025) · Neurologie pro praxi · doi:10.36290/neu.2024.042

The potential therapeutic effect of donepezil on a ketamine rat model of psychosis

Mehdar, K. M. (2025) · Journal Of Advanced Pharmacy Education And Research · doi:10.51847/oddqdge3fy

NETSseq Reveals Inflammatory and Aging Mechanisms in Distinct Cell Types Driving Cerebellar Decline in Ataxia TelangiectasiaPreprint

Stirparo, G. G., Xu, X., Toni, T., Page, K. J., Harvey, J. R. M., Cadwalladr, D., Lawrence, J. M. K., Burley, R., Juvvanapudi, J., Megan, R., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.13.653662

Microglia-drive IRF8 upregulates complement pathway in Parkinson's disease

Yao, H., Liu, C., Jin, L., & Song, Y. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167928

Lysosomal stress induces amyloid-β aggregate release and reactive transformation in human astrocytesPreprint

Goldsworthy, S., Fertan, E., Dyal, P. L., Domoney, S., Livesey, F. J., Klenerman, D., Patani, R., & Hung, C. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.27.656416

Computational Mining of Genesets in Unraveling Angelman Syndrome: A Genomic Exploration

Kumar, A., & Kumar, V. (2025) · International Conference on Signal Processing, Computing and Control (ISPCC) · doi:10.1109/ispcc66872.2025.11039570

PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylationPreprint

Wang, S., Baumert, R., Sejourne, G. M., Bindu, D. S., Dimond, K., Sakers, K., Vazquez, L., Moore, J. L., Tan, C. X., Takano, T., et al. (2025) · eLife · doi:10.7554/elife.107556.1

Whole-Brain Cell-Cell Interaction Axes Explaining Tissue Vulnerability Across the Neurodegenerative SpectrumPreprint

Pak, V., Hong, J. H., Baumeister, T. R., Bezgin, G., Nagy, C., Ducharme, S., Dadar, M., Zeighami, Y., & Iturria‐Medina, Y. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.21.665217

Automated Detection and Segmentation of Astrocytes in GFAP-labeled Micrographs using YOLOv8Preprint

Syed, S., Rahman, M. R., Papadakis, M., & Demetrio Labate, A. (2025) · Research Square · doi:10.21203/rs.3.rs-7330566/v1

GSDME unlocks astrocyte-driven neurotoxicity in Alzheimer’s DiseasePreprint

Xie, X., Ji, C., Xu, J., Lu, X., Guo, G., Wu, X., Liu, W., Chen, Y., Zhang, Y., Wang, J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.28.672784

Parkinson's Disease and Cancer: Mechanistic Insights and Therapeutic Opportunities From Cancer Neuroscience

Pan, T., Yuan, L., Zhao, R., Lu, L., Zhi, Y., Li, Y., Wu, M., & Huang, Y. (2025) · MedComm – Oncology · doi:10.1002/mog2.70044

Glymphatic impairment in Moyamoya disease

Chen, Y., & Liu, X. (2025) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2025.104053

Star-shaped cells make a molecule that can ‘rewire’ the brains of mice with Down syndrome – understanding how could lead to new treatments

Brandebura, A. N. (2025) · doi:10.64628/aai.7rphpqcsn

iPSC-derived neurospheres: A cellular platform for Tau and Alzheimer’s disease immunotherapy

Chinnathambi, S., Adityan, A., Chandrashekar, M., & Velmurugan, G. (2025) · Advances in immunology · doi:10.1016/bs.ai.2025.11.001 · Cited by 1

Astrocytic Interleukin‐33 Deficiency Reduces Glial Fibrillary Acidic Protein Expression and Exacerbates Microglial Activation and Neuronal Damage in a Chemically Induced Inflamed Frontal Cortex

Zheng, Y., Chen, W., Wang, C., & Tzeng, S. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70310

Pharmacologically increasing O-GlcNAcylation increases complexity of astrocytes in the dentate gyrus of TgF344-AD rats

Garcia, M. L., Denton, A. R., Jackson, N. L., Scofield, M. D., & McMahon, L. L. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1690410

Bivariate GSA-MiXeR: A Novel Tool for Functional Genomic Analyses Implicates Diverse Neural Cell Types for Psychiatric and Neurodegenerative DisordersPreprint

Parker, N., Furher, J., Nguyen, D. T., Fominykh, V., Jaholkowski, P. P., Akkouh, I. A., O’Connell, K. S., Hagen, E., Bahrahmi, S., Årsland, D., et al. (2025) · medRxiv · doi:10.64898/2025.12.16.25342384 · Cited by 1

Additional file 1 of Interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunction

Henry, R. J., Barrett, J. P., Vaida, M. L., Khan, N., Makarevich, O. D., Ritzel, R. M., Faden, A. I., & Stoica, B. A. (2024) · Figshare · doi:10.6084/m9.figshare.26714257

Additional file 1 of α-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosis

Wang, P., Lan, G., Xu, B., Yu, Z., Tian, C., Lei, X., Meissner, W. G., Feng, T., Yang, Y., & Zhang, J. (2024) · Figshare · doi:10.6084/m9.figshare.26612756

Neurodegenerative Diseases and Glucose Metabolism of Neuroglial Cells

王, 书. (2026) · Advances in Clinical Medicine · doi:10.12677/acm.2026.162418

Astrocyte-Targeted Nanotherapeutics Modulate Iron Homeostasis in Cerebral Amyloid Angiopathy by Restoring the Astrocytic Trafficking Hub Function

Zhou, L., Xu, Y., Yang, P., Zhou, J., Wang, M., Li, Y., Yang, X., Liu, X., Wang, T., Yao, C., et al. (2026) · ACS Nano · doi:10.1021/acsnano.5c16884

GFAP and the genetic code of astrocyte activation in Alzheimer’s disease

Upadhyay, R., Srinivasan, T. B., Umapriya, R., Chandrapragasam, V., & Sevanan, M. (2026) · International review of neurobiology · doi:10.1016/bs.irn.2026.01.007

How molecular mechanisms of aging drive Alzheimer's disease pathology

Chang, J., Liu, T., Cheng, X., & Wei, J. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112426

Mechanisms and clinical prospects of mesenchymal stem cells and their derivatives in treating hypothyroidism-induced injuries: A focus on cardiovascular, skeletal muscle, and nervous systems

Wang, Y., Zhu, J., Li, Z., Yu, F., Fu, Y., Gao, H., Wang, M., Yuan, L., Zheng, L., & He, Q. (2026) · Cell Transplantation · doi:10.1177/09636897261418754

The effect of astrocyte depletion and repopulation approaches in pathological condition of CNS

Tahmasebi, F., Safarian, A., Asl, E. R., Vahidinia, Z., & Barati, S. (2026) · Acta Neurologica Belgica · doi:10.1007/s13760-026-03005-z

Recurrent intermittent hyponatremia: A new experimental model

Tejedor, M., Cussó, L., González-Nicolás, M. Á., Felipe, D. S., Calle, D., Martín‐Sánchez, B., Uzun, B., Martín-Palumbo, G., Walther, L. A. Á.-S., Marco, E. M., et al. (2026) · PLoS ONE · doi:10.1371/journal.pone.0341743

Orchestrating the Parkinson’s disease microenvironment in 3D for pathogenesis study and therapeutic development

Tang, X., Cui, H., & Cui, H. (2026) · Biofabrication · doi:10.1088/1758-5090/ae4895

Effects of plasmalogens on microglial function and neuroinflammation: mechanisms and implications in aging and neurodegenerative diseases

Xu, Z., & Deng, Y. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-27340-7.00012-7

Hopx expression marks Aβ clearance astrocytes in Alzheimer’s diseasePreprint

Cao, D.-D., Dong, J., Liao, X.-Y., Teng, Y.-Y., Gu, Y., & Luo, Z. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.27.708674

Spinal glia–neuron interactions in chronic itch

Tsuda, M. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-34172-4.00018-5

Dynamic regional divergence of SV2A expression in a mouse model of primary tauopathy: A longitudinal multi-tracer PET study

Li, Y., Zatcepin, A., Palumbo, G., Oos, R., Wind-Mark, K., Lindner, S., Gildehaus, F., Gnörich, J. S., Werner, R. A., Brendel, M., et al. (2026) · NeuroImage · doi:10.1016/j.neuroimage.2026.121932

Alzheimer’s Spinal Pathology: Neuronal, Glial, and Cholesterol Metabolic Changes in Female and Male 5xFAD Mice

Wang, X., Harnett, W., Shu, X., & Jiang, H. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27083593

Cytoskeleton-mediated autophagy regulation in neuroimmune contexts: molecular mechanisms and functional perspectives

Cao, X., Zhang, H., & Wang, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1732775

The human olfactory bulb in Huntington's disease: sex-specific differences in volume and gliosis

Flores-Thomas, A. P., Retamosa-Sanchez, E., Gómez, A. A., Flores‐Cuadrado, A., Saiz‐Sánchez, D., Astillero‐Lopez, V., Rábano, A., Martı́nez-Marcos, A., & Úbeda‐Bañón, I. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107413

Decoding shared pathogenic networks of oxidative stress in neuropsychiatric disorders to prioritize multi-target therapeutics from natural products

Xu, X. J., Ni, Z., Wang, Y.-B., Fan, S., Du, Y., Wang, X., & Meng, X. (2026) · Cell Biology and Toxicology · doi:10.1007/s10565-026-10208-w

Neuroprotective effect of astrocytic dopamine Drd2 receptor on mitochondrial complex I in a mouse model of Parkinson’s disease through β-arrestin2-NDUFA10 regulation

Huang, Q.-H., Zhang, N.-X., Guo, J.-J., Fan, C.-Y., Ding, J.-H., Wei, Y., Liu, Y., & Hu, G. (2026) · Cell Death and Differentiation · doi:10.1038/s41418-026-01756-z

Catalpol and tetramethylpyrazine relieve Alzheimer's disease by facilitating AQP4 protein expression and polarized distribution in hippocampal astrocytes via inducing the STAT3-mediated UCHL1 expression

Deng, C., Zhu, M., Yuan, J., Yin, T., Chen, H., & Meng, S. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05435-1

Dual Pathways Coupled to Oxytocin Molecular Signals in Cultured Astrocytes

Farsetti, E., Amato, S., Averna, M., Gatta, E., Guidolin, D., Pedrazzi, M., Lori, L., Matilde, G., Maura, G., Agnati, L. F., et al. (2026) · Cells · doi:10.3390/cells15100950

Luteolin and neuroinflammation: a multi-target therapeutic strategy for central nervous system disorders

Huang, J., Yu, M., Zou, Y., Wang, L., Ma, Y., Ma, Y., Kong, X., & Rong, F. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1844585

Astrocyte-microglia crosstalk via CSF1 and IFN-β promotes central nervous system repair

Cao, T., Hemati-Gourabi, M., Liu, Y., Mills, A. E., Baur, L., Rice, E. P., Klippel, T., Yan, Y., Xu, X. Q., Fenske, W. K., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117418 · Cited by 1

Identification of a Small-Molecule Modulator of Astrocyte Reactivity for Optic Nerve Protection

Li, T., Peng, H., Wu, N., Zhu, M., Li, Z., Dai, Q., Jin, M., Pan, S.-T., & Wu, W. (2026) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.67.5.73

Ginkgo Biloba Extract Ameliorates Age-Related Mitochondrial Deficits in Human iPSCs and Their Derived Neurons and Astrocytes

Lejri, I., Grimm, A., & Eckert, A. (2026) · Antioxidants · doi:10.3390/antiox15060689 · Cited by 1

Astrocytic μ-δ opioid receptor heterodimers mediate the antidepressant effects of ketamine’s metabolitePreprint

Yang, S., Wang, L. J., Sun, Y., Ma, X. Y., Rong, Y., Fong, T. H., Li, T., Deng, D., Li, X.-X., Zhang, Z., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.31.727553

ALDOC modulates astrocytic glycolysis and AMPK/mTOR/HIF-1α signaling in Alzheimer’s disease

Zhang, Z., Bai, Y., Xiangjian, Z., Zhang, J., & Yang, G. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1847340

Deciphering the role of mitochondrial NDUFA11 in Parkinson's disease: An integrated study of bioinformatics and A53T mouse model

Gong, J., Li, X., Yang, S., Zhu, Y., Li, X., Wen, D., Huang, Z., Zou, Z., & Guo, Z. (2026) · Genes & Diseases · doi:10.1016/j.gendis.2026.102277

Statin-Induced Mitochondrial Coenzyme Q Deficiency Alters Mitochondrial Redox Homeostasis and Bioenergetic Function in AstrocytesPreprint

Wojcicki, K., Gałgański, Ł., Budzinska, A., Figura, G., Pijanowski, W., & Jarmuszkiewicz, W. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.10.731318

Single-cell Transcriptomics Reveals that the SORBS1/FBXO22/BAG3 Axis Drives Astrocyte Senescence via Calcium Signaling and Affects Alzheimer’s Disease-Related Neuronal Damage

Li, Y., & He, X. (2026) · NeuroMolecular Medicine · doi:10.1007/s12017-026-08937-6

Region-specific features of early glial activation and Aquaporin-4 dysregulation in conditional mouse models of TDP-43 proteinopathies

Nieva, G. V., Vassallu, F., Depino, A. M., Netti, V. A., & Igaz, L. M. (2026) · Discovery Immunology · doi:10.1093/discim/kyag011

Contribution of astrocytes to neuropathology of neurodegenerative diseases

Acıoğlu, Ç., Li, L., & Elkabes, S. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147291 · Cited by 119

Mechanisms of Disease: astrocytes in neurodegenerative disease

Maragakis, N. J., & Rothstein, J. D. (2006) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0355 · Cited by 836

Common alterations to astrocytes across neurodegenerative disorders

Derevyanko, A., Tao, T., & Allen, N. J. (2025) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2025.102970 · Cited by 10

Astrocytes in Neurodegenerative Disease: Table 1.

Phatnani, H., & Maniatis, T. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020628 · Cited by 420

Astrocytes: The Stars in Neurodegeneration?

Dittlau, K. S., & Freude, K. (2024) · Biomolecules · doi:10.3390/biom14030289 · Cited by 39