Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

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Neurotoxic reactive astrocytes are induced by activated microglia

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A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

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Glutamate uptake

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Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

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The Classical Complement Cascade Mediates CNS Synapse Elimination

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Single-cell transcriptomic analysis of Alzheimer’s disease

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Reactive astrocyte nomenclature, definitions, and future directions

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Epidemiology of Parkinson’s disease

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Genomic analysis of reactive astrogliosis

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A polymorphic DNA marker genetically linked to Huntington's disease

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Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation

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Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

Jansen, I. E., Savage, J. E., Watanabe, K., Bryois, J., Williams, D. M., Steinberg, S., Sealock, J., Karlsson, I. K., Hägg, S., Athanasiu, L., et al. (2019) · Nature Genetics · doi:10.1038/s41588-018-0311-9 · Cited by 2,277

Amyotrophic lateral sclerosis

Hardiman, O. M., Al‐Chalabi, A., Chiò, A., Corr, E. M., Logroscino, G., Robberecht, W., Shaw, P. J., Simmons, Z., & van den Berg, L. H. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.71 · Cited by 2,262

Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers

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The epidemiology of Parkinson's disease: risk factors and prevention

Ascherio, A., & Schwarzschild, M. A. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30230-7 · Cited by 1,930

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

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Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis

Christopherson, K. S., Ullian, E. M., Stokes, C. C. A., Mullowney, C. E., Hell, J. W., Agah, A., Lawler, J., Mosher, D. F., Bornstein, P., & Barres, B. A. (2005) · Cell · doi:10.1016/j.cell.2004.12.020 · Cited by 1,688

Physiology of Astroglia

Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678

The role of apolipoprotein E in Alzheimer's disease

Kim, J., Basak, J. M., & Holtzman, D. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.026 · Cited by 1,661

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

Hardingham, G. E., & Bading, H. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2911 · Cited by 1,644

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

Chung, W.-S., Clarke, L. E., Wang, G. X., Stafford, B. K., Sher, A., Chakraborty, C., Joung, J., Foo, L. C., Thompson, A., Chen, C., et al. (2013) · Nature · doi:10.1038/nature12776 · Cited by 1,377

Gliotransmitters Travel in Time and Space

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Human ApoE isoforms differentially regulate brain amyloid-β peptide clearance

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Diversity of astrocyte functions and phenotypes in neural circuits

Khakh, B. S., & Sofroniew, M. V. (2015) · Nature Neuroscience · doi:10.1038/nn.4043 · Cited by 1,239

Normal aging induces A1-like astrocyte reactivity

Clarke, L. E., Liddelow, S. A., Chakraborty, C., Münch, A. E., Heiman, M., & Barres, B. A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1800165115 · Cited by 1,237

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex

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Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

Nagai, M., Re, D. B., Nagata, T., Chalazonitis, A., Jessell, T. M., Wichterle, H., & Przedborski, S. (2007) · Nature Neuroscience · doi:10.1038/nn1876 · Cited by 1,220

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

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Decreased Glutamate Transport by the Brain and Spinal Cord in Amyotrophic Lateral Sclerosis

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APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

Lin, Y.-T., Seo, J., Gao, F., Feldman, H. M., Wen, H.-L., Penney, J., Cam, H. P., Gjoneska, E., Raja, W. K., Cheng, J., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.05.008 · Cited by 1,125

Cell Biology of Astrocyte-Synapse Interactions

Allen, N. J., & Eroglu, C. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.056 · Cited by 1,098

Disease-associated astrocytes in Alzheimer’s disease and aging

Habib, N., McCabe, C., Medina, S., Varshavsky, M., Kitsberg, D., Dvir-Szternfeld, R., Green, G., Dionne, D., Nguyen, L., Marshall, J. L., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0624-8 · Cited by 1,009

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

Johnson, E. C. B., Dammer, E. B., Duong, D. M., Ping, L., Zhou, M., Yin, L., Higginbotham, L. A., Guajardo, A., White, B., Troncoso, J. C., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0815-6 · Cited by 1,001

A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation

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Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer?s disease

HYND, M. (2004) · Neurochemistry International · doi:10.1016/j.neuint.2004.03.007 · Cited by 938

Lipid raft microdomains and neurotransmitter signalling

Allen, J., Halverson-Tamboli, R. A., & Rasenick, M. M. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn2059 · Cited by 880

The genetic landscape of Alzheimer disease: clinical implications and perspectives

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Astrocytes Control Synapse Formation, Function, and Elimination

Chung, W.-S., Allen, N. J., & Eroglu, C. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020370 · Cited by 839

The blood–brain barrier in health and disease: Important unanswered questions

Profaci, C. P., Munji, R. N., Pulido, R. S., & Daneman, R. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20190062 · Cited by 811

GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

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Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

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Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors

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The molecular basis of water transport in the brain

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The aging astrocyte transcriptome from multiple regions of the mouse brain.

Boisvert, M. M., Erikson, G. A., Shokhirev, M. N., & Allen, N. J. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.039 · Cited by 702

Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease

Brenner, M., Johnson, T., Boespflug‐Tanguy, O., Rodriguez, D., Goldman, J. E., & Messing, A. (2001) · Nature Genetics · doi:10.1038/83679 · Cited by 698

Deciphering molecular interactions by proximity labeling

Qin, W., Cho, K. F., Cavanagh, P. E., & Ting, A. Y. (2021) · Nature Methods · doi:10.1038/s41592-020-01010-5 · Cited by 671

Function and therapeutic value of astrocytes in neurological diseases

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Astrocytes Are Endogenous Regulators of Basal Transmission at Central Synapses

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Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC

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Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

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Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice

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Neuroinflammatory astrocyte subtypes in the mouse brain

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Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression

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Large-scale deep multi-layer analysis of Alzheimer’s disease brain reveals strong proteomic disease-related changes not observed at the RNA level

Johnson, E. C. B., Carter, E. K., Dammer, E. B., Duong, D. M., Gerasimov, E. S., Liu, Y., Liu, J., Betarbet, R., Ping, L., Yin, L., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-021-00999-y · Cited by 561

Incidence and impact of subclinical epileptiform activity in Alzheimer’s disease.

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Regional Astrocyte Allocation Regulates CNS Synaptogenesis and Repair

Tsai, H., Li, H., Fuentealba, L. C., Molofsky, A. V., Taveira‐Marques, R., Zhuang, H., Tenney, A., Murnen, A. T., Fancy, S. P. J., Merkle, F. T., et al. (2012) · Science · doi:10.1126/science.1222381 · Cited by 555

Local Ca2+ detection and modulation of synaptic release by astrocytes

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Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease

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Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

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Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits

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Cholesterol metabolism in neurons and astrocytes

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The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: Potential targets for neurotherapeutics

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The mechanism of γ‐Secretase dysfunction in familial Alzheimer disease

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Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease

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Molecular characterization of selectively vulnerable neurons in Alzheimer’s disease

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Reversing a model of Parkinson's disease with in situ converted nigral neurons

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Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease

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NACP/α-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson’s disease brains

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Frontotemporal Dementia and Corticobasal Degeneration in a Family with a P301S Mutation in Tau

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Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice

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Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis

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GLUTAMATE-INDUCED NEURONAL NECROSIS IN THE INFANT MOUSE HYPOTHALAMUS

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Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer’s disease.

Sadick, J. S., O’Dea, M. R., Hasel, P., Dykstra, T., Faustin, A., & Liddelow, S. A. (2022) · Neuron · doi:10.1016/j.neuron.2022.03.008 · Cited by 415

Cholesterol and matrisome pathways dysregulated in astrocytes and microglia

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Correlations between apolipoprotein E ε4 gene dose and brain-imaging measurements of regional hypometabolism

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Isolation of glia from Alzheimer’s mice reveals inflammation and dysfunction

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Glutamate-induced excitotoxicity in Parkinson's disease: The role of glial cells

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Alzheimer's DiseasePreprint

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Astrocyte phenotype in relation to Alzheimer‐type pathology in the ageing brain

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Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms

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Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy

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Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model

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Three-dimensional Ca 2+ imaging advances understanding of astrocyte biology

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