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Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders
Open accessAbstract
There is increasing appreciation that non-neuronal cells contribute to the initiation, progression and pathology of diverse neurodegenerative disorders. This Review focuses on the role of astrocytes in disorders including Alzheimer disease, Parkinson disease, Huntington disease and amyotrophic lateral sclerosis. The important roles astrocytes have in supporting neuronal function in the healthy brain are considered, along with studies that have demonstrated how the physiological properties of astrocytes are altered in neurodegenerative disorders and may explain their contribution to neurodegeneration. Further, the question of whether in neurodegenerative disorders with specific genetic mutations these mutations directly impact on astrocyte function, and may suggest a driving role for astrocytes in disease initiation, is discussed. A summary of how astrocyte transcriptomic and proteomic signatures are altered during the progression of neurodegenerative disorders and may relate to functional changes is provided. Given the central role of astrocytes in neurodegenerative disorders, potential strategies to target these cells for future therapeutic avenues are discussed.
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“The astrocytic calcium signaling underlies vital physiological functions, and its dysregulation has been associated with neuroinflammation and neurodegeneration.246,252”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [252]
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Metadata
- Authors
- Brandebura, A. N., Paumier, A., Onur, T. S., & Allen, N. J.
- Affiliations
- Salk Institute for Biological Studies (US)
- Corresponding author
- Allen, Nicola J.
- Venue
- Nature Reviews Neuroscience
- Published
- 2022-10-31
- Volume
- 24
- Issue
- 1
- Pages
- 23-39
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC10198620
- OpenAlex
- W4307895613
- Cited by
- 427
- References
- 201
- Citations by year
- 2026: 94 · 2025: 121 · 2024: 130 · 2023: 78 · 2022: 4
- FWCI
- 8.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (F32NS117776)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- astrocytes, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, astrocyte dysfunction, disease initiation, disease progression, genetic mutations, astrocyte-targeted therapy, glial cells
- MeSH terms
- Amyotrophic Lateral Sclerosis, Astrocytes, Humans, Neurons, Neurodegenerative Diseases, Proteomics
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