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Functional circuit architecture underlying parental behaviour
Abstract
Parenting is essential for the survival and wellbeing of mammalian offspring. However, we lack a circuit-level understanding of how distinct components of this behaviour are coordinated. Here we investigate how galanin-expressing neurons in the medial preoptic area (MPOAGal) of the hypothalamus coordinate motor, motivational, hormonal and social aspects of parenting in mice. These neurons integrate inputs from a large number of brain areas and the activation of these inputs depends on the animal’s sex and reproductive state. Subsets of MPOAGal neurons form discrete pools that are defined by their projection sites. While the MPOAGal population is active during all episodes of parental behaviour, individual pools are tuned to characteristic aspects of parenting. Optogenetic manipulation of MPOAGal projections mirrors this specificity, affecting discrete parenting components. This functional organization, reminiscent of the control of motor sequences by pools of spinal cord neurons, provides a new model for how discrete elements of a social behaviour are generated at the circuit level. Galanin-expressing neurons in the medial preoptic area coordinate different aspects of motor, motivational, hormonal and social behaviour associated with parenting by projecting to different brain regions depending on the type of behaviour and sex and reproductive state of mice.
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“Neuronal networks are the standard heuristic model today for describing brain activity associated with animal behavior.”
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Cites
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907
Hypothalamic integration: organization of the paraventricular and supraoptic nuclei
Swanson, L. W., & Sawchenko, P. E. (1983) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.06.030183.001413 · Cited by 1,991
The mysterious motivational functions of mesolimbic dopamine
Salamone, J. D., & Correa, M. (2012) · Neuron · doi:10.1016/j.neuron.2012.10.021 · Cited by 1,418
Natural neural projection dynamics underlying social behavior
Gunaydin, L. A., Grosenick, L., Finkelstein, J. C., Kauvar, I. V., Fenno, L. E., Adhikari, A., Lammel, S., Mirzabekov, J. J., Airan, R. D., Zalocusky, K. A., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.017 · Cited by 1,389
Monosynaptic Restriction of Transsynaptic Tracing from Single, Genetically Targeted Neurons
Wickersham, I. R., Lyon, D. C., Barnard, R. J. O., Mori, T., Finke, S., Conzelmann, K.-K., Young, J. A. T., & Callaway, E. M. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.033 · Cited by 1,187
Circuit architecture of VTA dopamine neurons revealed by systematic input-output mapping
Beier, K. T., Steinberg, E. E., DeLoach, K. E., Xie, S., Miyamichi, K., Schwarz, L., Gao, X. J., Kremer, E. J., Malenka, R. C., & Luo, L. (2015) · Cell · doi:10.1016/j.cell.2015.07.015 · Cited by 1,068
Self-citationViral-genetic tracing of the input-output organization of a central noradrenaline circuit
Schwarz, L. A., Miyamichi, K., Gao, X. J., Beier, K. T., Weissbourd, B., DeLoach, K. E., Ren, J., Ibanes, S., Malenka, R. C., Kremer, E. J., et al. (2015) · Nature · doi:10.1038/nature14600 · Cited by 744
Self-citationOxytocin enables maternal behaviour by balancing cortical inhibition
Marlin, B. J., Mitre, M., D’amour, J. A., Chao, M. V., & Froemke, R. C. (2015) · Nature · doi:10.1038/nature14402 · Cited by 744
Retrograde neuronal tracing with a deletion-mutant rabies virus
Wickersham, I. R., Finke, S., Conzelmann, K.-K., & Callaway, E. M. (2007) · Nature Methods · doi:10.1038/nmeth999 · Cited by 682
Galanin neurons in the medial preoptic area govern parental behaviour
Wu, Z., Autry, A. E., Bergan, J. F., Watabe‐Uchida, M., & Dulac, C. G. (2014) · Nature · doi:10.1038/nature13307 · Cited by 617
Self-citationToward a Wiring Diagram Understanding of Appetite Control
Andermann, M. L., & Lowell, B. B. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.014 · Cited by 606
Neural control of maternal and paternal behaviors
Dulac, C., O’Connell, L. A., & Wu, Z. (2014) · Science · doi:10.1126/science.1253291 · Cited by 457
Self-citationMedial preoptic area and onset of maternal behavior in the rat.
Numan, M., Rosenblatt, J. S., & Komisaruk, B. R. (1977) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077304 · Cited by 422
Eliava, M., Melchior, M., Knobloch-Bollmann, H. S., Wahis, J., da Silva Gouveia, M., Tang, Y., Ciobanu, A. C., Triana del Rio, R., Roth, L. C., Althammer, F., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.041 · Cited by 409
Hong, W., Kim, D.-W., & Anderson, D. J. (2014) · Cell · doi:10.1016/j.cell.2014.07.049 · Cited by 405
Circuit-based interrogation of sleep control
Weber, F., & Dan, Y. (2016) · Nature · doi:10.1038/nature19773 · Cited by 372
Central prolactin infusions stimulate maternal behavior in steroid-treated, nulliparous female rats.
Bridges, R. S., Numan, M. J., Ronsheim, P. M., MANN, P., & Lupini, C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.20.8003 · Cited by 352
Circuit modules linking internal states and social behaviour in flies and mice
Anderson, D. J. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.125 · Cited by 336
Osakada, F., Mori, T., Cetin, A. H., Marshel, J. H., Virgen, B., & Callaway, E. M. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.005 · Cited by 318
Molecular organization of vomeronasal chemoreception
Isogai, Y., Si, S., Pont-Lezica, L., Tan, T., Kapoor, V., Murthy, V. N., & Dulac, C. (2011) · Nature · doi:10.1038/nature10437 · Cited by 317
Self-citationMiyamichi, K., Shlomai, Y., Shu, M., Weissbourd, B., Luo, L., & Mizrahi, A. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.027 · Cited by 313
Self-citationMotor Circuits in Action: Specification, Connectivity, and Function
Arber, S. (2012) · Neuron · doi:10.1016/j.neuron.2012.05.011 · Cited by 306
Hormonal gain control of a medial preoptic area social reward circuit
McHenry, J. A., Otis, J. M., Rossi, M. A., Robinson, J. E., Kosyk, O., Miller, N. W., McElligott, Z. A., Budygin, E. A., Rubinow, D. R., & Stuber, G. D. (2017) · Nature Neuroscience · doi:10.1038/nn.4487 · Cited by 301
Brainstem nucleus MdV mediates skilled forelimb motor tasks
Esposito, M. S., Capelli, P., & Arber, S. (2014) · Nature · doi:10.1038/nature13023 · Cited by 292
Biased Oxytocinergic Modulation of Midbrain Dopamine Systems
Xiao, L., Priest, M. F., Nasenbeny, J., Lu, T., & Kozorovitskiy, Y. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.003 · Cited by 292
Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice
Li, Y., Mathis, A., Grewe, B. F., Osterhout, J. A., Ahanonu, B., Schnitzer, M. J., Murthy, V. N., & Dulac, C. (2017) · Cell · doi:10.1016/j.cell.2017.10.015 · Cited by 291
Self-citationAmygdaloid inhibition of maternal behavior in the nulliparous female rat☆
FLEMING, A., VACCARINO, F., & LUEBKE, C. (1980) · Physiology & Behavior · doi:10.1016/0031-9384(80)90377-7 · Cited by 271
The genetic basis of parental care evolution in monogamous mice
Bendesky, A., Kwon, Y.-M., Lassance, J.-M., Lewarch, C. L., Yao, S., Peterson, B. K., He, M. X., Dulac, C., & Hoekstra, H. E. (2017) · Nature · doi:10.1038/nature22074 · Cited by 268
Self-citationMenegas, W., Babayan, B. M., Uchida, N., & Watabe-Uchida, M. (2017) · eLife · doi:10.7554/elife.21886 · Cited by 265
Self-citationNeural circuits underlying thirst and fluid homeostasis
Zimmerman, C. A., Leib, D. E., & Knight, Z. A. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.71 · Cited by 263
A sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion
Scott, N., Prigge, M., Yizhar, O., & Kimchi, T. (2015) · Nature · doi:10.1038/nature15378 · Cited by 261
Keer, S. E., & Stern, J. M. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(99)00116-x · Cited by 255
Lesions of the hypothalamic paraventricular nucleus disrupt the initiation of maternal behavior
Insel, T. R., & Harbaugh, C. R. (1989) · Physiology & Behavior · doi:10.1016/0031-9384(89)90234-5 · Cited by 250
Johnson, Z. V., & Young, L. J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.034 · Cited by 242
Sex-specific processing of social cues in the medial amygdala
Bergan, J. F., Ben-Shaul, Y., & Dulac, C. (2014) · eLife · doi:10.7554/elife.02743 · Cited by 237
Self-citationForebrain expression of c-fos due to active maternal behaviour in lactating rats
Lonstein, J. S., Simmons, D. A., Swann, J. M., & Stern, J. M. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00283-2 · Cited by 237
Social behaviour shapes hypothalamic neural ensemble representations of conspecific sex
Remedios, R., Kennedy, A., Zelikowsky, M., Grewe, B. F., Schnitzer, M. J., & Anderson, D. J. (2017) · Nature · doi:10.1038/nature23885 · Cited by 222
Hansen, S., Harthon, C., Waslin, E., Löfberg, L., & al, E. (1991) · Behavioral Neuroscience · doi:10.1037//0735-7044.105.4.588 · Cited by 211
Time-contingent change in infanticide and parental behavior induced by ejaculation in male mice
Saal, F. S. V. (1985) · Physiology & Behavior · doi:10.1016/0031-9384(85)90069-1 · Cited by 209
Tachikawa, K. S., Yoshihara, Y., & Kuroda, K. O. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2364-12.2013 · Cited by 192
Numan, M., Numan, M. J., Pliakou, N., Stolzenberg, D. S., Mullins, O. J., Murphy, J. M., & Smith, C. D. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.6.1588 · Cited by 183
Numan, M., Numan, M., Numan, M., & Numan, M. (1996) · Developmental Psychobiology · doi:10.1002/(sici)1098-2302(199601)29:1<23::aid-dev2>3.0.co;2-o · Cited by 169
Sheehan, T. P., Paul, M., Amaral, E., Numan, M. J., & Numan, M. J. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00286-x · Cited by 162
Oxytocin signaling in the medial amygdala is required for sex discrimination of social cues
Yao, S., Bergan, J., Lanjuin, A., & Dulac, C. (2017) · eLife · doi:10.7554/elife.31373 · Cited by 151
Numan, M., & Numan, M. J. (1997) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1997.t01-1-00597.x · Cited by 149
The neurobiology of parenting: A neural circuit perspective
Kohl, J., Autry, A. E., & Dulac, C. G. (2016) · BioEssays · doi:10.1002/bies.201600159 · Cited by 148
Self-citationLi, M., & Fleming, A. S. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00135-9 · Cited by 142
Numan, M., Numan, M. J., & English, J. B. (1993) · Hormones and Behavior · doi:10.1006/hbeh.1993.1005 · Cited by 136
Hansen, S. (1994) · Physiology & Behavior · doi:10.1016/0031-9384(94)90034-5 · Cited by 132
Qualls‐Creekmore, E., Yu, S., Francois, M., Hoang, J. G., Huesing, C., Bruce‐Keller, A. J., Burk, D. H., Berthoud, H., Morrison, C. D., & Münzberg, H. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0155-17.2017 · Cited by 125
The effects of paraventricular hypothalamic lesions on maternal behavior in rats
Numan, M., & Corodimas, K. P. (1985) · Physiology & Behavior · doi:10.1016/0031-9384(85)90318-x · Cited by 119
Bridges, Mann, M. D., & Coppeta (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00322.x · Cited by 100
Sukikara, M. H., Ortiz, S. R. M., Baldo, M. V. C., Felício, L. F., & Canteras, N. S. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.01.048 · Cited by 89
Seip, K. M., & Morrell, J. I. (2009) · Behavioral Neuroscience · doi:10.1037/a0017666 · Cited by 67
D'Anna‐Hernandez, K., & Gammie, S. C. (2009) · Behavioral Neuroscience · doi:10.1037/a0014987 · Cited by 64
Weible, A. P., Schwarcz, L., Wickersham, I. R., DeBlander, L., Wu, H., Callaway, E. M., Seung, H. S., & Kentros, C. G. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2442-10.2010 · Cited by 64
Molecular and neural control of sexually dimorphic social behaviors
Yang, T., & Shah, N. M. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.04.015 · Cited by 62
Becoming a mother — circuit plasticity underlying maternal behavior
Elyada, Y. M., & Mizrahi, A. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2015.06.007 · Cited by 56
Preoptic area and substantia nigra interact in the control of maternal behavior in the rat.
Numan, M., & Nagle, D. S. (1983) · Behavioral Neuroscience · doi:10.1037//0735-7044.97.1.120 · Cited by 55
GABAA receptor signaling in the lateral septum regulates maternal aggression in mice.
Lee, G., & Gammie, S. C. (2009) · Behavioral Neuroscience · doi:10.1037/a0017535 · Cited by 53
Kudo, Y., Akita, K., Nakamura, T., Ogura, A., Makino, T., Tamagawa, A., OZAKI, K., & Miyakawa, A. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90451-7 · Cited by 39
Lee, G., & Gammie, S. C. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.05.001 · Cited by 29
Research works printed but not linked: 1
- Numan, M. & Insel, T. R. The Neurobiology of Parental Behavior (Springer, New York, 2011).
Cited by
Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region
Moffitt, J. R., Bambah-Mukku, D., Eichhorn, S. W., Vaughn, E., Shekhar, K., Perez, J. D., Rubinstein, N. D., Hao, J., Regev, A., Dulac, C., et al. (2018) · Science · doi:10.1126/science.aau5324 · Cited by 1,365
Self-citationNeuromodulation by the immune system: a focus on cytokines
Salvador, A. F., de Lima, K. A., & Kipnis, J. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00508-z · Cited by 389
Architectures of neuronal circuits
Luo, L. (2021) · Science · doi:10.1126/science.abg7285 · Cited by 390
Self-citationMultimodal analysis of cell types in a hypothalamic node controlling social behavior
Kim, D.-W., Yao, Z., Graybuck, L. T., Kim, T. K., Nguyen, T. N., Smith, K. A., Fong, O., Yi, L., Koulena, N., Pierson, N., et al. (2019) · Cell · doi:10.1016/j.cell.2019.09.020 · Cited by 259
Estimation of Current and Future Physiological States in Insular Cortex
Livneh, Y., Sugden, A. U., Madara, J. C., Essner, R. A., Flores, V. I., Sugden, L. A., Resch, J. M., Lowell, B. B., & Andermann, M. L. (2020) · Neuron · doi:10.1016/j.neuron.2019.12.027 · Cited by 209
Metadata
- Authors
- Kohl, J., Babayan, B. M., Rubinstein, N. D., Autry, A. E., Marin-Rodriguez, B., Kapoor, V., Miyamishi, K., Zweifel, L. S., Luo, L., Uchida, N., & Dulac, C.
- Venue
- Nature
- Published
- 2018-04
- Volume
- 556
- Issue
- 7701
- Pages
- 326-331
- ISSN
- 0028-0836
- 1476-4687
- PMC
- PMC5908752
- Cited by
- 444
- References
- 62
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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