The genetic basis of parental care evolution in monogamous mice
Open accessAbstract
Parental care is essential for the survival of mammals, yet the mechanisms underlying its evolution remain largely unknown. Here we show that two sister species of mice, Peromyscus polionotus and Peromyscus maniculatus, have large and heritable differences in parental behaviour. Using quantitative genetics, we identify 12 genomic regions that affect parental care, 8 of which have sex-specific effects, suggesting that parental care can evolve independently in males and females. Furthermore, some regions affect parental care broadly, whereas others affect specific behaviours, such as nest building. Of the genes linked to differences in nest-building behaviour, vasopressin is differentially expressed in the hypothalamus of the two species, with increased levels associated with less nest building. Using pharmacology in Peromyscus and chemogenetics in Mus, we show that vasopressin inhibits nest building but not other parental behaviours. Together, our results indicate that variation in an ancient neuropeptide contributes to interspecific differences in parental care.
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Chemogenetic inhibition of paraventricular vasopressin cell activity increases nest building in male mice (while excitation decreases nest building in females), without altering other aspects of parental behavior.
“Recent work has demonstrated that chemogenetic inhibition of PVN AVP cell activity increases nest building in male mice (while excitation decreases nest building in females), without altering other aspects of parental behavior (133).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [133]
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Self-citation
- Authors
- Bendesky, A., Kwon, Y.-M., Lassance, J.-M., Lewarch, C. L., Yao, S., Peterson, B. K., He, M. X., Dulac, C., & Hoekstra, H. E.
- Affiliations
- Howard Hughes Medical Institute (US)
- Harvard University (US)
- Corresponding author
- Hoekstra, Hopi E.
- ORCID
- Venue
- Nature
- Published
- 2017-04
- Volume
- 544
- Issue
- 7651
- Pages
- 434-439
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC5600873
- OpenAlex
- W2605705881
- Cited by
- 268
- References
- 63
- Citations by year
- 2026: 15 · 2025: 33 · 2024: 27 · 2023: 21 · 2022: 33 · 2021: 35 · 2020: 25 · 2019: 25 · 2018: 36 · 2017: 18
- FWCI
- 40.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- Open Repository and Bibliography (University of Liège) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (5t32gm007598-41)
- National Institute of General Medical Sciences (T32GM008313, T32-GM007598)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K99HD084732, R01HD082131, R00HD084732)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Evolutionary Psychology and Human Behavior
- Keywords
- parental care, Peromyscus polionotus, deer mouse, nest building, vasopressin, hypothalamus, quantitative genetics, sex-specific genetic effects, neuropeptide signaling, evolution of social behavior, chemogenetics
- MeSH terms
- Animals, Biological Evolution, Female, Hybridization, Genetic, Hypothalamus, Male, Maternal Behavior, Nesting Behavior, Pair Bond, Paternal Behavior, Peromyscus, Sex Characteristics, Species Specificity, Vasopressins, Genome, Genomics, Quantitative Trait Loci, Mice
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