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A stromal cell population that inhibits adipogenesis in mammalian fat depots
Open accessAbstract
Adipocyte development and differentiation have an important role in the aetiology of obesity and its co-morbidities 1,2 . Although multiple studies have investigated the adipogenic stem and precursor cells that give rise to mature adipocytes 3-14 , our understanding of their in vivo origin and properties is incomplete 2,15,16 . This is partially due to the highly heterogeneous and unstructured nature of adipose tissue depots 17 , which has proven difficult to molecularly dissect using classical approaches such as fluorescence-activated cell sorting and Cre-lox lines based on candidate marker genes 16,18 . Here, using the resolving power of single-cell transcriptomics 19 in a mouse model, we reveal distinct subpopulations of adipose stem and precursor cells in the stromal vascular fraction of subcutaneous adipose tissue. We identify one of these subpopulations as CD142 + adipogenesis-regulatory cells, which can suppress adipocyte formation in vivo and in vitro in a paracrine manner. We show that adipogenesis-regulatory cells are refractory to adipogenesis and that they are functionally conserved in humans. Our findings point to a potentially critical role for adipogenesis-regulatory cells in modulating adipose tissue plasticity, which is linked to metabolic control, differential insulin sensitivity and type 2 diabetes.
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“scRNA-seq has been used to characterize the dynamics of cell populations underlying adipose tissue remodeling, with a focus on the cell types within stromal vascular fractions, particularly preadipocytes (Schwalie et al., 2018; Burl et al., 2018; Hepler et al., 2018; Merrick et al., 2019).”
From Robust single-nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity (2025) · cites this paper as Schwalie et al., 2018
In the citing paper
“APC3 was identified as ‘adipose regulatory cells’, expressing F3 (encoding CD142) and showed strong expression of secretory signaling proteins (Figure 3A, Figure 3—figure supplement 1C), supporting its paracrine regulatory role (Schwalie et al., 2018).”
From Robust single-nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity (2025) · cites this paper as Schwalie et al., 2018
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STAR: ultrafast universal RNA-seq aligner
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Items 201–300 of 400
Ni, G., Liu, X., Li, H., Fogarty, C. E., Chen, S., Zhang, P., Liu, Y., Wu, X., Wei, M. Q., Chen, G., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.754770 · Cited by 17
“Fibroblast (cluster 6; Nusap1, Top2a, Pclaf and Mki67) (28), adipogenic stem and precursor cells (ASPCs) (cluster 11; Col11a1, Plpp3, Col6a1 and Gas1) (23, 29), basal cells (cluster 12; Ccnb2, Cdkn3, Hmmr and Birc5) (30) and osteoclast (Cluster 17; Oscar, Ctsk and Mmp9) (31) were detected as possible contaminants (als…”
BackgroundDevelopmental and functional heterogeneity of thermogenic adipose tissue
Ruan, H. (2020) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjaa029 · Cited by 16
Dai, S., Zhao, P., Li, W., Peng, L., Jiang, E., Du, Y., Zhang, W., Dai, X., Yang, L., Li, Z., et al. (2025) · Molecular Biology and Evolution · doi:10.1093/molbev/msaf205 · Cited by 17
“Previous studies have also shown that certain stromal cell populations can regulate adipogenesis (Schwalie et al. 2018), supporting the hypothesis that IGFBP7+ cells may act as regulatory cells.”
PPARγ-dependent remodeling of translational machinery in adipose progenitors is impaired in obesity
Siqueira, M. K. D., Li, G., Zhao, Y., Wang, S., Ahn, I. S., Tamboline, M., Hildreth, A. D., Larios, J., Schcolnik‐Cabrera, A., Nouhi, Z., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114945 · Cited by 22
“Our dataset was proven to be similar to previously characterized APCs in eWAT and iWAT 43,44 and single-nucleus RNA-seq from high-fat-fed mice.”
Uhrbom, M., Muhl, L., Genové, G., Liu, J., Palmgren, H., Alexandersson, I., Karlsson, F., Zhou, A., Lunnerdal, S., Gustafsson, S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51867-9 · Cited by 17
“Schwalie et al. 20 used a similar FACS-strategy to isolate ASC1b cells by dividing a Lin − /CD34 + /SCA1 + fraction into either CD142 positive (ASC1b) or negative (ASC2 and ASC1a) cells, but in contrast to Merrick et al, their ASC1b (a.k.a. adipogenesis regulatory cells (Aregs)) demonstrated an inhibitory activity on…”
InfluentialStrieder‐Barboza, C., Flesher, C. G., Geletka, L. M., DelProposto, J. B., Eichler, T. E., Akinleye, O., Ky, A., Ehlers, A. P., O’Rourke, R. W., & Lumeng, C. N.-K. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.29.496888 · Cited by 18
Nakayama, M., Okada, H., Seki, M., Suzuki, Y., Chung, U., Ohba, S., & Hojo, H. (2022) · Regenerative Therapy · doi:10.1016/j.reth.2022.05.001 · Cited by 15
Recent advances of single-cell RNA sequencing technology in mesenchymal stem cell research
Guan, Z., Xie, Z., Wang, P., Wu, Y., & Shen, H. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i6.438 · Cited by 15
Immune outposts in the adventitia: One foot in sea and one on shore
Cautivo, K. M., Steer, C. A., & Molofsky, A. B. (2020) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.03.005 · Cited by 18
“Il6, Tnfa, Col1a1, Col3a1), similar to previously defined vascular associated-SCs [17,19,36].”
BackgroundTyurin‐Kuzmin, P. A., Chechekhin, V. I., Ivanova, A. M., Dyikanov, D. T., Sysoeva, V., Kalinina, N., & Va, T. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123712 · Cited by 15
“Recently, a single-cell transcriptomic approach has revealed several subpopulations within primary adMSCs of adipose tissue [12].”
BackgroundmicroRNA-449a reduces growth hormone-stimulated senescent cell burden through PI3K-mTOR signaling
Noureddine, S. A., Nie, J., Schneider, A., Menon, V., Fliesen, Z., Dhahbi, J. M., Victoria, B., Oyer, J. L., Robles-Carrillo, L. D., Nunes, A. D. D. C., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2213207120 · Cited by 17
“FAP3 closely resembled ICAM1+ clusters (25), adipose stem cell 1 (ASC1) clusters (26), adipocyte progenitor and committed preadipocyte clusters (18), and P2 progenitor clusters (27).”
AFF4 regulates cellular adipogenic differentiation via targeting autophagy
Chen, Y.-Q., Li, Q.-W., Liu, Y.-T., Chen, X., Jiang, S., Lin, W.-M., Zhang, Y.-N., Liu, R., Shao, B., Chen, C., et al. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010425 · Cited by 14
The composition, function, and regulation of adipose stem and progenitor cells
Liao, X., Zhou, H., & Deng, T. (2022) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2022.02.014 · Cited by 14
Neuroimmune regulation of white adipose tissues
Qian, X., Meng, X., Zhang, S., & Zeng, W. (2021) · FEBS Journal · doi:10.1111/febs.16213 · Cited by 17
Single‐cell RNA sequencing of preadipocytes reveals the cell fate heterogeneity induced by melatonin
Li, Z., Zheng, M., Mo, J., Li, K., Yang, X. X., Guo, L., Zhang, X., Abdalla, B. A., & Nie, Q. (2021) · Journal of Pineal Research · doi:10.1111/jpi.12725 · Cited by 18
Identification and characterization of adipose surface epitopes
Onogi, Y., Khalil, A., & Ussar, S. (2020) · Biochemical Journal · doi:10.1042/bcj20190462 · Cited by 16
Hatzmann, F. M., Großmann, S., Waldegger, P., Wiegers, G. J., Mandl, M., Rauchenwald, T., Pierer, G., & Zwerschke, W. (2022) · Adipocyte · doi:10.1080/21623945.2022.2129060 · Cited by 16
“This ASC population accounts for approximately 50% of all SVF cells and contains the major ASC fraction; however, it still consists of heterogeneous cell types, most likely including specific ASC types, progenitor cells and regulatory stromal cells [12,31].”
Backgroundde Biagi, C. A. O., Cury, S. S., Alves, C. P., Rabhi, N., Silva, W. A., Farmer, S. R., Carvalho, R. F., & Júnior, M. L. B. (2021) · Cells · doi:10.3390/cells10113073 · Cited by 25
“Most WAT scRNA-Seq studies to date derive the transcriptomes of the cell types within SVF without providing critical information about the status of the adipocytes in animal models (Burl et al., 2018; Cho et al., 2019; Gu et al., 2019; Henriques et al., 2020; Hepler et al., 2018; Jaitin et al., 2019; Merrick et al., 2…”
BackgroundBone marrow fat: friend or foe in people with diabetes mellitus?
Santopaolo, M., Gu, Y., Spinetti, G., & Madeddu, P. R. (2020) · Clinical Science · doi:10.1042/cs20200220 · Cited by 16
“level (18, 19) Recently, Schwalie and colleagues have performed single-cell RNA sequencing to determine the diversity of gene expression in each cell.(20) Using bioinformatic approaches, they identified two major adipocyte populations associated with stemness or the early steps of adipocyte formation.”
BackgroundApplications of single cell RNA sequencing to research of stem cells
Zhang, X., & Liu, L. (2019) · World Journal of Stem Cells · doi:10.4252/wjsc.v11.i10.722 · Cited by 19
Ejaz, A., Hatzmann, F. M., Hammerle, S., Ritthammer, H., Mattesich, M., Zwierzina, M., Waldegger, P., & Zwerschke, W. (2019) · Adipocyte · doi:10.1080/21623945.2019.1608751 · Cited by 13
“Moreover, a recent study detected specialized regulatory stromal cells in the niche that influence adipogenesis [30].”
BackgroundA unique spontaneously immortalised cell line from pig with enhanced adipogenic capacity
Thrower, T., Riley, S. E., Lee, S., Esteves, C., & Donadeu, F. X. (2025) · npj Science of Food · doi:10.1038/s41538-025-00413-y · Cited by 12
“2D), whereas others such as GATA3 and, particularly, MEOX2 , two transcriptional inhibitors of adipogenesis 24 – 26 , were markedly down-regulated, again keeping with FaTTy ’ s sustained adipogenic capacity in culture.”
Dissecting human adipose tissue heterogeneity using single‐cell omics technologies
Rocco, G. D., Trivisonno, A., Trivisonno, G., & Toietta, G. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03931-w · Cited by 14
“Image available at the following URL: v23.proteinatlas.org/humancell [76, 137] population in humans [84]; the dipeptidyl peptidase-4 expressing (DPP4 + ) mesenchymal cell population, which in virtue of its highly proliferative potential may be used for regenerative medicine applications, was…”
BackgroundAnti-DKK1 Enhances the Early Osteogenic Differentiation of Human Adipose-Derived Stem/Stromal Cells
Wang, Y.-Y., Negri, S., Li, Z., Xu, J.-J., Hsu, C.-Y., Péault, B., Broderick, K. P., & James, A. (2020) · Stem Cells and Development · doi:10.1089/scd.2020.0070 · Cited by 12
Liu, W., Saelens, W., Rainer, P. Y., Biočanin, M., Gardeux, V., Gralak, A. J., van Mierlo, G., Gebhart, A., Russeil, J., Liu, T., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02343-7 · Cited by 26
“A customized gene set containing more mature adipocyte markers 92 (Supplementary Note 13) was used to compute the adipocyte module score (referred to as the adiposcore) by using the AddModuleScore function from Seurat.”
Self-citationNew concepts in the roles of AMPK in adipocyte stem cell biology
Pollard, A. E. (2024) · Essays in Biochemistry · doi:10.1042/ebc20240008 · Cited by 11
Tissue fibrosis associated depletion of lipid‐filled cells
Jussila, A. R., Zhang, B., Kirti, S., & Atit, R. P. (2024) · Experimental Dermatology · doi:10.1111/exd.15054 · Cited by 10
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The multifaceted progenitor fates in healthy or unhealthy adipose tissue during obesity
Marcelin, G., & Clément, K. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09662-0 · Cited by 14
Khalyfa, A., Warren, W. C., Andrade, J., Bottoms, C. A., Rice, E. S., Cortese, R., Gozal, D., & Gozal, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010261 · Cited by 15
“scRNA-seq was also used in the study of mouse adipose tissue progenitor cells [50,84], and subcutaneous adipose tissues [45].”
MethodSingle-nucleus RNA-Seq reveals a new type of brown adipocyte regulating thermogenesisPreprint
Sun, W., Dong, H., Baláž, M., Slyper, M., Drokhlyansky, E., Colleluori, G., Giordano, A., Kovaničová, Z., Stefanicka, P., Ding, L., et al. (2020) · bioRxiv · doi:10.1101/2020.01.20.890327 · Cited by 11
Self-citationExpansion and inflammation of white adipose tissue - focusing on adipocyte progenitors
Liu, W., Li, D., Cao, H., Li, H., & Wang, Y. (2020) · Biological Chemistry · doi:10.1515/hsz-2019-0451 · Cited by 12
Sysoeva, V., Semina, E. V., Сергеевна, К. П., Kulebyakin, K. Y., Dzreyan, V., Sotskaya, E., Shchipova, A., Popov, V. S., Shilova, A., Brodsky, I. B., et al. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1446363 · Cited by 10
Jiang, W., Sun, W., Peng, Y., Xu, H., Fan, H., Jin, X., Xiao, Y., Wang, Y., Yang, P., Shu, W., et al. (2024) · Life Medicine · doi:10.1093/lifemedi/lnae041 · Cited by 10
“2A, 2B, S2A and S2B; Table S3), including myogenic cells (MGCs, Mylpf ) [29], myofibroblasts (MFCs, Acta2 , Myh11 , and Tagln ) [30], smooth muscle cells (SMCs, Pdgfrb , Rgs5 , and Notch3 ) [31], and three stromal cell subpopulations according to their co-expressions of Tcf21 , Col5a2 , Lum , and…”
Self-citationLiu, Y., Yin, M., Mao, X., Wu, S., Wei, S., Heng, S., Yang, Y., Huang, J., Guo, Z., Li, C., et al. (2024) · eLife · doi:10.7554/elife.94698 · Cited by 13
“Basophils and mast cells have similar functions and developmental processes, and both cell types express the high-affinity Fc receptor for IgE (FceR1a), the activation of which triggers degranulation and release of proteases, histamine, and a panel of proinflammatory cytokines (Hamey et al., 2021).”
BackgroundRegulation of adipogenesis by histone methyltransferases
Zhao, Y., Skovgaard, Z., & Wang, Q. (2024) · Differentiation · doi:10.1016/j.diff.2024.100746 · Cited by 12
Li, C.-W., Young, T.-H., Wang, M.-H., Pei, M., Hsieh, T.-Y., Hsu, C.-L., & Cheng, N.-C. (2023) · Stem cell research & therapeutics · doi:10.1186/s13287-023-03478-2 · Cited by 10
“ASCs [47, 48] or SVF [49, 50] derived from adipose tissue of diabetic or non-diabetic individuals have been found to exhibit a distinct pattern of cell subpopulation distribution on the t-SNE 2D cell map.”
BackgroundMaster of disguise: deconvoluting adipose tissue heterogeneity and its impact on metabolic health
Dewal, R. S., & Wolfrum, C. (2023) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2023.102085 · Cited by 14
Self-citationEnglish, J., Orofino, J., Cederquist, C., Paul, I., Li, H., Auwerx, J. H., Emili, A., Belkina, A. C., Cardamone, M. D., & Perissi, V. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101682 · Cited by 11
Zhao, H., Wu, M., Tang, X., Li, Q., Yi, X., Zhao, W., & Sun, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.889439 · Cited by 9
CHRNA2: a new paradigm in beige thermoregulation and metabolism
Ma, Y., Liu, S., Jun, H., & Wu, J. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.11.009 · Cited by 15
Beltrà, M., Pin, F., Costamagna, D., Duelen, R., Renzini, A., Ballarò, R., Garcia‐Castillo, L., Iannuzzi, A., Moresi, V., Coletti, D., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105480 · Cited by 12
“Recently, subpopulations of adipogenic regulators with the capacity of modulating adipogenesis have been identified in mammalian fat depots.(40,41) Moreover, cell populations with similar regulatory capabilities are found in the skeletal muscle as part of specific ISC subtypes.”
BackgroundResultA new perspective on mesenchymal–immune interactions in adipose tissue
Jimenez, M. T., Michieletto, M. F., & Henao‐Mejia, J. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.03.001 · Cited by 9
Aging-associated alterations in the mammary gland revealed by single-cell RNA sequencing
Li, C. M. C., Shapiro, H., Tsiobikas, C., Selfors, L., Chen, H., Gray, G. K., Oren, Y., Pinello, L., Regev, A., & Brugge, J. (2019) · bioRxiv · doi:10.1101/773408 · Cited by 10
snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis
Sun, W., Dong, H., Baláž, M., Slyper, M., Drokhlyansky, E., Colleluori, G., Giordano, A., Kovaničová, Z., Štefanička, P., Balážová, L., et al. (2020) · Nature · doi:10.1038/s41586-020-2856-x · Cited by 363
Self-citationRivera-Gonzalez, G. C., Butka, E. G., Gonzalez, C. E., Mintz, R. L., Kleb, S. S., Josephson, V., Kong, W., Jindal, K., Kamimoto, K., Shook, B. A., et al. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.07.004 · Cited by 9
Fibroblast hierarchy dynamics during mammary gland morphogenesis and tumorigenesis
Pascual, R., Cheng, J., Smet, A. H. D., Capaldo, B. D., Tsai, M., Kordafshari, S., Vaillant, F., Song, X., Giner, G., Milevskiy, M. J. G., et al. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00422-3 · Cited by 8
“…in the C1 subclusters (C0 C1 – C4 C1 ). adipogenesis-regulatory cells on the basis of expression of Clec11a , Gdf10 , and Fmo2 , amongst other genes (Schwalie et al, 2018; Yoshitake et al, 2022), and was enriched in puberty compared to the other stages, suggesting that adipogenesis and ductal…”
Dowker-Key, P. D., Kumar, J. P., Gill, N. B., Hubbard, K. N., Elshaarrawi, A., Alfatlawy, N. D., & Bettaieb, A. (2024) · Genes · doi:10.3390/genes15081017 · Cited by 13
“Additionally, another subpopulation of stromal cells, referred to as adipogenesis-regulatory (Areg) cells, have been shown to suppress adipocyte formation via paracrine crosstalk both in vitro and in vivo [171].”
BackgroundAdipocyte Microenvironment: Everybody in the Neighborhood Talks about the Temperature
Shamsi, F., Tseng, Y., & Kahn, C. R. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.012 · Cited by 9
“Indeed, data suggest that there is even a population of cells in adipose tissue that exerts an anti-adipogenic effect on other cells in the same depot, although the exact mediator remains unknown (Lee et al., 2019; Schwalie et al., 2018).”
BackgroundLin, C., Wan, Y., Xu, Y., Zou, Q., & Li, X. (2025) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-025-05793-1 · Cited by 8
“Additionally, single-cell RNA sequencing (scRNA-seq) has greatly expanded our knowledge of macrophage heterogeneity in various pathological contexts, identifying new cell clusters that were previously indistinguishable and uncovering new biological functions [13, 14].”
Oat beta-glucan inhibited obesity in mice though stem cell remodeling
Ji, T., Fang, B., Zhang, M., Cheng, L., Yuan, X., Jin, Y., Wu, F., Zheng, C., & Ma, Y. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.143747 · Cited by 7
Fu, Q.-L., Luo, Y.-D., Li, J.-J., Li, H., Liu, X.-S., Chen, Z., Ni, G.-Y., & Wang, T.-F. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05763-x · Cited by 8
“…Esco2 , H3c4 , Tk1 , and Asf1b ), adipogenic stem and precursor cells (ASPCs) (cluster 15; marker genes: Col6a2 , Col3a1 , Dpt , and Col1a1 ) [36], neuronal cells (cluster 17; marker genes: Prickle2 , Grik2 , and Npas3 ) [37–39], melanocyte ( Mlana , Pmel , and Tyrp1 ) [40–42], and…”
Mitochondrial Function and Dysfunction in White Adipocytes and Therapeutic Implications
Wang, F., Huynh, P. M., & An, Y. (2024) · Comprehensive physiology · doi:10.1002/cphy.c230009 · Cited by 10
Mechanisms and metabolic consequences of adipocyte progenitor replicative senescence
Lin, T., Mohammad, A., Kolonin, M. G., & Eckel‐Mahan, K. L. (2024) · Immunometabolism · doi:10.1097/in9.0000000000000046 · Cited by 8
“This CD142 + subpopulation, termed Aregs, lacks inherent adipogenic capacity and can exert an anti-adipogenic effect on ASCs in vitro and upon transplantation in vivo [9] .”
BackgroundHu, Z., Li, D., Wu, S., Pei, K., Fu, Z., Yang, Y., Huang, Y., Yang, J., Liu, C., Hu, J., et al. (2024) · Cell & Bioscience · doi:10.1186/s13578-024-01219-3 · Cited by 11
Bailin, S. S., Kropski, J. A., Gangula, R., Hannah, L., Simmons, J. D., Mashayekhi, M., Ye, F., Fan, R., Mallal, S. A., Warren, C. M., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1152003 · Cited by 13
“A second fibroblast population has high expression of MYOC and IGFBP7, which is consistent with antiadipogenic CD142 cells that have been previously described (77).”
ResultIshida, Y., Mabuchi, Y., Naraoka, Y., Hisamatsu, D., & Akazawa, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241511908 · Cited by 8
Single-cell transcriptome dataset of human and mouse in vitro adipogenesis models
Li, J.-H., Jin, C. A., Gustafsson, S., Rao, A. S., Wabitsch, M., Park, C. Y., Quertermous, T., Knowles, J., & Bielczyk-Maczynska, E. (2023) · Scientific Data · doi:10.1038/s41597-023-02293-x · Cited by 8
FK506 binding protein 51: Its role in the adipose organ and beyond
Galigniana, N. M., Ruiz, M. C., & Piwien‐Pilipuk, G. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30351 · Cited by 11
“151 Additional cell populations identified to date in the SVF correspond to fibroinflammatory progenitors (FIP) with capacity to restrain differentiation of APCs in visceral WAT, 152 adipogenic ‐ regulatory cells (AREG), 153 and aging ‐ dependent regulatory cells (ARC) in subcutaneous fat depots.”
Liu, Q., Song, Y., Cui, Y., Hu, C., Luo, Y., Hu, D., Wang, H., Li, K., Chen, J., & Xiao, H. (2021) · SSRN Electronic Journal · doi:10.1016/j.biocel.2022.106343 · Cited by 11
Zhi, L., Tian, C., Zhang, S., Yang, T., Gong, Y., Deng, H., Bai, D., Tian, W., & Chen, Y. (2022) · eLife · doi:10.7554/elife.77740 · Cited by 13
“of heterogeneous preadipocytes/adipocytes have been identified, the classification of each subset replies mainly on the expression of specific genes such as cell surface markers (Hepler et al., 2018; Oguri et al., 2020; Schwalie et al., 2018; Wu et al., 2012).”
BackgroundKuwano, T., Izumi, H., Aslam, M. R., Igarashi, Y., Bilal, M., Nishimura, A., Watanabe, Y., Nawaz, A., Kado, T., Ikuta, K., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0248267 · Cited by 7
Loft, A., Rydbirk, R., Gammelmark, E., Hauwaert, E. L. V., Wernberg, C. W., Møller, A. F., Dam, T. V., Hassan, M. N., Maniyadath, B., Nielsen, R., et al. (2026) · Nature Metabolism · doi:10.1038/s42255-025-01433-4 · Cited by 17
“6a), thereby supporting the notion that these ASPCs may have an alternative, regulatory role in the tissue, as previously suggested in mice 42,46 .”
Spatial Transcriptomics of Adipose Tissue: Technologies, Applications, and Challenges
Keesling, A. R., Rondini, E., & Granneman, J. G. (2025) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes25078 · Cited by 7
BBS8-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue
Sieckmann, K., Winnerling, N., Ribeiro, D. J. S., Yüksel, S., Kardinal, R., Steinheuer, L. M., Frechen, F., Corrêa, L. H., Schermann, G., Klausen, C., et al. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00524-y · Cited by 9
“Pseudo-temporal analysis predicted, in line with previous data (Merrick et al, 2019; Schwalie et al, 2018), that P1 progenitor cells develop into P2 or P3 (Fig.”
InfluentialKeidai, Y., Fujikura, J., & Yabe, D. (2025) · Cell Transplantation · doi:10.1177/09636897251346599 · Cited by 9
Yesian, A. R., Chalom, M. M., Knudsen, N. H., Hyde, A. L., Personnaz, J., Cho, H., Liou, Y.-H., Starost, K. A., Lee, C., Tsai, D.-Y., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci169152 · Cited by 10
“Although single-cell RNA-Seq studies have identified potential beige precursor populations (14–17), the delineation of factors that determine white versus beige adipocyte fate is ongoing.”
Adipose Tissue Stromal Cells: Rheostats for Adipose Tissue Function and Metabolic Disease Risk
Scheidl, T. B., Wager, J. L., & Thompson, J. A. (2025) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2025.02.025 · Cited by 8
Tong, X., Zhu, Q., Duo, T., Liang, Z., Zhang, C., Cai, S., Wang, X., Liu, Y., Li, Y., Liu, X., et al. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c00059 · Cited by 2
Molecular and Cellular Mechanisms Governing Adipogenic Differentiation
Sysoeva, V., Lazarev, M. A., Kulebyakin, K. Y., Semina, E. V., & Rubina, K. A. (2023) · Russian Journal of Developmental Biology · doi:10.1134/s1062360423070068 · Cited by 7
“…of single cells of adipose tissue reported the presence of mRNA T-cadherin in MSCs clustered with cells expressing PDGFR α (Pdgfr α ) and Meflin (Islr) markers (Nakamura et al., 2020; Nguyen, 2020; Ramirez et al., 2020), which are indicative of MSCs (Schwalie et al., 2018; Merrick et al., 2019).”
Convergent alteration of the mesenchymal stem cell heterogeneity in adipose tissue during aging
Liu, Q.-W., Zhao, Y., Wang, Q., Yan, L., Fu, X., & Xiao, R. (2023) · The FASEB Journal · doi:10.1096/fj.202300807r · Cited by 7
Ferrero, R., Rainer, P., Russeil, J., Zachara, M., Pezoldt, J., van Mierlo, G., Gardeux, V., Saelens, W., Alpern, D., Favre, L., et al. (2023) · bioRxiv · doi:10.1101/2023.05.01.538871 · Cited by 7
“Murine data integration 937 The integration of five datasets of adult mouse SC and OM ATs provided by Schwalie et 938 al.(12), Burl et al.”
MethodSelf-citationCharacterization of adipose depot-specific stromal cell populations by single-cell mass cytometry
Lee, J. H., Ealey, K. N., Patel, Y., Verma, N., Thakkar, N., Park, S., Kim, J., & Sung, H. (2022) · iScience · doi:10.1016/j.isci.2022.104166 · Cited by 10
“Taken as a whole, we have shown distinct clustering of APCs in IWAT and PWAT using CyTOF, and our data largely corroborate previous sc-RNAseq data from murine studies (Merrick et al., 2019; Schwalie et al., 2018) and bulk tissue RNA-sequencing data from human samples (Consortium, 2020).”
BackgroundResultZhang, X., Cheng, B., Jiang, H., Liu, C., Cao, Z., Luan, P., Wang, N., & Li, H. (2021) · Genes · doi:10.3390/genes12121971 · Cited by 8
“Obesity onset is closely linked with the differentiation of adipocytes [10,11].”
BackgroundCrohn’s Disease Increases the Mesothelial Properties of Adipocyte Progenitors in the Creeping Fat
Madeira, A., Serena, C., Ejarque, M., Maymó-Masip, E., Millan, M., Navarro-Ruiz, M. C., Guzmán-Ruiz, R., Malagón, M., Espín, E., Martí, M., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084292 · Cited by 7
Insights into in vivo adipocyte differentiation through cell-specific labeling in zebrafish
Lepanto, P., Levin-Ferreyra, F., Koziol, U., Malacrida, L. S., & Badano, J. L. (2021) · Biology Open · doi:10.1242/bio.058734 · Cited by 11
Genome-wide molecular recording using Live-seqPreprint
Chen, W., Guillaume-Gentil, O. J., Dainese, R., Rainer, P. Y., Zachara, M., Gäbelein, C. G., Vorholt, J. A., & Deplancke, B. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.24.436752 · Cited by 13
Self-citationOliva‐Olivera, W., Castellano‐Castillo, D., von Meyenn, F., Cardona, F., Lönnberg, T., & Tinahones, F. J. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154466 · Cited by 7
Distinct precursor landscape of subcutaneous and visceral fat in development and aging
Lin, F., & Sul, H. S. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116706 · Cited by 7
Fang, B., Zheng, C., Ma, Y., Wu, F., Cheng, L., Li, Y., Wang, R., & Ren, F. (2024) · Food, Nutrition and Health. · doi:10.1007/s44403-024-00006-9 · Cited by 11
“At least three different types of ASCs were identified in sWAT, including adipogenesis regulatory cells highly expressing CD142 and ABCG1 [21]; ASCs expressing dipeptidyl peptidase 4 (DPP4 + ), which are highly proliferative but with limited differentiation ability; and ASCs expressing…”
Chen, H.-R., Sun, B., Chang, S.-J., Yu, Z., Qiu, Y.-J., Hua, C., & Lin, X.-X. (2024) · Stem cell research & therapeutics · doi:10.1186/s13287-024-03835-9 · Cited by 6
“Cluster 8 expressed high levels of FMO2 and F3 (CD142), which are characteristic markers of Aregs cells [18].”
BackgroundGlucagon-like peptide-1 analog liraglutide reduces fat deposition in chicken adipocytes
Zhang, J., Yang, G., Liu, J., Lin, Z., Zhang, J., Zhao, J. X., Sun, G., & Lin, H. (2024) · Poultry Science · doi:10.1016/j.psj.2024.103766 · Cited by 6
“Lipogenesis and obesity onset are closely linked with the proliferation and differentiation of adipocytes (Schwalie et al., 2018).”
BackgroundNOTCH1 as a Negative Regulator of Avian Adipocyte Differentiation: Implications for Fat Deposition
Wang, Z., Su, Y., Zhao, M., Ma, Z., Li, J., Hou, Z.-C., & Li, H. (2024) · Animals · doi:10.3390/ani14040585 · Cited by 6
“Excessive fat deposition is closely linked with adipocytes differentiation during animal growth [5].”
BackgroundFat grafts enriched with ex‐vivo expanded adipose stem cells improve hyperpigmentation of face
Bashir, A., Bashir, M., Afzaal, S., Ahmad, F. J., & Choudhery, M. S. (2023) · Cell Biology International · doi:10.1002/cbin.12005 · Cited by 6
“…applicability in a variety of conditions including COVID‐19‐induced pneumonia, improving hair growth, helps in longevity of fat, and improves texture of scars and pigmented skin (Butt et al., 2020; Choudhery & Harris, 2020; Gentile et al., 2019; M. M. Bashir et al., 2019; Schwalie et al., 2018).”
BackgroundMicroscopic image-based classification of adipocyte differentiation by machine learning
Noguchi, Y., Murakami, M., Murata, M., & Kano, F. (2022) · Histochemistry and Cell Biology · doi:10.1007/s00418-022-02168-z · Cited by 6
“…non-arbi-trary stage-setting methods such as clustering and trajectory analysis of large amounts of single-cell level transcriptome data, allows us to understand how heterogeneous cell populations change during adipocyte differentiation (Schwalie et al. 2018; Burl et al. 2018; Merrick et al. 2019).”
BackgroundQi, L., Wang, J., Chen, X., Ding, Y., Ling, B., Wang, W.-J., Xu, J., & Xue, Z. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e11148 · Cited by 6
“Lineage scores were calculated according to a published article [32] by calculating the sum of the logarithm of counts per million across selected genes (see as Supplemental Table 1).”
Miranda, C. S., Silva-Veiga, F. M., Santana-Oliveira, D. A., Fernandes‐da‐Silva, A., Brito, G. C., Martins, F. F., & Souza‐Mello, V. (2022) · Journal of the American Nutrition Association · doi:10.1080/07315724.2022.2062686 · Cited by 7
It Is Not Just Fat: Dissecting the Heterogeneity of Adipose Tissue Function
Efthymiou, V., & Patti, M. (2022) · Current Diabetes Reports · doi:10.1007/s11892-022-01455-2 · Cited by 10
Sun, D., Li, X., Yin, Z.-T., & Hou, Z.-C. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.767739 · Cited by 6
Functional diversity of human adipose tissue revealed by spatial mapping
Schéele, C., & Wolfrum, C. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00582-2 · Cited by 6
Self-citationMae, J., Nagaya, K., Okamatsu‐Ogura, Y., Tsubota, A., Matsuoka, S., Nio‐Kobayashi, J., & Kimura, K. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.698692 · Cited by 16
Zhao, L., Zhu, Q., Li, M., Yang, H., & Zhao, Y. (2025) · The Journal of Physiology · doi:10.1113/jp289263 · Cited by 6
“…are predominantly developed through the adipogenic differentiation of adipose progenitors and the browning of beige adipocytes, with high expression of genes such as fatty-acid binding protein 4 (FABP4), lipoprotein lipase (LPL), LEPTIN and transcription factor 21 (TCF21) (Schwalie et al., 2018).”
InfluentialAdipogenic characterization of immortalized CD55+ progenitor cells from human white adipose tissue
Couchet, M., Gao, H., Klingelhuber, F., Jalkanen, J., Barbosa, T. D. C., Omar-Hmeadi, M., Massier, L., Krahmer, N., Mejhert, N., & Rydén, M. (2023) · Adipocyte · doi:10.1080/21623945.2023.2283213 · Cited by 5
“While TNF-α did not increase glycerol release in WT-hAPCs, we observed a two-fold induction in TERT-hAPCs (Figure 3(c)), which is comparable to the effects observed in primary in vitro differentiated adipocytes [18].”
Adipose Tissue Plasticity in Aging
Wang, G., Song, A., Bae, M., & Wang, Q. A. (2022) · Comprehensive physiology · doi:10.1002/cphy.c220005 · Cited by 9
“Recent scRNA-seq analysis provides integrative details on the heterogeneity and hierarchical relationship of mouse and human APCs (Figure 2) (22, 71, 160, 167, 180).”
InfluentialWolmarans, E., Mellet, J., Durandt, C., Joubert, F., & Pepper, M. (2021) · Stem Cells International · doi:10.1155/2021/5595172 · Cited by 5
“Multiple human adipocyte subtypes and mechanisms of their development”Preprint
Min, S., Desai, A., Yang, Z., Sharma, A., Genga, R. M. J., Kucukural, A., Lifshitz, L. M., Maehr, R., Garber, M., & Corvera, S. (2019) · bioRxiv · doi:10.1101/537464 · Cited by 5
“Recent advances in the ability to study single-cell transcriptomes can be leveraged to better understand the cellular composition of adipose tissue [11-13].”
BackgroundContractile fibroblasts form a transient niche for the branching mammary epithelium
Sumbal, J., Journot, R. P., Attri, K., Danek, V., Merle, C., Faraldo, M. M., Koledova, Z. S., & Fré, S. (2025) · Nature Communications · doi:10.1038/s41467-025-63612-x · Cited by 5
“#3 were found lining blood vessels, as expected from studies in the male fat pad 38 , preadipocytesweredispersedbetweenadipocytesinthedistalfatpad, and interstitial progenitors were found in the fat pad septae and in the interstitial reticulum (Supplementary Fig.”
Omics characteristics and epigenetic modifications of adipose-derived stem cells
Feng, T., Rosen, C. J., & Li, Z. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110758 · Cited by 5
“Another fraction of adipose stem and precursor cells is characterized by high Cd142 and Abcg1 expression and negatively regulates the adipogenic capacity of other progenitor cells via paracrine mechanisms, including secretion of SPINK2, VIT and/or FGF12 (10).”
A key role of polyamine metabolism in adipose tissue homeostasis that regulates obesity
Mund, C., Sinha, A. N., Aderhold, A., Mateska, I., Hagag, E., Traikov, S., Gercken, B., Soto, A., Pollock, J., Arndt, L., et al. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156358 · Cited by 5
Metadata
- Authors
- Schwalie, P. C., Dong, H., Zachara, M., Russeil, J., Alpern, D., Akchiche, N., Caprara, C., Sun, W., Schlaudraff, K.-U., Soldati, G., Wolfrum, C., & Deplancke, B.
- Affiliations
- SIB Swiss Institute of Bioinformatics (CH)
- ETH Zurich (CH)
- Swiss Stem Cell Foundation (CH)
- Corresponding author
- Wolfrum, Christian
- Deplancke, Bart
- ORCID
- Venue
- Nature
- Published
- 2018-06-20
- Volume
- 559
- Issue
- 7712
- Pages
- 103-108
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2809355409
- Cited by
- 463
- References
- 49
- Citations by year
- 2026: 23 · 2025: 51 · 2024: 77 · 2023: 55 · 2022: 73 · 2021: 77 · 2020: 54 · 2019: 43 · 2018: 10
- FWCI
- 31.71
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Licence
- cc-by-nc-nd
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- Stiftelsen Kristian Gerhard Jebsen
- Public Health Agency of Canada
- École Polytechnique Fédérale de Lausanne
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- adipogenesis, adipose-derived stem cells, adipose precursor cells, stromal vascular fraction, paracrine signaling, adipose tissue plasticity, subcutaneous adipose tissue, obesity, type 2 diabetes, insulin sensitivity
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, Female, Humans, Insulin Resistance, Male, Stem Cells, Thromboplastin, Stromal Cells, Adipocytes, Paracrine Communication, Gene Expression Profiling, Subcutaneous Fat, Adipogenesis, Mice, Single-Cell Analysis
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