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A stromal cell population that inhibits adipogenesis in mammalian fat depots
Open accessAbstract
Adipocyte development and differentiation have an important role in the aetiology of obesity and its co-morbidities 1,2 . Although multiple studies have investigated the adipogenic stem and precursor cells that give rise to mature adipocytes 3-14 , our understanding of their in vivo origin and properties is incomplete 2,15,16 . This is partially due to the highly heterogeneous and unstructured nature of adipose tissue depots 17 , which has proven difficult to molecularly dissect using classical approaches such as fluorescence-activated cell sorting and Cre-lox lines based on candidate marker genes 16,18 . Here, using the resolving power of single-cell transcriptomics 19 in a mouse model, we reveal distinct subpopulations of adipose stem and precursor cells in the stromal vascular fraction of subcutaneous adipose tissue. We identify one of these subpopulations as CD142 + adipogenesis-regulatory cells, which can suppress adipocyte formation in vivo and in vitro in a paracrine manner. We show that adipogenesis-regulatory cells are refractory to adipogenesis and that they are functionally conserved in humans. Our findings point to a potentially critical role for adipogenesis-regulatory cells in modulating adipose tissue plasticity, which is linked to metabolic control, differential insulin sensitivity and type 2 diabetes.
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“scRNA-seq has been used to characterize the dynamics of cell populations underlying adipose tissue remodeling, with a focus on the cell types within stromal vascular fractions, particularly preadipocytes (Schwalie et al., 2018; Burl et al., 2018; Hepler et al., 2018; Merrick et al., 2019).”
From Robust single-nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity (2025) · cites this paper as Schwalie et al., 2018
In the citing paper
“APC3 was identified as ‘adipose regulatory cells’, expressing F3 (encoding CD142) and showed strong expression of secretory signaling proteins (Figure 3A, Figure 3—figure supplement 1C), supporting its paracrine regulatory role (Schwalie et al., 2018).”
From Robust single-nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity (2025) · cites this paper as Schwalie et al., 2018
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Items 301–400 of 400
Yang, Y., Zhang, G., Yi, T., Yang, S., Wu, S., Zhang, Y., Zhang, L., Li, X., Wu, X., Li, J., et al. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1578180 · Cited by 4
“Recent investigations have revealed the existence of at least three distinct ASPC subpopulations, each characterized by unique properties such as proliferative capacity and adipogenic potential (Schwalie et al., 2018; Merrick et al., 2019; Sarvari et al., 2021; Shao et al., 2021; Liu et al., 2023).”
Single-Cell Landscape and a Macrophage Subset Enhancing Brown Adipocyte Function in Diabetes
Gu, J.-F., Jin, J.-J., Ren, X.-Y., Zhang, X., Li, J., Wang, X.-W., Zhang, S.-C., Yin, X.-L., Zhang, Q.-Y., & Wang, Z. (2024) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2023.0278 · Cited by 4
“…to identify a new cell population in WAT SVF that inhibits white adipocyte differentiation, and the platelet derived growth factor receptor alpha ( PDGFRα )+stem cell antigen-1 ( Sca1 )+cluster of differentiation 81 ( CD81 )+adi pose stem/progenitor cells (ASPCs) with beige fat plasticity [13].”
Yousof, T., Mejía-Benítez, A., Morrison, K. M., & Austin, R. C. (2024) · Scientific Reports · doi:10.1038/s41598-024-51635-1 · Cited by 4
Frangi, G., Guicheteau, M., Jacquot, F., Pyka, G., Kerckhofs, G., Feyeux, M., Véziers, J., Guihard, P. J., Halgand, B., Sourice, S., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.921073 · Cited by 4
Single-cell dissection of obesity-exercise axis in adipose-muscle tissuesPreprint
Yang, J., Vamvini, M. T., Nigro, P., Ho, L., Galani, K., Alvarez, M., Tanigawa, Y., Laakso, M., Agudelo, L. Z., Pajukanta, P., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.22.469622 · Cited by 4
Ahmed, M., Lai, T. H., & Kim, D. R. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.753042 · Cited by 5
Whytock, K. L., Divoux, A., Gunsch, G., Nie, J., Kanshana, J. S., Basantani, M. K., Ross, Z., Pino, M. F., Glass, C. E., Musi, N., et al. (2026) · Obesity · doi:10.1002/oby.70135 · Cited by 2
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“Conventional markers described in a previous study were used to categorize each cell into a known biological cell type [20–22].”
Braud, L., Bernabe, M., Vernerey, J., Miranda, A. M. A., Dominguez, A., Churikov, D., Richaud, M., Jourquin, F., McAllan, L., Lachaud, C., et al. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102262 · Cited by 4
“S6C) [8,26,28 — 30].”
Han, J., Ma, S., Wei, Q., Zhao, Z., Zhao, Y., Pu, Y., Zhao, Q., He, X., Ma, Y., MacHugh, D. E., et al. (2025) · iScience · doi:10.1016/j.isci.2025.113496 · Cited by 3
“5,37 The PSC_C1, PSC_C4 and CTP_C2/C3 groups exhibited relatively high expression of DPP4 (Figure 3B).”
Regulating the cell differentiation trajectory of progenitor cells in adipose tissue fibrosis
Zhang, L., Cai, X., Wu, X.-J., Jing, Z., Zhao, Y., Yao, Y.-C., & Boström, K. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102231 · Cited by 3
“The ASC3 cluster is similar to the p2 cluster reported by Schwalie et al. [43], and the group 2 cells reported by Merrick et al. [12].”
Westcott, G. P., Emont, M., Gulko, A., Zhou, Z.-B., Kim, C., Varma, G., Tsai, L. L., O'Donnell, E. K., Loureiro, Z. Y., Liang, W., et al. (2025) · bioRxiv · doi:10.1101/2025.02.18.638907 · Cited by 3
“Quantification of paired biopsy sections demonstrated an increase in the number, average length, and total lymphatic length in lymphedema SAT ( Figure 7i ), consistent with our sequencing data as well as prior literature 37 .”
InfluentialYe, C., Wang, X., Lin, J., Wu, C., Gao, Y., Guo, C., Liao, Y., Rao, Z., Huang, S., Chen, W., et al. (2025) · Science China Life Sciences · doi:10.1007/s11427-024-2732-8 · Cited by 3
“The cluster with high expression of Fmo2 was annotated as “ Modulatory progenitor ” (Figure 1C and D), which has been reported to negatively regulate adipogenesis (Schwalie et al., 2018).”
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Depot‐specific differences and heterogeneity of adipose‐derived stem cells in diet‐induced obesity
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“For instance, Merrick et al. and Schwalie et al. identified 10 cell types and three cell populations, respectively, in mouse subcutaneous SVF [23, 24].”
Regional primary preadipocyte characteristics in humans with obesity and type 2 diabetes mellitus
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“It has been demonstrated that subpopulations of ASCs CD142 + have less capacity to differentiate into adipocytes in in vitro and in vivo experiments [35].”
Bo, S., Barker, C. S., Theraulaz, H., Zhang, X., Ping, Y., Gupta, R. K., Shao, M.-L., & Wu, Y. (2023) · STAR Protocols · doi:10.1016/j.xpro.2023.102676 · Cited by 3
Single-cell lineage tracing reveals hierarchy and mechanism of adipocyte precursor maturationPreprint
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Maintenance of adipose progenitors in adipogenesis
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“This cluster is negatively enriched for genes involved in adipogenesis and expresses high levels of VIT (encoding the ECM protein VITRIN), which has been shown to actively suppress adipogenesis [22].”
BackgroundDani, V., Bruni-Favier, S., Chignon‐Sicard, B., Loubat, A., Doglio, A., & Dani, C. (2022) · Cells · doi:10.3390/cells11182798 · Cited by 3
“The role of CD142 APCs in adipogenesis is more controversial because this subpopulation is described as fully adipogenic or as an inhibitor of adipogenic differentiation via paracrine effects [36].”
BackgroundGupta, A., Shamsi, F., Patti, M., Tseng, Y.-H., & Streets, A. M. (2022) · bioRxiv · doi:10.1101/2022.05.30.494007 · Cited by 3
“This included thermogenic regulatory TFs such as SREBF1, KLF15 (Yamamoto et al. 2010), and TWIST1 (P. Seale 2010), along with TFs FOXL1, ZNF117, IRX6, OSR1, and PRRX2, whose involvement in the context of thermogenic response has not been previously characterized.”
BackgroundDeutsch, A., Reddy, N. D., McLellan, B. N., & Shinoda, K. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.02.012 · Cited by 3
Telomerase Reverse Transcriptase Expression Marks a Population of Rare Adipose Tissue Stem Cells
Lynes, M. D., Carlone, D. L., Townsend, K. L., Breault, D. T., & Tseng, Y. (2022) · Stem Cells · doi:10.1093/stmcls/sxab005 · Cited by 5
Buechler, M., Pradhan, R., Calviello, A. K., Muller, S., Bourgon, R., & Turley, S. (2021) · bioRxiv · doi:10.1101/2021.01.15.426912 · Cited by 3
Fat cell progenitors get singled out
Chau, Y.-Y., & Cawthorn, W. (2019) · Science · doi:10.1126/science.aax2967 · Cited by 3
Sun, W., & Wolfrum, C. (2018) · Nature · doi:10.1038/d41586-018-07739-6 · Cited by 3
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“With the advancement of single-cell and single-nucleus RNA sequencing (RNA-seq) technologies, multiple novel cell populations with stem, adipogenic, or anti-adipogenic potential and other previously unknown functions have been revealed within both white and brown adipose tissue 14,15 .”
Long, Q.-F., Zhang, Z.-X., Lin, B., Yu, Z.-H., Xu, M., Zhao, S.-T., Li, J., Gu, P., Xie, M.-Y., Zhao, X.-M., et al. (2026) · Research · doi:10.34133/research.1360 · Cited by 2
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“Schwalie et al. 20 revealed different subsets of ADSCs in subcutaneous adipose tissue in mice and identi fi ed one of them as Cd142 + adipogenic regulatory cells (Aregs), which can inhibit adipocyte formation in a paracrine manner.”
Advances in the Role of Adipose Tissue in Promoting Injury Repair and Resist Infection
Duan, X., Li, R., Fu, L., Yang, J., & Zhan, Z. (2026) · Immunity Inflammation and Disease · doi:10.1002/iid3.70341 · Cited by 4
“…are intercalated between mature adipocytes and occupy a perivascular niche, DPP4+ progenitors are located within the reticular interstitium [65, 66], a recently recognized but still not well‐studied, fluid‐filled network of collagen and elastin fibers that surrounds many organs, including…”
The dorsal aortic compartment is a developmental source of brown adipose tissue in mice
Heider, S., Fischer, C., Secener, A. K., Vallecillo-García, P., Kotsaris, G., Meisen, Z. G., Pawolski, V., Giesecke‐Thiel, C., Conrad, T., Schulz, T. J., et al. (2026) · Nature Communications · doi:10.1038/s41467-025-68147-9 · Cited by 2
Han, S.-X., Zhang, Q., Lu, F., & Cai, J.-R. (2025) · Stem cell research & therapeutics · doi:10.1186/s13287-025-04732-5 · Cited by 2
“The tendency of Aregs to form adipocytes is signi�cantly decreased and can negatively regulate the adipogenic capacity of other ADSCs through paracrine signaling mechanisms, such as Rtp3, Spink2, Fgf12, and Vit [24, 25].”
Aregs-IGFBP3-mediated SMC-like cells apoptosis impairs beige adipocytes formation in aged mice
Wang, S., Cui, Y., Wang, L., Feng, C., Sun, Y., Huo, B., Jiang, H., Zhao, M., Tu, Y., Wang, Q., et al. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102125 · Cited by 2
“Regarding CD142 þ ASPCs, Holman et al. reported normal adipogenesis, while other studies [17,19,63,64], including ours, demonstrate that Aregs inhibit adipogenesis.”
InfluentialYuan, X., Li, W., Liu, Q., Ou, Y., Li, J., Yan, Q., & Zhang, P. (2024) · Cellular and molecular neurobiology · doi:10.1007/s10571-024-01524-y · Cited by 2
“Advances in sequencing technology, cell capture methods, and bioinformatics—particularly single-cell RNA sequencing (scRNA-seq)—now enable detailed investigations of cell heterogeneity and gene expression dynamics at the single-cell level (Olsen and Baryawno 2018; Schwalie et al. 2018).”
Tao, T., Xu, Y., Zhang, C., Zhang, X., Chen, J., & Liu, J. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2024.159585 · Cited by 2
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Points of Significance: Principal Component Analysis for Biocentric Data Visualization
Arbatsky, M., Tyurin-Kuzmin, P., Kulebyakin, K., Chechekhin, V., Kalinina, N., Sysoeva, V., Semina, E., & Rubina, K. (2022) · BioNanoScience · doi:10.1007/s12668-022-01021-w · Cited by 2
GPCRs in the regulation of the functional activity of multipotent mesenchymal stromal cells
Chechekhin, V. I., Kulebyakin, K. Y., Kokaev, R. I., & Tyurin‐Kuzmin, P. A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.953374 · Cited by 2
“As shown in recent years, the synchronization of functional responses of the adipose tissue is achieved through a number of mechanisms that regulate hormonal sensitivity on an intercellular level (Mendez-Ferrer et al., 2010; Schwalie et al., 2018; Ferrero et al., 2020).”
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“In this regard, cells expressing high levels of ALPL (MSCA1) constitute a highly adipogenic population, whereas cells with high levels of CD271 [11] or CD142 have little or no adipogenic potential [47].”
BackgroundTemporal trajectories of human brown and white adipocyte progenitors at single cell resolutionPreprint
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Self-citationSORLA is required for insulin-induced expansion of the adipocyte precursor pool in visceral fat
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“In detail, we purified the Sca1+ precursor cell population from SVF of the epWAT of juvenile mice and transplanted them into the scWAT pad of recipient animals using Matrigel plugs (Schwalie et al., 2018).”
MethodSelf-citationNarrating the story ARC of adipose tissue aging.
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“Profiling of the SVF cells from WAT depots at the single-cell level has revealed a developmental hierarchy of white adipocyte precursors (Burl et al., 2018; Hepler et al., 2018; Schwalie et al., 2018; Cho et al., 2019; Merrick et al., 2019; Rajbhandari et al., 2019).”
BackgroundThe Cre/Lox System to Assess the Development of the Mouse Brain.
Kratochwil, C., & Rijli, F. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9732-9_28 · Cited by 2
Unexpected cell population gives fat a brake
Guertin, D. (2018) · Nature · doi:10.1038/d41586-018-05120-1 · Cited by 2
Bailin, S. S., Kropski, J. A., Gangula, R., Hannah, L., Simmons, J. D., Mashayekhi, M., Ye, F., Fan, R., Chopra, A., Ram, R., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4097122 · Cited by 2
“Similarly, we observed that the adipogenic clusters described by Schwalie et al. (Figure S4E) and Sarvari et al. (Figure S4F) overlap with distinct 16 clusters in our dataset (Sarvari et al., 2021; Schwalie et al., 2018).”
BackgroundUnderstanding adipocyte heterogeneity across species, depot, and disease
Kitto, E. S., Kult, S., & Emont, M. P. (2026) · Biochemical Society Transactions · doi:10.1042/bst20250327 · Cited by 1
“In adipose tissue, scRNA-seq studies have uncovered diverse stromal cell populations [4,52,53] and dynamic changes in cellular composition across lean, obese, weight-loss, and aged states [7,54,55].”
Reid, I., Ali, S. H., Shayan, R., & Karnezis, T. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1809914 · Cited by 1
“…progenitors with distinct transcriptional and functional properties (Figure 4) (Emont et al., 2022; Massier et al., 2023; Merrick et al., 2019; Schwalie et al., 2018). scRNA-seq enables interrogation of whether lipedema is associated with expansion of proliferative Adipose stem and progenitor…”
Adipogenesis Under Leptin Control: Mechanisms and Model-Specific Effects
Na’aim, A. A., Kamarudin, T. A., Arshad, N. ‘., Za'aba, N. F., Kamaruddin, N. A., & Ahmad, F. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27114778
“…distinct adipose progenitor populations and reported that cells enriched for F3/Cd142 tissue factor displayed limited adipogenic differentiation potential and exerted anti-adipogenic effects despite sharing an overall progenitor composition with other adipose precursor populations [138,140].”
Rapid Remodeling of Human White Adipose Tissue Following Bariatric SurgeryPreprint
Loureiro, Z. Y., Westcott, G. P., Gulko, A., Essene, A. L., Zhou, Z., Liang, W., Jacobs, C. L., Nagesh, S., Bozadjieva-Kramer, N., Seeley, R. J., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.09.717542
“Our attention was drawn to a population of ASPCs known as Aregs (identified as ASPC PTCH2+ in our study), which exert anti-adipogenic actions on neighboring cells, 17 and which decrease in abundance shortly after surgery.”
InfluentialHeterogeneity and Clinical Relevance of Human Adipose Stromal and Progenitor Cells
Albert, M., Nalir, K., Zhong, J., & Massier, L. (2026) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2025.1182 · Cited by 2
“In contrast, other differentiation pathways may be followed by adipogenic ASPC-subtypes, leading to the formation of clusters (V–VIII) and thus inhibiting adipogenesis, i.e., via Areg activity [23,89].”
Exploring cell types and their dynamic states in adipose tissue
Nahmgoong, H., & Kim, J. B. (2026) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2026.01.012 · Cited by 2
Jia, H., & Liu, D. (2025) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-025-01975-3 · Cited by 1
“The mechanism of this transformation may be related to metabolic disorders, especially the progression of metabolic diseases such as obesity and diabetes(31, 32).”
White and brown adipose tissue share a convergent fibro-adipogenic progenitor population
Bui, H. V., Hansen, J. K., Sardo, V. L., & Galmozzi, A. (2025) · EMBO Reports · doi:10.1038/s44319-025-00591-6 · Cited by 1
“Similarly, highly adipogenic mASPC1, mASPC5, and mASPC6 (Emont et al, 2022), APCs (Hepler et al, 2018), FAP2 and 3 (Sarvari et al, 2021), G1 and G2 (Schwalie et al, 2018), and Icam1 + preadipocytes (Holman et al, 2024; Merrick et al, 2019) mapped to wCAPs or their precursors wAPC 2 (Fig.”
InfluentialMechanical interplay between adipose tissues and disease progression
Zhou, H., Zhou, D., Wu, M., Huang, Y., Yu, E., Xie, J., Wang, Y., Chen, S., Song, Q., Xu, K., et al. (2025) · Bioengineering & Translational Medicine · doi:10.1002/btm2.70065 · Cited by 1
“27 Among these, the most significant attention has been directed toward understanding the characteristics and functions of ADSC as they have similar morphological features, immune phenotype, colony frequency, and differentiation capacity as bone marrow stem cells (BMSC).”
Rocha, K. C. E., Tan, B., Kempf, J., Medina, C., Beldona, V., Qian, C., Duan, Y., Xiang, Q., Yoo, A., Du, X., et al. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102246 · Cited by 1
“The Matrigel implant procedure was adapted from Schwalie et al., 2018 [46].”
Liao, X., Zeng, Q., Zhang, H.-W., Xie, L., & Deng, T. (2025) · STAR Protocols · doi:10.1016/j.xpro.2025.104035 · Cited by 1
Tang, Y., Xu, Z., Song, S., Song, Y.-J., Yang, L., Wang, L., Liu, Y., Qian, S., Pang, Z., Tang, Q., et al. (2025) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szaf004 · Cited by 1
“20,21 Single-cell RNA sequence analyses have identified that cells marker by dipeptidyl peptidase-4(DPP4)/CD26 expression are highly proliferative, multipotent progenitors.”
Yamada, K., Kubota, Y., Kosaka, K., Yamaji, Y., Akita, S., Kuroda, M., & Mitsukawa, N. (2025) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2025.152012 · Cited by 1
Diolintzi, A., Zhou, Y., Fomina, A., Sun, Y., Husain, S., Sidossis, L. S., Fried, S. K., & Storch, J. (2025) · Cells · doi:10.3390/cells14110760 · Cited by 1
“For example, the decreased expression of Cyp 2 e 1 is of particular interest, as its expression is enriched in CD142 + cells, a subpopulation of adipose stem and progenitor cells (ASPCs) that has been attributed non-and anti-adipogenic properties both in vivo and in vitro [32,53].”
Reconsidering KLK7's role in adipose inflammation: letter to the editor.
Zhong, Y., Wei, J.-Q., & Jiang, R. (2025) · Metabolism: Clinical and Experimental · doi:10.1016/j.metabol.2025.156255 · Cited by 1
Sumbal, J., Journot, R. P., Faraldo, M. M., Koledova, Z., & Fre, S. (2024) · bioRxiv · doi:10.1101/2024.06.05.597593 · Cited by 1
“More specifically, AREGs defined by cluster #2 were identified lining blood vessels as expected from studies in the male fat pad 29 , preadipocytes were dispersed between adipocytes, and interstitial progenitors were found in the fat pad septae and in the interstitial reticulum (Supplementary…”
BackgroundMethodLe tissu adipeux dans tous ses états : dernières avancées
Doukbi, E., Lasbleiz, A., Dutour, A., & Gaborit, B. (2023) · Nutrition Clinique et Métabolisme · doi:10.1016/s0985-0562(24)00005-0 · Cited by 1
[What if the origin of FAPs was contributing to their heterogeneity in muscle?]
Mathieu, M., Girousse, A., & Sengenès, C. (2023) · Medecine sciences : M/S · doi:10.1051/medsci/2023129 · Cited by 1
Askia, H., Dussaud, S., Oliveira, M. C., Oliveira, A. C., Poupel, L., Rebière, C., Ouhachi, M., Manuel, R., Merabtene, F., Genser, L., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.26.559540 · Cited by 4
A single nuclei atlas of aging human abdominal subcutaneous white adipose tissuePreprint
Sparks, L. M., Whytock, K. L., Divoux, A., Sun, Y., Pino, M., Yu, G., Smith, S. R., & Walsh, M. J. (2023) · Research Square · doi:10.21203/rs.3.rs-3097605/v1 · Cited by 3
Cellular and molecular brakes on adipogenesis
Cannavino, J., & Gupta, R. K. (2022) · Nature Metabolism · doi:10.1038/s42255-021-00519-z · Cited by 1
Marycz, K., Kornicka‐Garbowska, K., Galuppo, L. D., & Bourebaba, L. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10304-w · Cited by 1
Muoio, F., Panella, S., Harder, Y., & Tallone, T. (2021) · Biologics · doi:10.3390/biologics1020008 · Cited by 1
Zachara, M., Rainer, P., Russeil, J., Hashimi, H., Alpern, D., Ferrero, R., Litovchenko, M., & Deplancke, B. (2021) · bioRxiv · doi:10.1101/2021.02.24.432431 · Cited by 1
Self-citationPuluca, N., Vafadarnejad, E., Saleem, T., Rammoser, C., Wirth, F., Schwerdt, V., Dreßen, M., Gottmann, I., Reiminger, X., Yan, Y., et al. (2026) · Cardiovascular Research · doi:10.1093/cvr/cvag189 · Cited by 2
Cellular remodeling of lipedema affected subcutaneous adipose tissue
Gohlke, S., García-Carrizo, F., Upmeyer, R., & Schulz, T. J. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1893552
“…antigen six family member C1 ( Ly6C ) , collagen 14 A1 ( COL14A1 ) , disintegrin and metalloproteinase domain-containing protein 12 ( ADAM12 ) and periostin ( POSTN ) , (Schwalie et al., 2018; Ferrero et al., 2020; Emont et al., 2022; Massier et al., 2023; Wang et al., 2024; Reinisch et al., 2025).”
Chang, X., Su, Y., Zhai, M.-J., Meng, J., Zeng, Y.-Q., Wang, J.-W., Ren, W.-L., & Yao, X.-K. (2026) · Animals · doi:10.3390/ani16152412
“Subcutaneous adipose tissue is predominantly involved in lipid metabolism, demonstrating more active substrate utilization, energy turnover, and lipid cycling [3,4].”
Wang, X., Wang, Y., Yuan, R., Smith, G. R., Ruf-Zamojski, F. M., Homma, S. T., Sealfon, S. C., & Zhou, L. (2026) · iScience · doi:10.1016/j.isci.2026.116933
Liu, Y., Yin, M., Yang, Y., Heng, S., Zhang, W., Song, J. H., Feng, B., Yang, Y., Liu, W. J., & Zhang, L. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1875876
Chen, H.-R., Sun, B., Qiu, Y.-J., Hua, C., Lin, X.-X., & Gao, W. (2026) · Advancement of science · doi:10.1002/advs.76699
“…three main populations: adipose stem cells (ASCs), which exhibit stem-like properties and multipotent differentiation capacity; preadipocytes (PreAs), a group committed to adipogenesis; and adipogenesis-regulatory cells (Aregs), which inhibit the adipogenesis of other precursor cells [ 20, 21 ].”
Thomas, M., Pacary, A., Arnaud, E., Bernard, D., Maugis-Rabusseau, C., Guissard, C., Arlat, A., Davezac, N., Lorsignol, A., Paupert, J., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-58327-y
An, Q., Zou, Y., Wang, W.-L., Cheng, Z.-M., Zhang, Z., Liu, R.-W., Wang, X., Huang, K., Ding, F., Dai, Y., et al. (2026) · Advancement of science · doi:10.1002/advs.75678
Zhao, L., Zhu, Q.-J., Li, M.-H., Yang, H.-L., & Zhao, Y.-J. (2026) · Zoological Research · doi:10.24272/j.issn.2095-8137.2025.236
“Schwalie et al. (2018) identified three cellular subpopulations, P1, P2, and P3, with the F3 ( CD142 )- and ABCG1 -expressing P3 population classified as preadipocytes and showing high similarity to the preadipocytes identified in goat PRAT cluster 5.”
Long, J., Chen, G., Qin, Z., Jin, C.-X., Liu, H.-X., Chen, J., Song, B.-Q., & Zhang, Z. (2026) · Aesthetic Plastic Surgery · doi:10.1007/s00266-026-05870-8
“Cutting-edge research has provided critical clues: Petra C. Schwalie’s team [7] employed single-cell RNA sequencing (scRNA-seq) to identify a CD142+/ABCG1+ subpopulation that negatively regulates adipogenesis in adjacent adipose precursor cells (ASPs).”
Hematopoietic stem cell transplantation-associated partial lipodystrophy
Adachi, M. (2026) · Clinical Pediatric Endocrinology · doi:10.1297/cpe.2026-0005
“As stated above, whereas APCs mainly differentiate into mature adipocytes via preadipocytes, they can also differentiate into anti-adipogenic progenitors which will suppress adipogenic differentiation of other APCs (48, 49).”
Nothnagel, P. M. C., Meslin, P.-A., Wik, J. A., Dufour, D., Strøm, Y. E., Bjørås, M., Enserink, J. M., Skålhegg, B. S., Briand, N., Mathelier, A., et al. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag232 · Cited by 1
“WAT plasticity allows adaptive thermogenesis, which may occur via two routes: either through de novo differentiation of white/beige precursors into beige cells or the reversible conversion of white cells into beige cells [ 16 , 17 , 102 , 103 ].”
Gpc3 selectively suppresses subcutaneous adipogenesis in diet-induced obesity
Li, Y., Tao, M., Ibáñez, C. F., & Xie, M. (2026) · PLoS Biology · doi:10.1371/journal.pbio.3003700
“These findings are in line with previous work highlighting the divergent responses of subcutaneous and visceral progenitors during adipose remodeling [10,11].”
Sysoeva, V., Arbatskiy, M. S., Kulebyakin, K. Y., Tyurin‐Kuzmin, P. A., Semina, E. V., Сергеевна, К. П., Brodsky, I. B., Romashin, D. D., Altyeva, A. F., Сергеевич, В. Н., et al. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1734183
“…was identified in MSC cell clusters concurrently expressing mRNAs for PDGFR α (Pdgfr α ) and Meflin (Islr) (Nakamura et al., 2020), the latter being specific markers of MSC-like cells or mesenchymal progenitors (Challa et al., 2015; Merrick et al., 2019; Schwalie et al., 2018; Burl et al., 2018).”
Thomas, N. S., Sankofi, B. M., Cen, H. H., Sekhri, M., Murguia, S. J., Cherian, M. A., Stout, M. B., Miller, B. F., Rudolph, M. C., & Wellberg, E. A. (2026) · Communications Biology · doi:10.64898/2025.12.21.695772
“In addition to the expression level, the number of Wisp2 positive cells in the transitional progenitors, preadipocytes, and in the adipocyte regulatory (AREG) cluster, previously defined as a population that inhibits adipocyte differentiation (36), was affected by endocrine therapy.”
Trujillo-Viera, J., Wittmann, M. C., Lam, D., Shen, Y., Ghosh, A., Noé, F., Hoffmann, A., Viollet, C., Dick, A., Blüher, M., et al. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102161
“High expression of a set of genes, including CLEC11A , F3 ( CD142 ), FMO2 , ABCG1 , and EPHA3 , has been proposed as marker of Aregs [3,15,20].”
Self-citationYao, T., Wei, D., Tian, X., Zhao, L., Wan, Q., Zhang, X., Cai, J., Li, S., Diao, B., Feng, S., et al. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02069-1
Bailin, S. S., Kropski, J. A., Gangula, R., Hannah, L., Simmons, J. D., Mashayekhi, M., Ye, F., Fan, R., Mallal, S. A., Warren, C. M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.21.484794
Specific Features of Regulation of Hormonal Sensitivity in Stem Cells
Chechekhin, V. I., Kulebyakin, K., & Tyurin-Kuzmin, P. (2022) · Russian Journal of Developmental Biology · doi:10.1134/s106236042203002x
“These cells could reduce the sensitivity EVELOPMENTAL BIOLOGY Vol. 53 No. 3 2022 of MSCs to proadipogenic hormonal stimuli and suppress adipogenic differentiation (Schwalie et al., 2018, Ferrero et al., 2020).”
BackgroundResident T cells orchestrate adipose tissue remodeling in a site peripheral to infectionPreprint
Kabat, A. M., Hackl, A., Sanin, D. E., Zeis, P., Grzes, K. M., Baixauli, F., Kyle, R. L., Caputa, G., Edwards-Hicks, J., Villa, M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.24.481701
“Using recently published transcription profiles to delineate adipocyte differentiation stages, we identified Dpp4+ Pi16+ MPC (C2), intermediate uncommitted cells (C0), as well as Fabp4+ Pparg+ committed preadipocytes (C1) (14, 22, 23).”
MethodGupta, A., Shamsi, F., Altemose, N., Dorlhiac, G., Cypess, A. M., White, A. P., Patti, M., Tseng, Y., & Streets, A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.24.435852 · Cited by 3
“To date, different scRNA-seq studies of mouse stromal vascular fraction have identified multiple subpopulations of adipose progenitor cells (APCs) expressing distinct markers (Burl et al. 2018; Hepler et al. 2018; Merrick et al. 2019; Schwalie et al. 2018).”
Ahmed, M., Lai, T. H., & Kim, D. (2021) · bioRxiv · doi:10.1101/2021.03.10.434887
“It’s even been shown that a minority sub-population lacking the typical adipocyte features might take on a regulatory role to influence its surroundings in a paracrine manner [51].”
BackgroundZhou, W., Lin, J., Hu, X., Yao, X., & Ouyang, H. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.15.431264
Ni, G.-Y., Wu, X., Liu, Y., Li, H., Chen, S., Fogarty, C. E., Frazer, I., Chen, G., Liu, X.-S., & Wang, T.-F. (2020) · doi:10.21203/rs.3.rs-73533/v1
Sun, C.-B., Wang, L., Wang, H., Huang, T., & Zhang, X. (2019) · bioRxiv · doi:10.1101/723130
Etude des anomalies du métabolisme énergétique associées au syndrome de Noonan
Branka, S. (2019) · theses.fr (ABES) · doi:10.70675/b0d081a3z3492z4457za237zcabd6ccc0a76
“Une autre étude montre l’existence d’une nouvelle population (« Aregs » ó CD142+/ABCG1+) capable d’inhiber de façon paracrine la différenciation adipocytaire in vivo et in vitro (Schwalie et al., 2018).”
Mosaic Mutant Analysis Identifies PDGFRα/PDGFRβ As Negative Regulators of Adipogenesis
Sun, C.-Y., Sakashita, H., Kim, J. H., Tang, Z., Upchurch, G., Griffin, T., & Olson, L. (2019) · Social Science Research Network · doi:10.2139/ssrn.3379970
Metadata
- Authors
- Schwalie, P. C., Dong, H., Zachara, M., Russeil, J., Alpern, D., Akchiche, N., Caprara, C., Sun, W., Schlaudraff, K.-U., Soldati, G., Wolfrum, C., & Deplancke, B.
- Affiliations
- SIB Swiss Institute of Bioinformatics (CH)
- ETH Zurich (CH)
- Swiss Stem Cell Foundation (CH)
- Corresponding author
- Wolfrum, Christian
- Deplancke, Bart
- ORCID
- Venue
- Nature
- Published
- 2018-06-20
- Volume
- 559
- Issue
- 7712
- Pages
- 103-108
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2809355409
- Cited by
- 463
- References
- 49
- Citations by year
- 2026: 23 · 2025: 51 · 2024: 77 · 2023: 55 · 2022: 73 · 2021: 77 · 2020: 54 · 2019: 43 · 2018: 10
- FWCI
- 31.71
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Licence
- cc-by-nc-nd
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- Stiftelsen Kristian Gerhard Jebsen
- Public Health Agency of Canada
- École Polytechnique Fédérale de Lausanne
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- adipogenesis, adipose-derived stem cells, adipose precursor cells, stromal vascular fraction, paracrine signaling, adipose tissue plasticity, subcutaneous adipose tissue, obesity, type 2 diabetes, insulin sensitivity
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, Female, Humans, Insulin Resistance, Male, Stem Cells, Thromboplastin, Stromal Cells, Adipocytes, Paracrine Communication, Gene Expression Profiling, Subcutaneous Fat, Adipogenesis, Mice, Single-Cell Analysis
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