Cited by 490Memory and Neural MechanismsNeural dynamics and brain functionMemory Processes and Influences

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Integrating time from experience in the lateral entorhinal cortex

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Tsao, Albert, Sugar, Jørgen, Lu, Li, Wang, Cheng, Knierim, James J., Moser, May-Britt, Moser, Edvard I.·2018·Nature

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Abstract

The encoding of time and its binding to events are crucial for episodic memory, but how these processes are carried out in hippocampal-entorhinal circuits is unclear. Here we show in freely foraging rats that temporal information is robustly encoded across time scales from seconds to hours within the overall population state of the lateral entorhinal cortex. Similarly pronounced encoding of time was not present in the medial entorhinal cortex or in hippocampal areas CA3-CA1. When animals' experiences were constrained by behavioural tasks to become similar across repeated trials, the encoding of temporal flow across trials was reduced, whereas the encoding of time relative to the start of trials was improved. The findings suggest that populations of lateral entorhinal cortex neurons represent time inherently through the encoding of experience. This representation of episodic time may be integrated with spatial inputs from the medial entorhinal cortex in the hippocampus, allowing the hippocampus to store a unified representation of what, where and when.

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Authors: Tsao, A., Sugar, J., Lu, L., Wang, C., Knierim, J. J., Moser, M.-B., & Moser, E. I.
Affiliations: Norwegian University of Science and Technology (NO)
Baylor College of Medicine (US)
Johns Hopkins University (US)
Corresponding author: Tsao, Albert
Moser, Edvard I.
ORCID: Sugar, Jørgen
Lu, Li
Wang, Cheng
Knierim, James J.
Moser, May-Britt
Moser, Edvard I.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2018-08-29
Volume: 561
Issue: 7721
Pages: 57-62
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/s41586-018-0459-6
OpenAlex: W2889422159
Cited by: 490
References: 51
Citations by year: 2026: 35 · 2025: 69 · 2024: 74 · 2023: 51 · 2022: 78 · 2021: 66 · 2020: 56 · 2019: 51 · 2018: 10
FWCI: 27.26
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords: time encoding, lateral entorhinal cortex, medial entorhinal cortex, hippocampus, episodic memory, temporal binding, population coding, temporal flow, rats
MeSH terms: Animals, Behavior, Animal, Male, Time Factors, Entorhinal Cortex, Rats, Long-Evans, Rats

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Integrating time from experience in the lateral entorhinal cortex

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