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Integrating time from experience in the lateral entorhinal cortex
Open accessAbstract
The encoding of time and its binding to events are crucial for episodic memory, but how these processes are carried out in hippocampal-entorhinal circuits is unclear. Here we show in freely foraging rats that temporal information is robustly encoded across time scales from seconds to hours within the overall population state of the lateral entorhinal cortex. Similarly pronounced encoding of time was not present in the medial entorhinal cortex or in hippocampal areas CA3-CA1. When animals' experiences were constrained by behavioural tasks to become similar across repeated trials, the encoding of temporal flow across trials was reduced, whereas the encoding of time relative to the start of trials was improved. The findings suggest that populations of lateral entorhinal cortex neurons represent time inherently through the encoding of experience. This representation of episodic time may be integrated with spatial inputs from the medial entorhinal cortex in the hippocampus, allowing the hippocampus to store a unified representation of what, where and when.
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“Intriguingly, populations of LEC neurons also encode temporal information across different contexts (Tsao et al., 2018).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Tsao et al., 2018
In the citing paper
“This matches the anatomical features of LEC, as being a functional hub for integrating multisensory information (Bota et al., 2015), including both spatial and non-spatial characteristics, probably even time (Tsao et al., 2018).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Tsao et al., 2018
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Metadata
- Authors
- Tsao, A., Sugar, J., Lu, L., Wang, C., Knierim, J. J., Moser, M.-B., & Moser, E. I.
- Affiliations
- Norwegian University of Science and Technology (NO)
- Baylor College of Medicine (US)
- Johns Hopkins University (US)
- Corresponding author
- Tsao, Albert
- Moser, Edvard I.
- Venue
- Nature
- Published
- 2018-08-29
- Volume
- 561
- Issue
- 7721
- Pages
- 57-62
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2889422159
- Cited by
- 490
- References
- 51
- Citations by year
- 2026: 35 · 2025: 69 · 2024: 74 · 2023: 51 · 2022: 78 · 2021: 66 · 2020: 56 · 2019: 51 · 2018: 10
- FWCI
- 27.26
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- time encoding, lateral entorhinal cortex, medial entorhinal cortex, hippocampus, episodic memory, temporal binding, population coding, temporal flow, rats
- MeSH terms
- Animals, Behavior, Animal, Male, Time Factors, Entorhinal Cortex, Rats, Long-Evans, Rats
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