Internally Generated Cell Assembly Sequences in the Rat Hippocampus
Open accessAbstract
A long-standing conjecture in neuroscience is that aspects of cognition depend on the brain's ability to self-generate sequential neuronal activity. We found that reliably and continually changing cell assemblies in the rat hippocampus appeared not only during spatial navigation but also in the absence of changing environmental or body-derived inputs. During the delay period of a memory task, each moment in time was characterized by the activity of a particular assembly of neurons. Identical initial conditions triggered a similar assembly sequence, whereas different conditions gave rise to different sequences, thereby predicting behavioral choices, including errors. Such sequences were not formed in control (nonmemory) tasks. We hypothesize that neuronal representations, evolved for encoding distance in spatial navigation, also support episodic recall and the planning of action sequences.
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The sequential activation of place cells is thought to reflect specific episodic-like memories.
“In fact, the sequential activation of place cells is thought to reflect specific episodic-like memories, occurring across similar time scales to the actual experience, all while the rat is concurrently engaged in other activities (and thus is not confusing imagined representations with current reality) [127].”
From Is episodic-like memory <i>like</i> episodic memory? (2024) · cites this paper as [127]
Place cell activity in rats can encode information about the 'what' and 'when' of events.
“evidence suggests that place cell activity in rats can also encode information about the ‘what’ (e.g. odours and their status, i.e. match/non-match [124–126]) and ‘when’ (i.e. elapsed time [127,128]) of events.”
From Is episodic-like memory <i>like</i> episodic memory? (2024) · cites this paper as [127]
Recent remodelling of sharp-wave-ripple events suggests that neuronal replay often occurs at 'real-world' speeds that reflect actual experience.
“recent remodelling of sharp-wave-ripple events suggests that this neuronal replay often occurs at ‘real-world’ speeds that reflect actual experience [185], as observed in other studies [127].”
From Is episodic-like memory <i>like</i> episodic memory? (2024) · cites this paper as [127]
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- Authors
- Pastalkova, E., Itskov, V., Amarasingham, A., & Buzsáki, G.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA.
- Corresponding author
- Itskov, Vladimir
- Venue
- Science
- Published
- 2008-09-05
- Volume
- 321
- Issue
- 5894
- Pages
- 1322-1327
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2570043
- OpenAlex
- W2172122397
- Cited by
- 1,301
- References
- 40
- Citations by year
- 2026: 63 · 2025: 100 · 2024: 101 · 2023: 84 · 2022: 81 · 2021: 85 · 2020: 83 · 2019: 97 · 2018: 82 · 2017: 94 · 2016: 65 · 2015: 67 · 2014: 69 · 2013: 63 · 2012: 38
- FWCI
- 21.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH054671, MH54671)
- National Institute of Neurological Disorders and Stroke (R01NS034994, NS-34994)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- cell assemblies, hippocampus, spontaneous neuronal activity, spatial navigation, episodic memory, action planning, behavior prediction
- MeSH terms
- Action Potentials, Animals, Behavior, Animal, Choice Behavior, Cues, Hippocampus, Interneurons, Male, Memory, Models, Neurological, Motor Activity, Mental Recall, Pyramidal Cells, Maze Learning, Rats, Long-Evans, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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