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Bile acid metabolites control TH17 and Treg cell differentiation
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Abstract
Bile acids are abundant in the mammalian gut, where they undergo bacteria-mediated transformation to generate a large pool of bioactive molecules. Although bile acids are known to affect host metabolism, cancer progression and innate immunity, it is unknown whether they affect adaptive immune cells such as T helper cells that express IL-17a (T H 17 cells) or regulatory T cells (T reg cells). Here we screen a library of bile acid metabolites and identify two distinct derivatives of lithocholic acid (LCA), 3-oxoLCA and isoalloLCA, as T cell regulators in mice. 3-OxoLCA inhibited the differentiation of T H 17 cells by directly binding to the key transcription factor retinoid-related orphan receptor-γt (RORγt) and isoalloLCA increased the differentiation of T reg cells through the production of mitochondrial reactive oxygen species (mitoROS), which led to increased expression of FOXP3. The isoalloLCA-mediated enhancement of T reg cell differentiation required an intronic Foxp3 enhancer, the conserved noncoding sequence (CNS) 3; this represents a mode of action distinct from that of previously identified metabolites that increase T reg cell differentiation, which require CNS1. The administration of 3-oxoLCA and isoalloLCA to mice reduced T H 17 cell differentiation and increased T reg cell differentiation, respectively, in the intestinal lamina propria. Our data suggest mechanisms through which bile acid metabolites control host immune responses, by directly modulating the balance of T H 17 and T reg cells.
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“Nevertheless, it is noteworthy that certain secondary BAs serve significant biological functions, including the regulation of host metabolism, immunity, and resistance against intestinal pathogen expansion.21,360–364”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [363]
In the citing paper
“On the other hand, certain secondary BAs exert anti-inflammatory effects by stimulating Treg cell differentiation and inhibiting TH17 cell differentiation.361,363,364,702,710”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [363]
In the citing paper
“Hence, in humans BACH2 might be an important regulator of homeostatic Th17 cells that could be exploited for the treatment of human autoimmune diseases.”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [60]
In the citing paper
“multiple single-nucleotide polymorphisms (SNPs) in the BACH2 locus are associated with human autoimmune diseases and a protective allele for MS disease correlates with an increase of BACH2 expression in CD4+ T cells”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [60]
In the citing paper
“by integrating single-cell ATAC-seq and single-cell RNA-seq, we generated a regulatory network across npTh17, pTh17, and Th1 cells”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [60]
In the citing paper
“Predicted regulators of the non-pathogenic- and general- Th17 program included RORγt, ETS1, BACH2, FOSL2, and RBPJ.”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [60]
In the citing paper
“The network predicted the pathogenic Th17- and Th1- program to be regulated by the transcription factors ATF3, BHLHE40, FOS, NR4A1, EOMES, and T-BET.”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [60]
In the citing paper
“We validated BACH2 as a novel regulator of Th17 pathogenicity that promoted immunomodulatory programs and restrained pro-inflammatory Th1-like programs in Th17 cells.”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [60]
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Cites
DADA2: High–resolution sample inference from Illumina amplicon data
Callahan, B. J., McMurdie, P. J., Rosen, M. J., Han, A. W., Johnson, A. J. A., & Holmes, S. P. (2016) · Nature Methods · doi:10.1038/nmeth.3869 · Cited by 35,698
Bokulich, N. A., Kaehler, B. D., Rideout, J. R., Dillon, M. R., Bolyen, E. K., Knight, R. D., Huttley, G. A., & Caporaso, J. G. (2018) · Microbiome · doi:10.1186/s40168-018-0470-z · Cited by 6,037
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
Self-citationBile salt biotransformations by human intestinal bacteria
Ridlon, J. M., Kang, D.-J., & Hylemon, P. B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r500013-jlr200 · Cited by 2,829
Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
Buffie, C. G., Bucci, V., Stein, R. R., McKenney, P. T., Ling, L., Gobourne, A., No, D., Liu, H., Kinnebrew, M., Viale, A., et al. (2015) · Nature · doi:10.1038/nature13828 · Cited by 1,872
Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells
Ma, C., Han, M., Heinrich, B., Fu, Q., Zhang, Q., Sandhu, M., Agdashian, D., Terabe, M., Berzofsky, J. A., Fako, V., et al. (2018) · Science · doi:10.1126/science.aan5931 · Cited by 1,508
Sena, L. A., Li, S., Jairaman, A., Prakriya, M., Ezponda, T., Hildeman, D. A., Wang, C.-R., Schumacker, P. T., Licht, J. D., Perlman, H., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.10.020 · Cited by 1,338
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T cell metabolism drives immunity
Buck, M. D., O’Sullivan, D., & Pearce, E. L. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20151159 · Cited by 1,238
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Zhang, Y., Gao, X., Gao, S., Liu, Y., Wang, W., Feng, Y., Pei, L., Sun, Z., Liu, L., & Wang, C. (2023) · Immunology · doi:10.1111/imm.13672 · Cited by 49
Chang, L., Wang, C., Peng, J., Song, Y., Zhang, W., Chen, Y., Peng, Q., Li, X., Liu, X., & Lan, Y. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c08462 · Cited by 48
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Biagioli, M., Giorgio, C. D., Massa, C., Marchianò, S., Bellini, R., Bordoni, M., Urbani, G., Roselli, R., Lachi, G., Morretta, E., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117731 · Cited by 54
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Wang, X., Shen, C., Wang, X., Tang, J., Wu, Z., Huang, Y., Shao, W., Geng, K., Xie, H., & Pu, Z. (2023) · Chinese Medicine · doi:10.1186/s13020-023-00815-8 · Cited by 45
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Dong, X., Qi, M., Cai, C., Zhu, Y., Li, Y., Coulter, S., Sun, F., Liddle, C., Uboha, N. V., Halberg, R. B., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.170428 · Cited by 47
Xia, L., Zhu, X., Wang, Y., & Lü, S. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217123 · Cited by 50
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Cui, X., Ye, Z., Wang, D., Yang, Y., Jiao, C., Ma, J., Tang, N., & Zhang, H. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00780-z · Cited by 45
John, P., Pulanco, M. C., Galbo, P. M., Yao, W., Ohaegbulam, K. C., Zheng, D., & Zang, X. (2022) · Nature Communications · doi:10.1038/s41467-022-30143-8 · Cited by 44
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Lefort, C., & Cani, P. D. (2021) · Cells · doi:10.3390/cells10020400 · Cited by 44
Volkova, A., & Ruggles, K. V. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.621310 · Cited by 45
Miltiadous, O., Waters, N. R., Andrlová, H., Dai, A., Nguyen, C. L., da Silva, M. B., Lindner, S., Slingerland, J., Giardina, P., Clurman, A., et al. (2022) · Blood · doi:10.1182/blood.2021014255 · Cited by 45
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Ly, L. K., Doden, H. L., & Ridlon, J. M. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111174 · Cited by 45
Xiao, Y., Wang, Y., Liu, Y., Wang, W., Tian, X., Chen, S., Lu, Y., Du, J., & Cai, W. (2021) · Liver International · doi:10.1111/liv.14906 · Cited by 43
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Gerrick, E. R., Zlitni, S., West, P. T., Carter, M. M., Mechler, C. M., Olm, M. R., Caffrey, E. B., Li, J. A., Higginbottom, S. K., Severyn, C. J., et al. (2023) · Cell · doi:10.1016/j.cell.2023.11.018 · Cited by 42
You, Y., Xiang, T., Yang, C. H., Xiao, S., Tang, Y., Luo, G., Ling, Z., Luo, F., & Chen, Y. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2545417 · Cited by 45
Rubas, N. C., Torres, A., & Maunakea, A. K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178658 · Cited by 46
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Huang, Z., Li, Y., Park, H., Ho, M., Bhardwaj, K., Sugimura, N., Lee, H. W., Meng, H., Ebert, M. P., Chao, K., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2237645 · Cited by 41
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Xiao, R., Lei, K., Kuok, H., Deng, W., Zhuang, Y., Tang, Y., Guo, Z., Qin, H., Bai, L.-P., & Li, T. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.1ma0122-513r · Cited by 41
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Zhou, Y., Han, W., Feng, Y., Wang, Y., Sun, T., & Xu, J. (2024) · International Journal of Oncology · doi:10.3892/ijo.2024.5661 · Cited by 41
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Little, M., Dutta, M., Li, H., Matson, A. P., Shi, X., Mascarinas, G., Molla, B., Weigel, K. M., Gu, H., Mani, S., et al. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.07.022 · Cited by 41
Schubert, M., Rohrbach, R., Schmitt, M. W., & Stein‐Thoeringer, C. K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.670286 · Cited by 40
Zhu, Y., Li, Y., Zhang, Q., Song, Y., Wang, L., & Zhu, Z. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.798917 · Cited by 40
Yang, W., Yu, T., & Cong, Y. (2022) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbac018 · Cited by 42
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Zhao, L., Zhao, C., Miao, Y., Lei, S., Li, Y., Gong, J., & Peng, C. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155852 · Cited by 38
Cencicchio, M. A., Montini, F., Palmieri, V., Massimino, L., Nobili, A., Conte, M. L., Finardi, A., Mandelli, A., Asnicar, F., Pavlovic, R., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102028 · Cited by 44
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Jin, C., Yuan, X., Wang, C., Fu, Z., & Jin, Y. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.123668 · Cited by 38
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Jia, B., Park, D., Chun, B. H., Hahn, Y., & Jeon, C. O. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073652 · Cited by 39
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Gao, R. Y., Shearn, C. T., Orlicky, D. J., Battista, K. D., Alexeev, E. E., Cartwright, I. M., Lanis, J. M., Kostelecky, R. E., Ju, C., Colgan, S. P., et al. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-00347-6 · Cited by 37
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Fu, Z., Dean, J. W., Xiong, L., Dougherty, M. W., Oliff, K. N., Chen, Z. E., Jobin, C., Garrett, T. J., & Zhou, L. (2021) · Nature Communications · doi:10.1038/s41467-021-24755-9 · Cited by 36
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Metadata
- Authors
- Hang, S., Paik, D., Yao, L., Kim, E., Trinath, J., Lu, J., Ha, S., Nelson, B. N., Kelly, S. P., Wu, L., Zheng, Y., Longman, R. S., Rastinejad, F., Devlin, A. S., Krout, M. R., Fischbach, M. A., Littman, D. R., & Huh, J. R.
- Affiliations
- Harvard University (US)
- Birla Institute of Technology and Science - Hyderabad Campus (IN)
- Bucknell University (US)
- New York University (US)
- Salk Institute for Biological Studies (US)
- Weill Cornell Medicine (US)
- University of Oxford (GB)
- Stanford University (US)
- Howard Hughes Medical Institute (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Fischbach, Michael A.
- Littman, Dan R.
- Huh, Jun R.
- ORCID
- Venue
- Nature
- Published
- 2019-11-27
- Volume
- 576
- Issue
- 7785
- Pages
- 143-148
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC6949019
- OpenAlex
- W2990182987
- Cited by
- 1,457
- References
- 59
- Citations by year
- 2026: 274 · 2025: 287 · 2024: 260 · 2023: 207 · 2022: 174 · 2021: 158 · 2020: 94 · 2019: 3
- FWCI
- 43.07
- Type
- journal article
- Language
- en
- Update notices
- correction (2020-02-25)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- Wellcome Trust (210664/Z/18/Z)
- National Institute of Allergy and Infectious Diseases (R01AI107027, R01AI080885)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK103358, R01DK114252, R01DK110559, P30DK034854)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- bile acid metabolites, lithocholic acid, Th17 cell differentiation, regulatory T cells, RORγt, Foxp3, mitochondrial reactive oxygen species, gut microbiota, intestinal lamina propria, IL-17A, T cell regulation
- MeSH terms
- Animals, Cell Differentiation, Lithocholic Acid, Mice, Inbred C57BL, Reactive Oxygen Species, T-Lymphocytes, Regulatory, Mice, Forkhead Transcription Factors, Th17 Cells
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