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Bile acid metabolites control TH17 and Treg cell differentiation
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Abstract
Bile acids are abundant in the mammalian gut, where they undergo bacteria-mediated transformation to generate a large pool of bioactive molecules. Although bile acids are known to affect host metabolism, cancer progression and innate immunity, it is unknown whether they affect adaptive immune cells such as T helper cells that express IL-17a (T H 17 cells) or regulatory T cells (T reg cells). Here we screen a library of bile acid metabolites and identify two distinct derivatives of lithocholic acid (LCA), 3-oxoLCA and isoalloLCA, as T cell regulators in mice. 3-OxoLCA inhibited the differentiation of T H 17 cells by directly binding to the key transcription factor retinoid-related orphan receptor-γt (RORγt) and isoalloLCA increased the differentiation of T reg cells through the production of mitochondrial reactive oxygen species (mitoROS), which led to increased expression of FOXP3. The isoalloLCA-mediated enhancement of T reg cell differentiation required an intronic Foxp3 enhancer, the conserved noncoding sequence (CNS) 3; this represents a mode of action distinct from that of previously identified metabolites that increase T reg cell differentiation, which require CNS1. The administration of 3-oxoLCA and isoalloLCA to mice reduced T H 17 cell differentiation and increased T reg cell differentiation, respectively, in the intestinal lamina propria. Our data suggest mechanisms through which bile acid metabolites control host immune responses, by directly modulating the balance of T H 17 and T reg cells.
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“Nevertheless, it is noteworthy that certain secondary BAs serve significant biological functions, including the regulation of host metabolism, immunity, and resistance against intestinal pathogen expansion.21,360–364”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [363]
In the citing paper
“On the other hand, certain secondary BAs exert anti-inflammatory effects by stimulating Treg cell differentiation and inhibiting TH17 cell differentiation.361,363,364,702,710”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [363]
In the citing paper
“Hence, in humans BACH2 might be an important regulator of homeostatic Th17 cells that could be exploited for the treatment of human autoimmune diseases.”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [60]
In the citing paper
“multiple single-nucleotide polymorphisms (SNPs) in the BACH2 locus are associated with human autoimmune diseases and a protective allele for MS disease correlates with an increase of BACH2 expression in CD4+ T cells”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [60]
In the citing paper
“by integrating single-cell ATAC-seq and single-cell RNA-seq, we generated a regulatory network across npTh17, pTh17, and Th1 cells”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [60]
In the citing paper
“Predicted regulators of the non-pathogenic- and general- Th17 program included RORγt, ETS1, BACH2, FOSL2, and RBPJ.”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [60]
In the citing paper
“The network predicted the pathogenic Th17- and Th1- program to be regulated by the transcription factors ATF3, BHLHE40, FOS, NR4A1, EOMES, and T-BET.”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [60]
In the citing paper
“We validated BACH2 as a novel regulator of Th17 pathogenicity that promoted immunomodulatory programs and restrained pro-inflammatory Th1-like programs in Th17 cells.”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [60]
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Cites
DADA2: High–resolution sample inference from Illumina amplicon data
Callahan, B. J., McMurdie, P. J., Rosen, M. J., Han, A. W., Johnson, A. J. A., & Holmes, S. P. (2016) · Nature Methods · doi:10.1038/nmeth.3869 · Cited by 35,698
Bokulich, N. A., Kaehler, B. D., Rideout, J. R., Dillon, M. R., Bolyen, E. K., Knight, R. D., Huttley, G. A., & Caporaso, J. G. (2018) · Microbiome · doi:10.1186/s40168-018-0470-z · Cited by 6,037
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
Self-citationBile salt biotransformations by human intestinal bacteria
Ridlon, J. M., Kang, D.-J., & Hylemon, P. B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r500013-jlr200 · Cited by 2,829
Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
Buffie, C. G., Bucci, V., Stein, R. R., McKenney, P. T., Ling, L., Gobourne, A., No, D., Liu, H., Kinnebrew, M., Viale, A., et al. (2015) · Nature · doi:10.1038/nature13828 · Cited by 1,872
Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells
Ma, C., Han, M., Heinrich, B., Fu, Q., Zhang, Q., Sandhu, M., Agdashian, D., Terabe, M., Berzofsky, J. A., Fako, V., et al. (2018) · Science · doi:10.1126/science.aan5931 · Cited by 1,508
Sena, L. A., Li, S., Jairaman, A., Prakriya, M., Ezponda, T., Hildeman, D. A., Wang, C.-R., Schumacker, P. T., Licht, J. D., Perlman, H., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.10.020 · Cited by 1,338
Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments
Angelin, A., Gil‐de‐Gómez, L., Dahiya, S., Jiao, J., Guo, L., Levine, M. H., Wang, Z., Quinn, W. J., Kopinski, P. K., Wang, L., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.12.018 · Cited by 1,304
T cell metabolism drives immunity
Buck, M. D., O’Sullivan, D., & Pearce, E. L. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20151159 · Cited by 1,238
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Liu, Y., Lau, H. C.-H., & Yu, J. Q. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2203968 · Cited by 84
Kim, Y. S., Hurley, E., Park, Y., & Ko, S. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01042-9 · Cited by 79
Bile Acid Signaling in Metabolic and Inflammatory Diseases and Drug Development
Li, T., & Chiang, J. Y. L. (2024) · Pharmacological Reviews · doi:10.1124/pharmrev.124.000978 · Cited by 85
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Jin, W., Xiao, L., Jeong, M., Han, S.-J., Zhang, W., Yano, H., Shi, H., Arifuzzaman, M., Lyu, M., Wang, D., et al. (2025) · Cell · doi:10.1016/j.cell.2025.02.029 · Cited by 94
Shah, A., Macdonald, G. A., Morrison, M., & Holtmann, G. (2020) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000604 · Cited by 78
Th17 cell pathogenicity in autoimmune disease
Park, E., & Ciofani, M. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01535-9 · Cited by 75
MahmoudianDehkordi, S., Bhattacharyya, S., Brydges, C. R., Jia, W., Fiehn, O., Rush, A. J., Dunlop, B. W., & Kaddurah-Daouk, R. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.937906 · Cited by 75
Circadian Host-Microbiome Interactions in Immunity
Butler, T. D., & Gibbs, J. E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01783 · Cited by 75
Kiriyama, Y., & Nochi, H. (2023) · Microorganisms · doi:10.3390/microorganisms11112730 · Cited by 77
Novel approaches in IBD therapy: targeting the gut microbiota-bile acid axis
Pan, Y., Zhang, H., Li, M., He, T., Guo, S., Zhu, L., Tan, J., & Wang, B. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2356284 · Cited by 84
Microbiome, bile acids, and obesity: How microbially modified metabolites shape anti‐tumor immunity
Sipe, L. M., Chaib, M., Pingili, A. K., Pierre, J. F., & Makowski, L. (2020) · Immunological Reviews · doi:10.1111/imr.12856 · Cited by 75
Manipulation of epithelial integrity and mucosal immunity by host and microbiota‐derived metabolites
Kayama, H., & Takeda, K. (2020) · European Journal of Immunology · doi:10.1002/eji.201948478 · Cited by 77
The gut microbiota–bile acid axis: A potential therapeutic target for liver fibrosis
Zhang, Y., Li, Z.-J., Gou, H.-Z., Song, X., & Zhang, L. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.945368 · Cited by 77
Mar, J. S., Ota, N., Pokorzynski, N. D., Peng, Y., Jaochico, A., Sangaraju, D., Skippington, E., Lekkerkerker, A., Rothenberg, M. E., Tan, M., et al. (2023) · Microbiome · doi:10.1186/s40168-023-01486-1 · Cited by 78
Gut microbiota mediated T cells regulation and autoimmune diseases
Bhutta, N. K., Xu, X., Jian, C., Wang, Y., Liu, Y., Sun, J., Han, B., Wu, S., & Javeed, A. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1477187 · Cited by 80
Local and systemic effects of microbiome‐derived metabolites
Spivak, I., Fluhr, L., & Elinav, E. (2022) · EMBO Reports · doi:10.15252/embr.202255664 · Cited by 75
Microbiota and IBD: Current knowledge and future perspectives
Foppa, C., Rizkala, T., Repici, A., Hassan, C., & Spinelli, A. (2023) · Digestive and Liver Disease · doi:10.1016/j.dld.2023.11.015 · Cited by 86
Advances in the study of IL-17 in neurological diseases and mental disorders
Lu, Y., Zhang, P., Xu, F., Zheng, Y., & Zhao, H. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1284304 · Cited by 71
Self-citationPeiseler, M., & Tacke, F. (2021) · Cancers · doi:10.3390/cancers13040730 · Cited by 77
Li, N., Ma, P.-G., Li, Y., Shang, X., Nan, X., Shi, L., Han, X., Liu, J., Hong, Y., Li, Q., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2290315 · Cited by 76
Zheng, M., Zhai, Y., Yu, Y., Shen, J., Chu, S., Focaccia, E., Tian, W., Wang, S., Liu, X., Yuan, X., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.06.008 · Cited by 74
Wei, H., Suo, C., Gu, X., Shen, S., Lin, K., Zhu, C., Yan, K., Bian, Z., Chen, L., Zhang, T., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.01.011 · Cited by 72
Noto, J. M., Piazuelo, M. B., Shah, S. C., Romero–Gallo, J., Hart, J. L., Di, C., Carmichael, J. D., Delgado, A. G., Halvorson, A. E., Greevy, R. A., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci147822 · Cited by 73
Formation of secondary allo-bile acids by novel enzymes from gut Firmicutes
Lee, J., Cowley, E. S., Wolf, P. G., Doden, H. L., Murai, T., Caicedo, K. Y. O., Ly, L. K., Sun, F.-R., Takei, H., Nittono, H., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2132903 · Cited by 71
Lindner, S., Miltiadous, O., Ramos, R. J. J. F., Paredes, J., Kousa, A. I., Dai, A., Fei, T., Lauder, E., Frame, J., Waters, N. R., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01617-w · Cited by 74
Feng, L., Zhou, N., Li, Z., Fu, D., Guo, Y., Gao, X., & Liu, X. (2021) · The FASEB Journal · doi:10.1096/fj.202101088rrr · Cited by 67
The gut–liver axis: host microbiota interactions shape hepatocarcinogenesis
Silveira, M. A. D., Bilodeau, S., Greten, T. F., Wang, X. W., & Trinchieri, G. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.02.009 · Cited by 69
Research on Gut Microbiota-Derived Secondary Bile Acids in Cancer Progression
Yang, R., & Li, Q. (2022) · Integrative Cancer Therapies · doi:10.1177/15347354221114100 · Cited by 72
Odenwald, M. A., Lin, H., Lehmann, C. J., Dylla, N. P., Cole, C. G., Mostad, J. D., Pappas, T. E., Ramaswamy, R., Moran, A., Hutchison, A. L., et al. (2023) · Nature Microbiology · doi:10.1038/s41564-023-01493-w · Cited by 69
Mora, P. E., Valbuena, D., & Díez‐Juan, A. (2025) · Life · doi:10.3390/life15050762 · Cited by 81
Ricciuto, A., Kamath, B. M., Hirschfield, G. M., & Trivedi, P. J. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.02.030 · Cited by 76
Zhang, H., Xie, Y., Cao, F., & Song, X. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2382336 · Cited by 71
Rankin, L. C., Kaiser, K. A., Santos, K. D. L., Park, H., Uhlemann, A., Gray, D. H. D., & Arpaia, N. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112135 · Cited by 65
Ma, S., Sandhoff, R., Luo, X., Shang, F., Shi, Q., Li, Z., Wu, J., Ming, Y., Schwarz, F., Madi, A., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adg8817 · Cited by 65
Anti-infective bile acids bind and inactivate a Salmonella virulence regulator
Yang, X., Stein, K. R., & Hang, H. C. (2022) · Nature Chemical Biology · doi:10.1038/s41589-022-01122-3 · Cited by 61
Wang, Q., Jia, D., He, J., Sun, Y., Qian, Y., Ge, Q., Qi, Y., Wang, Q., Hu, Y., Wang, L., et al. (2023) · Advanced Science · doi:10.1002/advs.202303457 · Cited by 62
Dopamine receptor D2 confers colonization resistance via microbial metabolites
Scott, S. A., Fu, J., & Chang, P. V. (2024) · Nature · doi:10.1038/s41586-024-07179-5 · Cited by 68
McGlinchey, A., Sinioja, T., Lamichhane, S., Sen, P., Bodin, J., Siljander, H., Dickens, A. M., Geng, D., Carlsson, C., Duberg, D., et al. (2020) · Environment International · doi:10.1016/j.envint.2020.105935 · Cited by 61
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He, P., Yu, L., Tian, F., Zhang, H., Chen, W., & Zhai, Q. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac029 · Cited by 65
An overview of host‐derived molecules that interact with gut microbiota
Zhang, C., Liu, H., Sun, L., Wang, Y., Chen, X., Du, J., Sjöling, Å., Yao, J., & Wu, S. (2023) · iMeta · doi:10.1002/imt2.88 · Cited by 62
Metabolism Characteristics of Th17 and Regulatory T Cells in Autoimmune Diseases
Qin, Y., Gao, C., & Luo, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.828191 · Cited by 68
Antigen-presenting cells as specialized drivers of intestinal T cell functions
Kedmi, R., & Littman, D. R. (2024) · Immunity · doi:10.1016/j.immuni.2024.09.011 · Cited by 66
Self-citationThe gut microbiota-bile acid axis: a crucial regulator of immune function and metabolic health
Tyagi, A., & Kumar, V. (2025) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-025-04395-7 · Cited by 68
Gut Microbial-Derived Metabolites as Immune Modulators of T Helper 17 and Regulatory T Cells
Calvo‐Barreiro, L., Zhang, L., Abdel‐Rahman, S. A., Naik, S. P., & Gabr, M. T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021806 · Cited by 62
Role of bile acids in liver diseases mediated by the gut microbiome
Shao, J., Ge, T., Chen, S., Wang, G., Yang, Q., Huang, C., Xu, L., & Chen, Z. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i22.3010 · Cited by 61
Yang, B., Huang, S., Zhao, G., & Ma, Q. (2022) · Animal nutrition · doi:10.1016/j.aninu.2022.08.003 · Cited by 59
Gut Microbial Metabolites on Host Immune Responses in Health and Disease
Yoon, J.-H., Do, J.-S., Velankanni, P., Lee, C., & Kwon, H. (2023) · Immune Network · doi:10.4110/in.2023.23.e6 · Cited by 64
Zhu, Y., Huang, X., Deng, Z., Bai, T., Gao, B., Xu, C., Fu, J., Zhao, Y., Zhang, Y., Zhang, M., et al. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02802-z · Cited by 59
Zhao, M., Jiafeng, Z., Yang, H., Ouyang, Z., Lv, C., Geng, Z., & Zhao, J. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118182 · Cited by 69
The outstanding antitumor capacity of CD4+ T helper lymphocytes
Li, T., Wu, B., Yang, T., Zhang, L., & Jin, K. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188439 · Cited by 60
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Gu, B., Kim, M., & Yun, C. (2021) · Nutrients · doi:10.3390/nu13010167 · Cited by 57
The intestinal and biliary microbiome in autoimmune liver disease—current evidence and concepts
Liwinski, T., Heinemann, M., & Schramm, C. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00936-6 · Cited by 60
Park, J. W., Kim, J. H., Kim, S. E., Jung, J. H., Jang, M. K., Park, S. H., Lee, M. S., Kim, H. S., Suk, K. T., & Kim, D. J. (2022) · Biomedicines · doi:10.3390/biomedicines10061288 · Cited by 60
Vincenzo, F. D., Puca, P., Lopetuso, L. R., Petito, V., Masi, L., Bartocci, B., Murgiano, M., Felice, M. D., Petronio, L., Gasbarrini, A., et al. (2022) · Nutrients · doi:10.3390/nu14132664 · Cited by 63
Retinoic acid and TGF-β orchestrate organ-specific programs of tissue residency
Obers, A., Poch, T., Rodrigues, G., Christo, S. N., Gandolfo, L. C., Fonseca, R., Zaid, A., Kuai, J. E. Y., Lai, H., Zareie, P., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.09.015 · Cited by 60
Intertwined Relationship of Mitochondrial Metabolism, Gut Microbiome and Exercise Potential
Imdad, S., Lim, W., Kim, J., & Kang, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052679 · Cited by 60
Son, S., Nam, J., Kim, A. S., Ahn, J., Park, K. S., Phoo, M. T., Sherren, B., Zou, W., Lee, S., Farokhzad, O. C., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00973-4 · Cited by 63
T helper 17 (Th17) cell responses to the gut microbiota in human diseases
Sun, C., Yang, N. Y., Zheng, Z., Liu, D., & Xu, Q. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114483 · Cited by 60
Gut microbiota in regulatory T cell generation and function: mechanisms and health implications
Sharma, A., Sharma, G., & Im, S. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2516702 · Cited by 68
Huang, F., Liu, Z., Song, Y., Wang, G., Shi, A., Chen, T., Huang, S., Lian, S., Li, K., Tang, Y., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.05.017 · Cited by 58
The microbiome(s) and cancer: know thy neighbor(s)
González‐Sánchez, P., & DeNicola, G. M. (2021) · The Journal of Pathology · doi:10.1002/path.5661 · Cited by 57
Jena, P. K., Sheng, L., Nguyen, M. V. L., Lucente, J. D., Hu, Y. C., Li, Y., Maezawa, I., Jin, L., & Wan, Y. Y. (2020) · Biomarker Research · doi:10.1186/s40364-020-00239-8 · Cited by 55
Xun, Z., Lin, J., Yu, Q., Liu, C., Huang, J., Shang, H., Guo, J., Ye, Y., Wu, W., Zeng, Y., et al. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00601-8 · Cited by 56
Bile Acid Signaling in Inflammatory Bowel Disease
Bromke, M. A., & Krzystek‐Korpacka, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22169096 · Cited by 54
Role of Interleukin-17 in Acute Pancreatitis
Li, G., Chen, H., Liu, L., Xiao, P., Xie, Y., Geng, X., Zhang, T., Zhang, Y., Lu, T., Tan, H., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.674803 · Cited by 55
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Matuz‐Mares, D., Vázquez‐Meza, H., & Vilchis‐Landeros, M. M. (2022) · Antioxidants · doi:10.3390/antiox11102038 · Cited by 58
Therapeutic role of ursodeoxycholic acid in colitis-associated cancer via gut microbiota modulation
He, Q., Wu, J., Ke, J., Zhang, Q., Zeng, W., Luo, Z., Gong, J., Chen, Y., He, Z., & Lan, P. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.10.014 · Cited by 55
Li, Z., Shen, Y., Xin, J., Xu, X., Ding, Q., Chen, W., Wang, J., Lv, Y., Wei, X., Wei, Y., et al. (2023) · Phytotherapy Research · doi:10.1002/ptr.7926 · Cited by 56
Vân, N. T. T., Zhang, K., Wigmore, R. M., Kennedy, A., DaSilva, C. R., Huang, J., Ambelil, M., Vilagomez, J. H., O’Connor, G. J., Longman, R., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43211-4 · Cited by 57
Self-citationIndrio, F., & Salatto, A. (2025) · Annals of Nutrition and Metabolism · doi:10.1159/000541999 · Cited by 57
Metabolic regulation in the immune response to cancer
Wu, Q., Yu, X., Li, J., Sun, S., & Tu, Y. (2021) · 癌症：英文版 · doi:10.1002/cac2.12182 · Cited by 57
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Chen, J., Hall, S., & Vitetta, L. (2021) · Reviews in Medical Virology · doi:10.1002/rmv.2211 · Cited by 55
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Gautier, T., Gall‐David, S. L., Sweidan, A., Tamanai‐Shacoori, Z., Jolivet‐Gougeon, A., Loréal, O., & Bousarghin, L. (2021) · Microorganisms · doi:10.3390/microorganisms9050941 · Cited by 59
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Adhikari, A. A., Ramachandran, D., Chaudhari, S. N., Powell, C. E., Li, W., McCurry, M. D., Banks, A. S., & Devlin, A. S. (2021) · ACS Chemical Biology · doi:10.1021/acschembio.1c00192 · Cited by 56
Self-citationPaine, A., Brookes, P. S., Bhattacharya, S., Li, D., García-Hernández, M. D. L. L., Tausk, F., & Ritchlin, C. T. (2022) · Arthritis & Rheumatology · doi:10.1002/art.42288 · Cited by 57
Hu, J., Zhang, Y., Yi, S., Wang, C., Huang, X., Pan, S., Yang, J., Yuan, G., Tan, S., & Li, H. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.71287 · Cited by 54
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Lamichhane, S., Sen, P., Dickens, A. M., Alves, M. A., Härkönen, T., Honkanen, J. K., Vatanen, T., Xavier, R. J., Hyötyläinen, T., Knip, M., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100762 · Cited by 58
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Boehme, M., Guzzetta, K. E., Wasén, C., & Cox, L. M. (2022) · Gut Microbiome · doi:10.1017/gmb.2022.11 · Cited by 57
Che, Y., Xu, W., Ding, C., He, T., Xu, X., Shuai, Y., Huang, H., Wu, J., Wang, Y., Wang, C., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112011 · Cited by 57
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Wei, J., Zheng, W., Chapman, N. M., Geiger, T. L., & Chi, H. (2021) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2021.02.003 · Cited by 52
Metadata
- Authors
- Hang, S., Paik, D., Yao, L., Kim, E., Trinath, J., Lu, J., Ha, S., Nelson, B. N., Kelly, S. P., Wu, L., Zheng, Y., Longman, R. S., Rastinejad, F., Devlin, A. S., Krout, M. R., Fischbach, M. A., Littman, D. R., & Huh, J. R.
- Affiliations
- Harvard University (US)
- Birla Institute of Technology and Science - Hyderabad Campus (IN)
- Bucknell University (US)
- New York University (US)
- Salk Institute for Biological Studies (US)
- Weill Cornell Medicine (US)
- University of Oxford (GB)
- Stanford University (US)
- Howard Hughes Medical Institute (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Fischbach, Michael A.
- Littman, Dan R.
- Huh, Jun R.
- ORCID
- Venue
- Nature
- Published
- 2019-11-27
- Volume
- 576
- Issue
- 7785
- Pages
- 143-148
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC6949019
- OpenAlex
- W2990182987
- Cited by
- 1,457
- References
- 59
- Citations by year
- 2026: 274 · 2025: 287 · 2024: 260 · 2023: 207 · 2022: 174 · 2021: 158 · 2020: 94 · 2019: 3
- FWCI
- 43.07
- Type
- journal article
- Language
- en
- Update notices
- correction (2020-02-25)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- Wellcome Trust (210664/Z/18/Z)
- National Institute of Allergy and Infectious Diseases (R01AI107027, R01AI080885)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK103358, R01DK114252, R01DK110559, P30DK034854)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- bile acid metabolites, lithocholic acid, Th17 cell differentiation, regulatory T cells, RORγt, Foxp3, mitochondrial reactive oxygen species, gut microbiota, intestinal lamina propria, IL-17A, T cell regulation
- MeSH terms
- Animals, Cell Differentiation, Lithocholic Acid, Mice, Inbred C57BL, Reactive Oxygen Species, T-Lymphocytes, Regulatory, Mice, Forkhead Transcription Factors, Th17 Cells
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