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Tissue‐resident macrophages provide a pro‐tumorigenic niche to early NSCLC cells

Casanova-Acebes, María, Dalla, Erica, Leader, Andrew M., LeBerichel, Jessica, Nikolic, Jovan, Morales, Blanca M., Brown, Markus, Chang, Christie, Troncoso, Leanna, Chen, Steven T., Sastre-Perona, Ana, Park, Matthew D., Tabachnikova, Alexandra, Dhainaut, Maxime, Hamon, Pauline, Maier, Barbara, Sawai, Catherine M., Agulló-Pascual, Esperanza, Schober, Markus, Brown, Brian D., Reizis, Boris, Marron, Thomas, Kenigsberg, Ephraim, Moussion, Christine, Benaroch, Philippe, Aguirre-Ghiso, Julio A., Merad, Miriam·2021·Nature
DOI 10.1038/s41586-021-03651-8PMC PMC8923521
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Citations

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Research works printed but not linked: 33

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  2. Leader, A. M. et al. CITEseq analysis of non-small-cell lung cancer lesions reveals an axis of immune cell activation associated with tumor antigen load and TP53 mutations. Preprint at https://doi.org/10.1101/2020.07.16.207605 (2020). · DOI
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  4. Schneider, C. et al. Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages. Nat. Immunol. 15, 1026–1037 (2014). · DOI
  5. Xue, W. et al. Response and resistance to NF-κB inhibitors in mouse models of lung adenocarcinoma. Cancer Discov. 1, 236–247 (2011). · DOI
  6. Zilionis, R. et al. Single-cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species. Immunity 50, 1317–1334 (2019). · DOI
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  8. Russell, D. G., Cardona, P. J., Kim, M. J., Allain, S. & Altare, F. Foamy macrophages and the progression of the human tuberculosis granuloma. Nat. Immunol. 10, 943–948 (2009). · DOI
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  13. Rhim, A. D. et al. EMT and dissemination precede pancreatic tumor formation. Cell 148, 349–361 (2012). · DOI · Paper page
  14. Krebs, A. M. et al. The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer. Nat. Cell Biol. 19, 518–529 (2017). · DOI
  15. Thiery, J. P. Epithelial-mesenchymal transitions in tumour progression. Nat. Rev. Cancer 2, 442–454 (2002). · DOI
  16. Yang, J. et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 117, 927–939 (2004). · DOI
  17. Dongre, A. & Weinberg, R. A. New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer. Nat. Rev. Mol. Cell Biol. 20, 69–84 (2019). · DOI · Paper page
  18. Lavin, Y. et al. innate immune landscape in early lung adenocarcinoma by paired single-cell analyses. Cell 169, 750–765 (2017). · DOI · Paper page
  19. Tada, Y. et al. Targeting VEGFR2 with Ramucirumab strongly impacts effector/ activated regulatory T cells and CD8+ T cells in the tumor microenvironment. J. Immunother. Cancer 6, 106 (2018). · DOI
  20. Battaglia, A. et al. Metastatic tumour cells favour the generation of a tolerogenic milieu in tumour draining lymph node in patients with early cervical cancer. Cancer Immunol. Immunother. 58, 1363–1373 (2009). · DOI
  21. He, F. et al. PLAU inferred from a correlation network is critical for suppressor function of regulatory T cells. Mol. Syst. Biol. 8, 624 (2012). · DOI
  22. Mucida, D. et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317, 256–260 (2007). · DOI · Paper page
  23. Mizukami, Y. et al. CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3+ regulatory T cells in gastric cancer. Int. J. Cancer 122, 2286–2293 (2008). · DOI · Paper page
  24. Liu, Z. et al. Fate mapping via Ms4a3-expression history traces monocyte-derived cells. Cell 178, 1509–1525 (2019). · DOI · Paper page
  25. Miyake, Y. et al. Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigens. J. Clin. Invest. 117, 2268–2278 (2007). · DOI
  26. Karasawa, K. et al. Vascular-resident CD169-positive monocytes and macrophages control neutrophil accumulation in the kidney with ischemia-reperfusion injury. J. Am. Soc. Nephrol. 26, 896–906 (2015). · DOI
  27. Zhang, Y. et al. Model-based analysis of ChIP–seq (MACS). Genome Biol. 9, R137 (2008). · DOI · Paper page
  28. Ramírez, F., Dündar, F., Diehl, S., Grüning, B. A. & Manke, T. deepTools: a flexible platform for exploring deep-sequencing data. Nucleic Acids Res. 42, W187–W191 (2014). · DOI · Paper page
  29. Sastre-Perona, A. et al. De novo PITX1 expression controls bi-stable transcriptional circuits to govern self-renewal and differentiation in squamous cell carcinoma. Cell Stem Cell 24, 390–404 (2019). · DOI
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  33. Remark, R. et al. In-depth tissue profiling using multiplexed immunohistochemical consecutive staining on single slide. Sci. Immunol. 1, aaf6925 (2016). · DOI

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Metadata

Authors
Casanova-Acebes, M., Dalla, E., Leader, A. M., LeBerichel, J., Nikolic, J., Morales, B. M., Brown, M., Chang, C., Troncoso, L., Chen, S. T., Sastre-Perona, A., Park, M. D., Tabachnikova, A., Dhainaut, M., Hamon, P., Maier, B., Sawai, C. M., Agulló-Pascual, E., Schober, M., Brown, B. D., Reizis, B., Marron, T., Kenigsberg, E., Moussion, C., Benaroch, P., Aguirre-Ghiso, J. A., & Merad, M.
ORCID
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2021-06-16
Volume
595
Issue
7868
Pages
578-584
ISSN
  • 0028-0836
  • 1476-4687
DOI
10.1038/s41586-021-03651-8
PMC
PMC8923521
Cited by
629
References
14
Language
en
Licence

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