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Immunosenescence and cancer: molecular hallmarks, tumor microenvironment remodeling, and age-specific immunotherapy challenges

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Chromatin accessibility illuminates single-cell regulatory dynamics of rice root tips

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Myeloid-specific KDM6B inhibition sensitizes glioblastoma to PD1 blockade

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Functional genomics data: privacy risk assessment and technological mitigation

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Emerging roles for endogenous retroviruses in immune epigenetic regulation*

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FoxP3 associates with enhancer-promoter loops to regulate Treg-specific gene expressionPreprint

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Single-cell ATAC-seq maps the comprehensive and dynamic chromatin accessibility landscape of CAR-T cell dysfunction

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Demystifying non-coding GWAS variants: an overview of computational tools and methods

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Interpretation of allele-specific chromatin accessibility using cell state–aware deep learning

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Chromatin accessibility landscapes of skin cells in systemic sclerosis nominate dendritic cells in disease pathogenesis

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Profiling Chromatin Accessibility at Single-Cell Resolution

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Rebalancing TGFβ1/BMP signals in exhausted T cells unlocks responsiveness to immune checkpoint blockade therapy

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Resolving the spatial architecture of myeloma and its microenvironment at the single-cell level

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epiAneufinder identifies copy number alterations from single-cell ATAC-seq data

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Joint profiling of chromatin accessibility and CAR-T integration site analysis at population and single-cell levels

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Single-cell ATAC-seq signal extraction and enhancement with SCATE

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Targeting pro-inflammatory T cells as a novel therapeutic approach to potentially resolve atherosclerosis in humans

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Bidirectional epigenetic editing reveals hierarchies in gene regulation

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Enhancer reprogramming: critical roles in cancer and promising therapeutic strategies

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GRHL2 motif is associated with intratumor heterogeneity of cis-regulatory elements in luminal breast cancer

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Microtechnologies for single-cell and spatial multi-omics

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Single-cell multiomics reveals the interplay of clonal evolution and cellular plasticity in hepatoblastoma

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Single-cell and spatial analyses of cancer cells: toward elucidating the molecular mechanisms of clonal evolution and drug resistance acquisition

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Human T lymphocytes at tumor sites

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maxATAC: Genome-scale transcription-factor binding prediction from ATAC-seq with deep neural networks

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Single-cell RNA-seq and chromatin accessibility profiling decipher the heterogeneity of mouse γδ T cells

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Single-cell genomics improves the discovery of risk variants and genes of atrial fibrillation

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Spatial microniches of IL-2 combine with IL-10 to drive lung migratory TH2 cells in response to inhaled allergen

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GPR37L1 identifies spinal cord astrocytes and protects neuropathic pain after nerve injury

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Graph neural networks for single-cell omics data: a review of approaches and applications

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Exploiting Single-Cell Tools in Gene and Cell Therapy

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Tracking single-cell evolution using clock-like chromatin accessibility loci

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Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas

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Spatially resolved genome-wide joint profiling of epigenome and transcriptome with spatial-ATAC-RNA-seq and spatial-CUT&Tag-RNA-seq

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Circulating immune cell dynamics as outcome predictors for immunotherapy in non-small cell lung cancer

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Single-cell analysis of cis-regulatory elements

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Single-cell multi-omics analysis of human testicular germ cell tumor reveals its molecular features and microenvironment

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Spotiphy enables single-cell spatial whole transcriptomics across an entire section

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MEDALT: single-cell copy number lineage tracing enabling gene discovery

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Temporal molecular program of human hematopoietic stem and progenitor cells after birth

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simATAC: a single-cell ATAC-seq simulation framework

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From morphology to single-cell molecules: high-resolution 3D histology in biomedicine

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BFF and cellhashR: analysis tools for accurate demultiplexing of cell hashing data

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Epigenetic regulation of HBV-specific tumor-infiltrating T cells in HBV-related HCC

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Tumor heterogeneity and tumor-microglia interactions in primary and recurrent IDH1-mutant gliomas

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Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Peripheral Mononuclear Cells in Patients With Ankylosing Spondylitis

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Discovery of Targets for Immune–Metabolic Antitumor Drugs Identifies Estrogen-Related Receptor Alpha

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Repression of latent NF-κB enhancers by PDX1 regulates β cell functional heterogeneity

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Emerging technologies for systems vaccinology — multi-omics integration and single-cell (epi)genomic profiling

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Revisiting 3D chromatin architecture in cancer development and progression

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Chromatin Landscape Underpinning Human Dendritic Cell Heterogeneity

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Genetic control of retinal ganglion cell genesis

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A single-cell based precision medicine approach using glioblastoma patient-specific models

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Single-Cell Analysis in Immuno-Oncology

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Genome-wide profiling of transcription factor activity in primary liver cancer using single-cell ATAC sequencing

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ETV7 limits the antiviral and antitumor efficacy of CD8+ T cells by diverting their fate toward exhaustion

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Hybrid Stomach-Intestinal Chromatin States Underlie Human Barrett’s Metaplasia

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Simple oligonucleotide-based multiplexing of single-cell chromatin accessibility

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Targeting metabotropic glutamate receptor 4 for cancer immunotherapy

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High-dimensional investigation of the cerebrospinal fluid to explore and monitor CNS immune responses

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Single-cell profiling reveals altered immune landscape and impaired NK cell function in gastric cancer liver metastasis

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SITC cancer immunotherapy resource document: a compass in the land of biomarker discovery

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Perspectives on rigor and reproducibility in single cell genomics

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Ranking reprogramming factors for cell differentiation

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Single-cell multi-omics and lineage tracing to dissect cell fate decision-making

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A Roadmap for a Consensus Human Skin Cell Atlas and Single-Cell Data Standardization

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Single-Cell Chromatin Accessibility Analysis Reveals the Epigenetic Basis and Signature Transcription Factors for the Molecular Subtypes of Colorectal Cancers

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Single-cell multiome and spatial profiling reveals pancreas cell type–specific gene regulatory programs of type 1 diabetes progression

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