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Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly
Open accessAbstract
Increasing age alters innate immune-mediated responses; however, the mechanisms underpinning these changes in humans are not fully understood. Using a human dermal model of acute inflammation, we found that, although inflammatory onset is similar between young and elderly individuals, the resolution phase was substantially impaired in elderly individuals. This arose from a reduction in T cell immunoglobulin mucin receptor-4 (TIM-4), a phosphatidylserine receptor expressed on macrophages that enables the engulfment of apoptotic bodies, so-called efferocytosis. Reduced TIM-4 in elderly individuals was caused by an elevation in macrophage p38 mitogen-activated protein kinase (MAPK) activity. Administering an orally active p38 inhibitor to elderly individuals rescued TIM-4 expression, cleared apoptotic bodies and restored a macrophage resolution phenotype. Thus, inhibiting p38 in elderly individuals rejuvenated their resolution response to be more similar to that of younger people. This is the first resolution defect identified in humans that has been successfully reversed, thereby highlighting the tractability of targeting pro-resolution biology to treat diseases driven by chronic inflammation.
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“This defect in resolution was due to lower expression of expression of T cell immunoglobulin mucin receptor-4 (TIM-4), a receptor that recognizes apoptotic cells, and a subsequent failure to phagocytose apoptotic neutrophils as compared to younger monocytes (33).”
From The impact of ageing on monocytes and macrophages (2021) · cites this paper as [33]
In the citing paper
“Ultimately this kind of mechanism, of failed resolution, might underlie chronic inflammation such as that seen in aged people (33).”
From The impact of ageing on monocytes and macrophages (2021) · cites this paper as [33]
In the citing paper
“Mononuclear phagocytes, consisting of monocytes and macrophages, were unable to engulf apoptotic immune cells following an inflammatory insult.”
From The impact of ageing on monocytes and macrophages (2021) · cites this paper as [33]
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“and thus identifies a therapeutic target for improving monocyte function in older people (33).”
From The impact of ageing on monocytes and macrophages (2021) · cites this paper as [33]
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“Interestingly this defect in resolution in the old could be reversed by pre-treatment with a p38-MAP Kinase inhibitor (Losmapimod)”
From The impact of ageing on monocytes and macrophages (2021) · cites this paper as [33]
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“Recently we have shown that mononuclear phagocytes, presumed to be inflammatory monocytes, from older adults, recruited to a site of tissue damage fail to resolve inflammation as effectively as younger monocytes (33).”
From The impact of ageing on monocytes and macrophages (2021) · cites this paper as [33]
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Citations
Cites
Macrophage plasticity and polarization: in vivo veritas
Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358
Mortality Associated With Influenza and Respiratory Syncytial Virus in the United States
Thompson, W. W., Shay, D. K., Weintraub, E., Brammer, L., Cox, N., Anderson, L. J., & Fukuda, K. (2003) · JAMA · doi:10.1001/jama.289.2.179 · Cited by 3,673
Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166
Aging, Cellular Senescence, and Cancer
Campisi, J. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183653 · Cited by 2,954
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
Tchkonia, T., Zhu, Y., van Deursen, J., Campisi, J., & Kirkland, J. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64098 · Cited by 1,774
Savill, J. S., Wyllie, A. H., Henson, J. E., Walport, M. J., Henson, P. M., & Haslett, C. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113970 · Cited by 1,536
Facing up to the global challenges of ageing
Partridge, L., Deelen, J., & Slagboom, P. E. (2018) · Nature · doi:10.1038/s41586-018-0457-8 · Cited by 1,475
Huynh, M.-L. N., Fadok, V., & Henson, P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci11638 · Cited by 1,333
Identification of Tim4 as a phosphatidylserine receptor
Miyanishi, M., Tada, K., Koike, M., Uchiyama, Y., Kitamura, T., & Nagata, S. (2007) · Nature · doi:10.1038/nature06307 · Cited by 1,180
Antibody response to influenza vaccination in the elderly: A quantitative review
GOODWIN, K., VIBOUD, C., & SIMONSEN, L. (2006) · Vaccine · doi:10.1016/j.vaccine.2005.08.105 · Cited by 1,064
Age-dependent dysregulation of innate immunity
Shaw, A. C., Goldstein, D. R., & Montgomery, R. R. (2013) · Nature Reviews Immunology · doi:10.1038/nri3547 · Cited by 1,061
Self-citationFranceschi, C., Garagnani, P., Vitale, G., Capri, M., & Salvioli, S. (2017) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.09.005 · Cited by 997
Huynh, M.-L. N., Fadok, V. A., & Henson, P. M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0211638 · Cited by 957
Resolution of inflammation: a new therapeutic frontier
Fullerton, J. N., & Gilroy, D. W. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.39 · Cited by 937
Autoimmunity and the Clearance of Dead Cells
Nagata, S., Hanayama, R., & Kawane, K. (2010) · Cell · doi:10.1016/j.cell.2010.02.014 · Cited by 907
Macrophage Phenotypes Regulate Scar Formation and Chronic Wound Healing
Hesketh, M., Sahin, K. B., West, Z. E., & Murray, R. Z. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071545 · Cited by 852
An Apoptotic ‘Eat Me’ Signal: Phosphatidylserine Exposure
Segawa, K., & Nagata, S. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.08.003 · Cited by 778
Molecular Circuits of Resolution: Formation and Actions of Resolvins and Protectins
Bannenberg, G. L., Chiang, N., Ariel, A., Arita, M., Tjonahen, E., Gotlinger, K. H., Hong, S., & Serhan, C. N. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.7.4345 · Cited by 699
Macrophage Dysfunction Impairs Resolution of Inflammation in the Wounds of Diabetic Mice
Khanna, S., Biswas, S., Shang, Y., Collard, E., Azad, A., Kauh, C., Bhasker, V., Gordillo, G. M., Sen, C. K., & Roy, S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009539 · Cited by 694
CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis
Kojima, Y., Volkmer, J.-P., McKenna, K., Civelek, M., Lusis, A. J., Miller, C. L., Direnzo, D., Nanda, V., Ye, J., Connolly, A. J., et al. (2016) · Nature · doi:10.1038/nature18935 · Cited by 683
Pedersen, M., Bruunsgaard, H., Weis, N., Hendel, H. W., Andreassen, B. U., Eldrup, E., Dela, F., & Pedersen, B. K. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00027-7 · Cited by 342
Signal transduction and functional changes in neutrophils with aging
Fülöp, T., Larbi, A., Douziech, N., Fortin, C. F., Guérard, K., Lesur, O., Khalil, A., & Dupuis, G. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00110.x · Cited by 331
Moser, R., Schleiffenbaum, B. E., Groscurth, P., & Fehr, J. S. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113903 · Cited by 319
The clearance of dying cells: table for two
Green, D. R., Oguin, T. H., & Martinez, J. (2016) · Cell Death & Differentiation · doi:10.1038/cdd.2015.172 · Cited by 314
Saha, R. N., Jana, M., & Pahan, K. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.10.7101 · Cited by 290
Frasch, S. C., Nick, J. A., Fadok, V. A., Bratton, D. L., Worthen, G. S., & Henson, P. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.14.8389 · Cited by 275
Arnardottir, H. H., Dalli, J., Colas, R. A., Shinohara, M., & Serhan, C. N. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401313 · Cited by 177
Wong, K., Valdez, P. A., Tan, C., Yeh, S. H., Hongo, J.-A., & Ouyang, W. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910929107 · Cited by 173
Soki, F. N., Koh, A. J., Jones, J., Kim, Y. W., Dai, J., Keller, E. T., Pienta, K. J., Atabai, K., Roca, H., & McCauley, L. K. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.571620 · Cited by 173
Clearance of Apoptotic Cells in Human SLE
Gaipl, U. S., Kuhn, A., Sheriff, A., Munoz, L. E., Franz, S., Voll, R. E., Kalden, J. R., & i, M. H. (2005) · KARGER eBooks · doi:10.1159/000090781 · Cited by 170
Tim4- and MerTK-Mediated Engulfment of Apoptotic Cells by Mouse Resident Peritoneal Macrophages
Nishi, C., Toda, S., Segawa, K., & Nagata, S. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01394-13 · Cited by 161
Aged marrow macrophages expand platelet-biased hematopoietic stem cells via interleukin-1B
Frisch, B. J., Hoffman, C. M., Latchney, S. E., LaMere, M. W., Myers, J., Ashton, J., Li, A. J., Saunders, J., Palis, J., Perkins, A. S., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.124213 · Cited by 160
Resolution of acute inflammation bridges the gap between innate and adaptive immunity
Newson, J., Stables, M. J., Karra, E., Vargas, F. A., Quezada, S. A., Motwani, M. P., Mack, M., Yona, S., Audzevich, T., & Gilroy, D. W. (2014) · Blood · doi:10.1182/blood-2014-03-562710 · Cited by 159
The Phosphatidylserine Receptor TIM-4 Does Not Mediate Direct Signaling
Park, D., Hochreiter, A. E., & Ravichandran, K. S. (2009) · Current Biology · doi:10.1016/j.cub.2009.01.042 · Cited by 158
Tibrewal, N., Wu, Y., D’Mello, V., Akakura, R., George, T. C., Varnum, B. C., & Birge, R. B. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706906200 · Cited by 156
Yang, P.-C., Xing, Z., Berin, M. C., Söderholm, J. D., Feng, B., Wu, L. H., & Yeh, C. H. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.08.006 · Cited by 151
Apoptotic Cells Protect Mice against Lipopolysaccharide-Induced Shock
Ren, Y., Xie, Y., Jiang, G., B, J. F. A., Yeung, J. S. L., Li, W., Tam, P. K. H., & Savill, J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.4978 · Cited by 150
New insights into the resolution of inflammation
Gilroy, D. W., & Maeyer, R. P. H. D. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.05.003 · Cited by 134
TNF-alpha-induced transendothelial neutrophil migration is IL-8 dependent
Smart, S. J., & Casale, T. B. (1994) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1994.266.3.l238 · Cited by 122
Poizat, C. I., Puri, P., Bai, Y., & Kedes, L. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.7.2673-2687.2005 · Cited by 116
Feng, B., Chen, X., He, S., Zheng, P., Foster, J. A., Xing, Z., Bienenstock, J., & Yang, P. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.04.036 · Cited by 107
TIM-4 Expressed on APCs Induces T Cell Expansion and Survival
Rodriguez‐Manzanet, R., Meyers, J. H., Balasubramanian, S., Slavik, J. M., Kassam, N., Dardalhon, V., Greenfield, E. A., Anderson, A. C., Sobel, R. A., Hafler, D. A., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.4706 · Cited by 105
Vukmanovic-Stejic, M., Chambers, E. S., Suárez-Fariñas, M., Sandhu, D., Fuentes-Duculan, J., Patel, N., Agius, E., Lacy, K. E., Turner, C. T., Larbi, A., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.10.032 · Cited by 103
Self-citationNavarro-Xavier, R., Newson, J., Silveira, V. L. F., Farrow, S. N., Gilroy, D. W., & Byström, J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902866 · Cited by 99
LXRα Regulates Macrophage Arginase 1 Through PU.1 and Interferon Regulatory Factor 8
Pourcet, B., Feig, J. E., Vengrenyuk, Y., Hobbs, A. J., Kepka-Lenhart, D., Garabedian, M. J., Morris, S. M., Fisher, E. A., & Pineda-Torra, I. (2011) · Circulation Research · doi:10.1161/circresaha.111.241810 · Cited by 97
Clearance of Dying Cells by Phagocytes: Mechanisms and Implications for Disease Pathogenesis
Fond, A. M., & Ravichandran, K. S. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-39406-0_2 · Cited by 97
Watz, H., Barnacle, H., Hartley, B. F., & Chan, R. H. (2013) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70200-5 · Cited by 96
Spontaneous and Fas-Induced Apoptotic Cell Death in Aged Neutrophils
Tortorella, C., Piazzolla, G., Spaccavento, F., Pece, S., Jirillo, E., & Antonaci, S. (1998) · Journal of Clinical Immunology · doi:10.1023/a:1023286831246 · Cited by 80
The role of the MAPK pathway alterations in GM-CSF modulated human neutrophil apoptosis with aging
Larbi, A., Douziech, N., Fortin, C. F., Linteau, A., Dupuis, G., & Fülöp, T. (2005) · Immunity & Ageing · doi:10.1186/1742-4933-2-6 · Cited by 79
Newson, J., Motwani, M. P., Kendall, A. C., Nicolaou, A., Muccioli, G. G., Alhouayek, M., Bennett, M., van de Merwe, R. C., Naomi-James, S., Maeyer, R. P. H. D., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.098 · Cited by 78
Neutrophil migration, oxidative metabolism, and adhesion in elderly and young subjects
Biasi, D., Carletto, A., Dell’Agnola, C., Caramaschi, P., Montesanti, F., Zavateri, G., Zeminian, S., Bellavite, P., & Bambara, L. M. (1996) · Inflammation · doi:10.1007/bf01488803 · Cited by 76
Laplante, P., Brillant-Marquis, F., Brissette, M.-J., Joannette-Pilon, B., Cayrol, R., Kokta, V., & Cailhier, J. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.04.030 · Cited by 68
Foks, A. C., Engelbertsen, D., Kuperwaser, F., Alberts-Grill, N., Gonen, A., Witztum, J. L., Lederer, J., Jarolim, P., DeKruyff, R. H., Freeman, G. J., et al. (2016) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.115.306860 · Cited by 64
Bewley, M. A., Belchamber, K. B. R., Chana, K. K., Budd, R. C., Donaldson, G., Wedzicha, J. A., Brightling, C. E., Kilty, I., Donnelly, L. E., Barnes, P. J., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0163139 · Cited by 64
Kinetic and comparative studies on localized leukocyte mobilization in normal man.
Senn, H.-J., Holland, J. F., & Banerjee, T. K. (1969) · PubMed · Cited by 62
Albacker, L. A., Yu, S., Bedoret, D., Lee, W.-L., Umetsu, S. E., Monahan, S., Freeman, G. J., Umetsu, D. T., & DeKruyff, R. H. (2012) · Mucosal Immunology · doi:10.1038/mi.2012.100 · Cited by 55
Wang, Q., Han, C., Zhao, R., Wani, G., Zhu, Q., Gong, L., Battu, A., Racoma, I. O., Sharma, N., & Wani, A. A. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1312 · Cited by 52
Sheth, K. R., Friel, J. C., Nolan, B. W., & Bankey, P. E. (2001) · Surgery · doi:10.1067/msy.2001.115902 · Cited by 52
Yi, Z., Li, L., Matsushima, G. K., Earp, H. S., Wang, B., & Tisch, R. (2009) · Blood · doi:10.1182/blood-2009-03-207522 · Cited by 46
Bonnefoy, F., Daoui, A., Valmary‐Degano, S., Toussirot, É., Saas, P., & Perruche, S. (2016) · Arthritis Research & Therapy · doi:10.1186/s13075-016-1084-0 · Cited by 39
Characterisation of Leukocytes in a Human Skin Blister Model of Acute Inflammation and Resolution
Jenner, W. J., Motwani, M. P., Veighey, K. V., Newson, J., Audzevich, T., Nicolaou, A., Murphy, S., MacAllister, R. J., & Gilroy, D. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089375 · Cited by 37
Fehr, S., Unger, A., Schaeffeler, E., Herrmann, S., Laufer, S., Schwab, M. G., & Albrecht, W. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000430188 · Cited by 25
Histone acetyltransferease p300 modulates TIM4 expression in dendritic cells
Yang, B., Li, L.-J., Xu, L., Liu, J., Zhang, H., Geng, X., Liu, Z.-G., & Yang, P. (2016) · Scientific Reports · doi:10.1038/srep21336 · Cited by 23
Validation of the cantharidin‐induced skin blister as an in vivo model of inflammation
Dinh, P., Corazza, F., Mestdagh, K., Kassengera, Z., Doyen, V., & Michel, O. (2011) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2011.04020.x · Cited by 21
Cantharidin-induced acantholysis.
Piérard-Franchimont, C., & Pierard, G. (1988) · PubMed · Cited by 14
‘This way please’: Apoptotic cells regulate phagocyte migration before and after engulfment
Ariel, A., & Ravichandran, K. S. (2016) · European Journal of Immunology · doi:10.1002/eji.201646505 · Cited by 12
Assessment of Leukocyte Trafficking in Humans using the Cantharidin Blister Model
Jenner, W. J., & Gilroy, D. W. (2012) · JRSM Cardiovascular Disease · doi:10.1258/cvd.2012.012009 · Cited by 9
Hilligan, K. L., Connor, L. M., Schmidt, A., & Ronchese, F. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158775 · Cited by 8
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Metadata
- Authors
- De Maeyer, R. P. H., van de Merwe, R. C., Louie, R., Bracken, O. V., Devine, O. P., Goldstein, D. R., Uddin, M., Akbar, A. N., & Gilroy, D. W.
- Affiliations
- University College London (GB)
- University of Michigan (US)
- AstraZeneca (Sweden) (SE)
- Corresponding author
- Gilroy, Derek W.
- ORCID
- Venue
- Nature Immunology
- Published
- 2020-04-06
- Volume
- 21
- Issue
- 6
- Pages
- 615-625
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC7983074
- OpenAlex
- W3014659762
- Semantic Scholar
- d20b763d1d35cbc8254cfdf16cc07adc8e7fcef2
- Cited by
- 182
- References
- 71
- Citations by year
- 2026: 25 · 2025: 38 · 2024: 30 · 2023: 21 · 2022: 26 · 2021: 27 · 2020: 15
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Update notices
- correction (2020-04-17)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- RCUK | Medical Research Council (MR/J006610/1, MR/M003833/1)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- p38 MAPK, efferocytosis, inflammation resolution, TIM-4, macrophages, aging, phosphatidylserine receptor, chronic inflammation, innate immunity
- MeSH terms
- Age Factors, Aged, Animals, Blister, Cantharidin, Humans, Immunity, Innate, Inflammation, Macrophages, Male, Membrane Proteins, Neutrophils, Phagocytosis, Receptors, Cell Surface, Signal Transduction, Gene Expression, Apoptosis, p38 Mitogen-Activated Protein Kinases
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