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Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection
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Abstract
The immune response to SARS-CoV-2 is critical in controlling disease, but there is concern that waning immunity may predispose to reinfection. We analyzed the magnitude and phenotype of the SARS-CoV-2-specific T cell response in 100 donors at 6 months following infection. T cell responses were present by ELISPOT and/or intracellular cytokine staining analysis in all donors and characterized by predominant CD4+ T cell responses with strong interleukin (IL)-2 cytokine expression. Median T cell responses were 50% higher in donors who had experienced a symptomatic infection, indicating that the severity of primary infection establishes a 'set point' for cellular immunity. T cell responses to spike and nucleoprotein/membrane proteins were correlated with peak antibody levels. Furthermore, higher levels of nucleoprotein-specific T cells were associated with preservation of nucleoprotein-specific antibody level although no such correlation was observed in relation to spike-specific responses. In conclusion, our data are reassuring that functional SARS-CoV-2-specific T cell responses are retained at 6 months following infection.
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“Using HLA class I and II predicted peptide “megapools,” circulating SARS-CoV-2-specific CD8+ and CD4+ T cells were identified in COVID-19 acute, mild and convalescent patients [110, 118-125].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [124]
Experimental — accuracy not yet measuredIn the citing paper
“documented examples of SARS-CoV-2 reinfection as well as evidence of short-lived immunity to endemic human coronavirus (hCoV) infections raise the prospect that protective immunity after SARS-CoV-2 infection may last for months instead of years.”
From Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection (2021) · cites this paper as [10]
In the citing paper
“Cellular responses to infection seem to be generally more stable3,8,10 (Fig. 1) but their role in immune protection is not yet clear”
From Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection (2021) · cites this paper as [10]
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Cites
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884
Grifoni, A., Weiskopf, D., Ramirez, S. I., Mateus, J., Dan, J. M., Moderbacher, C. R., Rawlings, S. A., Sutherland, A., Premkumar, L., Jadi, R. S., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.015 · Cited by 3,595
Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
Sallusto, F., Geginat, J., & Lanzavecchia, A. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104702 · Cited by 3,067
Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections
Long, Q.-X., Tang, X.-J., Shi, Q.-L., Li, Q., Deng, H.-J., Yuan, J., Hu, J.-L., Xu, W., Zhang, Y., Lv, F.-J., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0965-6 · Cited by 2,686
SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls
Le Bert, N., Tan, A. T., Kunasegaran, K., Tham, C. Y. L., Hafezi, M., Chia, A., Chng, M. H. Y., Lin, M., Tan, N., Linster, M., et al. (2020) · Nature · doi:10.1038/s41586-020-2550-z · Cited by 1,887
Rydyznski Moderbacher, C., Ramirez, S. I., Dan, J. M., Grifoni, A., Hastie, K. M., Weiskopf, D., Belanger, S., Abbott, R. K., Kim, C., Choi, J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.038 · Cited by 1,790 · cited 2×
“IFN-g responses are broadly equivalent to IL2 at early time points after infection (24) but the profile at 6 months suggests that the relative proportion of Th1 effector cells decreases over time or they revert to central memory state (25).”
A serological assay to detect SARS-CoV-2 seroconversion in humans
Amanat, F., Stadlbauer, D., Strohmeier, S., Nguyen, T. H. O., Chromikova, V., McMahon, M., Jiang, K., Arunkumar, G. A., Jurczyszak, D., Polanco, J., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0913-5 · Cited by 1,769
T-cell quality in memory and protection: implications for vaccine design
Seder, R. A., Darrah, P. A., & Roederer, M. (2008) · Nature reviews. Immunology · doi:10.1038/nri2274 · Cited by 1,565
Mathew, D., Giles, J. R., Baxter, A. E., Oldridge, D. A., Greenplate, A. R., Wu, J. E., Alanio, C., Kuri-Cervantes, L., Pampena, M. B., D’Andrea, K., et al. (2020) · Science · doi:10.1126/science.abc8511 · Cited by 1,509
Viral Load Dynamics and Clinical Disease Severity in Patients with SARS-CoV-2 Infection
Zheng, S., Fan, J., Yu, F., Feng, B., Lou, B., Zou, Q., Xie, G., Lin, S., Wang, R., Yang, X., et al. (2020) · BMJ · doi:10.1136/bmj.m1443 · Cited by 1,479
Cited by
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Items 201–300 of 392
Pathophysiological conditions induced by SARS-CoV-2 infection reduce ACE2 expression in the lung
Miura, Y., Ohkubo, H., Nakano, A., Bourke, J. E., & Kanazawa, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1028613 · Cited by 9
Dang, T. T. T., Anzurez, A., Nakayama‐Hosoya, K., Miki, S., Yamashita, K., de Souza, M. S., Matano, T., & Kawana‐Tachikawa, A. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.02143-23 · Cited by 10
Humoral and cellular immunity against diverse SARS-CoV-2 variants
Chen, C., Wang, X., & Zhang, Z. (2023) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2023.10.003 · Cited by 10
Adaptive immune responses to SARS-CoV-2 in recovered severe COVID-19 patients
Olea, B., Albert, E., Torres, I., Amat, P., Remigia, M. J., Gozalbo‐Rovira, R., Rodríguez‐Díaz, J., Buesa, J., Blasco, M. L., Redón, J., et al. (2021) · Journal of Clinical Virology · doi:10.1016/j.jcv.2021.104943 · Cited by 9
Strategies and safety considerations of booster vaccination in COVID-19
Meng, H., Mao, J., & Ye, Q. (2022) · Biomolecules and Biomedicine · doi:10.17305/bjbms.2021.7082 · Cited by 12
T-cell proliferation assay for the detection of SARS-CoV-2-specific T-cells
Chu, C., Schönbrunn, A., Elitok, S., Kern, F., Schnatbaum, K., Wenschuh, H., Klemm, K., von Baehr, V., Krämer, B. K., & Hocher, B. (2022) · Clinica Chimica Acta · doi:10.1016/j.cca.2022.05.025 · Cited by 9
Longitudinal survey of humoral and cellular response to SARS-CoV-2 infection in children
Ruedas-López, A., Berzosa, A., Illán-Ramos, M., Caballero, I. C., Guillén-Martín, S., Bodas-Pinedo, A., Rueda-Esteban, S., Pérez‐Rodríguez, O., López, R. V., Lara, D. L., et al. (2022) · Microbiological Research · doi:10.1016/j.micres.2022.127145 · Cited by 9
Huang, R., Ying, L., Wang, J., Xia, J. L., Zhang, Y., Mao, H., Zhang, R., Zang, R., Le, Z., Shu, Q., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1139620 · Cited by 9
Culinary spices and herbs in managing early and long‐COVID‐19 complications: A comprehensive review
Maurya, D. K., & Sharma, D. (2023) · Phytotherapy Research · doi:10.1002/ptr.7957 · Cited by 9
Pinto, M. D. O. S., Pereira, L. D. P., Angelo, A. L. P. D. M., Pascoal-Xavier, M. A., Machado, A. V., & Russo, R. C. (2025) · Journal of Molecular Recognition · doi:10.1002/jmr.70002 · Cited by 8
Overheu, O., Quast, D. R., Schmidt, W. E., Sakιnç, T., & Reinacher‐Schick, A. (2021) · Oncology Research and Treatment · doi:10.1159/000520572 · Cited by 8
Odak, I., Schultze-Florey, C. R., Hammerschmidt, S. I., Ritter, C., Willenzon, S., Friedrichsen, M., Ravens, I., Sikora, R., Bayir, L. M., Jauregui, R. G., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.863039 · Cited by 8
Waning Immunity 14 Months After SARS-CoV-2 Infection
Stich, M., Benning, L., Speer, C., Garbade, S. F., Bartenschlager, M., Kim, H., Gleich, F., Jeltsch, K., Haase, B., Janda, A., et al. (2022) · PEDIATRICS · doi:10.1542/peds.2022-057151 · Cited by 9
Measuring T-Cell Responses against SARS-CoV-2 Is of Utility for Disease and Vaccination Management
Safont, G., Latorre, I., Villar-Hernández, R., Stojanović, Z., Marín, A., Pérez-Cano, C., Lacoma, A., Molina-Moya, B., Solis, A. J., Arméstar, F., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11175103 · Cited by 8
Wehr, C., Meyer, T., Ihorst, G., Bartsch, I., Zeiser, R., Wäsch, R., Bertz, H., Finke, J., & Huzly, D. (2022) · Vaccines · doi:10.3390/vaccines10111782 · Cited by 9
CD4 and IL-2 mediated NK cell responses after COVID-19 infection and mRNA vaccination in adults
Alhajjat, A. M., Redden, C. R., Langereis, M. M., Papastefan, S. T., Ito, J. A. S., Ott, K. C., Turner, L. E., Kang, H. K., & Shaaban, A. F. (2022) · Immunobiology · doi:10.1016/j.imbio.2022.152304 · Cited by 9
Benede, N., Tincho, M. B., Walters, A., Subbiah, V., Ngomti, A., Baguma, R., Butters, C., Hähnle, L., Mennen, M., Skelem, S., et al. (2023) · iScience · doi:10.1016/j.isci.2023.108728 · Cited by 10
Future developments in the prevention, diagnosis and treatment of COVID-19
Coltart, C. E. M., & Collet-Fenson, L. B. (2021) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2021.03.012 · Cited by 9
García‐Torre, A., Bueno‐García, E., López‐Martínez, R., Rioseras, B., Moro‐García, M. A., Alonso, S., Lluna-González, A., Sousa-Fernández, A., Fernández-Gudin, M., Campos-Riopedre, L., et al. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab206 · Cited by 7
Cellular and humoral responses to SARS-CoV-2 vaccination in immunosuppressed patients
Mohanraj, D., Baldwin, S., Singh, S., Gordon, A., & Whitelegg, A. M. E. (2022) · Cellular Immunology · doi:10.1016/j.cellimm.2022.104501 · Cited by 10
Tut, G., Lancaster, T., Butler, M. S., Sylla, P., Spalkova, E., Bone, D., Kaur, N., Bentley, C., Amin, U., Jadir, A., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00224-w · Cited by 9
Self-citationSARS-CoV-2 Spike-Derived Peptides Presented by HLA Molecules
Nguyen, A., Szeto, C. W., Jayasinghe, D., Lobos, C. A., Halim, H., Chatzileontiadou, D. S. M., Grant, E. J., & Gras, S. (2021) · Biophysica · doi:10.3390/biophysica1020015 · Cited by 10
Covid-19: T cell response lasts for at least six months after infection, study shows
Wise, J. (2020) · BMJ · doi:10.1136/bmj.m4257 · Cited by 8
Weisbrod, L., Capriotti, L., Hofmann, M., Spieler, V., Dersch, H., Voedisch, B., Schmidt, P. M., & Knake, S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1386160 · Cited by 7
Design of a Multi-Valent SARS-CoV-2 Peptide Vaccine for Broad Immune Protection via Deep Learning
Feng, Z., Pang, X., Xu, Q., Gu, Z., Li, S., Zhu, L., & Li, H. (2025) · Engineering · doi:10.1016/j.eng.2025.04.025 · Cited by 7
Hu, W., He, M., Wang, X., Sun, Q., & Kuang, M. (2021) · Vaccines · doi:10.3390/vaccines9101093 · Cited by 7
Pregnant Women Develop a Specific Immunological Long-Lived Memory Against SARS-COV-2
Fenizia, C., Cetin, I., Mileto, D., Vanetti, C., Saulle, I., Giminiani, M. D., Saresella, M., Parisi, F., Trabattoni, D., Clerici, M., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.827889 · Cited by 7
Aleksova, M., Todorova, Y., Emilova, R., Baymakova, M. P., Yancheva, N., Andonova, R., Zasheva, A., Grifoni, A., Weiskopf, D., Sette, A., et al. (2023) · Diagnostics · doi:10.3390/diagnostics13071280 · Cited by 7
Nonconserved epitopes dominate reverse preexisting T cell immunity in COVID-19 convalescents
Wang, X., Zhang, J., Liu, M., Guo, Y., Guo, P., Yang, X., Shang, B., Li, M., Tian, J., Zhang, T., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01876-3 · Cited by 7
Sjöwall, J., Hjorth, M., Gustafsson, A., Göransson, R., Larsson, M., Waller, H., Nordgren, J., Nilsdotter‐Augustinsson, Å., & Nyström, S. N. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11123535 · Cited by 7
Distorted TCR repertoires define multisystem inflammatory syndrome in children
Malik, A., Tóth, E. N., Teng, M. S., Hurst, J. M., Watt, E., Wise, L., Kent, N., Bartram, J. L., Grandjean, L., Dominguez‐Villar, M., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0274289 · Cited by 8
Rosa, C. L., Chiuppesi, F., Park, Y., Zhou, Q., Yang, D., Gendzekhadze, K., Ly, M., Li, J., Kaltcheva, T. I., Ortega‐Francisco, S., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1114131 · Cited by 7
Seo, Y. J., Oh, I., Nam, M., Shin, S., Roh, E. Y., & Song, E. Y. (2023) · Annals of Laboratory Medicine · doi:10.3343/alm.2023.43.6.596 · Cited by 8
Pitiriga, V. C., Papamentzelopoulou, M., Konstantinakou, K. E., Vasileiou, I. V., Sakellariou, K. S., Spyrou, N. I., & Tsakris, A. (2023) · Vaccines · doi:10.3390/vaccines11121764 · Cited by 7
Diego, J. G.-B., Singh, G., Jangra, S., Handrejk, K., Laporte, M., Chang, L. A., Zahed, S. S. E., Pache, L., Chang, M. W., Warang, P., et al. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1011805 · Cited by 8
Kang, H., Jung, J. H., Ko, G. Y., Lee, J., & Oh, E. (2024) · Vaccines · doi:10.3390/vaccines12030301 · Cited by 7
Topîrceanu, A. (2021) · Procedia Computer Science · doi:10.1016/j.procs.2021.08.217 · Cited by 9
Kinetics of SARS-CoV-2-Neutralising Antibodies of Residents of Long-Term Care Facilities
Moyet, J., Helle, F., Bourdenet, G., Joseph, C., Gubler, B., Deschasse, G., Defouilloy, I., Slovenski, T., François, C., Liabeuf, S., et al. (2021) · The journal of nutrition health & aging · doi:10.1007/s12603-021-1713-4 · Cited by 7
SARS-CoV-2 virus lacking the envelope and membrane open-reading frames as a vaccine platform
Kuroda, M., Halfmann, P., Uraki, R., Yamayoshi, S., Kim, T., Armbrust, T. A., Spyra, S., Dahn, R., Babujee, L., & Kawaoka, Y. (2025) · Nature Communications · doi:10.1038/s41467-025-59533-4 · Cited by 6
Fenn, J. R., Koycheva, A., Kundu, R., Tolosa-Wright, M., Wang, L., Narean, J. S., Conibear, E., Hakki, S., Jonnerby, J., Baldwin, S., et al. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105795 · Cited by 6
Impact of Maternal Exposure to SARS-CoV-2 on Immunological Components of Breast Milk
Graciliano, N. G., Goulart, M. O. F., & de Oliveira, A. C. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062600 · Cited by 6
Müller, T. M., Becker, E. M., Wiendl, M., Schulze, L. L., Voskens, C., Völkl, S., Kremer, A. E., Neurath, M. F., & Zundler, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.639329 · Cited by 10
Kamińska, D., Augustyniak‐Bartosik, H., Kościelska−Kasprzak, K., Żabińska, M., Bartoszek, D., Poznański, P., Kuriata-Kordek, M., Kusztal, M. A., Mazanowska, O., & Krajewska, M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10214833 · Cited by 6
The effect of age on the magnitude and longevity of Th1‐directed CD4 T‐cell responses to SARS‐CoV ‐2
Nattrass, R. G., Krafft, L., Zjablovskaja, P., Schuster, M., Kasmapour, B., Sarisoy, C., Minich, J., Bach, E., & Streeck, H. (2022) · Immunology · doi:10.1111/imm.13475 · Cited by 4
CoVITEST: A Fast and Reliable Method to Monitor Anti-SARS-CoV-2 Specific T Cells From Whole Blood
Egri, N., Olivé, V., Hernández‐Rodríguez, J., Castro, P., Guzman, C. D., Heredia, L., Segura, A. C., Fernandez, M. D., de Moner, N., Torradeflot, M., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.848586 · Cited by 6
Act Early and at the Right Location: SARS-CoV-2 T Cell Kinetics and Tissue Localization
Bertoletti, A., Bert, N. L., & Tan, A. T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810679 · Cited by 6
Clemenceau, B., Bourgeois, A. L., Guillaume, T., Coste‐Burel, M., Péterlin, P., Garnier, A., Jullien, M., Ollier, J., Grain, A., Béné, M. C., et al. (2022) · Cells · doi:10.3390/cells11193010 · Cited by 6
Vangeti, S., Periasamy, S., Sun, P., Balinsky, C. A., Mahajan, A. S., Kuzmina, N. A., Schanoski, A. S., Cooper, E. S., Beckett, C. G., Marayag, J., et al. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.01837-22 · Cited by 7
Hong, L., Nian, X., Wu, J., Liu, D., Feng, L. Z., Lu, J., Peng, Y., Zhou, Z., Deng, T., Liu, J., et al. (2022) · Cell Discovery · doi:10.1038/s41421-022-00496-x · Cited by 6
Topîrceanu, A. (2023) · Mathematics · doi:10.3390/math11061336 · Cited by 11
Gui, Y., Cao, Y., He, J., Zhao, C., Zheng, W., Qian, L., Cheng, J., Yu, C., Chen, Y., Lou, K., et al. (2023) · Life Metabolism · doi:10.1093/lifemeta/load019 · Cited by 6
The coevolution of Covid-19 and host immunity
Haque, A., & Pant, A. B. (2024) · Exploration of Medicine · doi:10.37349/emed.2024.00214 · Cited by 8
Two-Step In Vitro Model to Evaluate the Cellular Immune Response to SARS-CoV-2
Melgaço, J. G., Azamor, T., da Silva, A. M. V., Linhares, J., Santos, T. P., Mendes, Y. S., de Lima, S. M. B., Fernandes, C. B., da Silva, J., de Souza, A. P., et al. (2021) · Cells · doi:10.3390/cells10092206 · Cited by 8
Li, X., Pang, L., Yin, Y., Zhang, Y., Xu, S., Xu, D., & Shen, T. (2022) · Viruses · doi:10.3390/v14010080 · Cited by 6
Kim, S.-J., Kim, Y., Jeon, S., Park, U., Kang, J.-I., Jeon, K., Kim, H. R., Oh, S., Rhee, J.-Y., Choi, J., et al. (2024) · Science Advances · doi:10.1126/sciadv.adk6425 · Cited by 6
Deng, S., Xu, Z., Hu, J., Yang, Y., Zhu, F., Liu, Z., Zhang, H., Wu, S., & Jin, T. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1468456 · Cited by 5
Potensi Curcumin dan 4 Herbal Empon-Empon Dalam Memodulasi Kekebalan Sel T Terhadap Covid-19
Tedjo, A., Noor, D. R., & Heryanto, R. (2021) · Herb-Medicine Journal Terbitan Berkala Ilmiah Herbal Kedokteran dan Kesehatan · doi:10.30595/hmj.v4i3.10209 · Cited by 5
Zavaglio, F., Cassaniti, I., Sammartino, J. C., Tonello, S., Sainaghi, P. P., Novelli, V., Meloni, F., Lilleri, D., & Baldanti, F. (2022) · Microorganisms · doi:10.3390/microorganisms10061250 · Cited by 4
Prospects of animal models and their application in studies on adaptive immunity to SARS-CoV-2
Wei, X., Rong, N., & Liu, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.993754 · Cited by 6
Zhou, D., Zhao, S., He, K., Liu, Q., Zhang, F., Pu, Z., Xiao, L., Zhang, L., Chen, S., Qian, X., et al. (2024) · BMC Infectious Diseases · doi:10.1186/s12879-024-09464-0 · Cited by 5
Blasco, A., Royuela, A., García-Gómez, S., Gómez‐Lozano, N., Sánchez-Arjona, A., de la Fuente, J., Anel, J., Galarraga, I. S., Redondo, M. P., González, E., et al. (2024) · Vaccine · doi:10.1016/j.vaccine.2024.126305 · Cited by 7
Tripathy, A. S., Singh, D., Trimbake, D., Salwe, S., Tripathy, S. P., Kakrani, A. L., Jali, P., Chavan, H., Yadav, P. D., Sahay, R. R., et al. (2024) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2024.2410579 · Cited by 5
The immune response to the novel coronavirus infection
Fedorov, V. S., Ivanova, O. N., Karpenko, I. L., & Ivanov, A. V. (2021) · Journal of clinical practice · doi:10.17816/clinpract64677 · Cited by 7
The protective immunity induced by SARS-CoV-2 infection and vaccination: a critical appraisal
Tosta, E. (2021) · Exploration of Immunology · doi:10.37349/ei.2021.00014 · Cited by 5
An immunologist's perspective on anti-COVID-19 vaccines
Milota, T., Strizova, Z. O., Smetanová, J., & Šedivá, A. (2021) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000788 · Cited by 5
Hagens, A., Cordova-Pozo, K. L., Postma, M. J., Wilschut, J. A., Zino, L., & van der Schans, J. (2022) · Frontiers in Medical Technology · doi:10.3389/fmedt.2021.666581 · Cited by 5
Suntronwong, N., Kanokudom, S., Auphimai, C., Thongmee, T., Assawakosri, S., Vichaiwattana, P., Yorsaeng, R., Duangchinda, T., Chantima, W., Pakchotanon, P., et al. (2024) · Vaccines · doi:10.3390/vaccines12020180 · Cited by 7
Zhang, C., Jin, X., Chen, X., Li, Q., Leng, Q., & Qiu, T. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.599562 · Cited by 5
Viana, K. F., Zarpelon, L. F. B., Leandro, A., Terêncio, M. L., Lopes, R. D., Martins, C. A., Silva, I., Sibim, A. C., Marques, F., SILVA, R. D., et al. (2021) · Journal of General Virology · doi:10.1099/jgv.0.001684 · Cited by 4
Time-dependent contraction of the SARS-CoV-2–specific T-cell responses in convalescent individuals
Fernandes, E. R., Apostólico, J. D. S., Jacintho, L. C., Marin, M. L. C., Júnior, R. C. V. D. S., Rodrigues, H., Santos, K. S., Coelho, V. P. C. V., Boscardin, S. B., Kalil, J. E., et al. (2022) · Journal of Allergy and Clinical Immunology Global · doi:10.1016/j.jacig.2022.05.002 · Cited by 4
Improved Performance of the QuantiFERON-SARS-CoV-2 Assay with the Extended Set
Mahammed, L. L., Bensaid, K., Ait-Seddik, S., Larinouna, A., Brahimi, G., Belkaid, R., Hamzaoui, O., Rouaki, S. M., Idder, C., Allam, I., et al. (2023) · Viruses · doi:10.3390/v15051179 · Cited by 4
Piñana, J. L., Guerreiro, M., & Solano, C. (2023) · Hemato · doi:10.3390/hemato4020014 · Cited by 4
Ssali, I., Mugaba, S., Watelo, A. K., Bemanzi, J., Katende, J. S., Oluka, G. K., Ankunda, V., Baine, C., Kato, L., Onyachi, N., et al. (2023) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2023.09.001 · Cited by 4
Baum, H. E., Santopaolo, M., Francis, O., Milodowski, E., Entwistle, K., Oliver, E., Hitchings, B., Diamond, D., Thomas, A. C., Mitchell, R. E., et al. (2025) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaf246 · Cited by 5
Immunological Biomarkers in Blood to Monitor the Course and Therapeutic Outcomes of COVID-19
Wieland, E. (2021) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0000000000000945 · Cited by 4
Dowell, A. C., Powell, A. A., Davis, C., Scott, S., Logan, N. A., Willett, B. J., Bruton, R. K., Ayodele, M., Jinks, E., Gunn, J., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.882515 · Cited by 5
Self-citationVallejo, A., Vizcarra, P., Martín-Hondarza, A., Gómez-Maldonado, S., Häemmerle, J., Velasco, H., & Casado, J. L. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1002748 · Cited by 4
Highly Networked SARS-CoV-2 Peptides Elicit T Cell Responses with Enhanced Specificity
Duette, G., Lee, E., Gomes, G. M. C., Tungatt, K., Doyle, C. M., Stylianou, V. V., Lee, A., Maddocks, S., Taylor, J., Khanna, R., et al. (2023) · ImmunoHorizons · doi:10.4049/immunohorizons.2300034 · Cited by 4
Available COVID-19 serial seroconversion panel for validation of SARS-CoV-2 antibody assays.
Belda, F., López‐Martínez, M., Torres, N., Cherenzia, R., & Crowley, M. (2021) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2021.115340 · Cited by 4
Mongkolsucharitkul, P., Surawit, A., Pumeiam, S., Sookrung, N., Tungtrongchitr, A., Phisalprapa, P., Sayabovorn, N., Srivanichakorn, W., Washirasaksiri, C., Auesomwang, C., et al. (2022) · Vaccines · doi:10.3390/vaccines10071131 · Cited by 4
Immune Dynamics Involved in Acute and Convalescent COVID-19 Patients
Silva-Junior, A. L., Oliveira, L. D. S., Belezia, N. C. T., Tarragô, A. M., Costa, A. G., & Malheiro, A. (2023) · Immuno · doi:10.3390/immuno3010007 · Cited by 4
Tut, G., Lancaster, T., Krutikov, M., Sylla, P., Bone, D., Spalkova, E., Bentley, C., Amin, U., Jadir, A., Hulme, S., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3990239 · Cited by 4
Self-citationRapid diagnostic test for assessment of cellular immune response in a viral infection as a model
Bernuz, M., Porras, J. C., Egri, N., González‐Navarro, E. A., Juan, M., Pividori, M. I., & Martı́, M. (2024) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2024.136185 · Cited by 3
Immune Responses of Dendritic Cells to Zoonotic DNA and RNA Viruses
Miao, X., Han, Y., Yin, Y., Yang, Y., Chen, S., Jiao, X., Qin, T., & Peng, D. (2025) · Veterinary Sciences · doi:10.3390/vetsci12080692 · Cited by 3
Suryawanshi, P. V., Patil‐Takbhate, B., Athavale, P. V., MIRZA, S. B., Tripathy, A. S., Kanitkar, S. A., Shivnitwar, S. K., Barthwal, M. S., Dole, S. S., Chavan, H., et al. (2024) · Immunity Inflammation and Disease · doi:10.1002/iid3.1238 · Cited by 3
McMahon, W. C., Kwatra, G., Izu, A., Jones, S. A., Mbele, N. J., Jafta, N., Lala, R., Shalekoff, S., Tiemessen, C. T., Madhi, S. A., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-70725-8 · Cited by 3
Wang, L., Xu, R., Huang, D., Peng, P., Sun, K., Hu, J., Liu, B., Fang, L., Zhang, L., Sun, X., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-07048-x · Cited by 2
Hsu, C.-Y., Chiu, C.-H., Lin, T., & Chang, F. (2025) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2025.03.009 · Cited by 3
Stich, M., Benning, L., Speer, C., Garbade, S. F., Bartenschlager, M., Kim, H., Jeltsch, K., Tabatabai, J., Niesert, M., Janda, A., et al. (2023) · Journal of Medical Virology · doi:10.1002/jmv.28582 · Cited by 3
Иванов, А. В., Kryshen, E., & Semenova, E. V. (2023) · Journal of Clinical Virology · doi:10.1016/j.jcv.2023.105448 · Cited by 4
Bensaid, K., Mahammed, L. L., Habchi, K., Saidani, M., Allam, I., & Djidjik, R. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12123900 · Cited by 3
Fallet, B., Foglierini, M., Porret, R., Alcaraz‐Serna, A., Sauvage, C., Jenelten, R., Seremet, T., Gilliet, M. F., Perez, L. H., Fenwick, C. W., et al. (2023) · Journal of Infection · doi:10.1016/j.jinf.2023.06.005 · Cited by 4
Petersen, M. S., Pérez‐Alós, L., Kongsstovu, S. Í., Eliasen, E. H., Hansen, C. B., Larsen, S., Hansen, J. L., Bayarri‐Olmos, R., Fjallsbak, J. P., Weihe, P., et al. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.00865-23 · Cited by 3
Misra, P., Garg, P. K., Awasthi, A., Kant, S., Rai, S. K., Ahmad, M., Guleria, R., Deori, T. J., Mandal, S., Jaiswal, A., et al. (2023) · Cureus · doi:10.7759/cureus.48824 · Cited by 3
Study of the cellular and humoral immune responses to SARS-CoV-2 vaccination
Montmaneix-Engels, F., Dimeglio, C., Staes, L., Silva, I. D., Porcheron, M., Jougla, I., Hérin, F., & Izopet, J. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e29116 · Cited by 4
Konuma, T., Hamatani‐Asakura, M., Nagai, E., Adachi, E., Kato, S., Isobe, M., Monna‐Oiwa, M., Takahashi, S., Yotsuyanagi, H., & Nannya, Y. (2024) · International Journal of Hematology · doi:10.1007/s12185-024-03802-3 · Cited by 3
Li, K., Wu, Y., Zhang, H., Chen, S., Wu, B., Li, T., Li, E., Luo, F., Jin, A., Zhang, B., et al. (2024) · Journal of Medical Virology · doi:10.1002/jmv.70134 · Cited by 3
Fukushima, K., Kubo, T., Ito, Y., Oda, Y., Nagayoshi, Y., Fukuda, M., Takazono, T., Sakamoto, N., & Mukae, H. (2025) · Journal of Infection and Chemotherapy · doi:10.1016/j.jiac.2025.102695 · Cited by 3
Reinfection of SARS-CoV-2: reports of three cases from a tertiary care hospital of Bangladesh
Islam, M. J., Ahmed, J. U., & Haque, I. U. (2020) · BIRDEM Medical Journal · doi:10.3329/birdem.v10i0.50994 · Cited by 3
Davarcı, İ., Eryıldız, C., & Gürcan, Ş. (2021) · Flora the Journal of Infectious Diseases and Clinical Microbiology · doi:10.5578/flora.20219813 · Cited by 3
Metadata
- Authors
- Zuo, J., Dowell, A. C., Pearce, H., Verma, K., Long, H. M., Begum, J., Aiano, F., Amin-Chowdhury, Z., Hoschler, K., Brooks, T., Taylor, S., Hewson, J., Hallis, B., Stapley, L., Borrow, R., Linley, E., Ahmad, S., Parker, B., Horsley, A., Amirthalingam, G., Brown, K., Ramsay, M. E., Ladhani, S., & Moss, P.
- Affiliations
- University of Birmingham (GB)
- Manchester Royal Infirmary (GB)
- Manchester Academic Health Science Centre (GB)
- Manchester University NHS Foundation Trust (GB)
- University of Manchester (GB)
- St George's, University of London (GB)
- Corresponding author
- Ladhani, Shamez
- Moss, Paul
- ORCID
- Venue
- Nature Immunology
- Published
- 2021-03-05
- Volume
- 22
- Issue
- 5
- Pages
- 620-626
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC7610739
- OpenAlex
- W3134099704
- Cited by
- 392
- References
- 39
- Citations by year
- 2026: 10 · 2025: 31 · 2024: 37 · 2023: 56 · 2022: 115 · 2021: 137
- FWCI
- 27.48
- Type
- journal article
- Language
- en
- Update notices
- correction (2021-05-20)
- Open access
- bronze
- doi.org
- Locations
- Nature Immunology (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nd)
- Research Square (acceptedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
- Research Explorer (The University of Manchester) (submittedVersion, cc-by-nd)
- Research Explorer (The University of Manchester) (submittedVersion, other-oa)
- Funders
- RCUK | Medical Research Council (MR/R011230/1)
- Bloodwise (17009)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- SARS-CoV-2, COVID-19 pandemic, T cell immunity, CD4+ T cells, waning immunity, reinfection, interleukin-2, spike protein, nucleocapsid protein, membrane proteins, antibody kinetics, symptomatic infection, set point
- MeSH terms
- COVID-19, SARS-CoV-2, Adult, Aged, Antibodies, Viral, Antigens, Viral, Female, Humans, Immunity, Cellular, Interleukin-2, Male, Middle Aged, Phenotype, Time Factors, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Host-Pathogen Interactions, Young Adult
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