Cited by 514Spinal Cord Injury ResearchNerve injury and regenerationMultiple Sclerosis Research Studies

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Spinal cord repair: advances in biology and technology

Courtine, Grégoire, Sofroniew, Michael V.·2019·Nature Medicine

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Abstract

Individuals with spinal cord injury (SCI) can face decades with permanent disabilities. Advances in clinical management have decreased morbidity and improved outcomes, but no randomized clinical trial has demonstrated the efficacy of a repair strategy for improving recovery from SCI. Here, we summarize recent advances in biological and engineering strategies to augment neuroplasticity and/or functional recovery in animal models of SCI that are pushing toward clinical translation.

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Authors: Courtine, G., & Sofroniew, M. V.
Affiliations: Centre Hospitalier Universitaire Vaudois (CH)
University of California, Los Angeles (US)
Corresponding author: Courtine, Grégoire
ORCID: Courtine, Grégoire
Sofroniew, Michael V.
Venue: Nature Medicine
Publisher: Springer Science and Business Media LLC
Published: 2019-06
Volume: 25
Issue: 6
Pages: 898-908
ISSN: 1078-8956 (ISSN-L)
1546-170X
DOI: 10.1038/s41591-019-0475-6
OpenAlex: W2948888731
Cited by: 508
References: 172
Citations by year: 2026: 61 · 2025: 76 · 2024: 66 · 2023: 77 · 2022: 82 · 2021: 73 · 2020: 59 · 2019: 14
FWCI: 8.51
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Medicine (publishedVersion)
PubMed (publishedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Keywords: spinal cord injury, spinal cord repair, neuroplasticity, functional recovery, cell regeneration, animal models, clinical translation
MeSH terms: Animals, Biocompatible Materials, Disease Models, Animal, Humans, Models, Neurological, Neuronal Plasticity, Spinal Cord Injuries, Recovery of Function, Bioengineering, Translational Research, Biomedical, Spinal Cord Regeneration

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