The DOI matches its Crossref record; 172 of the 172 references it cites were found in a registry or an index.
Spinal cord repair: advances in biology and technology
Abstract
Individuals with spinal cord injury (SCI) can face decades with permanent disabilities. Advances in clinical management have decreased morbidity and improved outcomes, but no randomized clinical trial has demonstrated the efficacy of a repair strategy for improving recovery from SCI. Here, we summarize recent advances in biological and engineering strategies to augment neuroplasticity and/or functional recovery in animal models of SCI that are pushing toward clinical translation.
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“Although the majority of spinal cord injuries do not directly damage these neurons, the disruption of descending pathways interrupts the brain-derived commands that are necessary for these neurons to produce walking8.”
From Walking naturally after spinal cord injury using a brain–spine interface (2023) · cites this paper as [8]
In the citing paper
“A severe spinal cord injury (SCI) scatters this exquisitely organized communication system15.”
From The neurons that restore walking after paralysis (2022) · cites this paper as [15]
In the citing paper
“To walk, the brain broadcasts commands through descending pathways that cascade from the brainstem to activate these neurons15,16.”
From The neurons that restore walking after paralysis (2022) · cites this paper as [15]
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Falco, M. V., Fabbiani, G., Prieto, D., Panario, M. V., Verdier, M. B., Rehermann, M. I., Silvera, M. C., Simeone, R., Trigo, F. F., & Russo, R. E. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2605647123
Zhou, P., Zhong, J., Zheng, S., Zhou, L., Zhou, L., Liu, S., Qin, R., Wen, G., 李志忠, Zhu, L., et al. (2026) · Chinese Chemical Letters · doi:10.1016/j.cclet.2026.113539
Calabrò, R. S., Quartarone, A., Calderone, A., Ardizzone, A., Raciti, L., & Morini, E. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27219610
Metadata
- Authors
- Courtine, G., & Sofroniew, M. V.
- Affiliations
- Centre Hospitalier Universitaire Vaudois (CH)
- University of California, Los Angeles (US)
- Corresponding author
- Courtine, Grégoire
- Venue
- Nature Medicine
- Published
- 2019-06
- Volume
- 25
- Issue
- 6
- Pages
- 898-908
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2948888731
- Cited by
- 508
- References
- 172
- Citations by year
- 2026: 61 · 2025: 76 · 2024: 66 · 2023: 77 · 2022: 82 · 2021: 73 · 2020: 59 · 2019: 14
- FWCI
- 8.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Keywords
- spinal cord injury, spinal cord repair, neuroplasticity, functional recovery, cell regeneration, animal models, clinical translation
- MeSH terms
- Animals, Biocompatible Materials, Disease Models, Animal, Humans, Models, Neurological, Neuronal Plasticity, Spinal Cord Injuries, Recovery of Function, Bioengineering, Translational Research, Biomedical, Spinal Cord Regeneration
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