The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Social transmission and buffering of synaptic changes after stress
Abstract
Stress can trigger enduring changes in neural circuits and synapses. The behavioral and hormonal consequences of stress can also be transmitted to others, but whether this transmitted stress has similar effects on synapses is not known. We found that authentic stress and transmitted stress in mice primed paraventricular nucleus of the hypothalamus (PVN) corticotropin-releasing hormone (CRH) neurons, enabling the induction of metaplasticity at glutamate synapses. In female mice that were subjected to authentic stress, this metaplasticity was diminished following interactions with a naive partner. Transmission from the stressed subject to the naive partner required the activation of PVN CRH neurons in both subject and partner to drive and detect the release of a putative alarm pheromone from the stressed mouse. Finally, metaplasticity could be transmitted sequentially from the stressed subject to multiple partners. Our findings demonstrate that transmitted stress has the same lasting effects on glutamate synapses as authentic stress and reveal an unexpected role for PVN CRH neurons in transmitting distress signals among individuals.
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“although sample sizes were consistent with those of previous studies [19,23,80].”
From Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice (2019) · cites this paper as [80]
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Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369
Biobehavioral responses to stress in females: Tend-and-befriend, not fight-or-flight.
Taylor, S. E., Klein, L. C., Lewis, B. P., Gruenewald, T. L., Gurung, R. A. R., & Updegraff, J. A. (2000) · Psychological Review · doi:10.1037/0033-295x.107.3.411 · Cited by 3,308
Development of concern for others.
Zahn-Waxler, C., Radke-Yarrow, M., Wagner, E., & Chapman, M. (1992) · Developmental Psychology · doi:10.1037/0012-1649.28.1.126 · Cited by 1,314
The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173
Promoting social behavior with oxytocin in high-functioning autism spectrum disorders.
Andari, E., Duhamel, J.-R., Zalla, T., Herbrecht, E., Leboyer, M., & Sirigu, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910249107 · Cited by 941
Empathy and pro-social behavior in rats
Bartal, I. B.-A., Decety, J., & Mason, P. (2011) · Science · doi:10.1126/science.1210789 · Cited by 934
Social Modulation of Pain as Evidence for Empathy in Mice
Langford, D. J., Crager, S. E., Shehzad, Z., Smith, S. B., Sotocinal, S. G., Levenstadt, J. S., Chanda, M. L., Levitin, D. J., & Mogil, J. S. (2006) · Science · doi:10.1126/science.1128322 · Cited by 865
Oxytocin-dependent consolation behavior in rodents
Burkett, J. P., Andari, E., Johnson, Z. V., Curry, D. C., de Waal, F. B. M., & Young, L. J. (2016) · Science · doi:10.1126/science.aac4785 · Cited by 692
Distinct representations of olfactory information in different cortical centres
Sosulski, D. L., Bloom, M. L., Cutforth, T., Axel, R., & Datta, S. R. (2011) · Nature · doi:10.1038/nature09868 · Cited by 479
Social buffering of the stress response: diversity, mechanisms, and functions
Hennessy, M. B., Kaiser, S., & Sachser, N. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.06.001 · Cited by 477
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The future of rodent models in depression research
Gururajan, A., Reif, A., Cryan, J. F., & Slattery, D. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0221-6 · Cited by 269
Daviu, N., Füzesi, T., Rosenegger, D. G., Rasiah, N. P., Sterley, T.-L., Peringod, G., & Bains, J. S. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0591-0 · Cited by 217
Self-citationStress and perceived social isolation (loneliness)
Campagne, D. M. (2019) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2019.02.007 · Cited by 240
Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice
Ferretti, V., Maltese, F., Contarini, G., Nigro, M., Bonavia, A., Huang, H., Gigliucci, V., Morelli, G., Scheggia, D., Managò, F., et al. (2019) · Current Biology · doi:10.1016/j.cub.2019.04.070 · Cited by 212
Metadata
- Authors
- Sterley, T.-L., Baimoukhametova, D., Füzesi, T., Zurek, A. A., Daviu, N., Rasiah, N. P., Rosenegger, D., & Bains, J. S.
- Affiliations
- University of Calgary (CA)
- Corresponding author
- Bains, Jaideep S.
- Venue
- Nature Neuroscience
- Published
- 2018-01-08
- Volume
- 21
- Issue
- 3
- Pages
- 393-403
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2778525502
- Cited by
- 179
- References
- 46
- Citations by year
- 2026: 14 · 2025: 25 · 2024: 25 · 2023: 25 · 2022: 20 · 2021: 20 · 2020: 17 · 2019: 18 · 2018: 15
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- metaplasticity, glutamatergic synapses, paraventricular nucleus, corticotropin-releasing hormone neurons, alarm pheromone, stress buffering, social interaction, female mice
- MeSH terms
- CRF Receptor, Type 1, Animals, Corticotropin-Releasing Hormone, Female, Glutamates, Male, Neuronal Plasticity, Paraventricular Hypothalamic Nucleus, Pheromones, Sex Characteristics, Social Behavior, Stress, Psychological, Synapses, Receptors, Corticotropin-Releasing Hormone, Patch-Clamp Techniques, Mice, Optogenetics
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