Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress
Open accessAbstract
Postsynaptic remodeling of glutamatergic synapses on ventral striatum (vSTR) medium spiny neurons (MSNs) is critical for shaping stress responses. However, it is unclear which presynaptic inputs are involved. Susceptible mice exhibited increased synaptic strength at intralaminar thalamus (ILT), but not prefrontal cortex (PFC), inputs to vSTR MSNs following chronic social stress. Modulation of ILT-vSTR versus PFC-vSTR neuronal activity differentially regulated dendritic spine plasticity and social avoidance.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Each glutamatergic projection to the NAcc from the PFC, thalamus, amygdala, and hippocampus has a distinct contribution to modulating social anhedonia following social stress.
“each of these projections has been shown to have a distinct contribution to modulating social anhedonia following social stress”
From Social functioning in major depressive disorder (2016) · cites this paper as Christoffel et al., 2015
Susceptible mice show increased synaptic strength at thalamic inputs to NAcc.
“susceptible mice show increased synaptic strength at thalamic inputs to NAcc”
From Social functioning in major depressive disorder (2016) · cites this paper as Christoffel et al., 2015
Modulating thalamo-NAcc projections bi-directionally alters social interaction after social stress.
“modulating thalamo-NAcc projections bi-directionally alters social interaction after social stress (Christoffel et al., 2015).”
From Social functioning in major depressive disorder (2016) · cites this paper as Christoffel et al., 2015
Enhancing hippocampal and thalamic input to the nucleus accumbens promotes depressive-like outcomes.
“In contrast to PFC-NAc afferents, enhancing hippocampal and thalamic input to the NAc promotes depressive-like outcomes.”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [48]
Increased synaptic strength is observed on intralaminar thalamic nucleus accumbens inputs.
“Increased synaptic strength is observed on intralaminar thalamic NAc inputs and driving the thalamic inputs promotes susceptibility to CSDS (48).”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [48]
Driving thalamic inputs promotes susceptibility to chronic social defeat stress.
“Increased synaptic strength is observed on intralaminar thalamic NAc inputs and driving the thalamic inputs promotes susceptibility to CSDS (48).”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [48]
CSDS induced enhancement of synaptic transmission at thalamic inputs, but not cortical inputs to the NAc, promoted social avoidance.
“CSDS induced enhancement of synaptic transmission at thalamic inputs, but not cortical inputs to the NAc, promoted social avoidance [160].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [160]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · see citing works
Self-citationEssential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works
Self-citationThe brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870 · see citing works
Self-citationA standardized protocol for repeated social defeat stress in mice
Golden, S. A., Covington, H. E., Berton, O., & Russo, S. J. (2011) · Nature Protocols · doi:10.1038/nprot.2011.361 · Cited by 1,581 · see citing works
Self-citationThe Expression of Vesicular Glutamate Transporters Defines Two Classes of Excitatory Synapse
Fremeau, R. T., Troyer, M. D., Pahner, I., Nygaard, G. O., Tran, C. H., Reimer, R. J., Bellocchio, E. E., Fortin, D. L., Storm‐Mathisen, J., & Edwards, R. H. (2001) · Neuron · doi:10.1016/s0896-6273(01)00344-0 · Cited by 1,266 · see citing works
Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons
Chaudhury, D., Walsh, J. J., Friedman, A. K., Juarez, B., Ku, S. M., Koo, J. W., Ferguson, D., Tsai, H.-C., Pomeranz, L., Christoffel, D. J., et al. (2013) · Nature · doi:10.1038/nature11713 · Cited by 1,156 · see citing works
Self-citationDopamine neurons modulate neural encoding and expression of depression-related behaviour
Tye, K. M., Mirzabekov, J. J., Warden, M. R., Ferenczi, E. A., Tsai, H.-C., Finkelstein, J., Kim, S.-Y., Adhikari, A., Thompson, K. R., Andalman, A. S., et al. (2013) · Nature · doi:10.1038/nature11740 · Cited by 1,073 · see citing works
Self-citationExcitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking
Stuber, G. D., Sparta, D. R., Stamatakis, A. M., van Leeuwen, W. A., Hardjoprajitno, J. E., Cho, S., Tye, K. M., Kempadoo, K. A., Zhang, F., Deisseroth, K., et al. (2011) · Nature · doi:10.1038/nature10194 · Cited by 878 · see citing works
Self-citationRepeated Stress Induces Dendritic Spine Loss in the Rat Medial Prefrontal Cortex
Radley, J. J., Rocher, A. B., Miller, M., Janssen, W. G. M., Liston, C., Hof, P. R., McEwen, B. S., & Morrison, J. H. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhi104 · Cited by 820 · see citing works
Burger, C., Gorbatyuk, O. S., Velardo, M. J., Peden, C. S., Williams, P., Zolotukhin, S., Reier, P. J., Mandel, R. J., & Muzyczka, N. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.05.024 · Cited by 741 · see citing works
Synaptic and Behavioral Profile of Multiple Glutamatergic Inputs to the Nucleus Accumbens
Britt, J. P., Benaliouad, F., McDevitt, R. A., Stuber, G. D., Wise, R. A., & Bonci, A. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.040 · Cited by 716 · see citing works
Diverging neural pathways assemble a behavioural state from separable features in anxiety
Kim, S.-Y., Adhikari, A., Lee, S. Y., Marshel, J. H., Kim, C. K., Mallory, C. S., Lo, M., Pak, S., Mattis, J., Lim, B. K., et al. (2013) · Nature · doi:10.1038/nature12018 · Cited by 666 · see citing works
Self-citationAntidepressant effect of optogenetic stimulation of the medial prefrontal cortex
Covington, H. E., Lobo, M. K., Maze, I., Vialou, V., Hyman, J. M., Zaman, S., LaPlant, Q., Mouzon, E., Ghose, S., Tamminga, C. A., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-10.2010 · Cited by 621 · see citing works
Self-citationRodriguez, A., Ehlenberger, D. B., Dickstein, D. L., Hof, P. R., & Wearne, S. L. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001997 · Cited by 571 · see citing works
The paraventricular thalamus controls a central amygdala fear circuit
Penzo, M. A., Robert, V., Tucciarone, J., De Bundel, D., Wang, M., Van Aelst, L., Darvas, M., Parada, L. F., Palmiter, R. D., He, M., et al. (2015) · Nature · doi:10.1038/nature13978 · Cited by 506 · see citing works
Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking
Chen, B. T., Yau, H.-J., Hatch, C., Kusumoto-Yoshida, I., Cho, S. L., Hopf, F. W., & Bonci, A. (2013) · Nature · doi:10.1038/nature12024 · Cited by 498 · see citing works
Construction of implantable optical fibers for long-term optogenetic manipulation of neural circuits
Sparta, D. R., Stamatakis, A. M., Phillips, J. L., Hovelsø, N., van Zessen, R., & Stuber, G. D. (2012) · Nature Protocols · doi:10.1038/nprot.2011.413 · Cited by 394 · see citing works
Structural and synaptic plasticity in stress-related disorders
Christoffel, D. J., Golden, S. A., & Russo, S. J. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.044 · Cited by 334 · see citing works
Self-citationEpigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression
Golden, S. A., Christoffel, D. J., Heshmati, M., Hodes, G. E., Magida, J., Davis, K., Cahill, M. E., Dias, C., Ribeiro, E., Ables, J. L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3090 · Cited by 322 · see citing works
Self-citationVialou, V., Bagot, R. C., Cahill, M. E., Ferguson, D., Robison, A. J., Dietz, D. M., Fallon, B., Mazei-Robison, M., Ku, S. M., Harrigan, E., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1787-13.2014 · Cited by 283 · see citing works
IκB Kinase Regulates Social Defeat Stress-Induced Synaptic and Behavioral Plasticity
Christoffel, D. J., Golden, S. A., Dumitriu, D., Robison, A. J., Janssen, W. G., Ahn, H. F., Krishnan, V., Reyes, C. M., Han, M.-H., Ables, J. L., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4763-10.2011 · Cited by 267 · see citing works
Self-citationBrowning, J. R., Jansen, H. T., & Sorg, B. A. (2013) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2013.09.021 · Cited by 64 · see citing works
Silencing neurotransmission with membrane-tethered toxins
Auer, S., Stürzebecher, A., Jüttner, R., Santos‐Torres, J., Hanack, C., Frahm, S., Liehl, B., & Ibáñez-Tallon, I. (2010) · Nature Methods · doi:10.1038/nmeth.1425 · Cited by 53 · see citing works
Bubser, M., & Deutch, A. Y. (1999) · Synapse · doi:10.1002/(sici)1098-2396(199904)32:1
Flagged first, then by citations
Cited by
Sorted by citations
Social functioning in major depressive disorder
Kupferberg, A., Bicks, L., & Hasler, G. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.002 · Cited by 663 · see citing works
Pathogenesis of depression: Insights from human and rodent studies
Ménard, C., Hodes, G. E., & Russo, S. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.053 · Cited by 593 · see citing works
Self-citationImmune and neuroendocrine mechanisms of stress vulnerability and resilience
Ménard, C., Pfau, M. L., Hodes, G. E., & Russo, S. J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.90 · Cited by 374 · see citing works
Self-citationBagot, R. C., Cates, H. M., Purushothaman, I., Lorsch, Z. S., Walker, D. M., Wang, J., Huang, X., Schlüter, O. M., Maze, I., Peña, C. J., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.015 · Cited by 333 · see citing works
Neurobiology of Resilience: Interface Between Mind and Body
Cathomas, F., Murrough, J. W., Nestler, E. J., Han, M.-H., & Russo, S. J. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.04.011 · Cited by 296 · see citing works
“By contrast, stimulation of PFC-NAc glutamate inputs promotes resilience, but only under very specific conditions, and studies to silence these inputs using halorhodopsin have no effect (62) (61).”
BackgroundSelf-citationWang, J., Hodes, G. E., Zhang, H., Zhang, S., Zhao, W., Golden, S. A., Bi, W., Menard, C., Kana, V., Leboeuf, M., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02794-5 · Cited by 274 · see citing works
Self-citationDistinct Ventral Pallidal Neural Populations Mediate Separate Symptoms of Depression
Knowland, D., Lilascharoen, V., Pacia, C. P., Shin, S., Wang, E. H.-J., & Lim, B. K. (2017) · Cell · doi:10.1016/j.cell.2017.06.015 · Cited by 273 · see citing works
Prefrontal cortical control of a brainstem social behavior circuit
Franklin, T. B., Silva, B. A., Perova, Z., Marrone, L., Masferrer, M. E., Zhan, Y., Kaplan, A., Greetham, L., Verrechia, V., Halman, A., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4470 · Cited by 231 · see citing works
Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression
Francis, T. C., & Lobo, M. K. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.09.007 · Cited by 230 · see citing works
The molecular and cellular mechanisms of depression: a focus on reward circuitry
Fox, M. E., & Lobo, M. K. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0415-3 · Cited by 232 · see citing works
In vivo fiber photometry reveals signature of future stress susceptibility in nucleus accumbens
Muir, J., Lorsch, Z. S., Ramakrishnan, C., Deisseroth, K., Nestler, E. J., Calipari, E. S., & Bagot, R. C. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.122 · Cited by 116 · see citing works
Self-citationCell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility
Heshmati, M., Aleyasin, H., Menard, C., Christoffel, D. J., Flanigan, M. E., Pfau, M. L., Hodes, G. E., Lepack, A. E., Bicks, L. K., Takahashi, A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1719014115 · Cited by 75 · see citing works
Self-citationNeural circuits regulating prosocial behaviors
Walsh, J. J., Christoffel, D. J., & Malenka, R. C. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-022-01348-8 · Cited by 72 · see citing works
Self-citationInput-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding
Christoffel, D. J., Walsh, J. J., Heifets, B. D., Hoerbelt, P., Neuner, S., Sun, G., Ravikumar, V. K., Wu, H., Halpern, C. H., & Malenka, R. C. (2021) · Nature Communications · doi:10.1038/s41467-021-22430-7 · Cited by 65 · see citing works
Self-citation
- Authors
- Christoffel, D. J., Golden, S. A., Walsh, J. J., Guise, K. G., Heshmati, M., Friedman, A. K., Dey, A., Smith, M., Rebusi, N., Pfau, M., Ables, J. L., Aleyasin, H., Khibnik, L. A., Hodes, G. E., Ben-Dor, G. A., Deisseroth, K., Shapiro, M. L., Malenka, R. C., Ibanez-Tallon, I., Han, M.-H., & Russo, S. J.
- Affiliations
- Stanford University (US)
- Icahn School of Medicine at Mount Sinai (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Russo, Scott J
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2015-06-01
- Volume
- 18
- Issue
- 7
- Pages
- 962-964
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC4482771
- OpenAlex
- W1524070957
- Cited by
- 101
- References
- 24
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 1 · 2022: 10 · 2021: 15 · 2020: 7 · 2019: 12 · 2018: 20 · 2017: 10 · 2016: 10 · 2015: 4
- FWCI
- 6.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA022445)
- National Institute of Mental Health (F31MH105217, F30MH100835, R01MH090264, P50MH096890, R01MH092306, R01MH065658, T32MH096678, F32MH096464, P50MH094263, F32MH106206, R01MH073689, R01MH104559, T32MH087004)
- National Institute on Drug Abuse (P01DA008227, T32DA035165)
- National Institute of General Medical Sciences (T32GM089626)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- chronic social stress, intralaminar thalamus, ventral striatum, medium spiny neurons, glutamatergic neurotransmission, synaptic plasticity, dendritic spine plasticity, social avoidance, depression vulnerability, behavioral coping, prefrontal cortex
- MeSH terms
- Animals, Behavior, Animal, Disease Susceptibility, Male, Mice, Inbred C57BL, Neuronal Plasticity, Reward, Social Behavior, Stress, Psychological, Thalamus, Prefrontal Cortex, Excitatory Postsynaptic Potentials, Dendritic Spines, Mice, Ventral Striatum
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
