The DOI matches its Crossref record; 67 of the 68 references it cites were found in a registry or an index, and 1 are not checked yet.
Mapping the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble
Open accessAbstract
The epigenome and three-dimensional (3D) genomic architecture are emerging as key factors in the dynamic regulation of different transcriptional programs required for neuronal functions. In this study, we used an activity-dependent tagging system in mice to determine the epigenetic state, 3D genome architecture and transcriptional landscape of engram cells over the lifespan of memory formation and recall. Our findings reveal that memory encoding leads to an epigenetic priming event, marked by increased accessibility of enhancers without the corresponding transcriptional changes. Memory consolidation subsequently results in spatial reorganization of large chromatin segments and promoter-enhancer interactions. Finally, with reactivation, engram neurons use a subset of de novo long-range interactions, where primed enhancers are brought in contact with their respective promoters to upregulate genes involved in local protein translation in synaptic compartments. Collectively, our work elucidates the comprehensive transcriptional and epigenomic landscape across the lifespan of memory formation and recall in the hippocampal engram ensemble.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“There is now emerging evidence that the 3D genome is actively regulated during learning and memory formation”
From Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration (2023) · cites this paper as [39]
In the citing paper
“The 3D genome plays an important role in neuronal gene expression and function”
From Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration (2023) · cites this paper as [39]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041
Fast gapped-read alignment with Bowtie 2
Langmead, B., & Salzberg, S. L. (2012) · Nature Methods · doi:10.1038/nmeth.1923 · Cited by 56,400
Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364
Model-based Analysis of ChIP-Seq (MACS)
Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386
Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382
Trapnell, C., Roberts, A., Goff, L. A., Pertea, G. M., Kim, D., Kelley, D. R., Pimentel, H., Salzberg, S. L., Rinn, J. L., & Pachter, L. S. (2012) · Nature Protocols · doi:10.1038/nprot.2012.016 · Cited by 12,145
Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration
Thorvaldsdottir, H., Robinson, J. T., & Mesirov, J. P. (2013) · Briefings in Bioinformatics · doi:10.1093/bib/bbs017 · Cited by 9,049
Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome
Lieberman-Aiden, E., van Berkum, N. L., Williams, L., Imakaev, M., Ragoczy, T., Telling, A., Amit, I., Lajoie, B. R., Sabo, P. J., Dorschner, M. O., et al. (2009) · Science · doi:10.1126/science.1181369 · Cited by 8,898
A scaling normalization method for differential expression analysis of RNA-seq data
Robinson, M. D., & Oshlack, A. (2010) · Genome Biology · doi:10.1186/gb-2010-11-3-r25 · Cited by 7,876
Buenrostro, J. D., Giresi, P. G., Zaba, L. C., Chang, H. Y., & Greenleaf, W. J. (2013) · Nature Methods · doi:10.1038/nmeth.2688 · Cited by 6,422
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
Nader, K., Schafe, G. E., & Le Doux, J. E. (2000) · Nature · doi:10.1038/35021052 · Cited by 2,706
Widespread transcription at neuronal activity-regulated enhancers
Kim, T.-K., Hemberg, M., Gray, J. M., Costa, A. M., Bear, D. M., Wu, J., Harmin, D. A., Laptewicz, M., Barbara-Haley, K., Kuersten, S., et al. (2010) · Nature · doi:10.1038/nature09033 · Cited by 2,450
Mediator and cohesin connect gene expression and chromatin architecture
Kagey, M. H., Newman, J. J., Bilodeau, S., Zhan, Y., Orlando, D. A., van Berkum, N. L., Ebmeier, C. C., Goossens, J., Rahl, P. B., Levine, S. S., et al. (2010) · Nature · doi:10.1038/nature09380 · Cited by 1,939
Ancient DNA and the rewriting of human history: be sparing with Occam’s razor
Haber, M., Mezzavilla, M., Xue, Y., & Tyler-Smith, C. (2016) · Genome Biology · doi:10.1186/s13059-015-0866-z · Cited by 1,924
The long-range interaction landscape of gene promoters
Sanyal, A., Lajoie, B. R., Jain, G., & Dekker, J. (2012) · Nature · doi:10.1038/nature11279 · Cited by 1,489
Transcriptional enhancers: from properties to genome-wide predictions
Shlyueva, D., Stampfel, G., & Stark, A. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3682 · Cited by 1,356
Multiscale 3D Genome Rewiring during Mouse Neural Development
Bonev, B., Mendelson Cohen, N., Szabo, Q., Fritsch, L., Papadopoulos, G. L., Lubling, Y., Xu, X., Lv, X., Hugnot, J.-P., Tanay, A., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.043 · Cited by 1,338
Rapid Spine Delivery and Redistribution of AMPA Receptors After Synaptic NMDA Receptor Activation
Shi, S.-H., Hayashi, Y., Petralia, R. S., Zaman, S. H., Wenthold, R. J., Svoboda, K., & Malinow, R. (1999) · Science · doi:10.1126/science.284.5421.1811 · Cited by 1,276
YY1 Is a Structural Regulator of Enhancer-Promoter Loops
Weintraub, A. S., Li, C. H., Zamudio, A. V., Sigova, A. A., Hannett, N. M., Day, D. S., Abraham, B. J., Cohen, M. A., Nabet, B., Buckley, D. L., et al. (2017) · Cell · doi:10.1016/j.cell.2017.11.008 · Cited by 992
Transcription Factors in Long-Term Memory and Synaptic Plasticity
Alberini, C. M. (2009) · Physiological Reviews · doi:10.1152/physrev.00017.2008 · Cited by 991
Creating a False Memory in the Hippocampus
Ramirez, S., Liu, X., Lin, P.-A., Suh, J., Pignatelli, M., Redondo, R. L., Ryan, T. J., & Tonegawa, S. (2013) · Science · doi:10.1126/science.1239073 · Cited by 968
Chromatin-state discovery and genome annotation with ChromHMM
Ernst, J., & Kellis, M. (2017) · Nature Protocols · doi:10.1038/nprot.2017.124 · Cited by 905
Self-citationEpigenetic mechanisms in memory formation
Levenson, J. M., & Sweatt, J. D. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1604 · Cited by 767
Josselyn, S. A., Köhler, S., & Frankland, P. W. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn4000 · Cited by 749
HiCUP: pipeline for mapping and processing Hi-C data
Wingett, S., Ewels, P., Furlan-Magaril, M., Nagano, T., Schoenfelder, S., Fraser, P., & Andrews, S. (2015) · F1000Research · doi:10.12688/f1000research.7334.1 · Cited by 734
the 4D Nucleome Network, Dekker, J., Belmont, A. S., Guttman, M., Leshyk, V. O., Lis, J. T., Lomvardas, S., Mirny, L. A., O’Shea, C. C., Park, P. J., et al. (2017) · Nature · doi:10.1038/nature23884 · Cited by 732
An atlas of combinatorial transcriptional regulation in mouse and man
Ravasi, T., Suzuki, H., Cannistraci, C. V., Katayama, S., Bajic, V. B., Tan, K., Akalin, A., Schmeier, S., Kanamori-Katayama, M., Bertin, N., et al. (2010) · Cell · doi:10.1016/j.cell.2010.01.044 · Cited by 715
Guenthner, C. J., Miyamichi, K., Yang, H. H., Heller, H. C., & Luo, L. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.025 · Cited by 705
Hippocampal Memory Traces Are Differentially Modulated by Experience, Time, and Adult Neurogenesis
Denny, C. A., Kheirbek, M. A., Alba, E. L., Tanaka, K. F., Brachman, R. A., Laughman, K. B., Tomm, N. K., Turi, G. F., Losonczy, A., & Hen, R. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.018 · Cited by 599
Dendritic mRNA: transport, translation and function
Bramham, C. R., & Wells, D. G. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2150 · Cited by 596
Lun, A. T. L., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1191 · Cited by 503
Ostroff, L. E., Fiala, J. C., Allwardt, B., & Harris, K. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00785-7 · Cited by 461
The pluripotent regulatory circuitry connecting promoters to their long-range interacting elements
Schoenfelder, S., Furlan-Magaril, M., Mifsud, B., Tavares-Cadete, F., Sugar, R., Javierre, B.-M., Nagano, T., Katsman, Y., Sakthidevi, M., Wingett, S. W., et al. (2015) · Genome Research · doi:10.1101/gr.185272.114 · Cited by 460
AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection
Vierbuchen, T., Ling, E., Cowley, C. J., Couch, C. H., Wang, X., Harmin, D. A., Roberts, C. W. M., & Greenberg, M. E. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.11.026 · Cited by 455
CHiCAGO: robust detection of DNA looping interactions in Capture Hi-C data
Cairns, J., Freire-Pritchett, P., Wingett, S. W., Várnai, C., Dimond, A., Plagnol, V., Zerbino, D., Schoenfelder, S., Javierre, B.-M., Osborne, C., et al. (2016) · Genome Biology · doi:10.1186/s13059-016-0992-2 · Cited by 417
What is memory? The present state of the engram
Poo, M.-M., Pignatelli, M., Ryan, T. J., Tonegawa, S., Bonhoeffer, T., Martin, K. C., Rudenko, A., Tsai, L., Tsien, R. W., Fishell, G., et al. (2016) · BMC Biology · doi:10.1186/s12915-016-0261-6 · Cited by 409
Self-citationInterregional synaptic maps among engram cells underlie memory formation
Choi, J., Sim, S.-E., Kim, J., Choi, D. I., Oh, J., Ye, S., Lee, J., Kim, T., Ko, H., Lim, C., et al. (2018) · Science · doi:10.1126/science.aas9204 · Cited by 392
Different Neuronal Activity Patterns Induce Different Gene Expression Programs
Tyssowski, K. M., DeStefino, N. R., Cho, J.-H., Dunn, C. J., Poston, R. G., Carty, C. E., Jones, R. D., Chang, S. M., Romeo, P., Wurzelmann, M. K., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.04.001 · Cited by 390
Schep, A. N., Buenrostro, J. D., Denny, S. K., Schwartz, K., Sherlock, G., & Greenleaf, W. J. (2015) · Genome Research · doi:10.1101/gr.192294.115 · Cited by 375
The Three-Dimensional Organization of Mammalian Genomes
Yu, M., & Ren, B. (2017) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100616-060531 · Cited by 373
DNA methylation changes in plasticity genes accompany the formation and maintenance of memory
Halder, R., Hennion, M., Vidal, R. O., Shomroni, O., Rahman, R.-U., Rajput, A., Centeno, T. P., van Bebber, F., Capece, V., Vizcaino, J. C. G., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4194 · Cited by 358
Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories
Gräff, J., Joseph, N. F., Horn, M. E., Samiei, A., Meng, J., Seo, J., Rei, D., Bero, A. W., Phan, T. X., Wagner, F., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.020 · Cited by 357
Self-citationChandra, D., Jia, F., Liang, J., Peng, Z., Suryanarayanan, A., Werner, D. F., Spigelman, I., Houser, C. R., Olsen, R. W., Harrison, N. L., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604304103 · Cited by 315
Gaidatzis, D., Burger, L., Florescu, M., & Stadler, M. B. (2015) · Nature Biotechnology · doi:10.1038/nbt.3269 · Cited by 313
Functionally Distinct Neuronal Ensembles within the Memory Engram
Sun, X., Bernstein, M. J., Meng, M., Rao, S., Sørensen, A. T., Yao, L., Zhang, X., Anikeeva, P., & Lin, Y. (2020) · Cell · doi:10.1016/j.cell.2020.02.055 · Cited by 282
Genome-wide identification and characterization of functional neuronal activity–dependent enhancers
Malik, A. N., Vierbuchen, T., Hemberg, M., Rubin, A. A., Ling, E., Couch, C. H., Stroud, H., Spiegel, I., Farh, K. K., Harmin, D. A., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3808 · Cited by 279
Stimulus-specific combinatorial functionality of neuronal c-fos enhancers
Joo, J.-Y., Schaukowitch, K., Farbiak, L., Kilaru, G., & Kim, T.-K. (2016) · Nature Neuroscience · doi:10.1038/nn.4170 · Cited by 271
Engram Cell Excitability State Determines the Efficacy of Memory Retrieval
Pignatelli, M., Ryan, T. J., Roy, D. S., Lovett, C., Smith, L. M., Muralidhar, S., & Tonegawa, S. (2018) · Neuron · doi:10.1016/j.neuron.2018.11.029 · Cited by 267
Neuronal activity modifies the chromatin accessibility landscape in the adult brain
Su, Y., Shin, J., Zhong, C., Wang, S. Z., Roychowdhury, P., Lim, J., Kim, D. S., Ming, G., & Song, H. (2017) · Nature Neuroscience · doi:10.1038/nn.4494 · Cited by 241
Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function
Schlisio, S., Halperin, T., Vidal, M., & Nevins, J. R. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf577 · Cited by 197
Turgeon, B., & Meloche, S. (2009) · Physiological Reviews · doi:10.1152/physrev.00040.2007 · Cited by 166
Immediate and deferred epigenomic signatures of in vivo neuronal activation in mouse hippocampus
Fernandez-Albert, J., Lipinski, M., Lopez-Cascales, M. T., Rowley, M. J., Martin-Gonzalez, A. M., del Blanco, B., Corces, V. G., & Barco, A. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0476-2 · Cited by 166
Nagano, T., Lubling, Y., Yaffe, E., Wingett, S., Dean, W., Tanay, A., & Fraser, P. (2015) · Nature Protocols · doi:10.1038/nprot.2015.127 · Cited by 165
Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity
Korb, E., Wilkinson, C. L., Delgado, R. N., Lovero, K. L., & Finkbeiner, S. M. (2013) · Nature Neuroscience · doi:10.1038/nn.3429 · Cited by 151
High-throughput functional comparison of promoter and enhancer activities
Nguyen, T. A., Jones, R. D., Snavely, A. R., Pfenning, A. R., Kirchner, R., Hemberg, M., & Gray, J. M. (2016) · Genome Research · doi:10.1101/gr.204834.116 · Cited by 146
Reactivation of recall-induced neurons contributes to remote fear memory attenuation
Khalaf, O., Resch, S., Dixsaut, L., Gorden, V., Glauser, L., & Gräff, J. (2018) · Science · doi:10.1126/science.aas9875 · Cited by 146
Engram-specific transcriptome profiling of contextual memory consolidation
Rao‐Ruiz, P., Couey, J. J., Marcelo, I. M., Bouwkamp, C. G., Slump, D. E., Matos, M. R., van der Loo, R. J., Martins, G. J., van den Hout, M. C. G. N., van IJcken, W. F. J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09960-x · Cited by 146
DNA methylation in the gene body influences MeCP2-mediated gene repression
Kinde, B., Wu, D. Y., Greenberg, M. E., & Gabel, H. W. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618737114 · Cited by 118
Liao, P., Zeng, S. X., Zhou, X. Y., Chen, T., Zhou, F., Cao, B., Jung, J. H., Sal, G. D., Luo, S., & Lu, H. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.11.006 · Cited by 115
Specialized roles of neurofilament proteins in synapses: Relevance to neuropsychiatric disorders
Yuan, A., & Nixon, R. A. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.09.002 · Cited by 88
Spatial genome organization and cognition
Rajarajan, P., Espeso‐Gil, S., Brennand, K., & Akbarian, S. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.124 · Cited by 83
Jaeger, B. N., Linker, S. B., Parylak, S., Barron, J. J., Gallina, I. S., Saavedra, C. D., Fitzpatrick, C., Lim, C. K., Schafer, S. T., Lacar, B., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05418-8 · Cited by 83
Sensory experience remodels genome architecture in neural circuit to drive motor learning
Yamada, T., Yang, Y., Valnegri, P., Juric, I., Abnousi, A., Markwalter, K. H., Guthrie, A. N., Godec, A., Oldenborg, A., Hu, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1190-7 · Cited by 83
Prickett, A. R., Barkas, N., McCole, R. B., Hughes, S., Amante, S. M., Schulz, R., & Oakey, R. J. (2013) · Genome Research · doi:10.1101/gr.150136.112 · Cited by 70
Genome-wide analysis of H4K5 acetylation associated with fear memory in mice
Park, C., Rehrauer, H., & Mansuy, I. M. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-539 · Cited by 58
Rory Stark<Rory.Stark@Cruk.Cam.Ac.Uk>, G. B. C. (2017) · NCI BioConductor · doi:10.18129/b9.bioc.diffbind · Cited by 54
Zac1 plays a key role in the development of specific neuronal subsets in the mouse cerebellum
Chung, S., Marzban, H., Aldinger, K. A., Dixit, R., Millen, K. J., Schuurmans, C. J., & Hawkes, R. B. (2011) · Neural Development · doi:10.1186/1749-8104-6-25 · Cited by 38
Albo, Z., & Gräff, J. (2019) · Neuron · doi:10.1016/j.neuron.2018.12.033 · Cited by 5
Cited by
Sorted by citations
Chromatin accessibility profiling by ATAC-seq
Grandi, F. C., Modi, H., Kampman, L., & Corces, M. R. (2022) · Nature Protocols · doi:10.1038/s41596-022-00692-9 · Cited by 557
Kundaković, M., & Rocks, D. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.101010 · Cited by 356
A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility
Sheu, S.-H., Upadhyayula, S., Dupuy, V., Pang, S., Deng, F., Wan, J., Walpita, D., Pasolli, H. A., Houser, J., Sanchez-Martinez, S., et al. (2022) · Cell · doi:10.1016/j.cell.2022.07.026 · Cited by 162
Dileep, V., Boix, C. A., Mathys, H., Marco, A., Welch, G. M., Meharena, H. S., Loon, A., Jeloka, R., Peng, Z., Bennett, D. A., et al. (2023) · Cell · doi:10.1016/j.cell.2023.08.038 · Cited by 130
Self-citationParp1 promotes sleep, which enhances DNA repair in neurons
Zada, D., Sela, Y., Matosevich, N., Monsonego, A., Lerer‐Goldshtein, T., Nir, Y., & Appelbaum, L. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.10.026 · Cited by 117
Metadata
- Authors
- Marco, A., Meharena, H. S., Dileep, V., Raju, R. M., Davila-Velderrain, J., Zhang, A. L., Adaikkan, C., Young, J. Z., Gao, F., Kellis, M., & Tsai, L.-H.
- Affiliations
- Massachusetts Institute of Technology (US)
- Boston Children's Hospital (US)
- Broad Institute (US)
- Corresponding author
- Marco, Asaf
- Tsai, Li-Huei
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2020-10-05
- Volume
- 23
- Issue
- 12
- Pages
- 1606-1617
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC7686266
- OpenAlex
- W3090072122
- Cited by
- 159
- References
- 68
- Citations by year
- 2026: 23 · 2025: 31 · 2024: 30 · 2023: 22 · 2022: 32 · 2021: 19 · 2020: 2
- FWCI
- 10.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Funders
- Alzheimer's Association (AARF-19-618751)
- JPB Foundation
- Cure Alzheimer's Fund
- Down Syndrome Research Foundation
- National Institutes of Health (NIH T32, T32 grant)
- National Institute on Aging (R01AG058002, R01AG062335, RF1AG054012, RF1AG062377, R01AG067151)
- National Institute of Mental Health (U01MH119509, R01MH109978)
- National Human Genome Research Institute (R01HG008155, U24HG009446)
- National Institute of Neurological Disorders and Stroke (U01NS110453, R01NS102730, UG3NS115064)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD098061)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- memory formation, memory retrieval, epigenome, 3D genome organization, enhancer accessibility, enhancer-promoter interactions, long-range chromatin interactions, memory consolidation, memory reactivation, transcriptional regulation, mRNA translation
- MeSH terms
- Memory Consolidation, Animals, Brain Mapping, Hippocampus, Memory, Mice, Transgenic, Neurons, Mental Recall, Synapses, Up-Regulation, Mice, Epigenomics, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
