Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory

Morris water maze: procedures for assessing spatial and related forms of learning and memory

Vorhees, C. V., & Williams, M. T. (2006) · Nature Protocols · doi:10.1038/nprot.2006.116 · Cited by 4,629

Plasticity in gray and white: neuroimaging changes in brain structure during learning

Zatorre, R. J., Fields, R. D., & Johansen-Berg, H. (2012) · Nature Neuroscience · doi:10.1038/nn.3045 · Cited by 1,685

A century of trends in adult human height

NCD Risk Factor Collaboration (NCD-RisC) (2016) · eLife · doi:10.7554/elife.13410 · Cited by 1,558

Motor skill learning requires active central myelination

McKenzie, I. A., Ohayon, D., Li, H., Paes de Faria, J., Emery, B., Tohyama, K., & Richardson, W. D. (2014) · Science · doi:10.1126/science.1254960 · Cited by 1,177

The ageing cortical synapse: hallmarks and implications for cognitive decline

Morrison, J. H., & Baxter, M. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3200 · Cited by 965

Top-down suppression deficit underlies working memory impairment in normal aging

Gazzaley, A., Cooney, J. W., Rissman, J., & D'Esposito, M. (2005) · Nature Neuroscience · doi:10.1038/nn1543 · Cited by 934

Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling

Young, K. M., Psachoulia, K., Tripathi, R. B., Dunn, S.-J., Cossell, L., Attwell, D., Tohyama, K., & Richardson, W. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.006 · Cited by 919

NG2+ CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration

Kang, S. H., Fukaya, M., Yang, J. K., Rothstein, J. D., & Bergles, D. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.009 · Cited by 815

Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain

Hughes, E. G., Kang, S. H., Fukaya, M., & Bergles, D. E. (2013) · Nature Neuroscience · doi:10.1038/nn.3390 · Cited by 808

Rejuvenation of Regeneration in the Aging Central Nervous System

Ruckh, J. M., Zhao, J.-W., Shadrach, J. L., van Wijngaarden, P., Rao, T. N., Wagers, A. J., & Franklin, R. J. M. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2011.11.019 · Cited by 649

Glial restricted precursor cells in central nervous system disorders: Current applications and future perspectives

Martins‐Macedo, J., Lepore, A. C., Domingues, H. S., Salgado, A. J., Gomes, E. D., & Pinto, L. (2020) · Glia · doi:10.1002/glia.23922 · Cited by 31

Novel therapeutic approaches to target neurodegeneration

de la Fuente, A. G., Pelucchi, S., Mertens, J., Luca, M. D., Mauceri, D., & Marcello, E. E. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16078 · Cited by 32

Myelin plasticity modulates neural circuitry required for learning and behavior

Kato, D., & Wake, H. (2021) · Neuroscience Research · doi:10.1016/j.neures.2020.12.005 · Cited by 30

Human Oligodendrocytes and Myelin In Vitro to Evaluate Developmental Neurotoxicity

Chesnut, M., Härtung, T., Högberg, H. T., & Pamies, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157929 · Cited by 30

Nanoparticles-based anti-aging treatment of Alzheimer’s disease

Chu, J., Ji, W., Zhuang, J., Gong, B., Chen, X., Cheng, W., Liang, W., Li, G., Gao, J., & Yin, Y. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2094501 · Cited by 30

Chronic d-ribose and d-mannose overload induce depressive/anxiety-like behavior and spatial memory impairment in mice

Xu, K., Wang, M., Zhou, W., Pu, J., Wang, H., & Xie, P. (2021) · Translational Psychiatry · doi:10.1038/s41398-020-01126-4 · Cited by 28

Early white matter pathology in the fornix of the limbic system in Huntington disease

Gabery, S., Kwa, J. E., Cheong, R. Y., Baldo, B., Bardile, C. F., Tan, B., McLean, C., Georgiou‐Karistianis, N., Poudel, G. R., Halliday, G. M., et al. (2021) · Acta Neuropathologica · doi:10.1007/s00401-021-02362-8 · Cited by 26

Disturbed Oligodendroglial Maturation Causes Cognitive Dysfunction in Schizophrenia: A New Hypothesis

Falkai, P., Rossner, M. J., Raabe, F. J., Wagner, E. M., Keeser, D., Maurus, I., Roell, L., Chang, E., Seitz‐Holland, J., Schulze, T. G., et al. (2023) · Schizophrenia Bulletin · doi:10.1093/schbul/sbad065 · Cited by 30

Extracellular vesicle‐associated cholesterol supports the regenerative functions of macrophages in the brain

Vanherle, S., Guns, J., Loix, M., Mingneau, F., Dierckx, T., Wouters, F., Kuipers, K., Vangansewinkel, T., Wolfs, E., Lins, P. M. P., et al. (2023) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12394 · Cited by 28

Icariin Ameliorates Alzheimer’s Disease Pathology by Alleviating Myelin Injury in 3 × Tg-AD Mice

Yu, H., Shi, J., Lin, Y., Zhang, Y., Luo, Q., Huang, S., Wang, S., Wei, J., Huang, J., Li, C., et al. (2022) · Neurochemical Research · doi:10.1007/s11064-021-03507-7 · Cited by 25

Epidermal Growth Factor Pathway in the Age-Related Decline of Oligodendrocyte Regeneration

Rivera, A. D., Azim, K., Macchi, V., Porzionato, A., Butt, A. M., & De, R. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.838007 · Cited by 26

Region-specific transcriptional signatures of brain aging in the absence of neuropathology at the single-cell level

Mesecar, M. E., Duffy, M. F., Acri, D. J., Ding, J., Langston, R. G., Shah, S. I., Nalls, M. A., Reed, X., Scholz, S. W., Whitaker, D. T., et al. (2026) · npj Aging · doi:10.1038/s41514-026-00391-9 · Cited by 28

Photobiomodulation attenuates oligodendrocyte dysfunction and prevents adverse neurological consequences in a rat model of early life adversity

Huang, Z., Zhang, Y., Ma, X., Feng, Y., Zong, X., Jordan, J. D., & Zhang, Q. (2023) · Theranostics · doi:10.7150/thno.78777 · Cited by 24

Longitudinal variation in resilient psychosocial functioning is associated with ongoing cortical myelination and functional reorganization during adolescence

Hettwer, M. D., Dorfschmidt, L., Puhlmann, L. M. C., Jacob, L. M., Paquola, C., Bethlehem, R. A. I., Bullmore, E. T., Eickhoff, S. B., & Valk, S. L. (2024) · Nature Communications · doi:10.1038/s41467-024-50292-2 · Cited by 27

Chronic Exposure to Alcohol Inhibits New Myelin Generation in Adult Mouse Brain

Guo, F., Zhang, Y., Liu, K., Huang, X., Li, R., Wang, S., Wang, F., Xiao, L., Mei, F., & Li, T. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.732602 · Cited by 22

Clemastine Rescues Chemotherapy-Induced Cognitive Impairment by Improving White Matter Integrity

Chen, Y., Sheng, J., Tang, X., Zhao, Y., Zhu, S., & Liu, Q. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.01.001 · Cited by 22

White Matter Injury in Preterm Infants: Pathogenesis and Potential Therapy From the Aspect of the Gut–Brain Axis

He, Y., Zhang, Y., Li, F., & Shi, Y. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.849372 · Cited by 21

Horizons in Human Aging Neuroscience: From Normal Neural Aging to Mental (Fr)Agility

Ridderinkhof, K. R., & Krugers, H. J. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.815759 · Cited by 25

The Memory Orchestra: Contribution of Astrocytes

Chen, Y., Jin, S., Yang, J., & Gao, T. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01024-x · Cited by 24

High spatial overlap but diverging age‐related trajectories of cortical magnetic resonance imaging markers aiming to represent intracortical myelin and microstructure

Parent, O., Olafson, E. R., Bussy, A., Tullo, S., Blostein, N., Dai, A., Salaciak, A., Bedford, S. A., Farzin, S., Béland, M., et al. (2023) · Human Brain Mapping · doi:10.1002/hbm.26259 · Cited by 18

Demyelination associated with chronic arsenic exposure in Wistar rats

Niño, S. A., Chi-Ahumada, É., Ortiz, J. J., Zarazúa, S., Concha, L., & Jiménez-Capdeville, M. E. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.114955 · Cited by 21

CNS Hypomyelination Disrupts Axonal Conduction and Behavior in Larval Zebrafish

Madden, M., Šuminaite, D., Ortiz, E. A., Early, J. J., Koudelka, S., Livesey, M. R., Bianco, I. H., Granato, M., & Lyons, D. A. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0842-21.2021 · Cited by 20

Seipin deficiency-induced lipid dysregulation leads to hypomyelination-associated cognitive deficits via compromising oligodendrocyte precursor cell differentiation

Cui, W., Yang, J., Tu, C., Zhang, Z., Zhao, H., Qiao, Y., Li, Y., Yang, W., Lim, K., Ma, Q., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06737-z · Cited by 22

Fear Deficits in HypomyelinatedTpppKnock-Out Mice

Nguyen, H., Meservey, L. M., Ishiko, N., Zhou, M., Huang, T., & Fu, M. (2020) · eNeuro · doi:10.1523/eneuro.0170-20.2020 · Cited by 20

Can oligodendrocyte precursor cells be a therapeutic target for mitigating cognitive decline in cerebrovascular disease?

Arai, K. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20929432 · Cited by 20

Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function

Della-Flora Nunes, G., Osso, L. A., Haynes, J. A., Conant, L., Thornton, M. A., Stockton, M. E., Brassell, K. A., Morris, A., Mancha Corchado, Y. I., Gaynes, J. A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56092-6 · Cited by 19

Anti‐LINGO‐1 antibody treatment alleviates cognitive deficits and promotes maturation of oligodendrocytes in the hippocampus of APP/PS1 mice

Yang, H., Jiang, L. H., Zhang, Y., Liang, X., Tang, J., He, Q., Luo, Y., Zhou, C., Zhu, L., Zhang, S., et al. (2022) · The Journal of Comparative Neurology · doi:10.1002/cne.25299 · Cited by 19

Pathogenesis from the microbial-gut-brain axis in white matter injury in preterm infants: A review

Wang, Y., Zhu, J., Zou, N., Zhang, L., Wang, Y., Zhang, M., Wang, C., & Yang, L. L. (2023) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2023.1051689 · Cited by 23

Insights on therapeutic potential of clemastine in neurological disorders

Jiang, S., Wang, X., Cao, T., Kang, R., & Huang, L. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1279985 · Cited by 20

Differential effect of dementia etiology on cortical stiffness as assessed by MR elastography

Pavuluri, K., Scott, J. M., Huston, J., Ehman, R. L., Manduca, A., Jack, C. R., Savica, R., Boeve, B. F., Kantarci, K., Petersen, R. C., et al. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103328 · Cited by 17

Insufficient Oligodendrocyte Turnover in Optic Nerve Contributes to Age-Related Axon Loss and Visual Deficits

Zhi, J.-J., Wu, S.-L., Wu, H., Ran, Q., Gao, X., Chen, J., Gu, X., Li, T., Wang, F., Xiao, L., et al. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.2130-22.2023 · Cited by 20

Long-term calorie restriction reduces oxidative DNA damage to oligodendroglia and promotes homeostatic microglia in the aging monkey brain

Vitantonio, A. T., Dimovasili, C., Mortazavi, F., Vaughan, K. L., Mattison, J. A., & Rosene, D. L. (2024) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2024.05.005 · Cited by 18

Clemastine-induced enhancement of hippocampal myelination alleviates memory impairment in mice with chronic pain

Zhu, T., Wang, H., Liu, P.-M., Gu, H., Pan, W., Zhao, M., Hashimoto, K., & Yang, J. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106375 · Cited by 17

Dynamics of myelin deficits in the 5xFAD mouse model for Alzheimer's disease and the protective role of BDNF

Zota, I., Chanoumidou, K., Charalampopoulos, I., & Gravanis, A. (2024) · Glia · doi:10.1002/glia.24505 · Cited by 17

Clemastine and metformin extend the window of NMDA receptor surface expression in ageing oligodendrocyte precursor cells

Kamen, Y., Evans, K. A., Sitnikov, S., Spitzer, S. O., de Faria, O., Yucel, M., & Káradóttir, R. T. (2024) · Scientific Reports · doi:10.1038/s41598-024-53615-x · Cited by 17

Spatial and temporal alterations of developing oligodendrocytes induced by repeated sevoflurane exposure in neonatal mice

Zhang, Z., Liu, H., Jia, S., Zhao, J., Wang, J., Liu, Y., Zhou, F., Li, Q., Li, Z., Dong, H., et al. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.11.105 · Cited by 16

Neuronal activation of Gαq EGL-30/GNAQ late in life rejuvenates cognition across species

Stevenson, M. E., Bieri, G., Kaletsky, R. L., Ange, J. S., Remesal, L., Pratt, K. J. B., Zhou, S., Weng, Y., Murphy, C. T., & Villeda, S. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113151 · Cited by 16

Fmrp regulates oligodendrocyte lineage cell specification and differentiation

Doll, C. A., Scott, K., & Appel, B. (2021) · Glia · doi:10.1002/glia.24041 · Cited by 15

Clinical Applications of Myelin Plasticity for Remyelinating Therapies in Multiple Sclerosis

Pan, S., & Chan, J. R. (2021) · Annals of Neurology · doi:10.1002/ana.26196 · Cited by 17

Oligodendrogenesis in Evolution, Development and Adulthood

Hu, H., Gao, T., Zhao, J., & Li, H. (2025) · Glia · doi:10.1002/glia.70033 · Cited by 16

Mesenchymal stem cell-derived exosomes–a promising therapeutic approach to improve neurocognitive disorders in chronic obstructive pulmonary disease

Xiao, H., Yu, X., Yushan, L., Jiang, W., Meng, X., Dong, Z., & Wang, F. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04457-5 · Cited by 17

Quantitative, structural and molecular changes in neuroglia of aging mammals: A review

Pannese, E. (2021) · European Journal of Histochemistry · doi:10.4081/ejh.2021.3249 · Cited by 16

Chronological versus immunological aging: Immune rejuvenation to arrest cognitive decline

Basurco, L., Abellanas, M. A., Purnapatre, M., Antonello, P., & Schwartz, M. (2024) · Neuron · doi:10.1016/j.neuron.2024.12.004 · Cited by 17

Resolving inflammatory links between myocardial infarction and vascular dementia

Thorp, E. B., Flanagan, M. E., Popko, B., & DeBerge, M. (2022) · Seminars in Immunology · doi:10.1016/j.smim.2022.101600 · Cited by 17

Antidepressant potential of total flavonoids from Astragalus in a chronic stress mouse model: Implications for myelination and Wnt/β-catenin/Olig2/Sox10 signaling axis modulation

Tao, Y., Yuan, J., Zhou, H., Li, Z., Yao, X., Wu, H., Shi, H., Huang, F., & Wu, X. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.117846 · Cited by 14

Not just neurons: The diverse cellular landscape of learning and memory

Alberini, C. M. (2025) · Neuron · doi:10.1016/j.neuron.2025.05.005 · Cited by 13

Long‐term demyelination and aging‐associated changes in mice corpus callosum; evidence for the role of accelerated aging in remyelination failure in a mouse model of multiple sclerosis

Parandavar, E., Shafizadeh, M., Ahmadian, S., & Javan, M. (2024) · Aging Cell · doi:10.1111/acel.14211 · Cited by 13

White Matter “Matters” in Alzheimer’s Disease

Xu, M., Xu, Z., & Wang, Y. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00803-8 · Cited by 14

Enhancing axonal myelination in seniors: A review exploring the potential impact cannabis has on myelination in the aged brain

Murray, C. J., Vecchiarelli, H. A., & Tremblay, M. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1119552 · Cited by 12

Transient regulation of focal adhesion via Tensin3 is required for nascent oligodendrocyte differentiation

Merour, E., Hmidan, H., Marie, C., Helou, P.-H., Lu, H., Potel, A., Huré, J.-B., Clavairoly, A., Shih, Y. P., Goudarzi, S., et al. (2022) · eLife · doi:10.7554/elife.80273 · Cited by 11

Unravelling the mechanotransduction pathways in Alzheimer’s disease

Donnaloja, F., Limonta, E., Mancosu, C., Morandi, F., Boeri, L., Albani, D., & Raimondi, M. T. (2023) · Journal of Biological Engineering · doi:10.1186/s13036-023-00336-w · Cited by 13

Inhibition of GPR17/ID2 Axis Improve Remyelination and Cognitive Recovery after SAH by Mediating OPC Differentiation in Rat Model

Wang, Y., Jiang, A., Yan, J., Wen, D., Gu, N., Li, Z., Sun, X., Wu, Y., & Guo, Z. (2023) · Translational Stroke Research · doi:10.1007/s12975-023-01201-0 · Cited by 13

Identification of the Potential Gene Regulatory Networks and Therapeutics in Aged Mice With Postoperative Neurocognitive Disorder

Wu, W., Peng, Y., Zhou, J., Zhang, X., Cao, L., Lin, W., Lu, Y., Wen, J., & Wang, Z. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.689188 · Cited by 12

Plasma proteomics in the UK Biobank reveals youthful brains and immune systems promote healthspan and longevityPreprint

Oh, H. S., Guen, Y. L., Rappoport, N., Urey, D. Y., Rutledge, J., Brunet, A., Greicius, M. D., & Wyss‐Coray, T. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.07.597771 · Cited by 12

TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration

Zhu, K., Liu, Y., Min, J.-H., Joshua, V., Lin, J., Li, Y., Kreutzmann, J. C., Guo, Y., Xia, W., Mohammadi, E., et al. (2026) · Nature Neuroscience · doi:10.1038/s41593-025-02161-4 · Cited by 11

6-shogaol improves the cognitive and memory declines of natural aging mice by modulating butyrate-producing microbiota and intestinal barrier

Zhu, H., Yang, D., Du, P., Qian, H., & Yang, Z. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157381 · Cited by 11

Immune–stem cell crosstalk in the central nervous system: how oligodendrocyte progenitor cells interact with immune cells

Cabeza‐Fernández, S., White, J. A., McMurran, C. E., Gomez-Sanchez, J. A., & de la Fuente, A. G. (2022) · Immunology and Cell Biology · doi:10.1111/imcb.12610 · Cited by 12

Minimum effective dose of clemastine in a mouse model of preterm white matter injury

Odell, E., Jabassini, N., Schniedewind, B., Pease-Raissi, S. E., Frymoyer, A. R., Christians, U., Green, A., Chan, J. R., & Ostrem, B. E. L. (2024) · Pediatric Research · doi:10.1038/s41390-024-03326-w · Cited by 11

Myelin-induced gain control in nonlinear neural networks

Lefebvre, J., Clappison, A. S., Longtin, A., & Hutt, A. (2025) · Communications Physics · doi:10.1038/s42005-025-02055-8 · Cited by 14

Adult brain cytogenesis in the context of mood disorders: From neurogenesis to the emergent role of gliogenesis

Martins‐Macedo, J., Salgado, A. J., Gomes, E. D., & Pinto, L. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.030 · Cited by 11

Electroacupuncture promotes remyelination and alleviates cognitive deficit via promoting OPC differentiation in a rat model of subarachnoid hemorrhage

Wang, Y., Yang, X., Cao, Y., Li, X., Xu, R. C., Yan, J., Guo, Z., Sun, S., Sun, X., & Wu, Y. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-01102-5 · Cited by 12

Biochemical Alterations in White Matter Tracts of the Aging Mouse Brain Revealed by FTIR Spectroscopy Imaging

Furber, K. L., Lacombe, R. J. S., Caine, S., Thangaraj, M. P., Read, S. T., Rosendahl, S. M., Bazinet, R. P., Popescu, B. F. G., & Nazarali, A. J. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03491-y · Cited by 11

Proliferation is a requirement for differentiation of oligodendrocyte progenitor cells during CNS remyelinationPreprint

Foerster, S., Neumann, B., McClain, C. R., Canio, L. D., Chen, C. Z.-Y., Reich, D. S., Simons, B. D., & Franklin, R. J. M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.21.108373 · Cited by 14

Enhancing axonal myelination: Clemastine attenuates cognitive impairment in a rat model of diffuse traumatic brain injury

Huang, Z., Feng, Y., Zhang, Y., Ma, X., Zong, X., Jordan, J. D., & Zhang, Q. (2024) · Translational research · doi:10.1016/j.trsl.2024.01.008 · Cited by 13

Skeletal phenotypes and molecular mechanisms in aging mice

Guan, Q., 上海体育大学运动健康学院, 上. 2., Zhang, Y., Wang, Z., Liu, X.-H., Zou, J., & Zhang, L.-L. (2024) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2023.397 · Cited by 13

Lingo1 in the hippocampus contributes to cognitive dysfunction after anesthesia and surgery in aged mice

Liu, C., Zhang, C., Chen, L., Liu, X., Wu, J., Sun, Y., Liu, J., & Chen, C. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.98376 · Cited by 10

Unveiling the impact of ferroptosis on diabetes‐associated cognitive decline through comprehensive single‐cell RNA sequencing and experimental studies

Zhang, Y., Hu, X., Chen, S., Hua, F., & Zeng, Z. (2025) · FEBS Journal · doi:10.1111/febs.70101 · Cited by 10

A Novel Cognitive Frailty Index for Geriatric Mice

Marcozzi, S., Bigossi, G., Giuliani, M. E., Lai, G., Bartozzi, B., Balietti, M., Casoli, T., Orlando, F., Amoroso, A., Giacconi, R., et al. (2025) · Aging Cell · doi:10.1111/acel.70056 · Cited by 10

Glial Cells and Aging: From the CNS to the Cerebellum

Sala, G. L., & Farini, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157553 · Cited by 12

C1ql1 expression in oligodendrocyte progenitor cells promotes oligodendrocyte differentiation

Altunay, Z. M., Biswas, J., Cheung, H. W., Pijewski, R. S., Papile, L. E., Akinlaja, Y. O., Tang, A., Kresic, L. C., Schouw, A. D., Ugrak, M. V., et al. (2024) · FEBS Journal · doi:10.1111/febs.17256 · Cited by 11

Dicer Deletion in Astrocytes Inhibits Oligodendroglial Differentiation and Myelination

Liu, K., Yu, B., Chen, J., Li, R., Chen, L., Ren, S.-Y., Wang, F., Mei, F., & Xiao, L. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00705-9 · Cited by 9

Spatial preferences account for inter-animal variability during the continual learning of a dynamic cognitive task

Kastner, D. B., Miller, E. A., Yang, Z., Roumis, D. K., Liu, D. F., Frank, L. M., & Dayan, P. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110708 · Cited by 9

Oligomeric amyloid beta prevents myelination in a clusterin-dependent mannerPreprint

Beiter, R. M., Ennerfelt, H. E., Rivet-Noor, C. R., Merchak, A. R., Bai, R., Johanson, D. M., Slogar, E. R., Sol‐Church, K., Phillips, J. L., Bathe, T., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.06.981373 · Cited by 11

Remyelination‐oriented clemastine treatment attenuates neuropathies of optic nerve and retina in glaucoma

Liu, K., Yang, Y., Wu, Z., Sun, C., Su, Y., Huang, N., Wu, H., Yi, C., Ye, J., Xiao, L., et al. (2024) · Glia · doi:10.1002/glia.24543 · Cited by 9

Nzf2 promotes oligodendrocyte differentiation and regeneration via repressing HDAC1-mediated histone deacetylation

Xu, X., Fang, M., Chen, L., Huang, H., Dai, Z., Yang, J., & Qiu, M. S. (2024) · Science Advances · doi:10.1126/sciadv.adf8405 · Cited by 9

The Many Lives of an Oligodendrocyte Precursor Cell

Buchanan, J., & Cheadle, L. (2025) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-112723-025806 · Cited by 11

Is age-related myelinodegenerative change an initial risk factor of neurodegenerative diseases?

Wu, S., & Chen, J. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00848 · Cited by 9

Deficient deposition of new myelin impairs adult optic nerve function in a murine model of diabetes

Wu, H., Chen, X., Yu, B., Zhang, J., Gu, X., Liu, W., Mei, F., Ye, J., & Xiao, L. (2023) · Glia · doi:10.1002/glia.24341 · Cited by 9

Brain region-specific myelinogenesis is not directly linked to amyloid-β in APP/PS1 transgenic mice

Wu, S.-L., Yu, B., Cheng, Y.-J., Ren, S.-Y., Wang, F., Xiao, L., Chen, J., & Mei, F. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114344 · Cited by 9

Myelin organoids for the study of Alzheimer's disease

Cerneckis, J., & Shi, Y. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1283742 · Cited by 9

miR-142-3p regulates cortical oligodendrocyte gene co-expression networks associated with tauopathy

Hinman, J. D., Ngo, K. J., Kim, D., Chen, C.-D., Abraham, C. R., Ghanbari, M., Ikram, M. A., Kushner, S. A., Kawaguchi, R., Coppola, G., et al. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa252 · Cited by 11

Latency structure of BOLD signals within white matter in resting-state fMRI

Guo, B., Zhou, F., Li, M., & Gore, J. C. (2022) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2021.12.010 · Cited by 9

Nalfurafine promotes myelination in vitro and facilitates recovery from cuprizone + rapamycin‐induced demyelination in mice

van de Wetering, R., Bibi, R., Biggerstaff, A., Hong, S., Pengelly, B., Prisinzano, T. E., Flamme, A. C. L., & Kivell, B. M. (2024) · Glia · doi:10.1002/glia.24583 · Cited by 8

KaiXinSan improves learning and memory impairment by regulating cholesterol homeostasis in mice overloaded with 27-OHC

Jing, R., Mu, L.-H., Wang, C., Liu, L., Wang, Y., Wang, Y., Li, X., Yin, H. J., & Hu, Y. (2024) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2024.106622 · Cited by 8

Seed-induced Aβ deposits in the corpus callosum disrupt white matter integrity in a mouse model of Alzheimer’s disease

Aires, V., Ziegler‐Waldkirch, S., Friesen, M., Reichardt, W., Erny, D., Loreth, D., Harborne, A. C., Kretz, O., von Elverfeldt, D., & Meyer‐Luehmann, M. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.862918 · Cited by 8

Hydrogen peroxide in breast milk is crucial for gut microbiota formation and myelin development in neonatal mice

Kambe, J., Usuda, K., Inoüe, R., Hirayama, K., Ito, M., Suenaga, K., Masukado, S., Liu, H., Miyata, S., Li, C., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2359729 · Cited by 8

Linking Plasma Amyloid Beta and Neurofilament Light Chain to Intracortical Myelin Content in Cognitively Normal Older Adults

Fernandez-Alvarez, M., Atienza, M., Zallo, F., Matute, C., Capetillo‐Zarate, E., & Cantero, J. L. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.896848 · Cited by 8

Demyelination in the medial prefrontal cortex by withdrawal from chronic nicotine causes impaired cognitive memory

Huang, B. Y., Chen, Z., Huang, F., Gao, F., Chen, J., Liu, P., Lu, Z., Chen, W., & Wu, J. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110901 · Cited by 7

Trajectory of changes in myelin basic protein levels in cerebrospinal fluid during ageing and its association with biomarkers of Alzheimer’s disease

Xu, M., Yi, X., Huang, S., Wang, Q.-H., Lai, Y., Wang, Z., Fan, D., Zeng, G., Bai, Y., Shen, Y., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03369-5 · Cited by 8

Plasticity of Myelination

Flower, G., Vorthmann, S., Fulton, D. J., & Hamilton, N. B. (2025) · Advances in neurobiology · doi:10.1007/978-3-031-87919-7_8 · Cited by 9

Synaptic and Myelin Plasticity and Their Synergistic Effects in Neuromorphic Networks

Li, X., Sun, J., Sun, Y., & Zhang, J. (2025) · IEEE Transactions on Circuits and Systems I Regular Papers · doi:10.1109/tcsi.2025.3577670 · Cited by 7

Ginsenoside Rb1 attenuates age-associated cognitive impairment by modulating oxidative stress and the SIRT1/eNOS/NO axis

Zhou, B., Wu, L., Liu, D., Xie, X., Zhang, X., Liu, Y., Hao, B., Shi, G., Yu, S., Zheng, Z., et al. (2025) · Journal of Ginseng Research · doi:10.1016/j.jgr.2025.06.002 · Cited by 7

Physiology of oligodendroglia

Butt, A. M., Niu, J., Yi, C., & Verkhratsky, A. (2026) · Physiological Reviews · doi:10.1152/physrev.00023.2025 · Cited by 7

Effects of adolescent alcohol exposure on oligodendrocyte lineage cells and myelination in mice: Age and subregion differences

Huang, D., Li, M., Qiao, Z., Zhou, H., Cai, Y., Li, X., Zhang, Z., & Zhou, J. (2024) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2024.06.006 · Cited by 7

Clemastine improves emotional and social deficits in adolescent social isolation mice by reversing demyelination

Guo, D., Yao, Y., Liu, X., & Han, Y. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173824 · Cited by 7

Hepatoma Derived Growth Factor Enhances Oligodendrocyte Genesis from Subventricular Zone Precursor Cells

Li, Y., Dittmann, N. L., Watson, A. E. S., de Almeida, M. M. A., Footz, T. K., & Voronova, A. (2022) · ASN NEURO · doi:10.1177/17590914221086340 · Cited by 8

Activity‐dependent alteration of early myelin ensheathment in a developing sensory circuit

Chorghay, Z., MacFarquhar, D., Li, V. J., Aufmkolk, S., Schohl, A., Wiseman, P. W., Káradóttir, R. T., & Ruthazer, E. S. (2021) · The Journal of Comparative Neurology · doi:10.1002/cne.25253 · Cited by 5

The Neurotrophic Receptor Tyrosine Kinase in MEC-mPFC Neurons Contributes to Remote Memory Consolidation

Hong, J., Jeong, Y., & Heo, W. D. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.2433-21.2022 · Cited by 8

Transient Upregulation of Procaspase-3 during Oligodendrocyte Fate Decisions

Kamen, Y., Chapman, T. W., Piedra, E. T., Ciolkowski, M. E., & Hill, R. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.2066-24.2025 · Cited by 6

Unlocking the Potential of l -α-Glycerylphosphorylcholine: From Metabolic Pathways to Therapeutic Applications

Che, X., Zhao, Y., Xu, Z., Hu, Y., Ren, A., Wu, C., & Yang, J. (2025) · Nutrition Reviews · doi:10.1093/nutrit/nuaf008 · Cited by 6

Aging compromises oligodendrocyte precursor cell maturation and efficient remyelination in the monkey brain

Dimovasili, C., Fair, A. E., Garza, I., Batterman, K. V., Mortazavi, F., Moore, T. L., & Rosene, D. L. (2022) · GeroScience · doi:10.1007/s11357-022-00621-4 · Cited by 74

Altered oligodendrocyte function promotes cognitive decline in aging

(2026) · Nature Medicine · doi:10.1038/s41591-026-04630-0

Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer’s disease

Chen, J.-F., Liu, K., Hu, B., Li, R.-R., Xin, W., Chen, H., Wang, F., Chen, L., Li, R.-X., Ren, S.-Y., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.05.012 · Cited by 346

Hippocampal expression of myelin‐associated inhibitors is induced with age‐related cognitive decline and correlates with deficits of spatial learning and memory

VanGuilder, H. D., Bixler, G. V., Sonntag, W. E., & Freeman, W. M. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07671.x · Cited by 49

Reduced Accumulation Rate and Morphological Changes of Newly Generated Myelinating Oligodendrocytes in the Corpus Callosum of Aged Mice

Looprasertkul, S., Yamazaki, R., Osanai, Y., & Ohno, N. (2025) · Glia · doi:10.1002/glia.70070 · Cited by 5