Cited by 348Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research StudiesMemory and Neural Mechanisms

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Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory

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Wang, Fei, Ren, Shu-Yu, Chen, Jing-Fei, Liu, Kun, Li, Rui-Xue, Li, Zhi-Fang, Hu, Bo, Niu, Jian-Qin, Xiao, Lan, Chan, Jonah R., Mei, Feng·2020·Nature Neuroscience

DOI 10.1038/s41593-020-0588-8PMC PMC7306053

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Abstract

Cognitive decline remains an unaddressed problem for the elderly. We show that myelination is highly active in young mice and greatly inhibited in aged mice, coinciding with spatial memory deficits. Inhibiting myelination by deletion of Olig2 in oligodendrocyte precursor cells impairs spatial memory in young mice, while enhancing myelination by deleting the muscarinic acetylcholine receptor 1 in oligodendrocyte precursor cells, or promoting oligodendroglial differentiation and myelination via clemastine treatment, rescues spatial memory decline during aging.

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Authors: Wang, F., Ren, S.-Y., Chen, J.-F., Liu, K., Li, R.-X., Li, Z.-F., Hu, B., Niu, J.-Q., Xiao, L., Chan, J. R., & Mei, F.
Affiliations: Army Medical University (CN)
University of California, San Francisco (US)
Corresponding author: Chan, Jonah R.
Mei, Feng
ORCID: Wang, Fei
Liu, Kun
Hu, Bo
Xiao, Lan
Chan, Jonah R.
Mei, Feng
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2020-02-10
Volume: 23
Issue: 4
Pages: 481-486
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/s41593-020-0588-8
PMC: PMC7306053
OpenAlex: W3005119588
Cited by: 348
References: 22
Citations by year: 2026: 51 · 2025: 58 · 2024: 53 · 2023: 44 · 2022: 59 · 2021: 57 · 2020: 24
FWCI: 18.13
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: Natural Science Foundation of Beijing Municipality (7172156)
Chongqing Science and Technology Commission (CSTCKJCXLJRC07)
U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R01NS062796, R01NS097428, R01NS095889)
Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (A130141)
National Natural Science Foundation of China (31771120)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: myelination, myelin degeneration, aging, spatial memory, cognitive decline, oligodendrocyte precursor cells, Olig2, clemastine, oligodendrocyte differentiation, myelin
MeSH terms: Oligodendrocyte Precursor Cells, Oligodendrocyte Transcription Factor 2, Aging, Animals, Demyelinating Diseases, Myelin Basic Protein, Memory Disorders, Mice, Transgenic, Myelin Sheath, Oligodendroglia, Mice

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Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory

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