Neuronal types in the mouse amygdala and their transcriptional response to fear conditioning
Open accessAbstract
The amygdala is a brain region primarily associated with emotional response. The use of genetic markers and single-cell transcriptomics can provide insights into behavior-associated cell state changes. Here we present a detailed cell-type taxonomy of the adult mouse amygdala during fear learning and memory consolidation. We perform single-cell RNA sequencing on naïve and fear-conditioned mice, identify 130 neuronal cell types and validate their spatial distributions. A subset of all neuronal types is transcriptionally responsive to fear learning and memory retrieval. The activated engram cells upregulate activity-response genes and coordinate the expression of genes associated with neurite outgrowth, synaptic signaling, plasticity and development. We identify known and previously undescribed candidate genes responsive to fear learning. Our molecular atlas may be used to generate hypotheses to unveil the neuron types and neural circuits regulating the emotional component of learning and memory.
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VIP+ GABAergic neurons have been identified within the MeA.
“though VIP+ GABAergic neurons have been identified within the MeA [73].”
From Rapid changes in plasma corticosterone and medial amygdala transcriptome profiles during social status change reveal molecular pathways associated with a major life history transition in mouse dominance hierarchies (2025) · cites this paper as [73]
The Results section, “Inhibitory cells mirror projection type and subregion” (page unavailable), identifies GABAergic populations in the MeA. Another Results section, “Two classes of glutamatergic neurons parcellate the amygdala” (page unavailable), identifies Vip-expressing GABAergic interneurons, but does not locate those cells within the MeA. The cited text therefore supports the cell type and the region separately, not their claimed overlap. (LLM, conf=0.82)
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Chromatin plasticity predetermines neuronal eligibility for memory trace formation
Santoni, G., Astori, S., Leleu, M., Glauser, L., Zamora, S. A., Schioppa, M., Tarulli, I., Sandi, C., & Gräff, J. (2024) · Science · doi:10.1126/science.adg9982 · Cited by 82 · see citing works
Chiaruttini, N., Castoldi, C., Requie, L. M., Camarena-Delgado, C., Bianco, B. D., Gräff, J., Seitz, A., & Silva, B. A. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115876 · Cited by 66 · see citing works
Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice
Lesuis, S. L., Park, S., Hoorn, A., Rashid, A. J., Mocle, A. J., Salter, E. W., Vislavski, S., Gray, M. T., Torelli, A. M., Cristofaro, A. D., et al. (2024) · Cell · doi:10.1016/j.cell.2024.10.034 · Cited by 72 · see citing works
A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution
Nardone, S., Luca, R. D., Zito, A., Klymko, N., Nicoloutsopoulos, D., Amsalem, O., Brannigan, C., Resch, J. M., Jacobs, C. L., Pant, D. B., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45907-7 · Cited by 64 · see citing works
Developmental origins and evolution of pallial cell types and structures in birds
Zaremba, B., Fallahshahroudi, A., Schneider, C., Schmidt, J., Sarropoulos, I., Leushkin, E. V., Berki, B., Poucke, E. V., Jensen, P., Senovilla-Ganzo, R., et al. (2025) · Science · doi:10.1126/science.adp5182 · Cited by 52 · see citing works
Psychedelic control of neuroimmune interactions governing fear
Chung, E. N., Lee, J., Polonio, C. M., Choi, J., Akl, C. F., Kilian, M., Weiß, W. M., Gunner, G., Ye, M., Heo, T. H., et al. (2025) · Nature · doi:10.1038/s41586-025-08880-9 · Cited by 33 · see citing works
An Honest Reckoning With the Amygdala and Mental Illness
Fox, A. S., & Shackman, A. J. (2024) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20240941 · Cited by 26 · see citing works
Transcriptomic and spatial organization of telencephalic GABAergic neurons
van Velthoven, C. T. J., Gao, Y., Kunst, M., Lee, C., McMillen, D., Chakka, A. B., Casper, T., Clark, M., Chakrabarty, R., Daniel, S. F., et al. (2025) · Nature · doi:10.1038/s41586-025-09296-1 · Cited by 30 · see citing works
Development and function of the medial amygdala
Prakash, N., Irqeba, A. A., & Corbin, J. G. (2024) · Trends in Neurosciences · doi:10.1016/j.tins.2024.11.004 · Cited by 22 · see citing works
Li, Y., Liu, X., Guo, L., Han, K., Fang, S., Wan, X., Wang, D., Xu, X., Jiang, L., Fan, G., et al. (2025) · Cell Systems · doi:10.1016/j.cels.2025.101243 · Cited by 19 · see citing works
Lim, H., Zhang, Y., Peters, C., Straub, T., Mayer, J. L., & Klein, R. (2024) · Nature Communications · doi:10.1038/s41467-024-50889-7 · Cited by 18 · see citing works
Temporal patterning of the vertebrate developing neural tube
Sagner, A. (2024) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2024.102179 · Cited by 17 · see citing works
Chen, J., Bai, Y., He, X., Xiao, W. L., Chen, L., Wong, Y., Wang, C., Gao, P., Cheng, G., Xu, L., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-52223-7 · Cited by 17 · see citing works
Río, J. P. D., Tsompanidis, A., Gaspar, P., Maturana, A., Rojas, G., Dagnino-Subiabre, A., Olea, A., Maliqueo, M., Echiburú, B., de Guevara, A. L., et al. (2025) · Frontiers in neuroendocrinology (Print) · doi:10.1016/j.yfrne.2025.101188 · Cited by 14 · see citing works
Integrating reproductive states and social cues in the control of sociosexual behaviors
Wang, Y., Song, X., Chen, X., Zhou, Y., Ma, J., Zhang, F., Wei, L., Qi, G., Yadav, N., Miao, B., et al. (2025) · Cell · doi:10.1016/j.cell.2025.04.035 · Cited by 14 · see citing works
Molecular diversity and functional dynamics in the central amygdala
Yeh, L.-F., Zuo, S., & Liu, P.-W. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1364268 · Cited by 13 · see citing works
Integration of Glucagon-Like Peptide 1 Receptor Actions Through the Central Amygdala
Duran, M., Willis, J. R., Dalvi, N., Fokakis, Z. N., VIRKUS, S., & Hardaway, J. A. (2025) · Endocrinology · doi:10.1210/endocr/bqaf019 · Cited by 13 · see citing works
Munguba, H., Srivastava, I., Gutzeit, V. A., Singh, A., Vijay, A., Kristt, M., Arefin, A., Thukral, S., Broichhagen, J., Stujenske, J. M., et al. (2024) · Neuron · doi:10.1016/j.neuron.2025.01.002 · Cited by 12 · see citing works
A molecularly defined mPFC-BLA circuit specifically regulates social novelty preference
Liu, Y., Wang, Y., Xie, G., Yang, Q., Bhattacherjee, A., Zhang, C., & Zhang, Y. (2025) · Science Advances · doi:10.1126/sciadv.adt9008 · Cited by 12 · see citing works
Zhang, B., Ling, X., Shen, Q., Zhang, Y., Li, Q., Xie, S., Li, H., Zhang, Q., Yung, W., Wang, J., et al. (2024) · The Journal of Physiology · doi:10.1113/jp286392 · Cited by 11 · see citing works
Barbier, M., Rajamani, K. T., Netser, S., Wagner, S., & Harony‐Nicolas, H. (2025) · Advanced Science · doi:10.1002/advs.202414813 · Cited by 12 · see citing works
Self-citationRegional and aging-specific cellular architecture of non-human primate brains
Wang, Y.-M., Wang, W., Pan, Y., Zeng, L., Wu, J., Wang, Z., Zhuang, X.-L., Li, M., Cooper, D. N., Wang, S., et al. (2025) · Genome Medicine · doi:10.1186/s13073-025-01469-x · Cited by 10 · see citing works
Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates
Totty, M. S., Cervera‐Juanes, R. P., Bach, S. V., Ameur, L. B., Valentine, M. R., Simons, E. A., Romac, M. D., Trinh, H., Henderson, K., Rosario, I. D., et al. (2025) · Science Advances · doi:10.1126/sciadv.adw1029 · Cited by 11 · see citing works
Identification of a stress-responsive subregion of the basolateral amygdala in male rats
Aukema, R. J., Petrie, G. N., Matarasso, A. K., Baglot, S. L., Molina, L. A., Füzesi, T., Kadhim, S., Nastase, A. S., Reyes, I. R., Bains, J. S., et al. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01927-x · Cited by 10 · see citing works
Phalip, A., Netser, S., & Wagner, S. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105856 · Cited by 11 · see citing works
Self-citationSpatial Transcriptomics: Biotechnologies, Computational Tools, and Neuroscience Applications
Wang, Q., Zhu, H., Deng, L., Xu, S., Xie, W., Li, M., Wang, R., Tie, L., Zhan, L., & Yu, G. (2025) · Small Methods · doi:10.1002/smtd.202401107 · Cited by 12 · see citing works
Integrating Aversive Memories in the Basolateral Amygdala
Liu, J., Totty, M. S., Bayer, H., & Maren, S. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.03.019 · Cited by 10 · see citing works
A nociceptive amygdala-striatal pathway for chronic pain aversionPreprint
Wojick, J. A., Paranjapye, A., Chiu, J. K., Mahmood, M., Oswell, C. S., Kimmey, B. A., Wooldridge, L. M., McCall, N. M., Han, A., Ejoh, L. L., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.12.579947 · Cited by 10 · see citing works
A nociceptive amygdala-striatal pathway modulating affective-motivational pain
Wojick, J. A., Paranjapye, A., Chiu, J. K., Oswell, C. S., Mahmood, M., Wooldridge, L. M., Kimmey, B. A., Ortega, R. A. S., McCall, N. M., Han, S., et al. (2025) · Science Advances · doi:10.1126/sciadv.ado2837 · Cited by 9 · see citing works
Liu, X.-T., Huang, C., Wang, M.-Y., Hu, L.-G., Song, Y., & Jiang, G.-B. (2025) · Environmental Science and Technology · doi:10.1021/acs.est.5c00613 · Cited by 10 · see citing works
Neurotransmitters in Neural Circuits and Neurological Diseases
Gholami, A., & Mortezaee, K. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00426 · Cited by 8 · see citing works
Kamboj, S., Carlson, E. L., Ander, B. P., Hanson, K. L., Murray, K. D., Fudge, J. L., Bauman, M. D., Schumann, C. M., & Fox, A. S. (2024) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20230602 · Cited by 8 · see citing works
Milewski, T. M., Lee, W., Young, R. L., Hofmann, H. A., & Curley, J. P. (2025) · PLoS Genetics · doi:10.1371/journal.pgen.1011548 · Cited by 7 · see citing works
Arai, M., Osanai, H., Snell, C. C., Gawf, K. E., 北村, 貴., & Ogawa, S. K. (2025) · Hippocampus · doi:10.1002/hipo.70030 · Cited by 7 · see citing works
Ma, H., Zhang, Y., Guo, X., Zhao, Q., Yang, P., Liu, Y., Guan, Y., Wei, Y., & Ma, H. (2026) · Journal of Clinical Investigation · doi:10.1172/jci195536 · Cited by 7 · see citing works
Matsumoto, Y., Miwa, H., Katayama, K., Watanabe, A., Yamada, K., Ito, T., Nakagawa, S., & Aruga, J. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1386924 · Cited by 7 · see citing works
Lei, M., Zhang, R., Wang, L., Zhang, Y., Li, K., Li, Y., Sang, Y., Dong, B., Zhou, H., Liu, H., et al. (2025) · ACS Nano · doi:10.1021/acsnano.5c10725 · Cited by 6 · see citing works
Control of innate olfactory valence by segregated cortical amygdala circuitsPreprint
Howe, J. R., Chan, C.-L., Lee, D., Blanquart, M., Lee, J. H., Decoster, L., Romero, H. K., Zadina, A. N., Lemieux, M., Mills, F., et al. (2025) · eLife · doi:10.7554/elife.104677 · Cited by 6 · see citing works
Neuronal physiology of amygdala neurons in the context of injury and pain
Paul, B. K., Nunez-Ordaz, M. I., Samuel, J. R., & Kolber, B. J. (2025) · Neurobiology of Pain · doi:10.1016/j.ynpai.2025.100190 · Cited by 5 · see citing works
Heterogeneous plasticity of amygdala interneurons in associative learning and extinction
Favila, N., Marsico, J. C., Pacheco, C. M., Kenet, S., Escribano, B., Bitterman, Y., Gründemann, J., Lüthi, A., & Krabbe, S. (2025) · Nature Communications · doi:10.1038/s41467-025-66122-y · Cited by 5 · see citing works
Anderson, J. Q., Darakjian, P., HITZEMANN, R. J., Cervera‐Juanes, R. P., Zimmerman, K. D., Reed, C. L., Lockwood, D. R., Ozburn, A. R., & Phillips, T. J. (2025) · Addiction Neuroscience · doi:10.1016/j.addicn.2025.100209 · Cited by 4 · see citing works
Dwortz, M. F., & Curley, J. P. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.05.025 · Cited by 4 · see citing works
Neuropeptide Y co-opts neuronal ensembles for memory lability and stability
Wu, Y., Gu, X., Kong, Y., Yang, S., Wang, H., Xu, M., Wang, Q., Yi, X., Lin, Z.-J., Jiao, Z.-H., et al. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02235-x · Cited by 4 · see citing works
Self-citationChen, S., Xing, L., Xie, Z., Zhao, M., Yu, H., Gan, J., Zhao, H., Ma, Z., & Li, H. (2024) · iScience · doi:10.1016/j.isci.2024.109880 · Cited by 4 · see citing works
Penker, S., Lawabny, N., Dhamshy, A., Licht, T., & Rokni, D. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.2420-23.2024 · Cited by 4 · see citing works
Zhao, D., Zhang, L., & Yang, Y. (2024) · Neurobiology of Stress · doi:10.1016/j.ynstr.2024.100688 · Cited by 4 · see citing works
Shu, H., Ziolkowski, L. H., Salvatore, S. V., Benz, A. M., Wozniak, D. F., Yuede, C. M., Paul, S. M., Zorumski, C. F., & Mennerick, S. J. (2024) · Biomolecules · doi:10.3390/biom14030254 · Cited by 4 · see citing works
Sniffen, S. E., Ryu, S. E., Kokoska, M. M., Bhattarai, J. P., Wang, Y., Thomas, E. R., Skates, G. M., Johnson, N. L., Chavez, A. A., Iaconis, S. R., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03075-0 · Cited by 4 · see citing works
Transcriptomic Analysis Corroborates the New Radial Model of the Mouse Pallial Amygdala
Fernández, G., López-González, L., Pons-Fuster, E., Puelles, L., & Garcı́a-Calero, E. (2025) · Biomolecules · doi:10.3390/biom15081160 · Cited by 3 · see citing works
Ueda, S., Kakita, M., Hosokawa, M., Arikawa, K., Takahashi, K., Shiota, R., Kakeyama, M., Matsunaga, H., Takeyama, H., & Takemoto‐Kimura, S. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1659846 · Cited by 2 · see citing works
Amygdala AVPR1A mediates susceptibility to chronic social isolation in female mice
François, M., Vranich, K. A., Delgado, I. C., Lafond, A., Lopatinsky, N. R., Davis, T., Lewis, E. M., Kuromaru, M., Hassouna, R., Williams, B. L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-64742-y · Cited by 10 · see citing works
Neurovascular coupling in the basolateral amygdala modulates negative emotions
Ruan, J., Quan, X., Xie, H., Zhang, Y., Zhang, D., Wang, W., Zhao, B., Lu, D., Niu, Y., Diao, M., et al. (2026) · Cell Research · doi:10.1038/s41422-026-01256-2 · Cited by 3 · see citing works
Zeballos, L., García-Peral, C., Ledesma, M. M., Auzmendi, J., Lazarowski, A., & López, D. E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052331 · Cited by 3 · see citing works
Brain-wide monosynaptic single-neuron connectivity with ROInet-seqPreprint
Lin, Z., Ophir, O., Trimbuch, T., Brokowski, B., Tibi, M., Schmidt, H., Rosenmund, C., Hochgerner, H., & Zeisel, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.04.588058 · Cited by 3 · see citing works
Self-citationControl of Innate Olfactory Valence by Segregated Cortical Amygdala CircuitsPreprint
Howe, J., Chan, C. L., Lee, D., Blanquart, M., Romero, H. K., Zadina, A. N., Lemieux, M., Mills, F., Desplats, P., Tye, K. M., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4884646 · Cited by 3 · see citing works
Spatial transcriptomics reveals brain-wide circadian disruption in an Alzheimer’s disease modelPreprint
Gelber, A., Romero, H. K., Burrows, D. R. W., Whittaker, D. S., Carlin, D. E., Mukamel, E. A., & Desplats, P. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.26.701799 · Cited by 3 · see citing works
Marquardt, A. E., Basu, M., VanRyzin, J. W., Ament, S. A., & McCarthy, M. M. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115782 · Cited by 2 · see citing works
Wang, D., Li, J., Li, H., Zhao, G., Wu, H., Zhang, X., Wang, Y., Wang, S., Li, B., Li, H., et al. (2025) · British Journal of Anaesthesia · doi:10.1016/j.bja.2025.07.097 · Cited by 2 · see citing works
Zhang, X., Mo, X., Zhou, X., Liu, X., Li, G., Songhui, H., Lu, Y., Zhu, C., Feng, J., Chen, Z., et al. (2026) · Advanced Science · doi:10.1002/advs.202517585 · Cited by 2 · see citing works
Control of innate olfactory valence by segregated cortical amygdala circuits
Howe, J. R., Chan, C.-L., Lee, D., Blanquart, M., Lee, J. H., Decoster, L., Romero, H. K., Zadina, A. N., Lemieux, M., Mills, F., et al. (2026) · eLife · doi:10.1101/2024.06.26.600895 · Cited by 2 · see citing works
Sniffen, S. E., Ryu, S. E., Kokoska, M. M., Bhattarai, J. P., Wang, Y.-Q., Thomas, E. R., Skates, G. M., Johnson, N. L., Chavez, A. A., Iaconis, S. R., et al. (2024) · bioRxiv · doi:10.1101/2024.06.19.599749 · Cited by 1 · see citing works
Bijoch, Ł., Szczypkowski, P., Wiśniewska, J., Pawłowska, M., Hajdukiewicz, K., Łapkiewicz, R., & Beroun, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.07.622413 · Cited by 2 · see citing works
Second-order threat conditioning in the amygdala-posterior piriform cortex network
Sepahvand, T., Qin, T., Hasan, Z., Power, K. D., Carew, S. J., Nazari, N., Janes, A. M., Salman, A., Xia, Y., Benoukraf, T., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-08287-2 · Cited by 1 · see citing works
Satake, S., Yokota, S., & Ikeda, K. (2025) · Journal of Neurophysiology · doi:10.1152/jn.00157.2025 · Cited by 1 · see citing works
Bijoch, Ł., Wiśniewska, J., & Beroun, A. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70292 · Cited by 1 · see citing works
Chen, J., Chen, T., Zhu, X., Dai, X., Fang, Z., Sun, Y., Zhao, Q., Zheng, B., Xu, S., Wang, Y., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-09204-3 · Cited by 1 · see citing works
Proce, R. O., Steinecker, M., Giacomelli, C., Uddstrom, E., Chatterjee, A., Wusthoff, S., Alves, L. G. T., Popp, O., Pohl, T. T., Maxwell, K., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03483-w · Cited by 1 · see citing works
You, Y., Lv, C.-T., Ni, P.-T., Wang, S.-J., Liu, L., Song, Y.-T., Hui, Z., Huang, Y., Liu, Y., Tong, K., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117281 · Cited by 1 · see citing works
Factors influencing the development of canine fear of thunder
Okamoto, K., Inoue, K., Kawai, J., Yamauchi, H., Hisamoto, S., Nishisue, K., Koyama, S., Satoh, T., Tsushima, M., & Irimajiri, M. (2024) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2023.106139 · Cited by 1 · see citing works
ZFHX3 plays a role in pain and cautious-like behaviours in micePreprint
Nolan, P. M., Gettings, S. M., Hillier, R., & Bourbia, N. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.18.599525 · Cited by 1 · see citing works
Wang, Y., Song, X., Chen, X., Zhou, Y., Ma, J., Zhang, F., Wei, L., Qi, G., Yadav, N., Miao, B., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.30.610466 · Cited by 1 · see citing works
Central Amygdala Neuronal Ensembles Coordinate Visceral Pain and Its Affective BehaviorsPreprint
Samineni, V. K., Sackey, J. N., Li, J., Yang, L., Chamessian, A. G., Sewell, S. B., Hahm, H., Zhang, Y., Zhang, B., & Gereau, R. W. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.21.666026 · Cited by 1 · see citing works
Control of innate olfactory valence by segregated cortical amygdala circuitsPreprint
Howe, J. R., Chan, C.-L., Lee, D., Blanquart, M., Lee, J. H., Decoster, L., Romero, H. K., Zadina, A. N., Lemieux, M., Mills, F., et al. (2026) · eLife · doi:10.7554/elife.104677.2 · Cited by 1 · see citing works
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Lamprecht, R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15754-7.00072-9
Yu, J., Farjami, S., Nechyporenko, K., Li, X. F., Yaseen, H., Lin, Y., Ye, J., Hollings, O., de Burgh, R., Singh, B., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.06.631361
Control of innate olfactory valence by segregated cortical amygdala circuitsPreprint
Howe, J. R., Chan, C.-L., Lee, D., Blanquart, M., Lee, J. H., Romero, H. K., Zadina, A. N., Lemieux, M., Mills, F., Desplats, P., et al. (2025) · eLife · doi:10.7554/elife.104677.1
Rubin, A. L., & Walth, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.20.633839 · Cited by 1 · see citing works
Zhang, F., Huang, K., Liu, Z., Liu, X., Zhao, Q., Li, X., Wei, W., & Li, X. (2025) · medRxiv · doi:10.1101/2025.07.28.25332052
mWAKE in the Central Amygdala Regulates Fear Learning and Memory
Xiong, J., Mehta, A., Liu, Q., Luo, A. X., Li, P. P., Janak, P. H., & Wu, M. N. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.0225-25.2025
Negwer, M., van der Werf, I., Oudakker, A. R., van Bokhoven, H., Schubert, D., & Kasri, N. N. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.15.676416
Single-cell long-read sequencing of the experience-induced transcriptomePreprint
Cavalier, S., Hook, P. W., Huganir, R. L., & Timp, W. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.12.674885
Non-overlapping social and food reward representations in the basolateral amygdalaPreprint
Javier, J. L., Balasubramanian, H., Isaac, J., Young, L. J., & Murugan, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.06.680770
Noradrenergic Modulation of an Amygdalo-thalamic CircuitPreprint
Yang, T. L., Bucalo, J., Andermann, M. L., & Chen, C. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.14.682083
Dwortz, M. F., Hofmann, H. A., & Curley, J. P. (2026) · Scientific Reports · doi:10.1038/s41598-026-52921-w
Zhang, Y., Cao, D., Cui, J., Yan, X., Zhang, X., Dang, Y., Zhao, H., Li, J., & Zhang, J. (2026) · Research Square · doi:10.21203/rs.3.rs-7986579/v1
A sexually dimorphic neuronal cluster in the mouse medial amygdala responds to male sexual status
Licht, T., Akarieh, A., Dhamshy, A., Zeisel, A., Ophir, O., & Rokni, D. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2518703123
Self-citationQiu, Q., Zhang, H., Xia, Z., Gao, W. N. D., Leu, J., Liang, D., Li, Y., Su, Y., Feierman, E. R., Horn, V., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.29.702431
Cao, D., Cui, J., Yan, X., Zhang, X., Dang, Y., Zhao, H., Li, J., Zhang, J., & Zhang, Y. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.16.688165
The role of amygdala GABA neurons in controlling stress and reproduction in female mice
Yu, J., Farjami, S., Nechyporenko, K., Li, X. F., Yaseen, H., Lin, Y., Ye, J., Hollings, O., de Burgh, R., Singh, B., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-70364-9
Aversive and reward circuits in itch processing
Pavlenko, D., & Akiyama, T. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-34172-4.00013-6
The Unexplored Role of Noncoding Regulatory RNAs in Engram Dynamics
Nanda, P., & Schratt, G. M. (2026) · The Neuroscientist · doi:10.1177/10738584261425960
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Self-citationLi, J., Lv, H., Jiang, F., & Yu, B. (2026) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2026.109112
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Walters, B., Garg, S., & Fernandez, D. C. (2026) · Journal of Biological Rhythms · doi:10.1177/07487304261448254
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- Authors
- Hochgerner, H., Singh, S., Tibi, M., Lin, Z., Skarbianskis, N., Admati, I., Ophir, O., Reinhardt, N., Netser, S., Wagner, S., & Zeisel, A.
- Affiliations
- Technion – Israel Institute of Technology (IL)
- University of Haifa (IL)
- Corresponding author
- Zeisel, Amit
- Venue
- Nature Neuroscience
- Published
- 2023-10-26
- Volume
- 26
- Issue
- 12
- Pages
- 2237-2249
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC10689239
- OpenAlex
- W4387965083
- Cited by
- 110
- References
- 78
- Citations by year
- 2026: 34 · 2025: 48 · 2024: 27 · 2023: 1
- FWCI
- 16.47
- Type
- journal article
- Language
- en
- Update notices
- correction (2024-01-19)
- Open access
- hybrid
- doi.org
- Locations
- Nature Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Israel Science Foundation (2028912)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- amygdala, neuronal cell types, fear conditioning, fear memory consolidation, memory retrieval, engram cells, single-cell transcriptomics, molecular atlas, synaptic plasticity, neurite outgrowth
- MeSH terms
- Amygdala, Animals, Fear, Memory, Neuronal Plasticity, Neurons, Mice
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