Conserved genetic signatures parcellate cardinal spinal neuron classes into local and projection subsets
Open accessAbstract
Neuronal identities: Neurons of the mouse spinal cord can be identified by any of several metrics, including what neurotransmitters they use, what cells they connect to, where they are located, and what neuroprogenitor gave rise to them. Osseward et al. generated a different metric, genetic signatures, and identified classes of local and projection neurons that were otherwise heterogeneous by other classification systems. With this focus on a cell's genetic signature, its neurotransmitter phenotype, which is accessible by a variety of transcriptional routes, can be seen as a parallel to convergent evolution in development. Science , this issue p. 385
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Ventral neuron cell types may be organized at a second, nested level of spatial trends that overlay embryonic lineage-defined cell types: a Pou6f2-Esrrg trend along the dorsal-ventral axis and a Nfib-Zfhx3/4 and birthdate trends along the medial-lateral axis.
“Ventral neuron cell types may be organized at a second, nested level of spatial trends that overlay embryonic lineage-defined cell types: a Pou6f2-Esrrg trend along the dorsal-ventral axis and a Nfib-Zfhx3/4 and birthdate trends along the medial-lateral axis, consistent with a recent report108.”
From A harmonized atlas of mouse spinal cord cell types and their spatial organization (2021) · cites this paper as [108]
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- Authors
- Osseward, P. J., Amin, N. D., Moore, J. D., Temple, B. A., Barriga, B. K., Bachmann, L. C., Beltran, F., Gullo, M., Clark, R. C., Driscoll, S. P., Pfaff, S. L., & Hayashi, M.
- Affiliations
- Salk Institute for Biological Studies (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Osseward, Peter J.
- Pfaff, Samuel L.
- Hayashi, Marito
- ORCID
- Venue
- Science
- Published
- 2021-04-23
- Volume
- 372
- Issue
- 6540
- Pages
- 385-393
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC8612134
- OpenAlex
- W3156624423
- Cited by
- 115
- References
- 51
- Citations by year
- 2026: 20 · 2025: 23 · 2024: 22 · 2023: 24 · 2022: 14 · 2021: 12
- FWCI
- 6.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1 U19 NS112959-01)
- Howard Hughes Medical Institute
- National Eye Institute
- Christopher and Dana Reeve Foundation
- National Cancer Institute, Cairo University (P30 014195, NINDS R24 C)
- the Sol Goldman Charitable Trust
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Keywords
- spinal cord, neuron classification, excitatory and inhibitory neurons, gene expression signatures
- MeSH terms
- RNA-Seq, Animals, Female, Male, Motor Neurons, Neural Pathways, Neurons, Proprioception, Sensory Receptor Cells, Spinal Cord, Transcription Factors, Mice, Single-Cell Analysis, Transcriptome, Spatial Analysis, Cervical Cord
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