Cited by 218Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorNeurobiology and Insect Physiology Research

Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons

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Kim, Jae-Ick, Ganesan, Subhashree, Luo, Sarah X., Wu, Yu-Wei, Park, Esther, Huang, Eric J., Chen, Lu, Ding, Jun B.·2015·Science

Abstract

An alternative way of making GABA: Midbrain dopaminergic neurons release both the inhibitory neurotransmitter GABA and dopamine. In the central nervous system, GABA synthesis is usually mediated by two glutamate decarboxylases (GAD65 and GAD67). Kim et al. found that midbrain dopaminergic neurons use a different, evolutionary conserved GABA synthesis pathway that is independent of GAD65 and GAD67. These cells synthesize GABA from putrescine via the enzymes diamine oxidase and aldehyde dehydrogenase 1a1. GABA synthesized by this pathway accounts for approximately 70% of co-released GABA. Science , this issue p. 102

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Authors
Kim, J.-I., Ganesan, S., Luo, S. X., Wu, Y.-W., Park, E., Huang, E. J., Chen, L., & Ding, J. B.
Affiliations
  • Stanford Medicine (US)
  • University of California, San Francisco (US)
  • San Francisco VA Medical Center (US)
Corresponding author
Ding, Jun B.
Venue
Science
Published
2015-10-02
Volume
350
Issue
6256
Pages
102-106
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2201272991
Cited by
217
References
50
Citations by year
2026: 15 · 2025: 15 · 2024: 19 · 2023: 22 · 2022: 17 · 2021: 21 · 2020: 28 · 2019: 20 · 2018: 9 · 2017: 23 · 2016: 26 · 2015: 2
FWCI
9.33
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
  • Scholarworks@UNIST (Ulsan National Institute of Science and Technology) (submittedVersion)
Funders
  • NIH (NS075136, NS091144, MH086403, MH091193)
  • National Institute of Mental Health
  • National Institute of Neurological Disorders and Stroke
  • Klingenstein Foundation
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords
ALDH1A1, midbrain dopaminergic neurons, glutamic acid decarboxylase, ethanol, binge drinking, alcohol preference, alcohol consumption, addiction, basal ganglia
MeSH terms
Aldehyde Dehydrogenase 1 Family, Ethanol, Aldehyde Dehydrogenase, Animals, Female, gamma-Aminobutyric Acid, Male, Mesencephalon, Reward, Sequence Deletion, Evolution, Molecular, Retinal Dehydrogenase, Mice, Metabolic Networks and Pathways, Gene Knockdown Techniques, Dopaminergic Neurons, Binge Drinking

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