Meaningful silences: how dopamine listens to the ACh pause

Cragg, Stephanie J.

doi:10.1016/j.tins.2006.01.003

Cited by 245Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Meaningful silences: how dopamine listens to the ACh pause

Cragg, Stephanie J.·2006·Trends in Neurosciences

DOI 10.1016/j.tins.2006.01.003

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Abstract

Mesostriatal dopaminergic neurons (DANs) and striatal cholinergic neurons (tonically active neurons, TANs) participate in signalling the behavioural or reward-related significance of stimuli in the environment. An antagonistic balance between dopamine (DA) and ACh is well known to regulate postsynaptic signal integration in the striatum. Recent findings have revealed additional presynaptic ACh-DA interactions of previously unappreciated sophistication. Striatal ACh acts presynaptically to polarize powerfully how opposing DAN activities are transduced into DA release. Furthermore, characteristic reward-related activities of TANs and DANs are temporally coincident but differently variant with reward probability. Reward-related DA signals could therefore be governed by the concomitant activity in TANs. This article discusses the dynamic implications for DA signalling when these phenomena act in concert. TAN pauses might powerfully enhance the contrast, or salience, of DA signals offered by reward-related bursts, and even by reward omission-related pauses, in DANs. Through such mechanisms, TAN-DAN interactions would be functionally cooperative.

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Authors: Cragg, S. J.
Affiliations: University of Oxford (GB)
Corresponding author: Cragg, Stephanie J.
ORCID: Cragg, Stephanie J.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2006-03
Volume: 29
Issue: 3
Pages: 125-131
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2006.01.003
OpenAlex: W2112338700
Cited by: 245
References: 73
Citations by year: 2026: 7 · 2025: 15 · 2024: 20 · 2023: 6 · 2022: 9 · 2021: 8 · 2020: 9 · 2019: 7 · 2018: 11 · 2017: 13 · 2016: 15 · 2015: 10 · 2014: 17 · 2013: 4 · 2012: 12
FWCI: 1.61
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: dopamine, acetylcholine, striatal cholinergic neurons, cholinergic interneurons, striatum, dopamine release, signal integration, reward probability, reward omission, salience
MeSH terms: Acetylcholine, Animals, Cholinergic Fibers, Dopamine, Humans, Learning, Neural Inhibition, Synaptic Transmission, Neurons, Perception, Reward, Signal Transduction, Neostriatum, Presynaptic Terminals

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