Stress Granules Contain Rbfox2 with Cell Cycle-related mRNAs
Open accessAbstract
Rbfox RNA-binding proteins play important roles in the regulation of alternative pre-mRNA splicing, but their role in other gene regulatory mechanisms is not well understood. Here, we show that Rbfox2 is a novel constituent of cytoplasmic stress granules, the translational silencing machinery assembled in response to cellular stress. We also show that the RNA binding activity of the Rbfox family protein is crucial for its localization into stress granules. To investigate the role of Rbfox2 in stress granules we used RNA-immunoprecipitation sequencing to identify cytoplasmic transcriptome-wide targets of Rbfox2. We report that a subset of cell cycle-related genes including retinoblastoma 1 is the target of Rbfox2 in cytoplasmic stress granules, and Rbfox2 regulates the retinoblastoma 1 mRNA and protein expression levels during and following stress exposure. Our study proposes a novel function for Rbfox2 in cytoplasmic stress granules.
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Both LGD and LPT are crucial components of the visual system and have dense reciprocal connections with visual cortex, but have radically different physiology and functions, and only the LGD has high numbers of GABAergic interneurons.
“Both nuclei are crucial components of the visual system and have dense reciprocal connections with visual cortex, but these nuclei have radically different physiology and functions, and only the LGD has high numbers of GABAergic interneurons52.”
From Magnetic resonance microscopy maps widespread effects of Alzheimer’s disease on brain structures and behavior in mice (2026) · cites this paper as [52]
The Introduction and Discussion passages concern Rbfox proteins and stress granules, not the visual nuclei described in the claim. Searches for LGD, LPT, reciprocal visual-cortex connections, and GABAergic interneurons found no passage addressing those points. No page numbers were available in our copy. (LLM, conf=0.78)
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- Authors
- Park, C., Choi, S., Kim, Y.-E., Lee, S., Park, S.-H., Adelstein, R. S., Kawamoto, S., & Kim, K. K.
- Affiliations
- Chonnam National University (KR)
- Chungnam National University (KR)
- Korea Advanced Institute of Science and Technology (KR)
- National Institutes of Health (US)
- Corresponding author
- Kawamoto, Sachiyo
- Kim, Kee K.
- Venue
- Scientific Reports
- Published
- 2017-09-11
- Volume
- 7
- Issue
- 1
- Pages
- 11211-11211
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5593835
- OpenAlex
- W2751991639
- Cited by
- 49
- References
- 43
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 11 · 2023: 8 · 2022: 5 · 2021: 7 · 2020: 5 · 2019: 4 · 2018: 1
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Research Foundation
- Chungnam National University
- National Research Foundation of Korea (NRF-2015R1C1A1A02036324)
- National Institutes of Health
- National Heart, Lung, and Blood Institute (Z01HL004236)
- NHLBI Division of Intramural Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
- Keywords
- RBFOX2, stress granules, RNA-binding proteins, translational silencing, cell cycle genes, retinoblastoma 1, RBX1, RNA-binding activity, mRNA regulation, cellular stress response
- MeSH terms
- RNA Splicing Factors, Cell Cycle, Cytoplasmic Granules, HeLa Cells, Humans, Protein Binding, Repressor Proteins, RNA, Messenger, Sequence Analysis, RNA, Gene Expression Profiling, Ubiquitin-Protein Ligases, Immunoprecipitation, Retinoblastoma Binding Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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